KEGG ENZYME: 2.7.11.9

ENZYME: 2.7.11.9

Entry

EC 2.7.11.9                 Enzyme

Name

Goodpasture-antigen-binding protein kinase;
GPBPK;
GPBP kinase;
STK11;
Goodpasture antigen-binding protein kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[Goodpasture antigen-binding protein] phosphotransferase

Reaction(IUBMB)

ATP + [Goodpasture antigen-binding protein] = ADP + [Goodpasture antigen-binding phosphoprotein]

Reaction(KEGG)

(other) R00162

Substrate

ATP [CPD:C00002];
[Goodpasture antigen-binding protein]

Product

ADP [CPD:C00008];
[Goodpasture antigen-binding phosphoprotein]

Comment

This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.

History

EC 2.7.11.9 created 2005 (EC 2.7.1.37 part-incorporated 2005)

Reference

1 [PMID:10212244]

Authors

Raya A, Revert F, Navarro S, Saus J

Title

Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen.

Journal

J Biol Chem 274:12642-9 (1999)
DOI:10.1074/jbc.274.18.12642

Reference

2 [PMID:11007769]

Authors

Raya A, Revert-Ros F, Martinez-Martinez P, Navarro S, Rosello E, Vieites B, Granero F, Forteza J, Saus J.

Title

Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis.

Journal

J Biol Chem 275:40392-9 (2000)
DOI:10.1074/jbc.M002769200

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.9

IUBMB Enzyme Nomenclature:

2.7.11.9

ExPASy - ENZYME nomenclature database:

2.7.11.9

BRENDA, the Enzyme Database:

2.7.11.9

CAS:	230316-19-5

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (19)   
   UniProt (12)   
   RefSeq(pep) (7)   
DNA sequence (28)   
   RefSeq(nuc) (14)   
   GenBank (14)   
All databases (53)   

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