| Entry |
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| Name |
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
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| Sysname |
ATP:[Fas-activated serine/threonine protein] phosphotransferase
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| Reaction(IUBMB) |
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
[Fas-activated serine/threonine protein]
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| Product |
ADP [CPD: C00008];
[Fas-activated serine/threonine phosphoprotein]
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| Comment |
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
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| History |
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
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| Orthology |
| K08290 | Fas-activated serine/threonine kinase |
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| Genes |
» show all
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| Reference |
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| Authors |
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P. |
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| Title |
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Li W, Simarro M, Kedersha N, Anderson P. |
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| Title |
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.11.8 |
| ExPASy - ENZYME nomenclature database: | 2.7.11.8 |
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