Entry
Name
DNA nucleotidylexotransferase;
terminal deoxyribonucleotidyltransferase;
terminal addition enzyme;
addase;
deoxynucleotidyl terminal transferase;
deoxyribonucleic acid nucleotidyltransferase;
deoxyribonucleic nucleotidyltransferase;
terminal deoxynucleotide transferase;
TdT
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
2'-deoxyribonucleoside-5'-triphosphate:DNA deoxynucleotidylexotransferase
Reaction(IUBMB)
2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 [RN:
R00379 ]
Reaction(KEGG)
Substrate
2'-deoxyribonucleoside 5'-triphosphate [CPD:
C00677 ];
DNAn [CPD:
C00039 ]
Product
Comment
Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or 2'-deoxyribo-.
History
EC 2.7.7.31 created 1972
Orthology
K00977 DNA nucleotidylexotransferase
Genes
SANH : 107689364 107689760
SGH : 107562388 107565064(dntt)
CCAR : 109061132 109084734
CAUA : 113056613 113077836 113113209 113113212
CGIB : 127969949 128025839
PPRM : 120460955 120460956
MASI : 127412006 127414375
SASA : 106576788 106605322
STRU : 115153048 115193964
OMY : 100136754(tdt) 110526770
OGO : 124037185 124040812(dntt)
ONE : 115113350 115135271(dntt)
OMM : 135510868(dntt) 135511671
SALP : 111951682 111977656
CCLU : 121553292 121569188
RTP : 109913711(dntt) 109929373(polm)
CPLA : 122543109(polm) 122561105(dntt)
HOC : 132826456(dntt) 132836879(polm)
LERI : 129704368 129713196(polm)
LPIC : 129273471 129273472
» show all
Taxonomy
Reference
Authors
Chang LM, Bollum FJ.
Title
Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase.
Journal
J Biol Chem 246:909-16 (1971)
Reference
Authors
Gottesman ME, Canellakis ES.
Title
The terminal nucleotidyltransferases of calf thymus nuclei.
Journal
J Biol Chem 241:4339-52 (1966)
Reference
Authors
KRAKOW JS, COUTSOGEORGOPOULOS C, CANELLAKIS ES.
Title
Studies on the incorporation of deoxyribonucleic acid.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.31
ExPASy - ENZYME nomenclature database: 2.7.7.31