KEGG   ENZYME: 2.7.4.24Help
Entry
EC 2.7.4.24                 Enzyme                                 

Name
diphosphoinositol-pentakisphosphate kinase;
PP-IP5 kinase;
diphosphoinositol pentakisphosphate kinase;
ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase;
PP-InsP5 kinase;
PPIP5K;
PPIP5K1;
PPIP5K2;
VIP1;
VIP2
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase
Reaction(IUBMB)
(1) ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [RN:R08964];
(2) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [RN:R05799]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate [CPD:C11526];
1D-myo-inositol hexakisphosphate [CPD:C01204]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [CPD:C20690];
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [CPD:C11174]
Comment
This enzyme is activated by osmotic shock [4]. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [4].
History
EC 2.7.4.24 created 2003 as EC 2.7.1.155, transferred 2007 to EC 2.7.4.24, modified 2014
Orthology
K13024  inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase
Genes
HSA: 23262(PPIP5K2) 9677(PPIP5K1)
PTR: 100608132(PPIP5K1) 461976(PPIP5K2)
PPS: 100969708(PPIP5K2) 100988268(PPIP5K1)
GGO: 101151797(PPIP5K2) 101153329(PPIP5K1)
PON: 100171621(PPIP5K2) 100436321(PPIP5K1)
NLE: 100580619(PPIP5K1) 100604852(PPIP5K2)
MCC: 703458(PPIP5K2) 710588(PPIP5K1)
MCF: 102130122(PPIP5K2) 102136482 102139156
CSAB: 103244287(PPIP5K2) 103245737 103246096(PPIP5K1)
RRO: 104659263 104669197(PPIP5K2) 104678070 104678492(PPIP5K1) 104680165
CJC: 100385007(PPIP5K1) 100394564(PPIP5K2)
SBQ: 101032990(PPIP5K2) 101053535(PPIP5K1)
MMU: 227399(Ppip5k2) 327655(Ppip5k1)
RNO: 311355(Ppip5k1)
CGE: 100767441(Ppip5k1) 100769408(Ppip5k2)
NGI: 103725077(Ppip5k1) 103738183(Ppip5k2)
HGL: 101719804(Ppip5k2) 101722963(Ppip5k1)
OCU: 100353531(PPIP5K2) 100357928(PPIP5K1)
TUP: 102468274(PPIP5K1) 102475948(PPIP5K2)
CFA: 478276(PPIP5K1) 488883(PPIP5K2)
AML: 100473672(PPIP5K1) 100482858(PPIP5K2)
UMR: 103656469(PPIP5K2) 103673397(PPIP5K1)
ORO: 101377056(PPIP5K1) 101384468(PPIP5K2)
FCA: 101091503(PPIP5K2) 101098233(PPIP5K1)
PTG: 102960108(PPIP5K2) 102971201(PPIP5K1)
AJU: 106968487(PPIP5K1) 106982284(PPIP5K2)
BTA: 510684(PPIP5K1) 780855(PPIP5K2)
BOM: 102273676(PPIP5K2) 102280665(PPIP5K1)
BIU: 109562366(PPIP5K2) 109575452(PPIP5K1)
PHD: 102335892(PPIP5K1) 102336419(PPIP5K2)
CHX: 102181541(PPIP5K1) 102190688(PPIP5K2)
OAS: 101107902(PPIP5K1) 101114441(PPIP5K2)
SSC: 100520287(PPIP5K1) 100625306(PPIP5K2)
CFR: 102510231(PPIP5K2) 102524244(PPIP5K1)
CDK: 105101754(PPIP5K1) 105106479(PPIP5K2)
BACU: 103002825(PPIP5K1) 103010253(PPIP5K2)
LVE: 103080540(PPIP5K1) 103087706(PPIP5K2)
OOR: 101275379(PPIP5K2) 101284000(PPIP5K1)
ECB: 100064726(PPIP5K2) 100070782(PPIP5K1)
EPZ: 103555846(PPIP5K2) 103556410(PPIP5K1)
EAI: 106831156(PPIP5K2) 106835020(PPIP5K1)
MYB: 102260148(PPIP5K1) 102260503(PPIP5K2)
MYD: 102758169(PPIP5K1) 102771195(PPIP5K2)
HAI: 109384033(PPIP5K1) 109394176(PPIP5K2)
RSS: 109444168(PPIP5K1) 109445513(PPIP5K2)
PALE: 102880534(PPIP5K1) 102896791(PPIP5K2)
LAV: 100654537(PPIP5K1) 100666509(PPIP5K2)
MDO: 100011533(PPIP5K1) 100030703(PPIP5K2)
SHR: 100925666(PPIP5K2) 100927893(PPIP5K1)
OAA: 100074142(PPIP5K2)
GGA: 415587(PPIP5K1) 427276(PPIP5K2)
MGP: 100538692(PPIP5K1) 104915181(PPIP5K2)
CJO: 107306344(PPIP5K2) 107318891(PPIP5K1)
APLA: 101796180(PPIP5K2) 101804165(PPIP5K1)
ACYG: 106043742(PPIP5K2) 106048657(PPIP5K1)
TGU: 100224061(PPIP5K2) 100225111(PPIP5K1)
GFR: 102038965(PPIP5K1) 102039505(PPIP5K2)
FAB: 101808161(PPIP5K1) 101820580(PPIP5K2)
PHI: 102102428(PPIP5K1) 102114390(PPIP5K2)
PMAJ: 107209309(PPIP5K1) 107215967(PPIP5K2)
CCW: 104683847(PPIP5K1) 104693196(PPIP5K2)
FPG: 101912634(PPIP5K1) 101918574(PPIP5K2)
FCH: 102047825(PPIP5K1) 102058743(PPIP5K2)
CLV: 102086840(PPIP5K2) 102090237(PPIP5K1)
EGZ: 104125988(PPIP5K1) 104135034(PPIP5K2)
ASN: 102373631(PPIP5K2) 102386038(PPIP5K1)
AMJ: 102570807(PPIP5K2) 106737015
PSS: 102459058(PPIP5K1) 102461289(PPIP5K2)
CMY: 102934620(PPIP5K1) 102946417(PPIP5K2)
CPIC: 101946048(PPIP5K2) 101952432(PPIP5K1)
ACS: 100554395(ppip5k1) 100568184(ppip5k2)
PVT: 110077303(PPIP5K1) 110079379(PPIP5K2)
PBI: 103057208(PPIP5K2) 103062654(PPIP5K1)
GJA: 107109714(PPIP5K1) 107121203(PPIP5K2)
XLA: 108711431 108712873 495012(ppip5k2.L)
XTR: 100135086(ppip5k2) 100493265(ppip5k1)
NPR: 108795628(PPIP5K1) 108797619(PPIP5K2)
DRE: 449862(ppip5k2) 556748(ppip5k1a)
IPU: 108259302(ppip5k1) 108268790 108277047(ppip5k2)
AMEX: 103021878(ppip5k2) 103029528 103039879
TRU: 101069369 101078927(ppip5k1)
LCO: 104927242(ppip5k1) 104932118
MZE: 101466386 101472009(ppip5k1)
OLA: 101157049(ppip5k2) 101165380(ppip5k1)
XMA: 102220438(ppip5k1) 102227875
PRET: 103462967(ppip5k1) 103465685
NFU: 107380822 107382027(ppip5k1)
CSEM: 103379791 103398477(ppip5k1)
LCF: 108889282 108894196(ppip5k1)
HCQ: 109514352(ppip5k1) 109518231
ELS: 105015023(ppip5k1) 105020458(ppip5k2) 105028542
LCM: 102345122 102345812(PPIP5K1) 102349094(PPIP5K2) 102356865
CMK: 103178403(ppip5k2) 103188433(ppip5k1)
CIN: 100182708(ppip5k1)
SPU: 574572(PPIP5K2)
APLC: 110977346
SKO: 102804963
DME: Dmel_CG14616(l(1)G0196)
DSI: Dsimw501_GD24413(Dsim_GD24413)
MDE: 101898430
AAG: 5571312
AME: 725179
BIM: 100746993
BTER: 100648113
SOC: 105194196
AEC: 105143273
ACEP: 105627545
PBAR: 105429101
HST: 105189565
CFO: 105254499
LHU: 105676938
PGC: 109855520
NVI: 100115546
TCA: 663934
DPA: 109536229
NVL: 108557917
PMAC: 106720156
PRAP: 110996893
DNX: 107163613
FCD: 110851237
TUT: 107371165
CEL: CELE_F46F11.1(F46F11.1)
CBR: CBG14896
BMY: Bm1_57300
TSP: Tsp_10123
LAK: 106156246
SHX: MS3_05592
EPA: 110240080
ADF: 107353158
AQU: 100635064
CPAP: 110820283
CIT: 102615825
TCC: 18601431
LJA: Lj1g3v2941810.1(Lj1g3v2941810.1) Lj1g3v2941810.2(Lj1g3v2941810.2) Lj2g3v1024290.1(Lj2g3v1024290.1) Lj2g3v1024290.2(Lj2g3v1024290.2) Lj2g3v1024290.3(Lj2g3v1024290.3) Lj2g3v1024290.4(Lj2g3v1024290.4)
FVE: 101300929
PPER: 18781674
PMUM: 103329961
PAVI: 110752434
PXB: 103928495
CSV: 101210866
CMO: 103498465
MCHA: 111006742
CMAX: 111487048
CMOS: 111455571
CPEP: 111789140
RCU: 8276011
JCU: 105642524
HBR: 110649775
VVI: 100262888
DCR: 108213130
BVG: 104887409
SOE: 110803819
NNU: 104608052
DOSA: Os01t0777700-00(Os01g0777700) Os03t0689100-01(Os03g0689100)
ATS: 109736091(LOC109736091) 109770944(LOC109770944)
PDA: 103720100
EGU: 105054063
ATR: 18446539
APRO: F751_6470
DFA: DFA_01506
SMIN: v1.2.029925.t1(symbB.v1.2.029925.t1) v1.2.029925.t2(symbB.v1.2.029925.t2)
AAF: AURANDRAFT_54159(ACP1)
 » show all
Taxonomy
Reference
1  [PMID:7737983]
  Authors
Shears SB, Ali N, Craxton A, Bembenek ME.
  Title
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo.
  Journal
J Biol Chem 270:10489-97 (1995)
DOI:10.1074/jbc.270.18.10489
Reference
2  [PMID:9359429]
  Authors
Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Brocker M, Shears SB, Mayr GW.
  Title
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
  Journal
Biochem J 327 ( Pt 2):553-60 (1997)
Reference
3  [PMID:17690096]
  Authors
Fridy PC, Otto JC, Dollins DE, York JD.
  Title
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.
  Journal
J Biol Chem 282:30754-62 (2007)
DOI:10.1074/jbc.M704656200
  Sequence
[hsa:23262 9677] [mmu:227399]
Reference
4  [PMID:17702752]
  Authors
Choi JH, Williams J, Cho J, Falck JR, Shears SB.
  Title
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.
  Journal
J Biol Chem 282:30763-75 (2007)
DOI:10.1074/jbc.M704655200
  Sequence
[hsa:23262 9677] [rno:311355]
Reference
5  [PMID:18981179]
  Authors
Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW
  Title
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.
  Journal
J Biol Chem 284:1863-72 (2009)
DOI:10.1074/jbc.M805686200
Reference
6  [PMID:22119861]
  Authors
Wang H, Falck JR, Hall TM, Shears SB
  Title
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
  Journal
Nat Chem Biol 8:111-6 (2012)
DOI:10.1038/nchembio.733
  Sequence
[hsa:23262]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.24
IUBMB Enzyme Nomenclature: 2.7.4.24
ExPASy - ENZYME nomenclature database: 2.7.4.24
BRENDA, the Enzyme Database: 2.7.4.24

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