KEGG   ENZYME: 2.7.2.15
Entry
EC 2.7.2.15                 Enzyme                                 
Name
propionate kinase;
PduW;
TdcD;
propionate/acetate kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
Sysname
ATP:propanoate phosphotransferase
Reaction(IUBMB)
ATP + propanoate = ADP + propanoyl phosphate [RN:R01353]
Reaction(KEGG)
R00315 R01353
Substrate
ATP [CPD:C00002];
propanoate [CPD:C00163]
Product
ADP [CPD:C00008];
propanoyl phosphate [CPD:C02876]
Comment
Requires Mg2+. Acetate can also act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [1]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [1].
History
EC 2.7.2.15 created 2005
Pathway
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K00932  propionate kinase
K19697  propionate kinase
Genes
ECOb3115(tdcD)
ECJJW5806(tdcD)
ECDECDH10B_3289(tdcD)
EBWBWG_2823(tdcD)
ECOKECMDS42_2583(tdcD)
ECEZ4467(tdcD)
ECSECs_3995(tdcD)
ECFECH74115_4428(tdcD)
ETWECSP_4087(tdcD)
ELXCDCO157_3736
EOIECO111_3939(tdcD)
EOJECO26_4220(tdcD)
EOHECO103_3862(tdcD)
ECOOECRM13514_4076(tdcD)
ECOHECRM13516_3879(tdcD)
ESLO3K_03365
ESOO3O_22280
ESMO3M_03405
ECKEC55989_3532(tdcD)
ECGE2348C_3405(tdcD)
EOKG2583_3837(tdcD)
ELRECO55CA74_18300
ELHETEC_3383
ECWEcE24377A_3589(tdcD)
EUNUMNK88_3870(ackA)
ECPECP_3208
ENAECNA114_4344(tdcD)
ECOSEC958_3518(tdcD)
ECVAPECO1_2288 APECO1_3309(tdcD)
ECOAAPECO78_19410
ECXEcHS_A3303(tdcD)
ECMEcSMS35_3411(tdcD)
ECYECSE_3399
ECRECIAI1_3264(tdcD)
ECQECED1_3455 ECED1_3780(tdcD)
EUMECUMN_3599(tdcD)
ECTECIAI39_3616(tdcD)
EOCCE10_3647(tdcD)
EBRECB_02982(tdcD)
EBLECD_02982(tdcD)
EBEB21_02933(tdcD)
EBDECBD_0625
ECIUTI89_C3550(tdcD)
EIHECOK1_3542(tdcD)
ECZECS88_3508(tdcD) ECS88_4678
ECCc3873 c4530(tdcD)
ELOEC042_3407(tdcD)
ELNNRG857_15490
ESEECSF_2955
ECLEcolC_0583
EKOEKO11_0602
EKFKO11_07110(tdcD)
EABECABU_c35320(tdcD)
EDHEcDH1_0588
EDJECDH1ME8569_3008(tdcD)
ELUUM146_00755
ELWECW_m3384(tdcD)
ELLWFL_16540(tdcD)
ELCi14_3561(tdcD)
ELDi02_3561(tdcD)
ELPP12B_c3231(tdcD)
ELFLF82_2233(tdcD)
ECOLLY180_16090
ECOIECOPMV1_03429(tdcD)
ECOJP423_17570
EFEEFER_2027
EALEAKF1_ch2818(tdcD)
EMAC1192_19945
ESZFEM44_06640(tdcD)
STYSTY2262 STY3424(tdcD)
STTt0817 t3162(tdcD)
SEXSTBHUCCB_33440 STBHUCCB_8720
SENTTY21A_04150 TY21A_16025
STMSTM2057(pduW) STM3242(tdcD)
SEOSTM14_2546(pduW) STM14_3924(tdcD)
SEVSTMMW_20871 STMMW_32421
SEYSL1344_2033(pduW) SL1344_3214(tdcD)
SEMSTMDT12_C20790 STMDT12_C33000
SEJSTMUK_2087(pduW) STMUK_3231(tdcD)
SEBSTM474_2142(pduW) STM474_3396(tdcD)
SEFUMN798_2223(pduW) UMN798_3526(tdcD)
SETUSTU288_06675 STU288_16420
SETCCFSAN001921_00795 CFSAN001921_06500
SENRSTMDT2_20301(pduW) STMDT2_31341(tdcD)
SENDDT104_21141(pduW) DT104_32371(tdcD)
SENICY43_11100 CY43_16895
SEENSE451236_16495 SE451236_22340
SPTSPA0814(pduW) SPA3111(tdcD)
SEKSSPA0761 SSPA2905
SPQSPAB_01047 SPAB_04045
SEISPC_1657(pduW) SPC_3318(tdcD)
SECSCH_2066(pduW) SCH_3188(tdcD)
SEHSeHA_C2280(ackA) SeHA_C3537(ackA)
SHBSU5_02651 SU5_03736
SENHCFSAN002069_15925 CFSAN002069_21535
SEEHSEEH1578_02355 SEEH1578_19565
SEESNSL254_A2234(ackA) SNSL254_A3504(ackA)
SENNSN31241_31580 SN31241_43720
SEWSeSA_A2227(ackA) SeSA_A3433(ackA)
SEASeAg_B2180(ackA) SeAg_B3430(ackA)
SENSQ786_10155 Q786_15815
SEDSeD_A2393(ackA) SeD_A3600(ackA)
SEGSG2086(pduW) SG3139(tdcD)
SELSPUL_0843(pduW) SPUL_3255(tdcD)
SEGASPUCDC_0843(pduW) SPUCDC_3241(tdcD)
SETSEN2055(pduW) SEN3083(tdcD)
SENAAU38_10370 AU38_15700
SENOAU37_10380 AU37_15900
SENVAU39_10380 AU39_15895
SENQAU40_11625 AU40_17685
SENLIY59_10665 IY59_16300
SENJCFSAN001992_01150 CFSAN001992_17325
SEECCFSAN002050_17245 CFSAN002050_23200
SEEBSEEB0189_003655 SEEB0189_009180
SEEPI137_03800 I137_15530
SENBBN855_21420(ackA) BN855_33230
SENEIA1_10265 IA1_15685
SENCSEET0819_17430 SEET0819_23220
SESSARI_00830 SARI_04377
SBGSBG_2879(tdcD)
SBZA464_3326
SBVN643_14175
SALZEOS98_03080 EOS98_08725
SFLSF3155(tdcD)
SFXS3367(tdcD)
SFVSFV_3156(tdcD)
SFESFxv_3462(tdcD)
SFNSFy_4506
SFSSFyv_4580
SFTNCTC1_03420(tdcD)
SSNSSON_3272(tdcD)
SBOSBO_2980(tdcD)
SBCSbBS512_E3242(tdcD)
SDYSDY_3307(tdcD)
SDZAsd1617_04413
SHQA0259_19315
ENCECL_04509
ENLA3UG_19935
ECLGEC036_38890
ECLEECNIH2_20420
ECLNECNIH4_03280
ECLIECNIH5_19030
ECLXLI66_19690
ECLYLI62_21665
ECLZLI64_18805
ECLOENC_33660
EHMAB284_05705
EXFBFV63_19165
ECLAECNIH3_19130
ECLCECR091_19055
EAUDI57_21325
EKBBFV64_20550
ENOECENHK_19385
EECEcWSU1_03927(tdcD)
ELGBH714_20165
ECANCWI88_02855
ERNBFV67_19230
ECLSLI67_021105
ECHGFY206_21550(tdcD)
ESHC1N69_20045
ENTEnt638_3562
EASEntas_3790
ENXNI40_019450
LNICWR52_15515
EBGFAI37_09660(tdcD)
ENDA4308_04045
ENZG0034_19960(tdcD)
ENSHWQ15_04935(tdcD)
ENKLOC22_07710(tdcD)
EHUD5067_0003025(tdcD)
EMORL6Y89_19245(tdcD)
ENBELK40_19810
KPNKPN_02293(tdcD) KPN_03222(pduW)
KPUKP1_3409(tdcD) KP1_4491(pduW)
KPMKPHS_33000 KPHS_42850
KPPA79E_0888 A79E_1945
KPHKPNIH24_07365 KPNIH24_12035
KPZKPNIH27_15965 KPNIH27_20765
KPVKPNIH29_16420 KPNIH29_21535
KPWKPNIH30_16740 KPNIH30_21555
KPYKPNIH31_15840 KPNIH31_20820
KPGKPNIH32_16635 KPNIH32_22415
KPCKPNIH10_16215 KPNIH10_21350
KPQKPR0928_16190 KPR0928_20840
KPTVK055_0163(ackA) VK055_4303(ackA2)
KPOKPN2242_14410 KPN2242_19060
KPRKPR_1811(pduW) KPR_3203(tdcD)
KPJN559_1017 N559_1981
KPID364_11650 D364_16355
KPAKPNJ1_01022 KPNJ1_02140
KPSKPNJ2_01053 KPNJ2_02101
KPXPMK1_00703(pduW) PMK1_04654(tdcD)
KPBFH42_07540 FH42_12070
KPNEKU54_005015 KU54_009880
KPNULI86_05025 LI86_09835
KPNKBN49_0886(pduW) BN49_3394(tdcD)
KVAKvar_0848 Kvar_1910
KPEKPK_0893(pduW) KPK_2016(tdcD)
KPKA593_01005 A593_06240
KVDKR75_03690 KR75_24715
KVQSP68_05075 SP68_10235
KOXKOX_01540
KOEA225_4773
KOYJ415_08155
KOMHR38_27675
KMIVW41_20010
KOKKONIH1_23980
KOCAB185_12410
KQUAVR78_20465 AVR78_25860
EAEEAE_22040
EARCCG29523
KQVB8P98_04945 B8P98_10940
KLLBJF97_23810
KLWDA718_05380
KARLGL98_04525 LGL98_09490(tdcD)
KGRJJJ10_05400
KPASLUW96_01635
RORRORB6_03475 RORB6_03645
RPLNB1209_10130
RAODSD31_09915 DSD31_10085
REEelectrica_01998(tdcD)
CROROD_21431(pduW) ROD_47621(tdcD)
CKOCKO_00779 CKO_04515
CFDCFNIH1_02830 CFNIH1_21280
CBRAA6J81_01030 A6J81_20315
CWECO701_00875 CO701_07945
CYOCD187_02965 CD187_09130
CPOTFOB25_14320(tdcD) FOB25_20440
CFQC2U38_15400 C2U38_22495
CSEDJY391_03185(tdcD) JY391_08705
CAMAF384_10495 F384_17135
CAFAL524_12185 AL524_23530
CIFAL515_09965 AL515_20455
CFARCI104_03160 CI104_16280
CIRC2U53_06265 C2U53_26090
CIEAN232_07665 AN232_13910
CPARCUC49_05340 CUC49_16185
CTELGBC03_14200 GBC03_27720(tdcD)
CITZE4Z61_02770 E4Z61_19980(tdcD)
CARSE1B03_16810 E1B03_23075(tdcD)
CNTJT31_15955
CEMLH23_01775
CENLH86_01770
ESCEntcl_0583 Entcl_1740
KLEAO703_13245 AO703_18520
KIENCTC12125_04515(tdcD)
KASKATP_35580(tdcD)
LAXAPT61_02980
LEHC3F35_14895
LAZA8A57_18455
LEFLJPFL01_3665
LEWDAI21_07615
BUFD8682_02415 D8682_19420
BAGEBADSM9389_07280
BFTMNO13_03720(tdcD) MNO13_13055(tdcD)
METYMRY16398_18410(pduW)
AHNNCTC12129_00736(tdcD_1)
ASUBNLZ15_11360(tdcD) NLZ15_18920(tdcD)
YREHEC60_15105(tdcD)
SGOEA8O29_005410(tdcD)
KINAB182_08055
PDZHHA33_11180
PSGCG163CM_41900(tdcD)
EBFD782_0577
EBCC2U52_18640
EBUCUC76_20200 CUC76_25145
YENYE0338(tdcD) YE2747(pduW)
YEPYE105_C0366 YE105_C1538
YEYY11_16341 Y11_35781
YELLC20_07360
YEWCH47_2096(ackA) CH47_3136(ackA)
YETCH48_1252(ackA) CH48_3134(ackA)
YEFFORC2_2728 FORC2_3741
YEEYE5303_31801(pduW)
YALAT01_2860(ackA) AT01_4016(ackA)
YFRAW19_702(ackA)
YINCH53_1391(ackA) CH53_3350(ackA)
YKRCH54_960(ackA)
YRUBD65_1333(ackA)
YRBUGYR_07395
YAKACZ76_01750
YMADA391_08055
YHID5F51_11595
YCAF0T03_14065
YMOHRD69_13070
YASN0H69_17175
YKIHRD70_00825(tdcD) HRD70_18715
GQUAWC35_20630
PWAPecwa_4098
PPARA8F97_20995
PECW5S_4257
PWSA7983_05625
SODSant_2126(tdcD)
SLIGGTU79_14980
MINTC7M51_00180(tdcD)
MTHIC7M52_02539(tdcD)
ETRETAE_0896(tdcD)
ETDETAF_0836
ETEETEE_2779(tdcD)
ETCETAC_04285
EDWQY76_15705
EDLAAZ33_04750(tdcD)
EHOA9798_12290
HAVAT03_21325
HPARAL518_05445 AL518_16415
OPODSM2777_04090
XBCELE36_10260 ELE36_12825
VEJVEJY3_08465
VZIG5S32_07755
EMODM558_02430
APRSBI364_08950
RFOREIFOR_01380
AVRB565_1141
AVOAMS64_07500
AEMCK911_02465
AALLI6G90_09750(tdcD)
AJDI6H43_17035(tdcD)
TAUTola_1703
KKOKkor_1315
SLIMSCL_1777
BOKDM82_5787(ackA)
BOCBG90_4841(ackA)
CABASBC2_35140(tdcD)
NENNCHU2750_31760(ackA)
NHANham_4372
SSASSA_0541
LNGBSQ50_09355
EAVEH197_11740
ERAFJ9537_04870
VCPH9L18_05065
VLUM2919_01940
AHELQ31a_48310(pduW)
TRSTerro_3746
 » show all
Reference
1  [PMID:9484901]
  Authors
Hesslinger C, Fairhurst SA, Sawers G
  Title
Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate.
  Journal
Mol Microbiol 27:477-92 (1998)
DOI:10.1046/j.1365-2958.1998.00696.x
  Sequence
[eco:b3115]
Reference
2  [PMID:12700259]
  Authors
Palacios S, Starai VJ, Escalante-Semerena JC.
  Title
Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol.
  Journal
J Bacteriol 185:2802-10 (2003)
DOI:10.1128/JB.185.9.2802-2810.2003
Reference
3  [PMID:10498722]
  Authors
Wei Y, Miller CG.
  Title
Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium.
  Journal
J Bacteriol 181:6092-7 (1999)
DOI:10.1128/JB.181.19.6092-6097.1999
  Sequence
[stm:STM3242]
Reference
4  [PMID:15774882]
  Authors
Ingram-Smith C, Gorrell A, Lawrence SH, Iyer P, Smith K, Ferry JG.
  Title
Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase.
  Journal
J Bacteriol 187:2386-94 (2005)
DOI:10.1128/JB.187.7.2386-2394.2005
Reference
5  [PMID:16508089]
  Authors
Simanshu DK, Murthy MR.
  Title
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:52-5 (2005)
DOI:10.1107/S1744309104026429
Reference
6  [PMID:16139298]
  Authors
Simanshu DK, Savithri HS, Murthy MR.
  Title
Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.
  Journal
J Mol Biol 352:876-92 (2005)
DOI:10.1016/j.jmb.2005.07.069
  Sequence
[stm:STM3242]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.2.15
IUBMB Enzyme Nomenclature: 2.7.2.15
ExPASy - ENZYME nomenclature database: 2.7.2.15
BRENDA, the Enzyme Database: 2.7.2.15
CAS: 39369-28-3

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