KEGG   ENZYME: 2.7.4.14Help
Entry
EC 2.7.4.14                 Enzyme                                 

Name
UMP/CMP kinase;
cytidylate kinase;
deoxycytidylate kinase;
CTP:CMP phosphotransferase;
dCMP kinase;
deoxycytidine monophosphokinase;
UMP-CMP kinase;
ATP:UMP-CMP phosphotransferase;
pyrimidine nucleoside monophosphate kinase;
uridine monophosphate-cytidine monophosphate phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:CMP(UMP) phosphotransferase
Reaction(IUBMB)
(1) ATP + (d)CMP = ADP + (d)CDP [RN:R00512 R01665];
(2) ATP + UMP = ADP + UDP [RN:R00158]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
dCMP [CPD:C00239];
UMP [CPD:C00105]
Product
ADP [CPD:C00008];
dCDP [CPD:C00705];
UDP [CPD:C00015]
Comment
This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.
History
EC 2.7.4.14 created 1961 as EC 2.7.4.5, transferred 1972 to EC 2.7.4.14, modified 1980, modified 2011
Pathway
ec00240  Pyrimidine metabolism
ec00983  Drug metabolism - other enzymes
ec01100  Metabolic pathways
Orthology
K13800  UMP-CMP kinase
K13809  UMP-CMP kinase 2, mitochondrial
Genes
HSA: 129607(CMPK2) 51727(CMPK1)
PTR: 456837(CMPK1) 459005(CMPK2)
PPS: 100977432(CMPK1) 100977684 100993076(CMPK2)
GGO: 101143292(CMPK2) 101147631(CMPK1)
PON: 100173458(CMPK2) 100437591(CMPK1)
NLE: 100583014(CMPK1) 100597489(CMPK2) 100600931
MCC: 700256 708602(CMPK2) 710196(CMPK1)
MCF: 101866162(CMPK2) 102118265(CMPK1)
CSAB: 103220884(CMPK2) 103224864(CMPK1)
RRO: 104657138(CMPK1) 104659046(CMPK2)
RBB: 108529614(CMPK1) 108545152(CMPK2)
CJC: 100386422(CMPK1) 100410513(CMPK2)
SBQ: 101043533(CMPK2) 101051541(CMPK1)
MMU: 22169(Cmpk2) 66588(Cmpk1)
RNO: 298410(Cmpk1) 314004(Cmpk2)
CGE: 100754791(Cmpk2) 100758717(Cmpk1)
NGI: 103733674(Cmpk1) 103747639(Cmpk2)
HGL: 101703729(Cmpk1) 101712024(Cmpk2)
CCAN: 109699348(Cmpk1) 109701851(Cmpk2)
OCU: 100339994(CMPK1) 100348784(CMPK2)
TUP: 102499904(CMPK2) 102500784(CMPK1)
CFA: 608996(CMPK2) 610291(CMPK1)
AML: 100464422(CMPK2) 100471225(CMPK1)
UMR: 103658121(CMPK2) 103670889(CMPK1)
ORO: 101371928 101378888(CMPK1) 101382525(CMPK2)
FCA: 101096470(CMPK2) 105260825(CMPK1)
PTG: 102951048(CMPK1) 102968167(CMPK2)
AJU: 106974144(CMPK1) 106982955(CMPK2)
BTA: 509965(CMPK1) 784304(CMPK2)
BOM: 102274423(CMPK1) 102283416(CMPK2)
BIU: 109556321(CMPK1) 109565611(CMPK2)
PHD: 102321979(CMPK2) 102335758(CMPK1)
CHX: 102189688(CMPK2) 102191483(CMPK1)
OAS: 101106892(CMPK1) 101123366(CMPK2)
SSC: 100521561(CMPK1) 100623872(CMPK2)
CFR: 102514270(CMPK2) 102523636(CMPK1)
CDK: 105092937(CMPK1) 105104265(CMPK2)
BACU: 103007186(CMPK1) 103018920(CMPK2)
LVE: 103070255(CMPK2) 103083702(CMPK1)
OOR: 101270951(CMPK1) 101282238(CMPK2)
ECB: 100063738(CMPK1) 100072617(CMPK2)
EPZ: 103549691(CMPK2) 103565624(CMPK1)
EAI: 106833861(CMPK1) 106847430(CMPK2)
MYB: 102243435(CMPK1) 102257808(CMPK2)
MYD: 102765692(CMPK2) 102769732(CMPK1)
HAI: 109371966(CMPK1) 109384700(CMPK2)
RSS: 109456890(CMPK1) 109461408(CMPK2)
PALE: 102878174(CMPK1) 102896687(CMPK2)
LAV: 100656870(CMPK2) 100672042(CMPK1)
MDO: 100023236(CMPK1) 100032226(CMPK2)
SHR: 100929742(CMPK1) 100931536(CMPK2)
OAA: 100084917(CMPK1) 100091189(CMPK2)
GGA: 421921(CMPK2) 429100(CMPK1)
MGP: 100538899(CMPK1) 100548481(CMPK2)
CJO: 107312186(CMPK2) 107317602(CMPK1)
APLA: 101790338(CMPK2) 101797132(CMPK1)
ACYG: 106030698(CMPK2) 106033039(CMPK1)
TGU: 100224095(CMPK2) 100229908(CMPK1)
GFR: 102039126(CMPK2) 102041969(CMPK1)
FAB: 101807969(CMPK1) 101818975(CMPK2)
PHI: 102099991(CMPK1) 102101770(CMPK2)
PMAJ: 107202543(CMPK2) 107208436(CMPK1)
CCW: 104685514(CMPK2) 104695218(CMPK1)
FPG: 101911053(CMPK1) 101923236(CMPK2)
FCH: 102050231(CMPK1) 102055054(CMPK2)
CLV: 102087661(CMPK1) 102096553(CMPK2)
EGZ: 104123503(CMPK1) 104127138(CMPK2)
AAM: 106489275(CMPK1) 106494719(CMPK2)
ASN: 102369091(CMPK1) 102374461(CMPK2)
AMJ: 102561664(CMPK2) 102569887(CMPK1)
PSS: 102447134(CMPK2) 102454984(CMPK1)
CMY: 102934308(CMPK2) 102938102(CMPK1)
CPIC: 101944522(CMPK2) 101953283(CMPK1)
ACS: 100562095(cmpk1) 100565288(cmpk2)
PVT: 110069787(CMPK2) 110086553(CMPK1)
PBI: 103054958(CMPK1) 103067607(CMPK2)
GJA: 107121335(CMPK1) 107125572(CMPK2)
XLA: 108714299 108717168(cmpk2.L) 108718229(cmpk2.S) 398670(cmpk1.S)
XTR: 100493600(cmpk2) 733534(cmpk1)
NPR: 108784266(CMPK1) 108788005(CMPK2)
DRE: 406383(cmpk) 570478(cmpk2)
IPU: 108267647(cmpk1) 108268039 108270477(cmpk2)
AMEX: 103043729(cmpk1) 103046469(cmpk2)
TRU: 101065612(cmpk1) 101074244(cmpk2)
LCO: 104920912(cmpk1) 109138539
NCC: 104945534(cmpk2) 104954191(cmpk1)
MZE: 101468245(cmpk2) 101481811
OLA: 101154834(cmpk2) 101156041(cmpk1)
XMA: 102222264(cmpk1) 106699691(cmpk2)
PRET: 103458796(cmpk2) 103479088(cmpk1)
NFU: 107392265(cmpk2) 107396217(cmpk1)
CSEM: 103396125(cmpk1)
LCF: 108883744(cmpk1) 108888149(cmpk2)
HCQ: 109520530(cmpk1) 109526145(cmpk2)
BPEC: 110173526(cmpk1)
ELS: 105026588(cmpk2) 105030370(cmpk1)
LCM: 102353387(CMPK2) 102363916(CMPK1)
CMK: 103185264(cmpk1) 103187110(cmpk2)
APLC: 110977720
SKO: 100367240
DME: Dmel_CG6092(Dak1)
DSI: Dsimw501_GD18150(Dsim_GD18150)
MDE: 101898297
AAG: 5570159
AME: 100578311
BIM: 100741048
BTER: 100643649
SOC: 105192860
AEC: 105147315
ACEP: 105625701
PBAR: 105433225
HST: 105191229
CFO: 105251862
LHU: 105673121
PGC: 109864250
NVI: 100118675
BMOR: 732890
PMAC: 106715779
PRAP: 110996305
API: 100165780
DNX: 107170544
TUT: 107361381
CEL: CELE_C29F7.3(C29F7.3) CELE_F40F8.1(F40F8.1)
BMY: Bm1_14420
TSP: Tsp_00848
OBI: 106884325
SHX: MS3_04586
EPA: 110238444
ADF: 107358144
HMG: 100204580
AQU: 100640424
LJA: Lj3g3v0618170.1(Lj3g3v0618170.1) Lj3g3v3751960.1(Lj3g3v3751960.1) Lj3g3v3751960.2(Lj3g3v3751960.2) Lj3g3v3751960.3(Lj3g3v3751960.3)
DOSA: Os02t0778400-01(Os02g0778400) Os04t0105500-01(Os04g0105500) Os06t0109600-01(Os06g0109600) Os06t0203500-01(Os06g0203500) Os07t0624700-01(Os07g0624700)
ATS: 109732607(LOC109732607) 109756452(LOC109756452) 109770959(LOC109770959) 109773617(LOC109773617) 109776431(LOC109776431)
ZMA: 100193828(pco123975) 100281735(uck1) 100282335(cl12258_2b) 100283047(cl15126_1)
ATR: 18428724
VCN: VOLCADRAFT_79151(adk2)
APRO: F751_5655
SCE: YKL024C(URA6)
ERC: Ecym_5638
NCS: NCAS_0H03560(NCAS0H03560)
NDI: NDAI_0C00140(NDAI0C00140)
TPF: TPHA_0N01890(TPHA0N01890)
TBL: TBLA_0C01030(TBLA0C01030)
TDL: TDEL_0B07620(TDEL0B07620)
KAF: KAFR_0C03790(KAFR0C03790)
PIC: PICST_90609(URA6)
CAL: CAALFM_C104420CA(URA6)
CAUR: QG37_05729
SLB: AWJ20_460(URA6)
NTE: NEUTE1DRAFT16968(NEUTE1DRAFT_16968) NEUTE1DRAFT93151(NEUTE1DRAFT_93151)
MGR: MGG_01594
MAW: MAC_01058
MAJ: MAA_05676
ANI: AN4258.2
ANG: ANI_1_534114(An13g00440)
CIM: CIMG_07499 CIMG_12500(CIMG10052)
ABE: ARB_00909
TVE: TRV_02564
PNO: SNOG_03519(SNOG_03518)
CNE: CNF00400
CNB: CNBF4290
ABP: AGABI1DRAFT97858(AGABI1DRAFT_97858)
ABV: AGABI2DRAFT148855(AGABI2DRAFT_148855)
MGL: MGL_3976
DDI: DDB_G0287495(pyrK)
DFA: DFA_05699(pyrK)
EHI: EHI_143580(121.t00014)
PYO: PY17X_0203700(PY05596)
PCB: PCHAS_020070(PC000415.01.0)
TAN: TA14600
TPV: TP02_0690
BBO: BBOV_II007680(18.m06637)
CPV: cgd1_3140
SMIN: v1.2.010444.t1(symbB.v1.2.010444.t1) v1.2.013539.t1(symbB.v1.2.013539.t1) v1.2.013539.t2(symbB.v1.2.013539.t2) v1.2.020315.t1(symbB.v1.2.020315.t1)
FMR: Fuma_00485(adk_1)
 » show all
Taxonomy
Reference
1  [PMID:14405566]
  Authors
HURWITZ J.
  Title
The enzymatic incorporation of ribonucleotides into polydeoxynucletide material.
  Journal
J Biol Chem 234:2351-8 (1959)
Reference
2  [PMID:5350952]
  Authors
Ruffner BW Jr, Anderson EP.
  Title
Adenosine triphosphate: uridine monophosphate-cytidine monophosphate phosphotransferase from Tetrahymena pyriformis.
  Journal
J Biol Chem 244:5994-6002 (1969)
Reference
3  [PMID:8703943]
  Authors
Scheffzek K, Kliche W, Wiesmuller L, Reinstein J
  Title
Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum  and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity.
  Journal
Biochemistry 35:9716-27 (1996)
DOI:10.1021/bi960642s
  Sequence
Reference
4  [PMID:9576794]
  Authors
Zhou L, Lacroute F, Thornburg R
  Title
Cloning, expression in Escherichia coli, and characterization of Arabidopsis thaliana UMP/CMP kinase.
  Journal
Plant Physiol 117:245-54 (1998)
  Sequence
[ath:AT5G26667]
Reference
5  [PMID:10462544]
  Authors
Van Rompay AR, Johansson M, Karlsson A
  Title
Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme.
  Journal
Mol Pharmacol 56:562-9 (1999)
  Sequence
[hsa:51727]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.14
IUBMB Enzyme Nomenclature: 2.7.4.14
ExPASy - ENZYME nomenclature database: 2.7.4.14
BRENDA, the Enzyme Database: 2.7.4.14
CAS: 37278-21-0

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