KEGG   ENZYME: 2.7.7.28
Entry
EC 2.7.7.28                 Enzyme                                 
Name
nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase;
NDP hexose pyrophosphorylase;
hexose 1-phosphate nucleotidyltransferase;
hexose nucleotidylating enzyme;
nucleoside diphosphohexose pyrophosphorylase;
hexose-1-phosphate guanylyltransferase;
GTP:alpha-D-hexose-1-phosphate guanylyltransferase;
GDP hexose pyrophosphorylase;
guanosine diphosphohexose pyrophosphorylase;
nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase;
NTP:hexose-1-phosphate nucleotidyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase
Reaction(IUBMB)
nucleoside triphosphate + alpha-D-aldose 1-phosphate = diphosphate + NDP-hexose [RN:R03149]
Reaction(KEGG)
R03149 > R03318
Substrate
nucleoside triphosphate [CPD:C00201];
alpha-D-aldose 1-phosphate [CPD:C00991]
Product
diphosphate [CPD:C00013];
NDP-hexose [CPD:C01600]
Comment
In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar.
History
EC 2.7.7.28 created 1972, modified 2004 (EC 2.7.7.29 created 1972, incorporated 2004)
Reference
1  [PMID:5946626]
  Authors
Verachtert H, Rodriguez P, Bass ST, Hansen RG.
  Title
Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues.
  Journal
J Biol Chem 241:2007-13 (1966)
Reference
2
  Authors
Hansen RG, Verachtert H, Rodriguez P, Bass ST.
  Title
GDP-hexose pyrophosphorylase from liver.
  Journal
Methods Enzymol 8:269-271 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.28
IUBMB Enzyme Nomenclature: 2.7.7.28
ExPASy - ENZYME nomenclature database: 2.7.7.28
BRENDA, the Enzyme Database: 2.7.7.28
CAS: 37278-26-5

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Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Protein sequence (1)   
   UniProt (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
All databases (13)   

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