KEGG   ENZYME: 2.7.11.8
Entry
EC 2.7.11.8                 Enzyme                                 
Name
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[Fas-activated serine/threonine protein] phosphotransferase
Reaction(IUBMB)
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Reaction(KEGG)
(other) R00162
Substrate
ATP [CPD:C00002];
[Fas-activated serine/threonine protein]
Product
ADP [CPD:C00008];
[Fas-activated serine/threonine phosphoprotein]
Comment
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
History
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K08290  Fas-activated serine/threonine kinase
Genes
HSA10922(FASTK)
PTR472626(FASTK)
PPS100978359(FASTK)
GGO101150125(FASTK)
PON100171584(FASTK)
NLE100593928(FASTK)
MCC714020(FASTK)
MCF101926723(FASTK)
MTHB126951601
CSAB103227240(FASTK)
CATY105584741(FASTK)
PANU100998246(FASTK)
TGE112620081(FASTK)
RRO104675400(FASTK)
RBB108532532(FASTK)
TFN117072836(FASTK)
PTEH111551518(FASTK)
CJC100409995(FASTK)
SBQ101037716(FASTK)
CSYR103275287(FASTK)
MMUR105883174(FASTK)
LCAT123647513(FASTK)
OGA100955654(FASTK)
MMU66587(Fastk)
MCAL110293884(Fastk)
MPAH110315921(Fastk)
RNO296741(Fastk)
MCOC116097549(Fastk)
MUN110562562(Fastk)
CGE100762130(Fastk)
MAUA101835825(Fastk)
PLEU114700084(Fastk)
MORG121439977(Fastk)
MFOT126489456
AAMP119808143(Fastk)
NGI103745309(Fastk)
HGL101707658(Fastk)
CCAN109694452(Fastk)
DORD105993877(Fastk)
DSP122105952(Fastk)
NCAR124990772
OCU100343065(FASTK)
OPI101518654(FASTK)
TUP102498075(FASTK)
CFA482802(FASTK)
CLUD112663739(FASTK)
VVP112916212(FASTK)
VLG121489294(FASTK)
AML100482824(FASTK)
UMR103660954(FASTK)
UAH113241480(FASTK)
UAR123788775(FASTK)
ELK111154327
LLV125081333
MPUF101681299(FASTK)
ORO101384446(FASTK)
EJU114198016(FASTK) 114213868
ZCA113911331(FASTK) 113925854
MLX118026803(FASTK)
NSU110582838(FASTK)
FCA101082140(FASTK)
PYU121022887(FASTK)
PBG122488533(FASTK)
LRUF124523525
PTG102956491(FASTK)
PPAD109252377(FASTK)
AJU106969574(FASTK)
HHV120230912(FASTK)
BTA509781(FASTK)
BOM102266409(FASTK)
BIU109557800(FASTK)
BBUB102388980(FASTK)
CHX102186744 108635865(FASTK)
OAS101103314(FASTK)
ODA120877889(FASTK)
CCAD122438873(FASTK)
SSC100233181(FASTK)
CFR102523278(FASTK)
CBAI105067015(FASTK)
CDK105105644(FASTK)
VPC102529432(FASTK)
BACU103019324(FASTK)
LVE103084660(FASTK)
OOR101282680(FASTK)
DLE111176805(FASTK)
PCAD102987574(FASTK)
PSIU116759264(FASTK)
ECB100063473(FASTK)
EPZ103564176(FASTK)
EAI106823328(FASTK)
MYB102254535(FASTK)
MYD102755949(FASTK)
MMYO118679404(FASTK)
MLF102432778(FASTK)
MNA107524906(FASTK)
PKL118704770(FASTK)
HAI109389645(FASTK)
DRO112308283(FASTK)
SHON118975548(FASTK)
AJM119039239(FASTK)
PDIC114507784(FASTK)
PHAS123817939(FASTK)
MMF118619784(FASTK)
RFQ117018039(FASTK) 117025120
PALE102878349(FASTK)
PGIG120601500(FASTK)
RAY107520316(FASTK)
MJV108391845(FASTK)
TOD119248884(FASTK)
SARA101548353(FASTK)
LAV100672710(FASTK)
TMU101358568
DNM101436971(FASTK)
OAA114816161(FASTK)
GGA426636(FASTK)
PCOC116242826(FASTK)
MGP100544059(FASTK)
CJO107308708(FASTK)
NMEL110390744(FASTK)
AFUL116485986(FASTK)
TGU100227496(FASTK)
LSR110475124(FASTK)
SCAN103824487(FASTK)
PMOA120510557(FASTK)
OTC121334865(FASTK)
PRUF121355532(FASTK)
GFR102034598(FASTK)
FAB101814009(FASTK)
PHI102100505(FASTK)
PMAJ107200647(FASTK)
CCAE111944798(FASTK)
CCW104684261(FASTK)
CBRC103617019(FASTK)
ETL114067997(FASTK)
FPG101913183(FASTK)
FCH102058389(FASTK)
CLV102096109(FASTK)
EGZ104127868(FASTK)
NNI104011535(FASTK)
PLET104627183(FASTK)
ACUN113477571(FASTK)
TALA116959979(FASTK)
PADL103922139(FASTK)
AFOR103897135(FASTK)
ACHC115339075(FASTK)
CCRI104164299(FASTK)
NNT104410871(FASTK)
DPUB104298511(FASTK)
CVF104290123(FASTK)
AAM106491561(FASTK)
AROW112976165(FASTK)
NPD112956375(FASTK)
DNE112994028(FASTK)
SCAM104141276(FASTK)
ASN102382446(FASTK)
AMJ102570632(FASTK)
CPOO109305652(FASTK)
CMY102940414(FASTK)
CPIC101930899(FASTK)
TST117871962(FASTK)
CABI116834487(FASTK)
MRV120397575(FASTK)
ACS103282002(fastk)
PVT110082558(FASTK)
SUND121932798(FASTK)
PMUA114607669(FASTK)
ZVI118092036(FASTK)
GJA107108218(FASTK)
STOW125440705(FASTK)
DRE564534(fastk)
SRX107709854 107718024
SANH107657442 107701011
SGH107557009 107599878
CCAR109047574 109088211
CAUA113045685 113118459 113118466
PPRM120482099(fastk)
MAMB125250388(fastk)
IPU108267814(fastk)
PHYP113540273(fastk)
SMEO124387612(fastk)
TFD113657462(fastk)
AMEX103039878(fastk)
EEE113590303(fastk)
TRU101064436(fastk)
TNGGSTEN00004492G001
LCO104932655(fastk)
ELY117272384(fastk)
EFO125902720(fastk)
PLEP121967003
SLUC116065601 116065877(fastk)
PFLV114566069(fastk)
GAT120816511(fastk)
PPUG119209125(fastk)
MSAM119902774(fastk)
CUD121519821(fastk)
ALAT119011428(fastk)
MZE101476418(fastk)
ONL100691686(fastk)
OAU116320456(fastk)
OLA111949112(fastk)
OML112144253(fastk)
XMA102236288(fastk)
XCO114146143(fastk)
XHE116721449(fastk)
PRET103460488(fastk)
PFOR103129941(fastk)
PLAI106960303(fastk)
PMEI106903891(fastk)
GAF122841513(fastk)
CVG107080741(fastk)
CTUL119776811(fastk)
GMU124869497(fastk)
NFU107383684(fastk)
KMR108228222(fastk)
ALIM106534218(fastk)
NWH119415305(fastk)
AOCE111576067(fastk)
MCEP125010899(fastk)
CSEM103398754(fastk)
POV109645871(fastk)
SSEN122775989(fastk)
HHIP117777830(fastk)
HSP118117430(fastk)
LCF108884940
SDU111237341(fastk)
SLAL111659187(fastk)
XGL120800230(fastk)
HCQ109518860
BPEC110173952(fastk)
MALB109965944(fastk)
BSPL114844236(fastk)
SASA106568668 106597078
STRU115156573 115170161
OTW112227246(fastk) 112260156
OMY110509102(fastk) 110529976
OGO124042155(fastk)
ONE115103360 115114246
SALP111957211 111979512
SNH120020707 120055453
CCLU121534771 121554836 121580592
ELS105025013(fastk)
SFM108937493(fastk)
PKI111837192(fastk)
AANG118234100(fastk)
LOC102694158
PSPA121313456 121314399(fastk)
ARUT117394833(fastk) 117399961
LCM102349276(FASTK)
CMK103190094(fastk)
RTP109925014
SKO102804167
 » show all
Reference
1  [PMID:7544399]
  Authors
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
  Title
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
  Journal
J Exp Med 182:865-74 (1995)
DOI:10.1084/jem.182.3.865
  Sequence
[hsa:10922]
Reference
2  [PMID:15572676]
  Authors
Li W, Simarro M, Kedersha N, Anderson P.
  Title
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
  Journal
Mol Cell Biol 24:10718-32 (2004)
DOI:10.1128/MCB.24.24.10718-10732.2004
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.8
IUBMB Enzyme Nomenclature: 2.7.11.8
ExPASy - ENZYME nomenclature database: 2.7.11.8
BRENDA, the Enzyme Database: 2.7.11.8
CAS: 170347-50-9

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