KEGG   ENZYME: 2.7.11.6Help
Entry
EC 2.7.11.6                 Enzyme                                 

Name
[tyrosine 3-monooxygenase] kinase;
pheochromocytoma tyrosine hydroxylase-associated kinase;
STK4;
tyrosine 3-monooxygenase kinase (phosphorylating)
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[tyrosine-3-monoxygenase] phosphotransferase
Reaction(IUBMB)
ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]
Reaction(KEGG)
(other) R04275
Show
Substrate
ATP [CPD:C00002];
[tyrosine-3-monooxygenase]
Product
ADP [CPD:C00008];
phospho-[tyrosine-3-monooxygenase]
Comment
The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation.
History
EC 2.7.11.6 created 1989 as EC 2.7.1.124, transferred 2005 to EC 2.7.11.6
Reference
1  [PMID:2872947]
  Authors
Pigeon D, Drissi-Daoudi R, Gros F, Thibault J.
  Title
[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]
  Journal
C R Acad Sci III 302:435-8 (1986)
Reference
2  [PMID:2883182]
  Authors
Pigeon D, Ferrara P, Gros F, Thibault J.
  Title
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
  Journal
J Biol Chem 262:6155-8 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.6
IUBMB Enzyme Nomenclature: 2.7.11.6
ExPASy - ENZYME nomenclature database: 2.7.11.6
BRENDA, the Enzyme Database: 2.7.11.6
CAS: 103537-12-8

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