KEGG ENZYME: 2.7.2.16

ENZYME: 2.7.2.16

Entry

EC 2.7.2.16                 Enzyme

Name

2-phosphoglycerate kinase;
pgk2 (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor

Sysname

ATP:2-phosphoglycerate 3-phosphotransferase

Reaction(IUBMB)

ATP + 2-phospho-D-glycerate = ADP + 2,3-diphospho-D-glycerate [RN:R02664]

Reaction(KEGG)

R02664

Substrate

ATP [CPD:C00002];
2-phospho-D-glycerate [CPD:C00631]

Product

ADP [CPD:C00008];
2,3-diphospho-D-glycerate [CPD:C01159]

Comment

The enzyme, found in a number of methanogenic archaeal genera, is involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. Activity is stimulated by potassium ions.

History

EC 2.7.2.16 created 2019

Orthology

K05715

2-phosphoglycerate kinase

Genes

FRA:	Francci3_2383

FRI:	FraEuI1c_1617

RXY:

Rxyl_0777

RRD:	RradSPS_0650

RUB:	GBA63_06080

RMAR:

GBA65_14470

DRA:

DR_1514

DGE:

Dgeo_1765

DDR:	Deide_06610

DMR:	Deima_2799

DPT:	Deipr_0721

DGO:	DGo_CA0902

DPD:	Deipe_0950

DSW:	QR90_06485

DCH:	SY84_00360

DPU:	SU48_12650

DEZ:	DKM44_05645

DWU:	DVJ83_03475

DFC:

DFI_08620

DEIN:

DAAJ005_13615

DGA:	DEGR_17140

DPH:	EHF33_12505

DRD:	LMT64_03035

DRB:	N0D28_04165

DAH:	DAETH_29320

TRA:	Trad_0850 Trad_2028

TTH:

TT_C0121

TTJ:	TTHA0495(TTHA0495)

TTS:	Ththe16_0495

TTL:	TtJL18_1583

TSC:	TSC_c19610

THC:	TCCBUS3UF1_17550

TOS:	Theos_1814

TAQ:

TO73_1841

TPAR:

AV541_08230

TBC:	A0O31_01897

TANT:

KNN15_01315

MRB:	Mrub_0491 Mrub_1022

MRE:	K649_02080 K649_04755

MSV:	Mesil_1353

MTAI:

Mtai_v1c04270

OPR:	Ocepr_1323

MHD:	Marky_1499

RBAR:

AWN76_018125

TAM:	Theam_0110

DTE:	Dester_0088

NFT:	FBF37_03295

CGW:	UR58_C0001G0492

MJA:

MJ_1482

MFE:	Mefer_1456

MVU:	Metvu_1257

MFS:	MFS40622_0982

MIF:	Metin_1099

MJH:	JH146_1500

MESG:

MLAUSG7_1394(pgk)

MESA:

MLASG1_0821(pgk)

MIG:	Metig_0799

MMP:	MMP1431(2pgk)

MMQ:	MmarC5_0147

MMX:	MmarC6_1242

MMZ:	MmarC7_0676

MMD:

GYY_07990

MMAK:

MMKA1_16550(pgk2)

MMAO:

MMOS7_15380(pgk2)

MMAD:

MMJJ_14080

MAE:

Maeo_0251

MVN:	Mevan_0742

MVO:

Mvol_1490

MOK:	Metok_0252

METF:

CFE53_05275

MTH:

MTH_1883

MMG:	MTBMA_c04540(pgk1)

MWO:	MWSIV6_0414(pgk2_3)

MTEE:

MTTB_11730

METC:

MTCT_1721

METE:

tca_01819

METZ:

METMT2_0217

METK:

FVF72_02290

MTHM:

FZP57_01945

METJ:

FZP68_06975

MST:	Msp_0443(pgk2-1)

METB:

AW729_03330

MRU:	mru_0822(pgk2B)

MSI:

Msm_0791

MEB:	Abm4_1302(pgk2)

MMIL:

sm9_1712(pgk2B)

MEYE:

TL18_07615

MOL:

YLM1_0409

MARO:

MarbSA_07000

METV:

K4897_07540

MEL:	Metbo_0705

MEW:	MSWAN_1548

METH:

MBMB1_1270(pgk2)

MFC:	BRM9_0486(pgk2B)

MFI:	DSM1535_0467(pgk2)

MCUB:

MCBB_1485(pgk2_1)

MSUB:

BK009_05265

METN:

BK008_00810

METT:

CIT01_08490

METO:

CIT02_11705

MEME:

HYG87_08930

MFV:

Mfer_0247

MKA:

MK0868

PFU:

PF0078

PFI:

PFC_07810

PHO:	PH0149(PH0149)

PAB:

PAB2253

PYN:

PNA2_0684

PYA:	PYCH_14390

PYS:

Py04_0159

PYC:	TQ32_06565

TKO:

TK1038

TON:

TON_0742

TGA:

TGAM_0724

TSI:

TSIB_0159

TBA:	TERMP_00451

THE:

GQS_01215

THA:

TAM4_889

THM:

CL1_1941

TLT:

OCC_11507

TNU:

BD01_0985

TEU:

TEU_10720

TGY:	X802_06790

THV:	ADU37_CDS00760

TCH:	CHITON_0180

TPEP:

A0127_10025

TPIE:

A7C91_09855

TGG:	A3K92_03150

TCE:	A3L02_08270

TBS:	A3L01_04475

THH:	CDI07_04390

TSL:	A3L11_08575

TTD:	A3L14_06425

TPRF:

A3L09_05020

TRL:	A3L10_02100

TPAF:

A3L08_07435

THY:	A3L12_07810

TIC:	FH039_08730

TCQ:	TIRI35C_1152(pgk)

THEM:

FPV09_00950

THEI:

K1720_03860

PPAC:

PAP_01540

» show all

Reference

1 [PMID:2226838]

Authors

Lehmacher A, Vogt AB, Hensel R

Title

Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus.

Journal

FEBS Lett 272:94-8 (1990)
DOI:10.1016/0014-5793(90)80456-s

Reference

2 [PMID:8159166]

Authors

Lehmacher A, Hensel R

Title

Cloning, sequencing and expression of the gene encoding 2-phosphoglycerate kinase from Methanothermus fervidus.

Journal

Mol Gen Genet 242:163-8 (1994)
DOI:10.1007/bf00391009

Sequence

[mfv:Mfer_0247]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.2.16

IUBMB Enzyme Nomenclature:

2.7.2.16

ExPASy - ENZYME nomenclature database:

2.7.2.16

BRENDA, the Enzyme Database:

2.7.2.16

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (907)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (145)   
   KEGG MGENES (761)   
Protein sequence (214)   
   UniProt (201)   
   SWISS-PROT (13)   
Protein domain (3)   
   InterPro (3)   
All databases (1131)   

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