Entry |
|
Name |
Goodpasture-antigen-binding protein kinase;
GPBPK;
GPBP kinase;
STK11;
Goodpasture antigen-binding protein kinase
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
 |
Sysname |
ATP:[Goodpasture antigen-binding protein] phosphotransferase
|
Reaction(IUBMB) |
ATP + [Goodpasture antigen-binding protein] = ADP + [Goodpasture antigen-binding phosphoprotein]
|
Reaction(KEGG) |
|
Substrate |
ATP [CPD: C00002];
[Goodpasture antigen-binding protein]
|
Product |
ADP [CPD: C00008];
[Goodpasture antigen-binding phosphoprotein]
|
Comment |
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
|
History |
EC 2.7.11.9 created 2005 (EC 2.7.1.37 part-incorporated 2005)
|
Reference |
|
Authors |
Raya A, Revert F, Navarro S, Saus J. |
Title |
Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen. |
Journal |
|
Reference |
|
Authors |
Raya A, Revert-Ros F, Martinez-Martinez P, Navarro S, Rosello E, Vieites B, Granero F, Forteza J, Saus J. |
Title |
Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.11.9 |
ExPASy - ENZYME nomenclature database: | 2.7.11.9 |
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