| Entry |
|
|---|
| Name |
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
|
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
 |
|---|
| Sysname |
ATP:[Fas-activated serine/threonine protein] phosphotransferase
|
|---|
| Reaction(IUBMB) |
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
ATP [CPD: C00002];
[Fas-activated serine/threonine protein]
|
|---|
| Product |
ADP [CPD: C00008];
[Fas-activated serine/threonine phosphoprotein]
|
|---|
| Comment |
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
|
|---|
| History |
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
|
|---|
| Orthology |
| K08290 | Fas-activated serine/threonine kinase |
|
|---|
| Genes |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P. |
|---|
| Title |
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. |
|---|
| Journal |
J Exp Med 182:865-74 (1995) |
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Li W, Simarro M, Kedersha N, Anderson P. |
|---|
| Title |
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.11.8 |
| ExPASy - ENZYME nomenclature database: | 2.7.11.8 |
|
|---|
