KEGG ENZYME: 2.7.4.24

ENZYME: 2.7.4.24

Entry

EC 2.7.4.24 Enzyme

Name

diphosphoinositol-pentakisphosphate kinase;
PP-IP5 kinase;
diphosphoinositol pentakisphosphate kinase;
ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase;
PP-InsP5 kinase;
PPIP5K;
PPIP5K1;
PPIP5K2;
VIP1;
VIP2

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor

Sysname

ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase

Reaction(IUBMB)

(1) ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [RN:R08964];
(2) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [RN:R05799]

Reaction(KEGG)

R05799 R08964

Substrate

ATP [CPD:C00002];
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate [CPD:C11526];
1D-myo-inositol hexakisphosphate [CPD:C01204]

Product

ADP [CPD:C00008];
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [CPD:C20690];
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [CPD:C11174]

Comment

This enzyme is activated by osmotic shock [4]. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [4].

History

EC 2.7.4.24 created 2003 as EC 2.7.1.155, transferred 2007 to EC 2.7.4.24, modified 2014

Orthology

K13024

inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase

Genes

HSA:	23262(PPIP5K2) 9677(PPIP5K1)

PTR:	100608132(PPIP5K1) 461976(PPIP5K2)

PPS:	100969708(PPIP5K2) 100988268(PPIP5K1)

GGO:	101151797(PPIP5K2) 101153329(PPIP5K1)

PON:	100171621(PPIP5K2) 100436321(PPIP5K1)

NLE:	100580619(PPIP5K1) 100604852(PPIP5K2)

MCC:	703458(PPIP5K2) 710588(PPIP5K1)

MCF:	102130122(PPIP5K2) 102136482 102139156

CSAB:

103244287(PPIP5K2) 103245737 103246096(PPIP5K1)

RRO:	104659263 104669197(PPIP5K2) 104678070 104678492(PPIP5K1) 104680165

RBB:	108520909 108522704 108526144 108527715(PPIP5K2)

CJC:	100385007(PPIP5K1) 100394564(PPIP5K2)

SBQ:	101032990(PPIP5K2) 101053535(PPIP5K1)

MMU:	227399(Ppip5k2) 327655(Ppip5k1)

RNO:	311355(Ppip5k1)

CGE:	100767441(Ppip5k1) 100769408(Ppip5k2)

NGI:	103725077(Ppip5k1) 103738183(Ppip5k2)

HGL:	101719804(Ppip5k2) 101722963(Ppip5k1)

CCAN:

109681437(Ppip5k1) 109689128 109689132 109689133

OCU:	100353531(PPIP5K2) 100357928(PPIP5K1)

TUP:	102468274(PPIP5K1) 102475948(PPIP5K2)

CFA:	478276(PPIP5K1) 488883(PPIP5K2)

AML:	100473672(PPIP5K1) 100482858(PPIP5K2)

UMR:	103656469(PPIP5K2) 103673397(PPIP5K1)

ORO:	101377056(PPIP5K1) 101384468(PPIP5K2)

FCA:	101091503(PPIP5K2) 101098233(PPIP5K1)

PTG:	102960108(PPIP5K2) 102971201(PPIP5K1)

AJU:	106968487(PPIP5K1) 106982284(PPIP5K2)

BTA:	510684(PPIP5K1) 780855(PPIP5K2)

BOM:	102273676(PPIP5K2) 102280665(PPIP5K1)

BIU:	109562366(PPIP5K2) 109575452(PPIP5K1)

PHD:	102335892(PPIP5K1) 102336419(PPIP5K2)

CHX:	102181541(PPIP5K1) 102190688(PPIP5K2)

OAS:	101107902(PPIP5K1) 101114441(PPIP5K2)

SSC:	100520287(PPIP5K1) 100625306(PPIP5K2)

CFR:	102510231(PPIP5K2) 102524244(PPIP5K1)

CDK:	105101754(PPIP5K1) 105106479(PPIP5K2)

BACU:

103002825(PPIP5K1) 103010253(PPIP5K2)

LVE:	103080540(PPIP5K1) 103087706(PPIP5K2)

OOR:	101275379(PPIP5K2) 101284000(PPIP5K1)

ECB:	100064726(PPIP5K2) 100070782(PPIP5K1)

EPZ:	103555846(PPIP5K2) 103556410(PPIP5K1)

EAI:	106831156(PPIP5K2) 106835020(PPIP5K1)

MYB:	102260148(PPIP5K1) 102260503(PPIP5K2)

MYD:	102758169(PPIP5K1) 102771195(PPIP5K2)

HAI:	109384033(PPIP5K1) 109394176(PPIP5K2)

RSS:	109444168(PPIP5K1) 109445513(PPIP5K2)

PALE:

102880534(PPIP5K1) 102896791(PPIP5K2)

LAV:	100654537(PPIP5K1) 100666509(PPIP5K2)

TMU:	101358049 101361952

MDO:	100011533(PPIP5K1) 100030703(PPIP5K2)

SHR:	100925666(PPIP5K2) 100927893(PPIP5K1)

OAA:	100074142(PPIP5K2)

GGA:	415587(PPIP5K1) 427276(PPIP5K2)

MGP:	100538692(PPIP5K1) 104915181(PPIP5K2)

CJO:	107306344(PPIP5K2) 107318891(PPIP5K1)

APLA:

101796180(PPIP5K2) 101804165(PPIP5K1)

ACYG:

106043742(PPIP5K2) 106048657(PPIP5K1)

TGU:	100224061(PPIP5K2) 100225111(PPIP5K1)

GFR:	102038965(PPIP5K1) 102039505(PPIP5K2)

FAB:	101808161(PPIP5K1) 101820580(PPIP5K2)

PHI:	102102428(PPIP5K1) 102114390(PPIP5K2)

PMAJ:

107209309(PPIP5K1) 107215967(PPIP5K2)

CCW:	104683847(PPIP5K1) 104693196(PPIP5K2)

FPG:	101912634(PPIP5K1) 101918574(PPIP5K2)

FCH:	102047825(PPIP5K1) 102058743(PPIP5K2)

CLV:	102086840(PPIP5K2) 102090237(PPIP5K1)

EGZ:	104125988(PPIP5K1) 104135034(PPIP5K2)

AAM:	106485771 106490813 106494103(PPIP5K1) 106496612

ASN:	102373631(PPIP5K2) 102386038(PPIP5K1)

AMJ:	102570807(PPIP5K2) 106737015

PSS:	102459058(PPIP5K1) 102461289(PPIP5K2)

CMY:	102934620(PPIP5K1) 102946417(PPIP5K2)

CPIC:

101946048(PPIP5K2) 101952432(PPIP5K1)

ACS:	100554395(ppip5k1) 100568184(ppip5k2)

PVT:	110077303(PPIP5K1) 110079379(PPIP5K2)

PBI:	103057208(PPIP5K2) 103062654(PPIP5K1)

GJA:	107109714(PPIP5K1) 107121203(PPIP5K2)

XLA:	108711431 108712873 495012(ppip5k2.L)

XTR:	100135086(ppip5k2) 100493265(ppip5k1)

NPR:	108795628(PPIP5K1) 108797619(PPIP5K2)

DRE:	449862(ppip5k2) 556748(ppip5k1a)

SRX:	107715836(ppip5k2) 107716621 107730229 107753644 107757809

SANH:

107665467(ppip5k2) 107665739 107666272 107670030 107695346 107701280

SGH:	107564109(ppip5k2) 107568648 107574468 107577937 107577938 107590852 107596413 107600465

CCAR:

109057084 109059708 109065224 109096549

IPU:	108259302(ppip5k1) 108268790 108277047(ppip5k2)

AMEX:

103021878(ppip5k2) 103029528 103039879

TRU:	101069369 101078927(ppip5k1)

TNG:	GSTEN00006411G001 GSTEN00019685G001

LCO:	104927242(ppip5k1) 104932118

NCC:	104941495 104941498 104950413 104961914

MZE:	101466386 101472009(ppip5k1)

OLA:	101157049(ppip5k2) 101165380(ppip5k1)

XMA:	102220438(ppip5k1) 102227875

PRET:

103462967(ppip5k1) 103465685

NFU:	107380822 107382027(ppip5k1)

CSEM:

103379791 103398477(ppip5k1)

LCF:	108889282 108894196(ppip5k1)

HCQ:	109514352(ppip5k1) 109518231

BPEC:

110169151 110171051

SASA:

106561102(ppip5k1) 106562522 106571936(ppip5k2) 106584645 106587746

ELS:	105015023(ppip5k1) 105020458(ppip5k2) 105028542

SFM:	108929920(ppip5k2) 108941115 108942030

LCM:	102345122 102345812(PPIP5K1) 102349094(PPIP5K2) 102356865

CMK:	103178403(ppip5k2) 103188433(ppip5k1)

BFO:	BRAFLDRAFT_118894

CIN:	100182708(ppip5k1)

SPU:	574572(PPIP5K2)

APLC:

110977346

SKO:

102804963

DME:	Dmel_CG14616(l(1)G0196)

DPO:	Dpse_GA13115

DER:	Dere_GG19746

DPE:	Dper_GL13299

DSE:	Dsec_GM11733

DSI:	Dsimw501_GD24413(Dsim_GD24413)

DWI:	Dwil_GK25772

DYA:	Dyak_GE17941

DGR:	Dgri_GH24076

DMO:	Dmoj_GI14473

DVI:	Dvir_GJ18811

MDE:

101898430

AGA:	AgaP_AGAP000926

AAG:

5571312

CQU:	CpipJ_CPIJ012460

AME:

BIM:

BTER:

SOC:

AEC:

ACEP:

PBAR:

HST:

CFO:

LHU:

PGC:

NVI:

TCA:

DPA:

NVL:

BMOR:

PMAC:

PRAP:

PXY:	105385667 105390149

DNX:

107163613

PHU:	Phum_PHUM208020

ZNE:	110838414 110840397

FCD:

110851237

DPX:	DAPPUDRAFT_260966

TUT:

107371165

CEL:	CELE_F46F11.1(F46F11.1)

CBR:

CBG14896

NAI:	NECAME_03348

BMY:

Bm1_57300

LOA:	LOAG_16663

TSP:

Tsp_10123

HRO:	HELRODRAFT_149890 HELRODRAFT_79032

LGI:	LOTGIDRAFT_124736

CRG:	105323940 105332818

MYI:	110441581 110458782

OBI:	106875122 106881428

LAK:

106156246

SMM:	Smp_045860.1

SHX:

MS3_05592

OVI:	T265_00972

NVE:	NEMVE_v1g20017

EPA:

110240080

ADF:

107353158

HMG:	100198226 100205859

TAD:	TRIADDRAFT_19973

AQU:

100635064

ATH:	AT3G01310 AT5G15070

ALY:	ARALYDRAFT_477396 ARALYDRAFT_488348

CRB:	17883966 17892518

CSAT:

104705781 104744228 104763827 104769747 104783681

EUS:	EUTSA_v10012536mg EUTSA_v10019952mg

BRP:	103846446 103850078 103856107 103858920

BNA:	106370558 106370766 106385352 106388663 106433432 106438902 111215227

BOE:	106316584 106332032 106334855 106343128

THJ:	104821047 104821051 104822374

CPAP:

110820283

CIT:

102615825

CIC:	CICLE_v100109631m

TCC:

18601431

GRA:	105779454 105798248

GHI:	107886855 107888634 107892349 107959819

DZI:	111292364 111299615

EGR:	104419338 104422556

GMX:	100776866 100793673 100815564 100817736

PVU:	PHAVU_004G025600g PHAVU_008G044100g

VRA:	106759256 106774350

VAR:	108328996 108345984

CCAJ:

109788027 109796117

MTR:	MTR_6g011290 MTR_7g009060

CAM:	101491178 101507767

LJA:	Lj1g3v2941810.1(Lj1g3v2941810.1) Lj1g3v2941810.2(Lj1g3v2941810.2) Lj2g3v1024290.1(Lj2g3v1024290.1) Lj2g3v1024290.2(Lj2g3v1024290.2) Lj2g3v1024290.3(Lj2g3v1024290.3) Lj2g3v1024290.4(Lj2g3v1024290.4)

ADU:	107471035 107486763

AIP:	107621444 107635282

LANG:

109335973 109347322 109354707

FVE:

PPER:

PMUM:

PAVI:

MDM:	103404600 103442791

PXB:

103928495

ZJU:	107415599 107435658

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

POP:	7472565 7482442

JRE:	108992859 109008927

VVI:

100262888

SLY:	101260910 101261282 109119716

SPEN:

107011191 107012572

SOT:	102595799 102605704

CANN:

107860563 107867810

NTA:	107761206 107816247 107823876 107826378

NSY:	104226272 104242605

NTO:	104086927 104096774 104097441

INI:	109158271 109180408

SIND:

105167762 105177205

HAN:	110879241 110903973 110927134

LSV:	111901966 111921582

DCR:

BVG:

SOE:

NNU:

OSA:	4327902 4333768

DOSA:

Os01t0777700-00(Os01g0777700) Os03t0689100-01(Os03g0689100)

OBR:	102716945 102719534

BDI:	100830891 100842336

ATS:	109736091(LOC109736091) 109770944(LOC109770944)

SBI:	8054149 8054701

ZMA:	103645542 103651148

SITA:

101753134 101778915

PDA:

103720100

EGU:

105054063

MUS:	103981915 103991473

DCT:	110098418 110102682

AOF:	109833738 109848517

ATR:

18446539

SMO:	SELMODRAFT_429797 SELMODRAFT_444048

PPP:	112280341 112289709

CRE:	CHLREDRAFT_115639(FAP160) CHLREDRAFT_116435

VCN:	VOLCADRAFT_103901 VOLCADRAFT_56293

MNG:	MNEG_11821

OTA:	OT_ostta03g03030

BPG:	Bathy09g03180

MIS:	MICPUN_80976

MPP:	MICPUCDRAFT_17536

CSL:	COCSUDRAFT_43885

CVR:	CHLNCDRAFT_57228

APRO:

F751_6470

CCP:	CHC_T00001956001

MBR:	MONBRDRAFT_37460

SRE:	PTSG_01584

DFA:

DFA_01506

BEQ:	BEWA_037690

TET:	TTHERM_00442020

PTM:	GSPATT00006245001 GSPATT00009575001

SMIN:

v1.2.029925.t1(symbB.v1.2.029925.t1) v1.2.029925.t2(symbB.v1.2.029925.t2)

PTI:	PHATR_46684

FCY:	FRACYDRAFT_184644

TPS:	THAPSDRAFT_12441

AAF:	AURANDRAFT_54159(ACP1)

PIF:	PITG_03590 PITG_17745

PSOJ:

PHYSODRAFT_309294 PHYSODRAFT_515553

SPAR:

SPRG_06077 SPRG_10627

EHX:	EMIHUDRAFT_427613 EMIHUDRAFT_429138 EMIHUDRAFT_447945 EMIHUDRAFT_471176 EMIHUDRAFT_68296

GTT:	GUITHDRAFT_161489

» show all

Reference

1 [PMID:7737983]

Authors

Shears SB, Ali N, Craxton A, Bembenek ME.

Title

Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo.

Journal

J Biol Chem 270:10489-97 (1995)
DOI:10.1074/jbc.270.18.10489

Reference

2 [PMID:9359429]

Authors

Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Brocker M, Shears SB, Mayr GW.

Title

Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.

Journal

Biochem J 327 ( Pt 2):553-60 (1997)

Reference

3 [PMID:17690096]

Authors

Fridy PC, Otto JC, Dollins DE, York JD.

Title

Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.

Journal

J Biol Chem 282:30754-62 (2007)
DOI:10.1074/jbc.M704656200

Sequence

[hsa:23262 9677] [mmu:227399]

Reference

4 [PMID:17702752]

Authors

Choi JH, Williams J, Cho J, Falck JR, Shears SB.

Title

Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.

Journal

J Biol Chem 282:30763-75 (2007)
DOI:10.1074/jbc.M704655200

Sequence

[hsa:23262 9677] [rno:311355]

Reference

5 [PMID:18981179]

Authors

Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW

Title

Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

Journal

J Biol Chem 284:1863-72 (2009)
DOI:10.1074/jbc.M805686200

Reference

6 [PMID:22119861]

Authors

Wang H, Falck JR, Hall TM, Shears SB

Title

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

Journal

Nat Chem Biol 8:111-6 (2012)
DOI:10.1038/nchembio.733

Sequence

[hsa:23262]