KEGG ENZYME: 2.7.11.4

ENZYME: 2.7.11.4

Entry

EC 2.7.11.4                 Enzyme

Name

[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase;
BCK;
BCKD kinase;
BCODH kinase;
branched-chain alpha-ketoacid dehydrogenase kinase;
branched-chain 2-oxo acid dehydrogenase kinase;
branched-chain keto acid dehydrogenase kinase;
branched-chain oxo acid dehydrogenase kinase (phosphorylating);
STK2

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase

Reaction(IUBMB)

ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate

Reaction(KEGG)

(other) R03516

Substrate

ATP [CPD:C00002];
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]

Product

ADP [CPD:C00008];
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate

Comment

The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).

History

EC 2.7.11.4 created 1986 as EC 2.7.1.115, transferred 2005 to EC 2.7.11.4

Orthology

K00905

[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase

Genes

HSA:	10295(BCKDK)

PTR:	741960(BCKDK)

PPS:	100988171(BCKDK)

PON:	100435349(BCKDK)

NLE:	100592408(BCKDK)

HMH:	116471186(BCKDK)

MCC:	712985(BCKDK)

MCF:	102135926(BCKDK)

MTHB:

126944216

MNI:	105482954(BCKDK)

CSAB:

103231287(BCKDK)

CATY:

105599511(BCKDK)

PANU:

101027030(BCKDK)

TGE:	112614202(BCKDK)

MLEU:

105541464(BCKDK)

RRO:	104661569(BCKDK)

RBB:	108529119(BCKDK)

TFN:	117087687(BCKDK)

PTEH:

111525669(BCKDK)

CANG:

105505704(BCKDK)

CJC:	100386931(BCKDK)

SBQ:	101039806(BCKDK)

CIMI:

108293885(BCKDK)

CSYR:

103264391(BCKDK)

MMUR:

105871047(BCKDK)

LCAT:

123632697(BCKDK)

PCOQ:

105823160(BCKDK)

OGA:	100947900(BCKDK)

MMU:	12041(Bckdk)

MCAL:

110297841(Bckdk)

MPAH:

110321236(Bckdk)

RNO:	29603(Bckdk)

MCOC:

116103042(Bckdk)

ANU:	117697241(Bckdk) 117702413

MUN:	110564541(Bckdk)

CGE:	100755998(Bckdk)

MAUA:

101822893(Bckdk)

PROB:

127217058 127228407(Bckdk)

PLEU:

114704397(Bckdk)

MORG:

121457571(Bckdk)

MFOT:

126496299 126515868

AAMP:

119815638(Bckdk)

NGI:	103726326(Bckdk)

HGL:	101715390(Bckdk)

CPOC:

100717874(Bckdk)

CCAN:

109682760(Bckdk)

DORD:

105982094(Bckdk)

DSP:	122096193(Bckdk)

NCAR:

124970051

OCU:

100341990

OPI:	101520752(BCKDK)

TUP:	102488075(BCKDK)

GVR:	103610041(BCKDK)

CFA:	479776(BCKDK)

CLUD:

112640132(BCKDK)

VVP:	112929264(BCKDK)

VLG:	121488356(BCKDK)

AML:	100476243(BCKDK)

UMR:	103657884(BCKDK)

UAH:	113267717(BCKDK)

UAR:	123784676(BCKDK)

ELK:

111162250

LLV:

125090575

MPUF:

101675298(BCKDK)

NVS:	122895620(BCKDK)

ORO:	101379705(BCKDK)

EJU:	114214545(BCKDK)

ZCA:	113933674(BCKDK)

MLX:	117999566(BCKDK)

NSU:	110589941(BCKDK)

LWW:	102726562(BCKDK)

FCA:	101089414(BCKDK)

PYU:	121022182(BCKDK)

PBG:	122471418(BCKDK)

LRUF:

124517968

PTG:	102964750(BCKDK)

PPAD:

109259022(BCKDK)

PUC:

125928113

AJU:	106979116(BCKDK)

HHV:	120242260(BCKDK)

BTA:	505005(BCKDK)

BOM:	102272790(BCKDK)

BIU:	109578528(BCKDK)

BBUB:

102404806(BCKDK)

BBIS:

104986680(BCKDK)

CHX:	102178232(BCKDK)

OAS:	101104290(BCKDK)

ODA:	120877678(BCKDK)

CCAD:

122432927(BCKDK)

SSC:	100522544(BCKDK)

CFR:	102514896(BCKDK)

CBAI:

105082778(BCKDK)

CDK:	105102713(BCKDK)

VPC:	102531026(BCKDK)

BACU:

103002138(BCKDK)

LVE:	103076626(BCKDK)

OOR:	101285430(BCKDK)

DLE:	111182112(BCKDK)

PCAD:

102984751(BCKDK)

PSIU:

116740163(BCKDK)

NASI:

112399308(BCKDK)

ECB:	100063321(BCKDK)

EPZ:	103547243(BCKDK)

EAI:	106831884(BCKDK)

MYB:	102256163(BCKDK)

MYD:	102771109(BCKDK)

MMYO:

118656742(BCKDK)

MLF:	102435805(BCKDK)

MNA:	107540820(BCKDK)

PKL:	118704940(BCKDK)

HAI:	109374188(BCKDK)

DRO:	112304677(BCKDK)

AJM:	119041166(BCKDK)

PDIC:

114503149(BCKDK)

PHAS:

123825479(BCKDK)

MMF:	118642782(BCKDK)

RFQ:	117019669(BCKDK)

PALE:

102887175(BCKDK)

PGIG:

120620059(BCKDK)

PVP:	105304509(BCKDK)

RAY:	107503982(BCKDK)

TOD:	119241708(BCKDK)

SARA:

101549573(BCKDK)

LAV:	100663738(BCKDK)

TMU:

101356582

ETF:	101661633(BCKDK)

DNM:	101447993(BCKDK)

MDO:	100013633(BCKDK)

GAS:	123231143(BCKDK)

SHR:	100930326(BCKDK)

AFZ:

127562729

PCW:	110223122(BCKDK)

OAA:	100080324(BCKDK)

NMEL:

110391739(BCKDK)

TGU:	115497487(BCKDK)

LSR:

110483485

PMOA:

120508515(BCKDK)

FAB:	101807123(BCKDK)

PHI:	102106406(BCKDK)

PMAJ:

107199235(BCKDK)

CCAE:

111922266 111943911

SVG:	106864428(BCKDK)

FPG:	101920590(BCKDK)

CLV:	106146054(BCKDK)

AFOR:

103903856(BCKDK)

ACHC:

115338556(BCKDK)

GCL:

127027938

ASN:	102385742(BCKDK)

AMJ:	102557785(BCKDK)

PSS:	102450847(BCKDK)

CMY:	102940861(BCKDK)

CPIC:

101952608(BCKDK)

TST:	117876269(BCKDK)

CABI:

116815528(BCKDK)

MRV:	120403409 120403410

ACS:	100555810(bckdk)

PVT:	110086395(BCKDK)

SUND:

121933323(BCKDK)

PBI:	103051605(BCKDK)

PMUR:

107294318(BCKDK) 107299945

CTIG:

120302257(BCKDK)

TSR:	106545492(BCKDK)

PGUT:

117666825(BCKDK)

PMUA:

114582840 114582841(BCKDK)

ZVI:	118094672(BCKDK)

GJA:	107106646(BCKDK)

STOW:

125444549(BCKDK)

XLA:	108703947(bckdk.L) 432076(bckdk.S)

XTR:	100380070(bckdk)

NPR:	108803576(BCKDK)

RTEM:

120943005(BCKDK)

BBUF:

121009053(BCKDK)

BGAR:

122945338(BCKDK)

DRE:	282677(bckdk)

SRX:	107710731(bckdk) 107712146

SANH:

107681895 107685622

SGH:	107587720 107595470

CCAR:

109045589(bckdk)

CAUA:

113049749 113081119

CGIB:

127958012 127995824

PPRM:

120472055(bckdk)

MAMB:

125267713(bckdk)

CIDE:

127512319

MASI:

127421397 127434948

IPU:	108260303(bckdk)

PHYP:

113531644(bckdk)

SMEO:

124378977(bckdk)

TFD:	113663375(bckdk)

AMEX:

103026403(bckdk)

EEE:	113573709(bckdk)

TRU:	101071747(bckdk)

TNG:	GSTEN00019477G001

LCO:	104921106(bckdk)

CGOB:

115018640(bckdk)

ELY:	117268193(bckdk)

EFO:	125898969(bckdk)

PLEP:

121952255(bckdk)

SLUC:

116055879(bckdk)

ECRA:

117954975(bckdk)

ESP:	116700204(bckdk)

PFLV:

114566983(bckdk)

GAT:	120822932(bckdk)

PPUG:

119215485(bckdk)

MSAM:

119895373(bckdk)

CUD:	121518713(bckdk)

ALAT:

119031148(bckdk)

MZE:	101470802(bckdk)

ONL:	100693463(bckdk)

OAU:	116326363(bckdk)

OLA:	101172677(bckdk)

OML:	112142877(bckdk)

XMA:	102232910(bckdk)

XCO:	114152515(bckdk)

XHE:	116728235(bckdk)

PRET:

103476315(bckdk)

PFOR:

103145532(bckdk)

PLAI:

106946269(bckdk)

PMEI:

106915550(bckdk)

GAF:	122844723(bckdk)

CVG:	107081858(bckdk)

CTUL:

119786817(bckdk)

GMU:	124876421(bckdk)

NFU:	107387216(bckdk)

KMR:	108238069(bckdk)

ALIM:

106525416(bckdk)

NWH:	119419902(bckdk)

AOCE:

111586755(bckdk)

MCEP:

125021037(bckdk)

CSEM:

103395393(bckdk)

POV:	109635794(bckdk)

SSEN:

122779765(bckdk)

HHIP:

117773929(bckdk)

HSP:	118121921(bckdk)

LCF:

108893638

SDU:	111217087(bckdk)

SLAL:

111651631(bckdk)

XGL:	120802328(bckdk)

HCQ:	109517958(bckdk)

SSCV:

125982520

BPEC:

110166962(bckdk)

MALB:

109959266(bckdk)

BSPL:

114869989(bckdk)

SASA:

106567669(BCKD) 106603456

STRU:

115148785 115154249

OTW:	112228513(bckdk) 112257931

OMY:	110533575(bckdk) 110537551

OGO:	123999522 124011317(bckdk)

ONE:	115105474 115135971

SALP:

111950264 111980924

SNH:	120030810 120057014(bckdk)

CCLU:

121550854 121579377(bckdk)

ELS:	105011092(bckdk)

SFM:	108928236(bckdk)

PKI:	111847878(bckdk)

AANG:

118209553 118235075(bckdk)

LOC:	102682703 102698785

PSPA:

121305157 121308469(bckdk)

ARUT:

117398293 117418356 117429291(bckdk)

PSEX:

120531318(bckdk) 120536704

LCM:	102360605(BCKDK)

CMK:	103180529(bckdk)

RTP:	109918994 109924425

CPLA:

122542053 122564137(bckdk)

BFO:

118425510

BBEL:

109465957

SCLV:

120341705

SPU:

574737

APLC:

110976612

AJC:

117121942

SKO:

100369777

FCD:

110862028

DPX:	DAPPUDRAFT_308613

DMK:	116933693 123474709

DPZ:

124327589

PVM:

113825010

PJA:

122257442

PCHN:

125031495

HAME:

121867985

PCLA:

123772092

PTRU:

123498494

ESN:

126999725

HAZT:

108678411

EAF:

111699483

LSM:

121127391

PPOI:

119098442

ISC:	IscW_ISCW005210

DSV:

119445285

RSAN:

119391051

RMP:

119168205

TUT:

107368956

DPTE:

113789621

DFR:

124498909

CSCU:

111620430

PTEP:

107444190

SDM:

118188450

HRO:	HELRODRAFT_193864 HELRODRAFT_66850

LGI:	LOTGIDRAFT_116873

PCAN:

112561778

BGT:

106075238

GAE:

121367979

HRF:

124132068

HRJ:

124254155

CRG:

105328662

MYI:

110455574

PMAX:

117333050

MCAF:

127712146

MMER:

123533898

DPOL:

127842804

OBI:

106879645

OSN:

115222452

LAK:

106155712

OVI:	T265_03130

NVE:

5509294

EPA:

110252284

ATEN:

116290344

ADF:

107358500

AMIL:

114958723

PDAM:

113684461

SPIS:

111345051

DGT:	114523680 114523987

XEN:

124435713

HMG:

100214984

TAD:	TRIADDRAFT_52704

CCP:	CHC_T00006845001

OPA:	HPODL_03307

MBR:	MONBRDRAFT_15226 MONBRDRAFT_5845

SRE:	PTSG_08628

TGO:	TGME49_318560

SMIN:

v1.2.008918.t1(symbB.v1.2.008918.t1) v1.2.010686.t1(symbB.v1.2.010686.t1) v1.2.010686.t2(symbB.v1.2.010686.t2) v1.2.012337.t1(symbB.v1.2.012337.t1)

» show all

Reference

1 [PMID:7142221]

Authors

Paxton R, Harris RA.

Title

Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation.

Journal

J Biol Chem 257:14433-9 (1982)

Reference

2 [PMID:10903321]

Authors

Wynn RM, Chuang JL, Cote CD, Chuang DT.

Title

Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase.

Journal

J Biol Chem 275:30512-9 (2000)
DOI:10.1074/jbc.M005075200

Reference

3 [PMID:12189132]

Authors

Chuang JL, Wynn RM, Chuang DT.

Title

The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase.

Journal

J Biol Chem 277:36905-8 (2002)
DOI:10.1074/jbc.C200430200

Reference

4 [PMID:9344245]

Authors

Popov KM, Hawes JW, Harris RA.

Title

Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases.

Journal

Adv Second Messenger Phosphoprotein Res 31:105-11 (1997)

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