KEGG   ENZYME: 2.7.4.14
Entry
EC 2.7.4.14                 Enzyme                                 

Name
UMP/CMP kinase;
cytidylate kinase (misleading);
deoxycytidylate kinase (misleading);
CTP:CMP phosphotransferase (misleading);
dCMP kinase (misleading);
deoxycytidine monophosphokinase (misleading);
UMP-CMP kinase;
ATP:UMP-CMP phosphotransferase;
pyrimidine nucleoside monophosphate kinase;
uridine monophosphate-cytidine monophosphate phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
Sysname
ATP:(d)CMP/UMP phosphotransferase
Reaction(IUBMB)
(1) ATP + (d)CMP = ADP + (d)CDP [RN:R00512 R01665];
(2) ATP + UMP = ADP + UDP [RN:R00158]
Reaction(KEGG)
R00158 R00512 R01665;
(other) R11891 R11892
Substrate
ATP [CPD:C00002];
dCMP [CPD:C00239];
UMP [CPD:C00105]
Product
ADP [CPD:C00008];
dCDP [CPD:C00705];
UDP [CPD:C00015]
Comment
This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, (d)CMP kinase and EC 2.7.4.22, UMP kinase.
History
EC 2.7.4.14 created 1961 as EC 2.7.4.5, transferred 1972 to EC 2.7.4.14, modified 1980, modified 2011
Pathway
ec00240  Pyrimidine metabolism
ec00983  Drug metabolism - other enzymes
ec01100  Metabolic pathways
Orthology
K13800  UMP-CMP kinase
K13809  UMP-CMP kinase 2, mitochondrial
Genes
HSA: 129607(CMPK2) 51727(CMPK1)
PTR: 456837(CMPK1) 459005(CMPK2)
PPS: 100977432(CMPK1) 100977684 100993076(CMPK2)
GGO: 101143292(CMPK2) 101147631(CMPK1)
PON: 100437591(CMPK1)
NLE: 100583014(CMPK1) 100597489(CMPK2)
MCC: 700256 708602(CMPK2) 710196(CMPK1)
MCF: 101866162(CMPK2) 102118265(CMPK1)
CSAB: 103220884(CMPK2) 103224864(CMPK1)
CATY: 105571700(CMPK1) 105587562(CMPK2)
PANU: 101013859(CMPK2) 101016720(CMPK1)
RRO: 104657138(CMPK1) 104659046(CMPK2)
RBB: 108529614(CMPK1) 108545152(CMPK2)
TFN: 117062773(CMPK2) 117092632(CMPK1)
PTEH: 111531563(CMPK2) 111548801(CMPK1)
CJC: 100386422(CMPK1) 100410513(CMPK2)
SBQ: 101043533(CMPK2) 101051541(CMPK1)
MMUR: 105870630(CMPK2) 105877517(CMPK1)
MMU: 22169(Cmpk2) 66588(Cmpk1)
MCAL: 110292621(Cmpk1) 110306881(Cmpk2)
MPAH: 110323387(Cmpk1) 110324821(Cmpk2)
RNO: 298410(Cmpk1) 314004(Cmpk2)
MCOC: 116080256(Cmpk2) 116096426(Cmpk1)
MUN: 110542937(Cmpk1) 110557117(Cmpk2)
CGE: 100754791(Cmpk2) 100758717(Cmpk1)
PLEU: 114685781 114702669(Cmpk2) 114706659(Cmpk1)
NGI: 103733674(Cmpk1) 103747639(Cmpk2)
HGL: 101703729(Cmpk1) 101712024(Cmpk2)
CCAN: 109699348(Cmpk1) 109701851(Cmpk2)
OCU: 100339994(CMPK1) 100348784(CMPK2)
OPI: 101528837(CMPK1) 101530841(CMPK2)
TUP: 102499904(CMPK2) 102500784(CMPK1)
CFA: 608996(CMPK2) 610291(CMPK1)
VVP: 112914744(CMPK1) 112927769(CMPK2)
VLG: 121481323(CMPK1) 121490382(CMPK2) 121496467
AML: 100464422(CMPK2) 100471225(CMPK1)
UMR: 103658121(CMPK2) 103670889(CMPK1)
UAH: 113254705(CMPK1) 113269399(CMPK2)
ORO: 101371928 101378888(CMPK1) 101382525(CMPK2)
MPUF: 101670174(CMPK1) 101680127(CMPK2)
EJU: 114205824(CMPK2) 114212162(CMPK1) 114213667
FCA: 101096470(CMPK2) 105260825(CMPK1)
PYU: 121027079(CMPK1) 121044608(CMPK2)
PBG: 122480473(CMPK1) 122497499(CMPK2)
PTG: 102951048(CMPK1) 102968167(CMPK2)
PPAD: 109266925(CMPK1) 109269078(CMPK2)
AJU: 106974144(CMPK1) 106982955(CMPK2) 113603551
HHV: 120222093(CMPK1) 120241902(CMPK2)
BTA: 509965(CMPK1) 784304(CMPK2)
BOM: 102274423(CMPK1) 102283416(CMPK2)
BIU: 109556321(CMPK1) 109565611(CMPK2)
BBUB: 102406686(CMPK2) 102411581(CMPK1)
CHX: 102189688(CMPK2) 102191483(CMPK1)
OAS: 101106892(CMPK1) 101123366(CMPK2)
ODA: 120852241(CMPK2) 120856182(CMPK1)
CCAD: 122437010(CMPK1) 122442103(CMPK2)
SSC: 100521561(CMPK1) 100623872(CMPK2)
CFR: 102514270(CMPK2) 102523636(CMPK1)
CBAI: 105066002(CMPK1) 105076045(CMPK2)
CDK: 105092937(CMPK1) 105104265(CMPK2)
BACU: 103007186(CMPK1) 103018920(CMPK2)
LVE: 103070255(CMPK2) 103083702(CMPK1)
OOR: 101270951(CMPK1) 101282238(CMPK2)
DLE: 111171354(CMPK2) 111175780(CMPK1)
PCAD: 102975058(CMPK2) 102979686(CMPK1)
ECB: 100063738(CMPK1) 100072617(CMPK2)
EPZ: 103549691(CMPK2) 103565624(CMPK1)
EAI: 106833861(CMPK1) 106847430(CMPK2)
MYB: 102243435(CMPK1) 102257808(CMPK2)
MYD: 102765692(CMPK2) 102769732(CMPK1)
MMYO: 118669313(CMPK2) 118675388(CMPK1)
MNA: 107526677(CMPK2) 107526744(CMPK1)
PKL: 118714850(CMPK2) 118722880(CMPK1)
HAI: 109371966(CMPK1) 109384700(CMPK2)
DRO: 112298006(CMPK2) 112314474(CMPK1)
SHON: 118985024(CMPK1) 118988738(CMPK2)
AJM: 119039829(CMPK1) 119053966(CMPK2)
MMF: 118627171(CMPK1) 118631104(CMPK2)
PALE: 102878174(CMPK1) 102896687(CMPK2)
PGIG: 120591532(CMPK2) 120620476(CMPK1)
RAY: 107498227(CMPK2) 107514029(CMPK1)
MJV: 108387670(CMPK2) 108404956(CMPK1)
TOD: 119235936(CMPK1) 119251858 119259580(CMPK2)
LAV: 100656870(CMPK2) 100672042(CMPK1)
MDO: 100023236(CMPK1) 100032226(CMPK2)
SHR: 100929742(CMPK1) 100931536(CMPK2)
PCW: 110209320(CMPK1) 110212690(CMPK2)
OAA: 100084917(CMPK1) 100091189(CMPK2)
GGA: 421921(CMPK2) 429100(CMPK1)
PCOC: 116234450(CMPK1) 116240577(CMPK2)
MGP: 100538899(CMPK1) 100548481(CMPK2)
CJO: 107312186(CMPK2) 107317602(CMPK1)
NMEL: 110396705(CMPK2) 110402518(CMPK1)
APLA: 101790338(CMPK2) 101797132(CMPK1)
ACYG: 106030698(CMPK2) 106033039(CMPK1)
TGU: 100224095(CMPK2) 100229908(CMPK1)
LSR: 110469862(CMPK1) 110482182(CMPK2)
SCAN: 103815002(CMPK1) 103822890(CMPK2)
PMOA: 120503220(CMPK1) 120505264(CMPK2)
OTC: 121344282(CMPK2) 121345041(CMPK1)
PRUF: 121359148(CMPK2) 121362141(CMPK1)
GFR: 102039126(CMPK2) 102041969(CMPK1)
FAB: 101807969(CMPK1) 101818975(CMPK2)
PHI: 102099991(CMPK1) 102101770(CMPK2)
PMAJ: 107202543(CMPK2) 107208436(CMPK1)
CCAE: 111926046(CMPK2) 111933079(CMPK1)
CCW: 104685514(CMPK2) 104695218(CMPK1)
FPG: 101911053(CMPK1) 101923236(CMPK2)
FCH: 102050231(CMPK1) 102055054(CMPK2)
CLV: 102087661(CMPK1) 102096553(CMPK2)
EGZ: 104123503(CMPK1) 104127138(CMPK2)
NNI: 104009161(CMPK2) 104015529(CMPK1)
ACUN: 113478960(CMPK2) 113482819(CMPK1)
PADL: 103919144(CMPK1) 103924060(CMPK2)
AAM: 106489275(CMPK1) 106494719(CMPK2)
AROW: 112966791(CMPK2) 112976045(CMPK1)
NPD: 112942861(CMPK1)
DNE: 112981506(CMPK2) 112985673(CMPK1)
ASN: 102369091(CMPK1) 102374461(CMPK2)
AMJ: 102561664(CMPK2) 102569887(CMPK1)
CPOO: 109307452(CMPK1) 109311671(CMPK2)
GGN: 109286677(CMPK1) 109300050(CMPK2)
PSS: 102447134(CMPK2) 102454984(CMPK1)
CMY: 102934308(CMPK2) 102938102(CMPK1)
CPIC: 101944522(CMPK2) 101953283(CMPK1)
TST: 117875278(CMPK2) 117881819(CMPK1)
CABI: 116817585(CMPK2) 116839239(CMPK1)
ACS: 100562095(cmpk1) 100565288(cmpk2)
PVT: 110069787(CMPK2) 110086553(CMPK1)
PBI: 103054958(CMPK1) 103067607(CMPK2)
PMUR: 107284483(CMPK1) 107298091(CMPK2)
TSR: 106554524(CMPK2) 106556776(CMPK1)
PGUT: 117664191(CMPK1) 117674200(CMPK2)
PMUA: 114593767(CMPK2) 114599034(CMPK1)
ZVI: 118082778(CMPK2) 118088654(CMPK1)
GJA: 107121335(CMPK1) 107125572(CMPK2)
XLA: 108714299(cmpk1.L) 108717168(cmpk2.L) 108718229(cmpk2.S) 398670(cmpk1.S)
XTR: 100493600(cmpk2) 733534(cmpk1)
NPR: 108784266(CMPK1) 108788005(CMPK2)
DRE: 406383(cmpk) 570478(cmpk2)
IPU: 108267647(cmpk1) 108268039 108270477(cmpk2)
AMEX: 103043729(cmpk1) 103046469(cmpk2)
EEE: 113570140(cmpk1) 113579135(cmpk2)
TRU: 101065612(cmpk1) 101074244(cmpk2)
LCO: 109138539(cmpk1)
NCC: 104945534(cmpk2) 104954191(cmpk1)
CGOB: 115022496(cmpk1) 115027501(cmpk2)
ELY: 117266868(cmpk2) 117272163(cmpk)
PLEP: 121951730(cmpk) 121953899(cmpk2)
SLUC: 116035916(cmpk2) 116046173(cmpk)
ECRA: 117936346(cmpk2) 117953764(cmpk)
PFLV: 114547204(cmpk2) 114565394(cmpk1)
GAT: 120815853(cmpk) 120833252(cmpk2)
PPUG: 119208371(cmpk) 119227344(cmpk2)
MSAM: 119902306(cmpk) 119910891(cmpk2)
CUD: 121519564(cmpk) 121526343(cmpk2)
MZE: 101468245(cmpk2) 101481811
ONL: 100703671(cmpk1) 100712569(cmpk2)
OAU: 116320425(cmpk) 116334848(cmpk2)
OLA: 101154834(cmpk2) 101156041(cmpk1)
OML: 112144419(cmpk) 112147681(cmpk2)
XMA: 102222264(cmpk1) 106699691(cmpk2)
XCO: 114134726(cmpk2) 114146793(cmpk1)
XHE: 116708680(cmpk2) 116721624(cmpk1)
PRET: 103458796(cmpk2) 103479088(cmpk1)
CVG: 107084706(cmpk2) 107102036
CTUL: 119774550(cmpk) 119797799(cmpk2)
NFU: 107392265(cmpk2) 107396217(cmpk1)
KMR: 108233569(cmpk2) 108248528(cmpk)
ALIM: 106521794(cmpk2) 106530400(cmpk1)
AOCE: 111583445(cmpk1) 111588694(cmpk2)
CSEM: 103396125(cmpk1)
POV: 109639703(cmpk1)
LCF: 108883744(cmpk1) 108888149(cmpk2)
SDU: 111225531(cmpk2) 111229038(cmpk1)
SLAL: 111644754(cmpk2) 111661246(cmpk1)
XGL: 120795670(cmpk2) 120798433(cmpk)
HCQ: 109520530(cmpk1) 109526145(cmpk2)
BPEC: 110173526(cmpk1)
MALB: 109951943(cmpk1) 109955070(cmpk2)
OTW: 112256494(cmpk2) 112260189(cmpk)
OMY: 110505317(cmpk2) 110530069(cmpk)
ELS: 105026588(cmpk2) 105030370(cmpk1)
SFM: 108919859(cmpk1) 108938120(cmpk2)
AANG: 118214480(cmpk2) 118224498 118229794(cmpk)
LOC: 102689410(cmpk1) 102698321(cmpk2)
ARUT: 117402694(cmpk2) 117416620(cmpk)
LCM: 102353387(CMPK2) 102363916(CMPK1)
CMK: 103185264(cmpk) 103187110(cmpk2)
RTP: 109930662(cmpk2) 109933953(cmpk1)
APLC: 110977720
SKO: 100367240
DME: Dmel_CG6092(Dak1)
DER: 6554407
DSE: 6617018
DSI: Dsimw501_GD18150(Dsim_GD18150)
DSR: 110186208
DWI: 6651186
DGR: 6563590
DAZ: 108621448
DNV: 108660154
DHE: 111595153
DVI: 6630933
CCAT: 101452810
BOD: 106618349
MDE: 101898297
SCAC: 106089955
LCQ: 111677696
ACOZ: 120948714
AARA: 120904803
AAG: 5570159
AALB: 109414508
CPII: 120420944
AME: 100578311
ACER: 108001048
BIM: 100741048
BBIF: 117213620
BVK: 117243046
BVAN: 117163212
BTER: 100643649
CCAL: 108630294
OBB: 114875334
MGEN: 117220720
NMEA: 116429739
CGIG: 122401474
SOC: 105192860
MPHA: 105833271
AEC: 105147315
ACEP: 105625701
PBAR: 105433225
VEM: 105570484
HST: 105191229
DQU: 106746135
CFO: 105251862
FEX: 115236251
LHU: 105673121
PGC: 109864250
OBO: 105275481
PCF: 106792326
PFUC: 122514678
NVI: 100118675
CSOL: 105362611
TPRE: 106650952
MDL: 103571784
FAS: 105264002
DAM: 107048415
CCIN: 107270285
ATD: 109609485
APLN: 108743104
PPYR: 116165247
BMOR: 732890
BMAN: 114239766
MSEX: 115451999
BANY: 112047040
PMAC: 106715779
PPOT: 106102149
PRAP: 110996305
ZCE: 119831646
HAW: 110381293
TNL: 113505327
API: 100165780
DNX: 107170544
AGS: 114122669
RMD: 113548546
BTAB: 109041201
NLU: 111050900
CSEC: 111872856
DMK: 116920367
HAME: 121857762
HAZT: 108667976
EAF: 111712499
DSV: 119433385
RSAN: 119405017
RMP: 119181294
VDE: 111243996
VJA: 111270817
TUT: 107361381
PTEP: 107452448
SDM: 118190408
CEL: CELE_C29F7.3(C29F7.3) CELE_F40F8.1(F40F8.1)
BMY: BM_BM3965(Bm3965)
TSP: Tsp_00848
BGT: 106070877
OBI: 106884325
OSN: 115218553
NVE: 5507612
EPA: 110238444
ATEN: 116299753
ADF: 107358144
AMIL: 114948003
PDAM: 113676867
SPIS: 111323076
HMG: 100204580
AQU: 100640424
LJA: Lj3g3v0618170.1(Lj3g3v0618170.1) Lj3g3v3751960.1(Lj3g3v3751960.1) Lj3g3v3751960.2(Lj3g3v3751960.2) Lj3g3v3751960.3(Lj3g3v3751960.3)
FVE: 101302371
DOSA: Os02t0778400-01(Os02g0778400) Os04t0105500-01(Os04g0105500) Os06t0109600-01(Os06g0109600) Os06t0203500-01(Os06g0203500) Os07t0624700-01(Os07g0624700)
ATR: 18428724
VCN: VOLCADRAFT_79151(adk2)
APRO: F751_5655
SCE: YKL024C(URA6)
ERC: Ecym_5638
NCS: NCAS_0H03560(NCAS0H03560)
NDI: NDAI_0C00140(NDAI0C00140)
TPF: TPHA_0N01890(TPHA0N01890)
TBL: TBLA_0C01030(TBLA0C01030)
TDL: TDEL_0B07620(TDEL0B07620)
KAF: KAFR_0C03790(KAFR0C03790)
PIC: PICST_90609(URA6)
CAL: CAALFM_C104420CA(URA6)
SLB: AWJ20_460(URA6)
BNN: FOA43_004544(URA6)
BBRX: BRETT_001875(URA6)
NTE: NEUTE1DRAFT16968(NEUTE1DRAFT_16968) NEUTE1DRAFT93151(NEUTE1DRAFT_93151)
MGR: MGG_01594
SSCK: SPSK_06620
MAW: MAC_01058
MAJ: MAA_05676
ANI: AN4258.2
ANG: ANI_1_534114(An13g00440)
CIM: CIMG_07499 CIMG_12500(CIMG10052)
ABE: ARB_00909
TVE: TRV_02564
PNO: SNOG_03519(SNOG_03518)
CNE: CNF00400
CNB: CNBF4290
TASA: A1Q1_04436
ABP: AGABI1DRAFT97858(AGABI1DRAFT_97858)
ABV: AGABI2DRAFT148855(AGABI2DRAFT_148855)
MGL: MGL_3976
MRT: MRET_4207
DDI: DDB_G0287495(pyrK)
DFA: DFA_05699(pyrK)
EHI: EHI_143580(121.t00014)
PCB: PCHAS_020070(PC000415.01.0)
TAN: TA14600
TPV: TP02_0690
BBO: BBOV_II007680(18.m06637)
CPV: cgd1_3140
SMIN: v1.2.010444.t1(symbB.v1.2.010444.t1) v1.2.013539.t1(symbB.v1.2.013539.t1) v1.2.013539.t2(symbB.v1.2.013539.t2) v1.2.020315.t1(symbB.v1.2.020315.t1)
MFF: MFFC18_42760(adk_3)
AHEL: Q31a_48850(adk_2)
FMR: Fuma_00485(adk_1)
GMR: GmarT_37970(adk_1)
 » show all
Reference
1  [PMID:14405566]
  Authors
HURWITZ J.
  Title
The enzymatic incorporation of ribonucleotides into polydeoxynucletide material.
  Journal
J Biol Chem 234:2351-8 (1959)
Reference
2  [PMID:5350952]
  Authors
Ruffner BW Jr, Anderson EP.
  Title
Adenosine triphosphate: uridine monophosphate-cytidine monophosphate phosphotransferase from Tetrahymena pyriformis.
  Journal
J Biol Chem 244:5994-6002 (1969)
Reference
3  [PMID:8703943]
  Authors
Scheffzek K, Kliche W, Wiesmuller L, Reinstein J
  Title
Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum  and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity.
  Journal
Biochemistry 35:9716-27 (1996)
DOI:10.1021/bi960642s
  Sequence
Reference
4  [PMID:9576794]
  Authors
Zhou L, Lacroute F, Thornburg R
  Title
Cloning, expression in Escherichia coli, and characterization of Arabidopsis thaliana UMP/CMP kinase.
  Journal
Plant Physiol 117:245-54 (1998)
DOI:10.1104/pp.117.1.245
  Sequence
[ath:AT5G26667]
Reference
5  [PMID:10462544]
  Authors
Van Rompay AR, Johansson M, Karlsson A
  Title
Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme.
  Journal
Mol Pharmacol 56:562-9 (1999)
DOI:10.1124/mol.56.3.562
  Sequence
[hsa:51727]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.14
IUBMB Enzyme Nomenclature: 2.7.4.14
ExPASy - ENZYME nomenclature database: 2.7.4.14
BRENDA, the Enzyme Database: 2.7.4.14
CAS: 37278-21-0

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