| Entry |
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| Name |
diphosphoinositol-pentakisphosphate kinase;
PP-IP5 kinase;
diphosphoinositol pentakisphosphate kinase;
ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase;
PP-InsP5 kinase;
PPIP5K;
PPIP5K1;
PPIP5K2;
VIP1;
VIP2
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
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| Sysname |
ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase
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| Reaction(IUBMB) |
(1) ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [RN: R08964];
(2) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [RN: R05799]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate [CPD: C11526];
1D-myo-inositol hexakisphosphate [CPD: C01204]
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| Product |
ADP [CPD: C00008];
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [CPD: C20690];
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [CPD: C11174]
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| Comment |
This enzyme is activated by osmotic shock [4]. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [4].
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| History |
EC 2.7.4.24 created 2003 as EC 2.7.1.155, transferred 2007 to EC 2.7.4.24, modified 2014
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| Orthology |
| K13024 | inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase |
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| Genes |
» show all
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| Reference |
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| Authors |
Shears SB, Ali N, Craxton A, Bembenek ME. |
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| Title |
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo. |
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| Journal |
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| Reference |
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| Authors |
Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Brocker M, Shears SB, Mayr GW. |
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| Title |
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells. |
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| Journal |
Biochem J 327 ( Pt 2):553-60 (1997) |
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| Reference |
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| Authors |
Fridy PC, Otto JC, Dollins DE, York JD. |
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| Title |
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Choi JH, Williams J, Cho J, Falck JR, Shears SB. |
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| Title |
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW |
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| Title |
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. |
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| Journal |
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| Reference |
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| Authors |
Wang H, Falck JR, Hall TM, Shears SB |
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| Title |
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.4.24 |
| ExPASy - ENZYME nomenclature database: | 2.7.4.24 |
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