Entry
Name
[tyrosine 3-monooxygenase] kinase;
pheochromocytoma tyrosine hydroxylase-associated kinase;
STK4;
tyrosine 3-monooxygenase kinase (phosphorylating)
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[tyrosine-3-monooxygenase] phosphotransferase
Reaction(IUBMB)
ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
[tyrosine-3-monooxygenase]
Product
ADP [CPD:
C00008 ];
phospho-[tyrosine-3-monooxygenase]
Comment
The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC
1.14.16.2 , tyrosine 3-monooxygenase, by phosphorylation.
History
EC 2.7.11.6 created 1989 as EC 2.7.1.124, transferred 2005 to EC 2.7.11.6
Reference
Authors
Pigeon D, Drissi-Daoudi R, Gros F, Thibault J.
Title
[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]
Journal
C R Acad Sci III 302:435-8 (1986)
Reference
Authors
Pigeon D, Ferrara P, Gros F, Thibault J.
Title
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
Journal
J Biol Chem 262:6155-8 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.6
ExPASy - ENZYME nomenclature database: 2.7.11.6