KEGG ENZYME: 2.7.2.16

ENZYME: 2.7.2.16

Entry

EC 2.7.2.16                 Enzyme

Name

2-phosphoglycerate kinase;
pgk2 (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor

Sysname

ATP:2-phosphoglycerate 3-phosphotransferase

Reaction(IUBMB)

ATP + 2-phospho-D-glycerate = ADP + 2,3-diphospho-D-glycerate [RN:R02664]

Reaction(KEGG)

R02664

Substrate

ATP [CPD:C00002];
2-phospho-D-glycerate [CPD:C00631]

Product

ADP [CPD:C00008];
2,3-diphospho-D-glycerate [CPD:C01159]

Comment

The enzyme, found in a number of methanogenic archaeal genera, is involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. Activity is stimulated by potassium ions.

History

EC 2.7.2.16 created 2019

Orthology

K05715

2-phosphoglycerate kinase

Genes

EBX:	D5085_08360

RLO:	GQ464_015285

RBAR:

AWN76_018125

TAM:	Theam_0110

DTE:	Dester_0088

FRA:	Francci3_2383

FRI:	FraEuI1c_1617

RXY:

Rxyl_0777

RRD:	RradSPS_0650

RUB:	GBA63_06080

RMAR:

GBA65_14470

DRA:

DR_1514

DGE:

Dgeo_1765

DDR:	Deide_06610

DMR:	Deima_2799

DPT:	Deipr_0721

DGO:	DGo_CA0902

DPD:	Deipe_0950

DSW:	QR90_06485

DCH:	SY84_00360

DPU:	SU48_12650

DEZ:	DKM44_05645

DWU:	DVJ83_03475

DFC:

DFI_08620

DEIN:

DAAJ005_13615

DGA:	DEGR_17140

DPH:	EHF33_12505

DRD:	LMT64_03035

DRB:	N0D28_04165

DAH:	DAETH_29320

DAQU:

M8445_11180

DTAE:

LAJ19_04735

DMB:	E5F05_08685

DSC:	ABOD76_11125

DEID:

HLB42_09915

TRA:	Trad_0850 Trad_2028

TTH:

TT_C0121

TTJ:	TTHA0495(TTHA0495)

TTS:	Ththe16_0495

TTL:	TtJL18_1583

TSC:	TSC_c19610

THC:	TCCBUS3UF1_17550

TOS:	Theos_1814

TAQ:

TO73_1841

TPAR:

AV541_08230

TBC:	A0O31_01897

TANT:

KNN15_01315

MRB:	Mrub_0491 Mrub_1022

MRE:	K649_02080 K649_04755

MTAI:

Mtai_v1c04270

MSV:	Mesil_1353

OPR:	Ocepr_1323

MHD:	Marky_1499

NFT:	FBF37_03295

CGW:	UR58_C0001G0492

MJA:

MJ_1482

MFE:	Mefer_1456

MVU:	Metvu_1257

MFS:	MFS40622_0982

MIF:	Metin_1099

MJH:	JH146_1500

MESG:

MLAUSG7_1394(pgk)

MESA:

MLASG1_0821(pgk)

MIG:	Metig_0799

MMP:	MMP1431(2pgk)

MMQ:	MmarC5_0147

MMX:	MmarC6_1242

MMZ:	MmarC7_0676

MMD:

GYY_07990

MMAK:

MMKA1_16550(pgk2)

MMAO:

MMOS7_15380(pgk2)

MMAD:

MMJJ_14080

MAE:

Maeo_0251

MVN:	Mevan_0742

MVO:

Mvol_1490

MOK:	Metok_0252

METF:

CFE53_05275

MTH:

MTH_1883

MMG:	MTBMA_c04540(pgk1)

MWO:	MWSIV6_0414(pgk2_3)

MTEE:

MTTB_11730

METC:

MTCT_1721

METE:

tca_01819

METZ:

METMT2_0217

METK:

FVF72_02290

MTHM:

FZP57_01945

METJ:

FZP68_06975

MST:	Msp_0443(pgk2-1)

METB:

AW729_03330

MEIS:

PXD04_07350

MRU:	mru_0822(pgk2B)

MSI:

Msm_0791

MEB:	Abm4_1302(pgk2)

MMIL:

sm9_1712(pgk2B)

MEYE:

TL18_07615

MOL:

YLM1_0409

MARO:

MarbSA_07000

METV:

K4897_07540

MEL:	Metbo_0705

MEW:	MSWAN_1548

METH:

MBMB1_1270(pgk2)

MFC:	BRM9_0486(pgk2B)

MFI:	DSM1535_0467(pgk2)

MCUB:

MCBB_1485(pgk2_1)

MSUB:

BK009_05265

METN:

BK008_00810

METT:

CIT01_08490

METO:

CIT02_11705

MEME:

HYG87_08930

MFEG:

GCM10025860_26150

MEER:

NKF70_03145

MRID:

FGU46_08660

MFV:

Mfer_0247

MKA:

MK0868

PFU:

PF0078

PFI:

PFC_07810

PHO:	PH0149(PH0149)

PAB:

PAB2253

PYN:

PNA2_0684

PYA:	PYCH_14390

PYS:

Py04_0159

PYC:	TQ32_06565

TKO:

TK1038

TON:

TON_0742

TGA:

TGAM_0724

TSI:

TSIB_0159

TBA:	TERMP_00451

THE:

GQS_01215

THA:

TAM4_889

THM:

CL1_1941

TLT:

OCC_11507

TNU:

BD01_0985

TEU:

TEU_10720

TGY:	X802_06790

THV:	ADU37_CDS00760

TCH:	CHITON_0180

TPEP:

A0127_10025

TPIE:

A7C91_09855

TGG:	A3K92_03150

TCE:	A3L02_08270

TBS:	A3L01_04475

THH:	CDI07_04390

TSL:	A3L11_08575

TTD:	A3L14_06425

TPRF:

A3L09_05020

TRL:	A3L10_02100

TPAF:

A3L08_07435

THY:	A3L12_07810

TIC:	FH039_08730

TCQ:	TIRI35C_1152(pgk)

THEM:

FPV09_00950

THEI:

K1720_03860

TAGG:

NF865_06410

PPAC:

PAP_01540

» show all

Reference

1 [PMID:2226838]

Authors

Lehmacher A, Vogt AB, Hensel R

Title

Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus.

Journal

FEBS Lett 272:94-8 (1990)
DOI:10.1016/0014-5793(90)80456-s

Reference

2 [PMID:8159166]

Authors

Lehmacher A, Hensel R

Title

Cloning, sequencing and expression of the gene encoding 2-phosphoglycerate kinase from Methanothermus fervidus.

Journal

Mol Gen Genet 242:163-8 (1994)
DOI:10.1007/bf00391009

Sequence

[mfv:Mfer_0247]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.2.16

IUBMB Enzyme Nomenclature:

2.7.2.16

ExPASy - ENZYME nomenclature database:

2.7.2.16

BRENDA, the Enzyme Database:

2.7.2.16

All links

Gene (905)   
   MGENES (905)   
Protein sequence (219)   
   UniProt (206)   
   SWISS-PROT (13)   
Protein domain (3)   
   InterPro (3)   
All databases (1127)   

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