KEGG   ENZYME: 2.7.7.39Help
Entry
EC 2.7.7.39                 Enzyme                                 

Name
glycerol-3-phosphate cytidylyltransferase;
CDP-glycerol pyrophosphorylase;
cytidine diphosphoglycerol pyrophosphorylase;
cytidine diphosphate glycerol pyrophosphorylase;
CTP:glycerol 3-phosphate cytidylyltransferase;
Gro-PCT;
tagD (gene name);
tarD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:sn-glycerol-3-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol [RN:R00856]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
sn-glycerol 3-phosphate [CPD:C00093]
Product
diphosphate [CPD:C00013];
CDP-glycerol [CPD:C00513]
Comment
Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.
History
EC 2.7.7.39 created 1972
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K00980  glycerol-3-phosphate cytidylyltransferase
Genes
ECC: c3696
ECQ: ECED1_2385(tagD)
ELN: NRG857_14640
ESE: ECSF_2781
ELF: LF82_472
EAS: Entas_2641
CTU: CTU_27380(tagD)
CRO: ROD_02971(tagD)
HDE: HDEF_0194
YFR: AW19_2175
YKR: CH54_3611
XPO: XPG1_3606
ASY: AUT07_00139(tagD)
PSHI: SAMEA2665130_0012(tagD)
MSU: MS0658(tagD)
ASU: Asuc_0816
APOR: DDU33_02505(tagD)
BTO: WQG_4220
BTRE: F542_17740
BTRH: F543_19600
SACZ: AOT14_19610(tagD)
PSUW: WQ53_08565
PPR: PBPRA2685(MW0603) PBPRA2703(TAGD1)
GHO: AL542_05075(tagD)
SFR: Sfri_3930
SBL: Sbal_2321
SLO: Shew_3695
SSE: Ssed_2953
SPL: Spea_1422
SHL: Shal_1505
SWD: Swoo_1692
SPSW: Sps_00159
PAT: Patl_3211
PSEO: OM33_09800
PPHE: PP2015_406
PTN: PTRA_a0499(tagD)
PSPO: PSPO_a1438(tagD)
PTU: PTUN_a1852(tagD)
AMAG: I533_04930
AMAC: MASE_04810
AAUS: EP12_00240
GNI: GNIT_0048(tagD) GNIT_2542 GNIT_3118(tagD)
FBL: Fbal_0144
MAH: MEALZ_0734(tagD)
FPH: Fphi_1472
FPI: BF30_1737
FPX: KU46_1835
HCO: LOKO_03355(tagD)
RMA: Rmag_0893
RGE: RGE_41190(tagD)
SUA: Saut_1161
CLX: CLAN_0122
NIS: NIS_1257
NAM: NAMH_1603(tagD)
DPI: BN4_12066(tagD)
DSF: UWK_02256
BMX: BMS_0350(tagD)
JAN: Jann_0819
PDE: Pden_5025
SPSE: SULPSESMR1_01614(tagD)
BSU: BSU35740(tagD)
BSR: I33_3703(tagD)
BSL: A7A1_1146
BSH: BSU6051_35740(tagD)
BSUT: BSUB_03801 BSUB_03807(tagD)
BSUL: BSUA_03801 BSUA_03807(tagD)
BSUS: Q433_19580
BSS: BSUW23_17550(tarD)
BST: GYO_3929(tarD)
BSO: BSNT_10218(tagD)
BSQ: B657_35740(tagD)
BSX: C663_3465(tarD)
BLI: BL02464(tagD)
BLD: BLi03818(tagD)
BLH: BaLi_c38300(tagD)
BAY: RBAM_032870(tagD)
BAQ: BACAU_3317(tagD)
BYA: BANAU_3476(tagD)
BAMP: B938_16880
BAML: BAM5036_3210(tagD)
BAMA: RBAU_3426(tagD)
BAMN: BASU_3204(tagD)
BAMT: AJ82_18560
BAMY: V529_35550(tagD)
BMP: NG74_03463(tagD)
BAO: BAMF_3413(tagD)
BAZ: BAMTA208_18085(tagD)
BQL: LL3_03708(tagD)
BXH: BAXH7_03697(tagD)
BQY: MUS_3915(tagD)
BAMI: KSO_002635
BAMC: U471_34140
BAMF: U722_17625
BMYC: DJ92_2374(tagD)
BMYO: BG05_725(tagD)
BCL: ABC3101(tagD)
BPU: BPUM_3230
BPUM: BW16_17240
BPUS: UP12_16730
BCK: BCO26_0717(tagD)
BAG: Bcoa_0458
BCOA: BF29_3238(tagD) BF29_3250(tagD)
BJS: MY9_3626
BACW: QR42_16235
BACP: SB24_12260
BACB: OY17_00115
BACY: QF06_16275
BACL: BS34A_38810(tagD_1) BS34A_38870(tagD_2)
BGY: BGLY_4215(tagD)
BKO: CKF48_13445(tagD)
BALT: CFN77_17150(tagD)
OIH: OB2908(tagD)
GTN: GTNG_3262
GEA: GARCT_03219(tagD)
AXL: AXY_20280(tagD)
VIL: CFK37_08175(tagD)
VNE: CFK40_03420(tagD)
VPN: A21D_00862(tagD)
SAU: SA0597(tagD)
SAV: SAV0641(tagD)
SAW: SAHV_0638(tagD)
SAM: MW0603(tagD)
SAS: SAS0607
SAR: SAR0651(tagD)
SAC: SACOL0698(tagD)
SAX: USA300HOU_0661(tagD)
SAE: NWMN_0611(tagD)
SAD: SAAV_0604(tagD)
SUE: SAOV_0676(tagD)
SUJ: SAA6159_00596(tagD)
SUK: SAA6008_00658(tagD)
SUC: ECTR2_593(tagD)
SUQ: HMPREF0772_12546(tagD)
SUZ: MS7_0692(tagD)
SUX: SAEMRSA15_05670(tagD)
SUW: SATW20_07160(tagD)
SUG: SAPIG0720(tagD)
SUF: SARLGA251_05750(tagD)
SAUA: SAAG_01064
SAUE: RSAU_000597(tagD)
SAUS: SA40_0582(tagD)
SAUU: SA957_0597(tagD)
SAUG: SA268_0595(tagD)
SAUZ: SAZ172_0653(tagD)
SAUF: X998_0689(tagD)
SAB: SAB0591(tagD)
SAUB: C248_0723(tagD)
SAUM: BN843_6430
SAUC: CA347_655(tagD)
SAUR: SABB_00689(tagD)
SAUI: AZ30_03360
SAUD: CH52_02555
SAMS: NI36_03210
SEP: SE0415
SER: SERP0300(tagD)
SEPP: SEB_00336
SEPS: DP17_1719(tagD)
SHA: SH2255(tagD)
SHH: ShL2_02105(tagD)
SSP: SSP2078
SCA: SCA_0290(tagD)
SLN: SLUG_21570(tagD)
SDT: SPSE_2109(tagD)
SPAS: STP1_1727
SXO: SXYL_02208(tagD)
SHU: SHYC_10500(tagD)
SCAP: AYP1020_0010(tagD)
SSCH: LH95_10095
SSCZ: RN70_10830
SAGQ: EP23_11670
SSIF: AL483_08400(tagD) AL483_11840(tagD)
SPET: CEP67_10195(tagD)
SSCU: CEP64_08350(tagD)
SKL: C7J89_12240(tagD)
MCL: MCCL_0651(tagD)
LMO: lmo1089(tagD)
LMN: LM5578_1172(tagD)
LMY: LM5923_1126(tagD)
LMF: LMOf2365_1105(tagD)
LMC: Lm4b_01104(tagD)
LMOG: BN389_11180(tagD)
LMH: LMHCC_1542(tagD)
LMQ: LMM7_1115(tagD)
LMS: LMLG_2572
LML: lmo4a_1093(tagD)
LMP: MUO_05695
LMW: LMOSLCC2755_1087(tagD)
LMX: LMOSLCC2372_1103(tagD)
LMZ: LMOSLCC2482_1133(tagD)
LMON: LMOSLCC2376_1056(tagD)
LMOC: LMOSLCC5850_1095(tagD)
LMOS: LMOSLCC7179_1070(tagD)
LMOO: LMOSLCC2378_1102(tagD)
LMOY: LMOSLCC2479_1103(tagD)
LMOT: LMOSLCC2540_1086(tagD)
LMOA: LMOATCC19117_1107(tagD)
LMOL: LMOL312_1085(tagD)
LMOE: BN418_1307
LMOB: BN419_1304
LMOZ: LM1816_14242(tagD)
LMOD: LMON_1099(tagD)
LMOW: AX10_14025
LMOX: AX24_02845
LMOQ: LM6179_1409(tagD)
LMR: LMR479A_1117(tagD)
LMOK: CQ02_05655
LMOM: IJ09_04840
LIN: tagD
LWE: lwe1066(tagD)
LSG: lse_0979(tagD)
LIV: LIV_1032(tagD)
BTHS: CNY62_04725(tagD)
ESI: Exig_0593
EAN: Eab7_0567(tagD)
PPY: PPE_04334
PPOL: X809_39540
PPQ: PPSQR21_045890(tagD)
PPOY: RE92_14550
PSAB: PSAB_18500
JEO: JMA_33870
KUR: ASO14_2496(tagD)
LLA: L150584(tagD2) L19816(tagD1)
LLK: LLKF_0212(tagD) LLKF_0953(tagD)
LLT: CVCAS_0200(tagD) CVCAS_0889(tagD2)
LLS: lilo_0873(tagD2) lilo_0874(tagD2)
LLD: P620_05005(tagD)
LLX: NCDO2118_0211(tagD1) NCDO2118_0945(tagD2)
LLM: llmg_1606(tagD2)
LLI: uc509_0217(tagD2)
LLW: kw2_0918(tagD)
LLJ: LG36_1400(tagD)
LGR: LCGT_1236
LGV: LCGL_1257
SNP: SPAP_0388(gct)
LPL: lp_0267(tagD1) lp_1248(tagD2)
LPJ: JDM1_1056(tagD2)
LPT: zj316_0466(tagD1) zj316_1214(tagD2) zj316_1275(tagD2) zj316_2p11(tagD)
LPS: LPST_C0955(tagD2) LPST_C1012(tagD2)
LJO: LJ_1738
LJF: FI9785_1524(tagD)
LJH: LJP_1487
LAC: LBA0518(tagD)
LAD: LA14_0544
LAF: SD55_0541(tagD)
LSA: LCA_1574(tagD)
LDB: Ldb1937(tagD)
LBU: LBUL_1800
LDL: LBU_1588
LBR: LVIS_1565
LGA: LGAS_1533
LHE: lhv_0535
LHL: LBHH_1599
LHV: lhe_0534
LHH: LBH_0430
LHD: HUO_09440
LCR: LCRIS_00516(tagD)
LAM: LA2_02795
LBN: LBUCD034_1702(tagD)
LKE: WANG_1150(tagD) WANG_1283
LAE: LBAT_1321
PPE: PEPE_0602
PPEN: T256_03240
PCE: PECL_1232(tagD)
EFA: EF1175(gct)
EFI: OG1RF_11712(tagD)
EFN: DENG_02216(tagD)
EFQ: DR75_1005(tagD)
ECAS: ECBG_01927
ETH: CK496_08440(tagD) CK496_09695(tagD)
THL: TEH_15990(tagD)
LMM: MI1_06320
LCI: LCK_01137(tagD1) LCK_01202(tagD2)
LKI: LKI_08940
LGS: LEGAS_0761(tagD)
WCE: WS08_0783
WCT: WS74_0786
WPA: CO680_04760(tagD)
CPE: CPE0483
CLS: CXIVA_01280(TagD_(BS))
ESR: ES1_01600
CCEL: CCDG5_1917
RCH: RUM_01080
CPY: Cphy_0300
BPRL: CL2_24210
HSD: SD1D_2044(tagD)
ERH: ERH_1439(tagD)
HCR: X271_00050(tagD_1) X271_00054(tagD_2)
CAR: cauri_0406(tagD)
SGB: WQO_27575
SFA: Sfla_1364
STRP: F750_5518
SFI: SFUL_5905
STRM: M444_23950
SRW: TUE45_01250(hldE_2) TUE45_07352(tagD)
SRN: A4G23_02069(tagD)
SLX: SLAV_12535(tagD)
CMI: CMM_0818(tagD)
CMC: CMN_00775(tagD)
AAI: AARI_14560(tagD)
BCV: Bcav_0992
IDO: I598_3090(tagD)
CFL: Cfla_0886
CFI: Celf_3031
SERJ: SGUI_2388
BLIN: BLSMQ_3091
MPH: MLP_04890(tagD)
NCA: Noca_1691
KFL: Kfla_2761
NML: Namu_4442
BSD: BLASA_0778(tagD)
MMAR: MODMU_0970(tagD)
SEN: SACE_3183
BLO: BL0210
OLS: Olsu_0610
LIL: LA_2410
LIC: LIC_11539(tagD)
LBJ: LBJ_1452
LBL: LBL_1676
FNU: FN0930
FSC: FSU_1415(tagD)
BCEL: BcellWH2_00393(tagD_1) BcellWH2_02468(tagD_2)
PGI: PG_2068(tagD)
PGT: PGTDC60_2216(tagD)
TFO: BFO_3031
SMIZ: 4412673_03834(tagD_1) 4412673_03840(tagD_2)
FJG: BB050_03964(tagD)
EAO: BD94_3276
ELB: VO54_03349(tagD)
AALG: AREALGSMS7_04015(tagD)
FBA: FIC_01923
AAE: aq_1368(tagD2)
TRQ: TRQ2_0301
TME: Tmel_1075
CABY: Cabys_1820
SAAL: L336_0516(tagD)
NMR: Nmar_1298
 » show all
Taxonomy
Reference
1  [PMID:13911452]
  Authors
SHAW DR.
  Title
Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol.
  Journal
Biochem J 82:297-312 (1962)
Reference
2  [PMID:8393871]
  Authors
Park YS, Sweitzer TD, Dixon JE, Kent C
  Title
Expression, purification, and characterization of CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis.
  Journal
J Biol Chem 268:16648-54 (1993)
Reference
3  [PMID:11487587]
  Authors
Sanker S, Campbell HA, Kent C
  Title
Negative cooperativity of substrate binding but not enzyme activity in wild-type  and mutant forms of CTP:glycerol-3-phosphate cytidylyltransferase.
  Journal
J Biol Chem 276:37922-8 (2001)
DOI:10.1074/jbc.M107198200
Reference
4  [PMID:12637027]
  Authors
Badurina DS, Zolli-Juran M, Brown ED
  Title
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values.
  Journal
Biochim Biophys Acta 1646:196-206 (2003)
DOI:10.1016/S1570-9639(03)00019-0
Reference
5  [PMID:14506262]
  Authors
Pattridge KA, Weber CH, Friesen JA, Sanker S, Kent C, Ludwig ML
  Title
Glycerol-3-phosphate cytidylyltransferase. Structural changes induced by binding  of CDP-glycerol and the role of lysine residues in catalysis.
  Journal
J Biol Chem 278:51863-71 (2003)
DOI:10.1074/jbc.M306174200
  Sequence
[bsu:BSU35740]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.39
IUBMB Enzyme Nomenclature: 2.7.7.39
ExPASy - ENZYME nomenclature database: 2.7.7.39
BRENDA, the Enzyme Database: 2.7.7.39
CAS: 9027-11-6

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