KEGG   ENZYME: 2.7.11.8
Entry
EC 2.7.11.8                 Enzyme                                 
Name
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[Fas-activated serine/threonine protein] phosphotransferase
Reaction(IUBMB)
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Reaction(KEGG)
(other) R00162
Substrate
ATP [CPD:C00002];
[Fas-activated serine/threonine protein]
Product
ADP [CPD:C00008];
[Fas-activated serine/threonine phosphoprotein]
Comment
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
History
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K08290  Fas-activated serine/threonine kinase
Genes
HSA: 10922(FASTK)
PTR: 472626(FASTK)
PPS: 100978359(FASTK)
GGO: 101150125(FASTK)
PON: 100171584(FASTK)
NLE: 100593928(FASTK)
MCC: 714020(FASTK)
MCF: 101926723(FASTK)
MTHB: 126951601
CSAB: 103227240(FASTK)
CATY: 105584741(FASTK)
PANU: 100998246(FASTK)
TGE: 112620081(FASTK)
RRO: 104675400(FASTK)
RBB: 108532532(FASTK)
TFN: 117072836(FASTK)
PTEH: 111551518(FASTK)
CJC: 100409995(FASTK)
SBQ: 101037716(FASTK)
CSYR: 103275287(FASTK)
MMUR: 105883174(FASTK)
LCAT: 123647513(FASTK)
OGA: 100955654(FASTK)
MMU: 66587(Fastk)
MCAL: 110293884(Fastk)
MPAH: 110315921(Fastk)
RNO: 296741(Fastk)
MCOC: 116097549(Fastk)
MUN: 110562562(Fastk)
CGE: 100762130(Fastk)
MAUA: 101835825(Fastk)
PLEU: 114700084(Fastk)
MORG: 121439977(Fastk)
MFOT: 126489456
AAMP: 119808143(Fastk)
NGI: 103745309(Fastk)
HGL: 101707658(Fastk)
CCAN: 109694452(Fastk)
DORD: 105993877(Fastk)
DSP: 122105952(Fastk)
NCAR: 124990772
OCU: 100343065(FASTK)
OPI: 101518654(FASTK)
TUP: 102498075(FASTK)
CFA: 482802(FASTK)
CLUD: 112663739(FASTK)
VVP: 112916212(FASTK)
VLG: 121489294(FASTK)
AML: 100482824(FASTK)
UMR: 103660954(FASTK)
UAH: 113241480(FASTK)
UAR: 123788775(FASTK)
ELK: 111154327
LLV: 125081333
MPUF: 101681299(FASTK)
ORO: 101384446(FASTK)
EJU: 114198016(FASTK) 114213868
ZCA: 113911331(FASTK) 113925854
MLX: 118026803(FASTK)
NSU: 110582838(FASTK)
FCA: 101082140(FASTK)
PYU: 121022887(FASTK)
PBG: 122488533(FASTK)
LRUF: 124523525
PTG: 102956491(FASTK)
PPAD: 109252377(FASTK)
AJU: 106969574(FASTK)
HHV: 120230912(FASTK)
BTA: 509781(FASTK)
BOM: 102266409(FASTK)
BIU: 109557800(FASTK)
BBUB: 102388980(FASTK)
CHX: 102186744 108635865(FASTK)
OAS: 101103314(FASTK)
ODA: 120877889(FASTK)
CCAD: 122438873(FASTK)
SSC: 100233181(FASTK)
CFR: 102523278(FASTK)
CBAI: 105067015(FASTK)
CDK: 105105644(FASTK)
VPC: 102529432(FASTK)
BACU: 103019324(FASTK)
LVE: 103084660(FASTK)
OOR: 101282680(FASTK)
DLE: 111176805(FASTK)
PCAD: 102987574(FASTK)
PSIU: 116759264(FASTK)
ECB: 100063473(FASTK)
EPZ: 103564176(FASTK)
EAI: 106823328(FASTK)
MYB: 102254535(FASTK)
MYD: 102755949(FASTK)
MMYO: 118679404(FASTK)
MLF: 102432778(FASTK)
MNA: 107524906(FASTK)
PKL: 118704770(FASTK)
HAI: 109389645(FASTK)
DRO: 112308283(FASTK)
SHON: 118975548(FASTK)
AJM: 119039239(FASTK)
PDIC: 114507784(FASTK)
PHAS: 123817939(FASTK)
MMF: 118619784(FASTK)
RFQ: 117018039(FASTK) 117025120
PALE: 102878349(FASTK)
PGIG: 120601500(FASTK)
RAY: 107520316(FASTK)
MJV: 108391845(FASTK)
TOD: 119248884(FASTK)
SARA: 101548353(FASTK)
LAV: 100672710(FASTK)
TMU: 101358568
DNM: 101436971(FASTK)
OAA: 114816161(FASTK)
GGA: 426636(FASTK)
PCOC: 116242826(FASTK)
MGP: 100544059(FASTK)
CJO: 107308708(FASTK)
NMEL: 110390744(FASTK)
AFUL: 116485986(FASTK)
TGU: 100227496(FASTK)
LSR: 110475124(FASTK)
SCAN: 103824487(FASTK)
PMOA: 120510557(FASTK)
OTC: 121334865(FASTK)
PRUF: 121355532(FASTK)
GFR: 102034598(FASTK)
FAB: 101814009(FASTK)
PHI: 102100505(FASTK)
PMAJ: 107200647(FASTK)
CCAE: 111944798(FASTK)
CCW: 104684261(FASTK)
CBRC: 103617019(FASTK)
ETL: 114067997(FASTK)
FPG: 101913183(FASTK)
FCH: 102058389(FASTK)
CLV: 102096109(FASTK)
EGZ: 104127868(FASTK)
NNI: 104011535(FASTK)
PLET: 104627183(FASTK)
ACUN: 113477571(FASTK)
TALA: 116959979(FASTK)
PADL: 103922139(FASTK)
AFOR: 103897135(FASTK)
ACHC: 115339075(FASTK)
CCRI: 104164299(FASTK)
NNT: 104410871(FASTK)
DPUB: 104298511(FASTK)
CVF: 104290123(FASTK)
AAM: 106491561(FASTK)
AROW: 112976165(FASTK)
NPD: 112956375(FASTK)
DNE: 112994028(FASTK)
SCAM: 104141276(FASTK)
ASN: 102382446(FASTK)
AMJ: 102570632(FASTK)
CPOO: 109305652(FASTK)
CMY: 102940414(FASTK)
CPIC: 101930899(FASTK)
TST: 117871962(FASTK)
CABI: 116834487(FASTK)
MRV: 120397575(FASTK)
ACS: 103282002(fastk)
PVT: 110082558(FASTK)
SUND: 121932798(FASTK)
PMUA: 114607669(FASTK)
ZVI: 118092036(FASTK)
GJA: 107108218(FASTK)
STOW: 125440705(FASTK)
DRE: 564534(fastk)
SRX: 107709854 107718024
SANH: 107657442 107701011
SGH: 107557009 107599878
CCAR: 109047574 109088211
CAUA: 113045685 113118459 113118466
PPRM: 120482099(fastk)
MAMB: 125250388(fastk)
IPU: 108267814(fastk)
PHYP: 113540273(fastk)
SMEO: 124387612(fastk)
TFD: 113657462(fastk)
AMEX: 103039878(fastk)
EEE: 113590303(fastk)
TRU: 101064436(fastk)
TNG: GSTEN00004492G001
LCO: 104932655(fastk)
ELY: 117272384(fastk)
EFO: 125902720(fastk)
PLEP: 121967003
SLUC: 116065601 116065877(fastk)
PFLV: 114566069(fastk)
GAT: 120816511(fastk)
PPUG: 119209125(fastk)
MSAM: 119902774(fastk)
CUD: 121519821(fastk)
ALAT: 119011428(fastk)
MZE: 101476418(fastk)
ONL: 100691686(fastk)
OAU: 116320456(fastk)
OLA: 111949112(fastk)
OML: 112144253(fastk)
XMA: 102236288(fastk)
XCO: 114146143(fastk)
XHE: 116721449(fastk)
PRET: 103460488(fastk)
PFOR: 103129941(fastk)
PLAI: 106960303(fastk)
PMEI: 106903891(fastk)
GAF: 122841513(fastk)
CVG: 107080741(fastk)
CTUL: 119776811(fastk)
GMU: 124869497(fastk)
NFU: 107383684(fastk)
KMR: 108228222(fastk)
ALIM: 106534218(fastk)
NWH: 119415305(fastk)
AOCE: 111576067(fastk)
MCEP: 125010899(fastk)
CSEM: 103398754(fastk)
POV: 109645871(fastk)
SSEN: 122775989(fastk)
HHIP: 117777830(fastk)
HSP: 118117430(fastk)
LCF: 108884940
SDU: 111237341(fastk)
SLAL: 111659187(fastk)
XGL: 120800230(fastk)
HCQ: 109518860
BPEC: 110173952(fastk)
MALB: 109965944(fastk)
BSPL: 114844236(fastk)
SASA: 106568668 106597078
STRU: 115156573 115170161
OTW: 112227246(fastk) 112260156
OMY: 110509102(fastk) 110529976
OGO: 124042155(fastk)
ONE: 115103360 115114246
SALP: 111957211 111979512
SNH: 120020707 120055453
CCLU: 121534771 121554836 121580592
ELS: 105025013(fastk)
SFM: 108937493(fastk)
PKI: 111837192(fastk)
AANG: 118234100(fastk)
LOC: 102694158
PSPA: 121313456 121314399(fastk)
ARUT: 117394833(fastk) 117399961
LCM: 102349276(FASTK)
CMK: 103190094(fastk)
RTP: 109925014
SKO: 102804167
 » show all
Reference
1  [PMID:7544399]
  Authors
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
  Title
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
  Journal
J Exp Med 182:865-74 (1995)
DOI:10.1084/jem.182.3.865
  Sequence
[hsa:10922]
Reference
2  [PMID:15572676]
  Authors
Li W, Simarro M, Kedersha N, Anderson P.
  Title
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
  Journal
Mol Cell Biol 24:10718-32 (2004)
DOI:10.1128/MCB.24.24.10718-10732.2004
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.8
IUBMB Enzyme Nomenclature: 2.7.11.8
ExPASy - ENZYME nomenclature database: 2.7.11.8
BRENDA, the Enzyme Database: 2.7.11.8
CAS: 170347-50-9

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (323)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (273)   
   KEGG MGENES (39)   
   RefGene (10)   
Protein sequence (17)   
   UniProt (4)   
   SWISS-PROT (2)   
   RefSeq(pep) (11)   
DNA sequence (14)   
   RefSeq(nuc) (12)   
   GenBank (2)   
Protein domain (3)   
   InterPro (3)   
All databases (363)   

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