Entry
Name
NEK6-subfamily protein kinase;
NEK6;
NEK7;
nekl-3
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Reaction(IUBMB)
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Substrate
ATP [CPD:
C00002 ];
[protein]-(L-serine/L-threonine)
Product
ADP [CPD:
C00008 ];
[protein]-(L-serine/L-threonine) phosphate
Comment
Requires Mg2+. NEK6 subfamily kinases are present in animals, though lost in insects, and include human NEK6 and NEK7 and C. elegans nekl-3. They are activated in mitosis by phosphorylation by NEK9 [1], and phosphorylate cytoskeletal proteins including EML4, KIF11A and KIF14 [4,2]. In C. elegans, nekl-3 is involved in clathrin-mediated endocytosis [5]. In peptide arrays, NEK6 prefers to phosphorylate Ser residues, with hydrophobic residues at -2 and +1 and charged residues at -1, -2 and +2 [3].
History
EC 2.7.11.34 created 2022
Orthology
K20875 serine/threonine-protein kinase Nek6
K20876 serine/threonine-protein kinase Nek7
Genes
HSA : 10783(NEK6) 140609(NEK7)
PTR : 736415(NEK7) 737739(NEK6)
PPS : 100991410(NEK7) 100994198(NEK6)
GGO : 101139360(NEK7) 101149774(NEK6)
PON : 100444655(NEK7) 100449065(NEK6)
NLE : 100594590(NEK6) 100604657(NEK7)
HMH : 116457548(NEK7) 116475642(NEK6)
MCC : 100427402(NEK6) 710464(NEK7)
MCF : 102144472(NEK6) 102146083(NEK7)
MTHB : 126937214 126939700
MNI : 105463902(NEK6) 105484949(NEK7)
CSAB : 103230368(NEK7) 103239890(NEK6)
CATY : 105575046(NEK7) 105576298(NEK6)
PANU : 101005789(NEK7) 101008460(NEK6)
TGE : 112608650(NEK6) 112634374(NEK7)
MLEU : 105532168(NEK7) 105545656(NEK6)
RRO : 104658270(NEK7) 104664368(NEK6)
RBB : 108531374(NEK6) 108545093(NEK7)
TFN : 117070957(NEK6) 117076252(NEK7)
PTEH : 111545944(NEK6) 111550958(NEK7)
CANG : 105504111(NEK6) 105504300(NEK7)
CJC : 100387933(NEK7) 100411122(NEK6)
SBQ : 101027717(NEK6) 101035094(NEK7)
CIMI : 108287565(NEK7) 108317704(NEK6)
CSYR : 103257361(NEK6) 103264707(NEK7)
MMUR : 105860017(NEK7) 105875177(NEK6)
LCAT : 123627048(NEK7) 123646302(NEK6)
PCOQ : 105806590(NEK6) 105815314(NEK7)
OGA : 100943307(NEK6) 100945370(NEK7)
MMU : 59125(Nek7) 59126(Nek6)
MCAL : 110290538(Nek6) 110296102(Nek7)
MPAH : 110317583(Nek6) 110321486(Nek7)
RNO : 360161(Nek6) 360850(Nek7)
MCOC : 116090106(Nek6) 116100137(Nek7)
ANU : 117703039(Nek6) 117716242(Nek7)
MUN : 110546497(Nek6) 110566503(Nek7)
CGE : 100765727(Nek7) 100772485(Nek6)
MAUA : 101826296(Nek6) 101839210(Nek7)
PROB : 127221294(Nek7) 127222862(Nek6)
PLEU : 114682781(Nek6) 114707203(Nek7)
MORG : 121446113(Nek7) 121462591(Nek6)
MFOT : 126490146 126507329
AAMP : 119818700(Nek6) 119827557(Nek7)
NGI : 103726875(Nek6) 103731798(Nek7)
HGL : 101708026(Nek7) 101719839(Nek6)
CPOC : 100730187(Nek6) 100731670(Nek7)
CCAN : 109688251(Nek6) 109698983(Nek7)
DORD : 105986505(Nek7) 105989384(Nek6)
DSP : 122107115(Nek6) 122126709(Nek7)
PLOP : 125348783(Nek6) 125359577(Nek7)
NCAR : 124961761 124964183
OPI : 101519306(NEK6) 101531154(NEK7)
TUP : 102490951(NEK6) 102503130(NEK7)
GVR : 103586707(NEK6) 103595895(NEK7)
CFA : 480008(NEK7) 609003(NEK6)
CLUD : 112648278(NEK7) 112677180(NEK6)
VVP : 112927862(NEK6) 112934506(NEK7)
VLG : 121472828(NEK6) 121493022(NEK7)
NPO : 129505870(NEK7) 129508960(NEK6) 129512390
AML : 100464490(NEK7) 100471607(NEK6)
UMR : 103657686(NEK7) 103670461(NEK6)
UAH : 113242585(NEK7) 113266394(NEK6)
UAR : 123785779(NEK7) 123787984(NEK6)
MPUF : 101672728(NEK6) 101679868(NEK7)
NVS : 122917263(NEK6) 122918753(NEK7)
ORO : 101382520(NEK7) 101384660(NEK6)
EJU : 114212762(NEK6) 114221925(NEK7)
ZCA : 113931912(NEK7) 113934711(NEK6)
MLX : 118014239(NEK7) 118017697(NEK6)
NSU : 110574091(NEK7) 110581338(NEK6)
FCA : 101080747(NEK6) 101093327(NEK7)
PYU : 121022418(NEK7) 121034970(NEK6)
PCOO : 112848830(NEK6) 112857762(NEK7)
PBG : 122475164(NEK6) 122476071(NEK7)
LRUF : 124504011 124510049
PTG : 102950632(NEK6) 102955086(NEK7)
PPAD : 109250187(NEK6) 109255767(NEK7)
HHV : 120220010(NEK7) 120236319(NEK6)
BTA : 515816(NEK6) 781355(NEK7)
BOM : 102270477(NEK7) 102287699(NEK6)
BIU : 109566448(NEK6) 109570463(NEK7)
BBUB : 102402230(NEK6) 102416535(NEK7)
BBIS : 104981843(NEK7) 104991531(NEK6)
CHX : 102171902(NEK7) 102182138(NEK6)
OAS : 101102161(NEK7) 101108466(NEK6)
BTAX : 128055397(NEK6) 128061414(NEK7)
ODA : 120851980(NEK6) 120880068(NEK7)
CCAD : 122442146(NEK6) 122451666(NEK7)
MBEZ : 129539898(NEK6) 129551210(NEK7)
SSC : 100514624(NEK6) 100521742(NEK7)
CFR : 102504849(NEK7) 102519174(NEK6)
CBAI : 105069919(NEK6) 105070019(NEK7)
CDK : 105090827(NEK7) 105092637(NEK6)
VPC : 102527414(NEK7) 102534843(NEK6)
BACU : 102999434(NEK6) 103017668(NEK7)
LVE : 103077439(NEK7) 103081468(NEK6)
OOR : 101271423(NEK6) 101278630(NEK7)
DLE : 111177230(NEK6) 111177432(NEK7)
PCAD : 102975020(NEK7) 102989396(NEK6)
PSIU : 116749693(NEK7) 116755188(NEK6)
NASI : 112391091(NEK7) 112411208(NEK6)
ECB : 100061722(NEK7) 100071002(NEK6)
EPZ : 103556373(NEK7) 103558426(NEK6)
EAI : 106823540(NEK7) 106830812(NEK6)
MYB : 102248927(NEK7) 102256962(NEK6)
MYD : 102754934(NEK7) 102769819(NEK6)
MMYO : 118667069(NEK6) 118678711(NEK7)
MLF : 102430604(NEK7) 102439997(NEK6)
MNA : 107535477(NEK6) 107540243(NEK7)
PKL : 118704362(NEK6) 118720361(NEK7)
HAI : 109380507(NEK7) 109391344(NEK6)
DRO : 112306463(NEK6) 112318794(NEK7)
SHON : 118980090(NEK6) 119003876(NEK7)
AJM : 119053368(NEK7) 119062675(NEK6)
PDIC : 114500575(NEK6) 114512328(NEK7)
PHAS : 123823374(NEK6) 123833421(NEK7)
MMF : 118629496(NEK6) 118640523(NEK7)
RFQ : 117018553(NEK7) 117031783(NEK6)
PALE : 102891953(NEK6) 102892548(NEK7)
PGIG : 120601685(NEK6) 120619225(NEK7)
PVP : 105294898(NEK6) 105296888(NEK7)
RAY : 107506649(NEK6) 107513633(NEK7)
MJV : 108392118(NEK7) 108400660(NEK6)
TOD : 119231473(NEK6) 119234344(NEK7)
SARA : 101552188(NEK7) 101556002(NEK6)
LAV : 100658662(NEK6) 100668444(NEK7)
ETF : 101655097(NEK7) 101659587(NEK6)
DNM : 101421242(NEK7) 101422150(NEK6)
MDO : 100018380(NEK6) 100026840(NEK7)
GAS : 123237364(NEK6) 123245042(NEK7)
SHR : 100913259(NEK7) 100919641(NEK6)
PCW : 110194932(NEK6) 110197682(NEK7)
OAA : 100078782(NEK6) 100086331(NEK7)
GGA : 417101(NEK6) 424350(NEK7)
PCOC : 116230559(NEK7) 116234383(NEK6)
CJO : 107317099(NEK7) 107321937(NEK6)
TPAI : 128072791(NEK7) 128073348(NEK6)
NMEL : 110402745(NEK7) 110406823(NEK6)
APLA : 101798885(NEK7) 101802634(NEK6)
ACYG : 106040678(NEK6) 106041966(NEK7)
AFUL : 116491717(NEK7) 116496826(NEK6)
TGU : 100224014(NEK6) 100229625(NEK7)
LSR : 110477672(NEK6) 110479853(NEK7)
SCAN : 103814835(NEK7) 103818925(NEK6)
PMOA : 120510426(NEK7) 120512378(NEK6)
OTC : 121337020(NEK6) 121344555(NEK7)
PRUF : 121360062(NEK7) 121362484(NEK6)
GFR : 102034001(NEK6) 102035573(NEK7)
FAB : 101810131(NEK6) 101817284(NEK7)
PHI : 102107912(NEK6) 102108320(NEK7)
PMAJ : 107208112(NEK7) 107211951(NEK6)
CCAE : 111932704(NEK7) 111937111(NEK6)
CCW : 104688385(NEK6) 104695414(NEK7)
CBRC : 103612550(NEK7) 103623099(NEK6)
ETL : 114055848(NEK7) 114061973(NEK6)
ZAB : 102061564(NEK6) 102068510(NEK7)
ACHL : 103801897 103807695 103812051(NEK6)
SVG : 106855386(NEK6) 106858837(NEK7)
FPG : 101912545(NEK6) 101917597(NEK7)
FCH : 102048718(NEK7) 102058370(NEK6)
CLV : 102085593(NEK6) 102091111(NEK7)
EGZ : 104123901(NEK7) 104135196(NEK6)
NNI : 104020935(NEK7) 104023228(NEK6)
PLET : 104617753(NEK7) 104624800
PCRI : 104027051(NEK7) 104037133
PCAO : 104044431(NEK7) 104052790
ACUN : 113483080(NEK7) 113486441(NEK6)
TALA : 104360548(NEK6) 104365175(NEK7)
PADL : 103912486(NEK6) 103918762(NEK7)
AFOR : 103900004(NEK6) 103902164(NEK7)
ACHC : 115334868(NEK6) 115348890(NEK7)
HALD : 104311300(NEK7) 104323996(NEK6)
HLE : 104829267(NEK7) 104833808(NEK6)
AGEN : 126041687 126051869
CCRI : 104161141(NEK7) 104167557(NEK6)
CSTI : 104555682 104556985(NEK7)
EHS : 104507460(NEK6) 104513624(NEK7)
CMAC : 104481024(NEK6) 104485729(NEK7)
BREG : 104638945(NEK6) 104641856(NEK7)
FGA : 104076236(NEK7) 104078006(NEK6)
GSTE : 104257002(NEK6) 104261174(NEK7)
LDI : 104346520(NEK7) 104347307
MNB : 103770209 103780558(NEK6)
OHA : 104329706(NEK7) 104329725(NEK6)
NNT : 104400074(NEK6) 104407455(NEK7)
SHAB : 115611201(NEK7) 115616931(NEK6)
DPUB : 104303674(NEK7) 104306507(NEK6)
PGUU : 104461221(NEK6) 104463851 104464986
ACAR : 104518062(NEK7) 104526509(NEK6)
CPEA : 104389782(NEK6) 104390708(NEK7)
AVIT : 104270267(NEK6) 104281476(NEK7)
CVF : 104286219(NEK7) 104292855(NEK6)
CUCA : 104054733(NEK7) 104066864(NEK6)
TEO : 104374469(NEK7) 104377683(NEK6)
BRHI : 104489011(NEK7) 104501965(NEK6)
AAM : 106495994(NEK6) 106499723(NEK7)
AROW : 112976511(NEK7) 112977561(NEK6)
NPD : 112951226(NEK7) 112955942(NEK6)
TGT : 104573326(NEK6) 104577215(NEK7)
DNE : 112983629(NEK6) 112994717(NEK7)
SCAM : 104140801(NEK7) 104153602(NEK6)
ASN : 102367920(NEK6) 102378461(NEK7)
AMJ : 102570230(NEK7) 102571441(NEK6)
CPOO : 109307052(NEK7) 109314065(NEK6)
GGN : 109287092(NEK7) 109293080(NEK6)
PSS : 102449735(NEK7) 102454715(NEK6)
CMY : 102942833(NEK6) 102943350(NEK7)
DCC : 119844029(NEK6) 119859815(NEK7)
CPIC : 101936652(NEK6) 101936828(NEK7)
TST : 117881234(NEK7) 117889567(NEK6)
CABI : 116817442(NEK6) 116819291(NEK7)
MRV : 120370153(NEK7) 120372982 120386698(NEK6)
ACS : 100561378(nek7) 100563444(nek6)
PVT : 110074465(NEK7) 110078818(NEK6)
SUND : 121928849(NEK7) 121936306(NEK6)
PBI : 103055816(NEK6) 103060104
PMUR : 107287593 107298815(NEK6)
CTIG : 120298110(NEK6) 120301851(NEK7)
TSR : 106544884(NEK7) 106545964(NEK6)
PGUT : 117658827(NEK6) 117677306(NEK7)
PTEX : 113436182(NEK7) 113443795(NEK6)
NSS : 113414733(NEK7) 113427529(NEK6)
VKO : 123024542(NEK7) 123028262(NEK6)
PMUA : 114589193(NEK6) 114598654(NEK7)
ZVI : 118083820(NEK6) 118088136(NEK7)
HCG : 128322943(NEK7) 128338923(NEK6)
GJA : 107115275(NEK7) 107116519(NEK6)
STOW : 125432798(NEK7) 125442175(NEK6)
XLA : 100036860(nek6.L) 380346(nek6.S) 414882(nek7.S)
XTR : 448328(nek6) 780029(nek7)
NPR : 108793572(NEK7) 108796682(NEK6)
RTEM : 120914238(NEK6) 120945591(NEK7)
BBUF : 120977126(NEK6) 120978723(NEK7)
BGAR : 122919336(NEK6) 122943088(NEK7)
DRE : 445223(nek7) 497165(nek6)
SRX : 107719540 107720928 107740205 107741550
SANH : 107662348 107674934 107699433 107701949
SGH : 107584567 107586417 107593338
CCAR : 109046708 109084372 109084383 109108147
CAUA : 113038924 113039889 113064382 113064979(nek7)
CGIB : 127941901 127941982 127943092 127977406 127986119 127988362
PTET : 122327670(nek7) 122341041(nek6)
LROH : 127152928(nek6) 127153553(nek7)
PPRM : 120477221(nek7) 120491454(nek6)
MAMB : 125252743(nek6) 125263747(nek7)
CIDE : 127503527 127521517
MASI : 127428927 127430785 127438318 127439309
AMEX : 103039387 103046491(nek7)
CMAO : 118802621(nek6) 118819217(nek7)
CHAR : 105898275(nek7) 105911108(nek6)
LCO : 104921802(nek7) 104936759(nek6)
NCC : 104945204 104965803(nek7)
ELY : 117254336(nek7) 117269621(nek6)
EFO : 125895821(nek7) 125905846(nek6)
PLEP : 121959582(nek6) 121964931(nek7)
SLUC : 116038216 116056272(nek7)
ECRA : 117950313(nek7) 117959461(nek6)
ESP : 116686876 116695399(nek7)
PFLV : 114562212 114571431
PPUG : 119216230(nek7) 119226839(nek6)
MSAM : 119900465(nek7) 119914329(nek6)
SCHU : 122865282(nek6) 122877205(nek7)
CUD : 121512122(nek7) 121525119(nek6)
ALAT : 119028205(nek7) 119030544(nek6)
MZE : 101471322 101482921(nek7)
ONL : 100698704(nek7) 100704402
OAU : 116319155(nek6) 116320215(nek7)
OLA : 101170580(nek7) 101173323(nek6)
OML : 112136185(nek6) 112150498(nek7)
XMA : 102221602 102221821(nek7)
XCO : 114149122 114150953(nek7)
XHE : 116723836 116725859(nek7)
GAF : 122838931(nek7) 122847134
CVG : 107093058(nek7) 107104011
CTUL : 119784406(nek7) 119798112(nek6)
GMU : 124872248(nek6) 124874029(nek7)
KMR : 108234381(nek7) 108242521(nek6)
ALIM : 106516793(nek7) 106522211
NWH : 119425114(nek6) 119430550(nek7)
MCEP : 124996512(nek6) 125009078(nek7)
SSEN : 122758251 122780915(nek7)
SLAL : 111648062 111654858
XGL : 120790916(nek7) 120806769(nek6)
BPEC : 110161415 110162837(nek7)
MALB : 109966859(nek7) 109970839(nek6)
BSPL : 114852883(nek7) 114866589(nek6)
SASA : 106560547 106570951
STRU : 115158780 115160027 115192187
OTW : 112220032(nek6) 112238186 112250981(nek7)
OMY : 110521834 110523220(nek6) 110524793
OGO : 123989442(nek6) 123996601 124037998
SALP : 111961898 111971413
SNH : 120025470(nek6) 120036017 120052683(nek7)
CCLU : 121534081(nek7) 121540415 121582025(nek6)
ELS : 105021768 105028869(nek7)
SFM : 108921945(nek6) 108922681 108934966 108935306 114909801 114911226
PKI : 111834937(nek7) 111858695(nek6) 111859020
AANG : 118206618 118213367(nek6) 118225572(nek7) 118230598
LOC : 102683969(nek6) 102684611(nek7)
PSPA : 121303551 121303637 121326836(nek7) 121330962
ARUT : 117396730 117400588 117417463
PSEX : 120514565(nek7) 120535112
LCM : 102361140(NEK7) 102363802(NEK6)
CPLA : 122554551(nek7) 122564836
SGRE : 126272285 126272410
PMEO : 129585317 129592313 129601521
CEL : CELE_F19H6.1(nekl-3)
CBR : CBG_00136(Cbr-nekl-3)
BMY : BM_BM3452(Bma-nekl-3)
GAE : 121366617 121383923 121388112
DPOL : 127836899 127837199 127843610 127844922
SHX : MS3_00003724(NEK7_1)
ATEN : 116292725 116294827 116300324
» show all
Taxonomy
Reference
Authors
Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J
Title
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
Journal
Reference
Authors
Cullati SN, Kabeche L, Kettenbach AN, Gerber SA.
Title
A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
Journal
Reference
Authors
van de Kooij B, Creixell P, van Vlimmeren A, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB.
Title
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.
Journal
Reference
Authors
Adib R, Montgomery JM, Atherton J, O'Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM.
Title
Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
Journal
Reference
Authors
Joseph BB, Wang Y, Edeen P, Lazetic V, Grant BD, Fay DS.
Title
Control of clathrin-mediated endocytosis by NIMA family kinases.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.11.34