KEGG   ENZYME: 2.7.3.2Help
Entry
EC 2.7.3.2                  Enzyme                                 

Name
creatine kinase;
ATP:creatine phosphotransferase;
CK;
MM-CK;
MB-CK;
BB-CK;
creatine phosphokinase;
creatine phosphotransferase;
phosphocreatine kinase;
adenosine triphosphate-creatine transphosphorylase;
Mi-CK;
CK-BB;
CK-MM;
CK-MB;
CKMiMi;
MiMi-CK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a nitrogenous group as acceptor
BRITE hierarchy
Sysname
ATP:creatine N-phosphotransferase
Reaction(IUBMB)
ATP + creatine = ADP + phosphocreatine [RN:R01881]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
creatine [CPD:C00300]
Product
ADP [CPD:C00008];
phosphocreatine [CPD:C02305]
Comment
N-Ethylglycocyamine can also act as acceptor.
History
EC 2.7.3.2 created 1961
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K00933  creatine kinase
Genes
HSA: 1152(CKB) 1158(CKM) 1159(CKMT1B) 1160(CKMT2) 548596(CKMT1A)
PTR: 100608872 453185(CKB) 461770(CKMT2) 742521 744935(CKM)
PON: 100173361(CKMT2) 100432695 100435206 100438059(CKB) 100455238(CKM)
MCC: 711167(CKB) 711434(CKMT2) 712886 714168(CKM)
MMU: 12709(Ckb) 12715(Ckm) 12716(Ckmt1) 76722(Ckmt2)
RNO: 24264(Ckb) 24265(Ckm) 29593(Ckmt1) 688698(Ckmt2)
MUN: 110539559 110551487(Ckm) 110556226 110560179(Ckb)
CFA: 100855552(CKB) 476435(CKM) 478277(CKMT1A) 479163(CKMT2)
AML: 100465658(CKB) 100473352(CKMT2) 100473415(CKMT1B) 100480943(CKM)
BTA: 281692(CKMT1B) 286822(CKM) 516210(CKB) 538944(CKMT2)
SSC: 100519994(CKMT1A) 100627332(CKB) 397264(CKM) 733602(CKMT2)
DLE: 111176038(CKB) 111180746(CKM) 111181669 111184776(CKMT2)
ECB: 100055201(CKB) 100056283 100065641(CKM) 100073253(CKMT2)
MNA: 107535083(CKMT2) 107536330 107536770(CKM)
MDO: 100011609(CKMT1A) 100012235(CKMT2) 100015112(CKM) 100017071(CKB)
PCW: 110197349(CKB) 110203641(CKM) 110222607(CKMT2) 110223738(CKMT1A)
OAA: 100076820(CKB) 100081308(CKMT2) 100082097(CKM) 100085972
GGA: 374002(CKMT1A) 396248(CKB) 396508(CKMT2)
MGP: 100538538 100550185(CKB) 104915281(CKMT2)
TGU: 100190470(CKB) 100225089(CKMT2) 100228000
LSR: 110469783(CKB) 110476679(CKMT1A) 110482537(CKMT2)
CPIC: 101951071(CKM)
XLA: 108700198 379216(ckmt1b.S) 379765(ckm.L) 380055(ckb.L) 380155(ckmt1b.L)
XTR: 395000(ckmt1b) 395005(ckm) 733543(ckb)
DRE: 140744(ckbb) 30095(ckma) 321892(ckmt1) 327506(ckmt2a) 564694(ckba) 794752(ckmb) 799492(ckmt2b)
SPU: 373287(TCK) 589605 762696
AME: 409807
NVI: 100118833(Argk)
CEL: CELE_ZC434.8(ZC434.8)
BMY: Bm1_23610
DPS: DP1035
MXA: MXAN_2252
 » show all
Taxonomy
Reference
1  [PMID:13235819]
  Authors
ENNOR AH, ROSENBERG H, ARMSTRONG MD.
  Title
Specificity of creatine phosphokinase.
  Journal
Nature 175:120 (1955)
Reference
2  [PMID:5750168]
  Authors
Keutel HJ, Jacobs HK, Okabe K, Yue RH, Kuby SA.
  Title
Studies on adenosine triphosphate transphosphorylases. VII. Isolation of the crystalline adenosine triphosphate--creatine transphosphorylase from calf brain.
  Journal
Biochemistry 7:4283-90 (1968)
Reference
3  [PMID:13192073]
  Authors
KUBY SA, NODA L, LARDY HA.
  Title
Adenosinetriphosphate-creatine transphosphorylase. I. Isolation of the crystalline enzyme from rabbit muscle.
  Journal
J Biol Chem 209:191-201 (1954)
Reference
4
  Authors
Kuby, S.A. and Noltmann, E.A.
  Title
ATP-creatine transphosphorylase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 515-603.
Other DBs
ExplorEnz - The Enzyme Database: 2.7.3.2
IUBMB Enzyme Nomenclature: 2.7.3.2
ExPASy - ENZYME nomenclature database: 2.7.3.2
BRENDA, the Enzyme Database: 2.7.3.2
CAS: 9001-15-4

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