Entry
Name
AMP-polyphosphate phosphotransferase;
PA3455 (locus name);
PPK2D;
PAP
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ADP:polyphosphate phosphotransferase
Reaction(IUBMB)
ADP + (phosphate)n = AMP + (phosphate)n+1 [RN:
R12633 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the bacteria Acinetobacter johnsonii and Pseudomonas aeruginosa, transfers a phosphate group from polyphosphates to nucleotide monophosphates. The highest activity is achieved with AMP, but the enzyme can also phosphorylate GMP, dAMP, dGMP, IMP, and XMP. The reverse reactions were not detected.
History
EC 2.7.4.33 created 2020
Orthology
K23753 AMP-polyphosphate phosphotransferase
Genes
PPRC : PFLCHA0_c44030(pvdS1)
PFW : PF1751_v1c38150(pap)
ALA : BFG52_01570 BFG52_15450
MOZ : MoryE10_10700(ppk-2)
MISZ : MishRS11D_08760(ppk-2)
CHAE : CH06BL_40070(ppk-2)
PLG : NCTC10937_01664(pvdS1)
FKU : FGKAn22_23720(ppk-2)
DVN : HQ394_01885(pap) HQ394_11650(pap)
CSCI : HDCHBGLK_02804(tmk)
SYY : SYNGTS_1003(slr1363)
SYT : SYNGTI_1003(slr1363)
SYS : SYNPCCN_1002(slr1363)
SYQ : SYNPCCP_1002(slr1363)
OBG : Verru16b_03149(tmk_2)
» show all
Taxonomy
Reference
Authors
Bonting CF, Kortstee GJ, Zehnder AJ
Title
Properties of polyphosphate: AMP phosphotransferase of Acinetobacter strain 210A.
Journal
Reference
Authors
Shiba T, Itoh H, Kameda A, Kobayashi K, Kawazoe Y, Noguchi T
Title
Polyphosphate:AMP phosphotransferase as a polyphosphate-dependent nucleoside monophosphate kinase in Acinetobacter johnsonii 210A.
Journal
Sequence
Reference
Authors
Nocek B, Kochinyan S, Proudfoot M, Brown G, Evdokimova E, Osipiuk J, Edwards AM, Savchenko A, Joachimiak A, Yakunin AF
Title
Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.33
ExPASy - ENZYME nomenclature database: 2.7.4.33