Entry |
|
Name |
N-acylneuraminate cytidylyltransferase;
CMP-sialate pyrophosphorylase;
CMP-sialate synthase;
cytidine 5'-monophosphosialic acid synthetase;
CMP-Neu5Ac synthetase;
CMP-NeuAc synthetase;
acylneuraminate cytidyltransferase;
CMP-N-acetylneuraminate synthetase;
CMP-N-acetylneuraminate synthase;
CMP-N-acetylneuraminic acid synthase;
CMP-NANA synthetase;
CMP-sialate synthetase;
CMP-sialic synthetase;
cytidine 5'-monophospho-N-acetylneuraminic acid synthetase;
cytidine 5-monophosphate N-acetylneuraminic acid synthetase;
cytidine monophosphosialic acid synthetase;
cytidine monophosphoacetylneuraminic synthetase;
cytidine monophosphosialate pyrophosphorylase;
cytidine monophosphosialate synthetase;
acetylneuraminate cytidylyltransferase
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Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
|
Sysname |
CTP:N-acylneuraminate cytidylyltransferase
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Reaction(IUBMB) |
CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate [RN: R02599]
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Reaction(KEGG) |
|
Substrate |
|
Product |
diphosphate [CPD: C00013];
CMP-N-acylneuraminate [CPD: C01064]
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Comment |
Acts on N-acetyl- and N-glycolyl- derivatives.
|
History |
EC 2.7.7.43 created 1972
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Pathway |
ec00520 | Amino sugar and nucleotide sugar metabolism |
ec00541 | O-Antigen nucleotide sugar biosynthesis |
|
Orthology |
K00983 | N-acylneuraminate cytidylyltransferase |
K21749 | N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase |
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Genes |
CJC: | 100406904 118144192(CMAS) |
CCAN: | 109684205(Cmas) 109700116 |
ECB: | 100064384(CMAS) 111767497 111772031 111772222 |
PBRV: | 138175777 138176099 |
DRE: | 100885772(cmasb) 561018(cmasa) |
SRX: | 107725656 107729858 107754376 |
SANH: | 107676932 107686963 107686964 107690429 |
SGH: | 107561146 107566237 107583561 107587160 |
CCAR: | 109050865 109055284 109078903 109079913 109087566 |
CAUA: | 113060713 113063685 113066549 113066552 113066554 113066638 113085421 |
CGIB: | 127946851 127946852 127956849 |
LROH: | 127156355(cmasb) 127163846 127164428 |
OMC: | 131524839 131534810(cmasb) 131538692(cmasa) |
PPRM: | 120475374(cmasb) 120475382 120475383 120476870(cmasa) |
RKG: | 130071122(cmasa) 130106465 130106506 |
MAMB: | 125246406(cmasa) 125247715 125247764 125247863 125247900 125247934 125251691 |
CERY: | 137014594 137014770 137014859 137014938 137023896(cmasa) |
MASI: | 127434850 127436916 |
TDW: | 130414207(cmasb) 130421002(cmasa) |
MANU: | 129432594(cmasa) 129433134 129433748 129445959 |
IPU: | 108260153 108279965(cmasa) |
IFU: | 128603811 128623380(cmasa) |
PHYP: | 113531521 113532112 |
SMEO: | 124378729 124400965 124401283 124401284 124401666 |
AMEX: | 103032957(cmasa) 125798997(cmasb) |
CMAO: | 118811158(cmasb) 118812198(cmasa) |
EEE: | 113569165 113569273 113571272 113587611 |
PLEP: | 121962198 121966280 |
ONL: | 100690888 100691152 100691690 |
OAU: | 116317091 116329280 116334504 |
XMA: | 102216878 102216980 111610925 111610926 |
XHE: | 116733436 116733437 116733438 |
PRET: | 103480600 103480601 |
PFOR: | 103156678 103156685(cmas) 103156781 |
PLAI: | 106956934 106956935 106956936 |
PMEI: | 106907823 106907824 |
PPRL: | 129356659 129379873 |
CVG: | 107083409 107095092 107104871 107104876 |
CTUL: | 119779748 119787166 |
GMU: | 124880206 124880382 124880383 124880384 124880385 124880456 |
ALIM: | 106519069 106519070 |
BPEC: | 110172765 110174880 |
MALB: | 109974198 109974201 |
SASA: | 100194895(neua) 106576595 106578766 106590764 106590838 106593487 106596479(NEUA) 106597166 106597185 106597441 106597467 106597528 106597536 |
STRU: | 115180552 115180553 115199177 115199178 115202177 |
OTW: | 112240998 112241039 112245012 121845714 |
OMY: | 100135794(cmas) 110490643 110497426 118936248 118942883 |
OGO: | 124002066 124017676(cmasa) 124027201 124028462 124028543 |
OKI: | 109876841 109877423 109893843 116366308 |
OKE: | 118362102 118377932 118377933 118377934 |
SALP: | 112068284(cmas) 112077130 |
SNH: | 120031773 120031774 120035099 120035151 120049417 120050104 |
CCLU: | 121535763 121557235 121557236 121561191 |
PSPA: | 121318009 121320279 |
ARUT: | 117414820 117419575 |
BFO: | 118406623 118406756 118407224 118421524 |
BBEL: | 109463567 109463577 109471768 109471775 |
SCLV: | 120331504 120331505 |
SPU: | 115923639 588508(cmas) |
ARUN: | 117292241 117292429 |
SKO: | 100378063 100378406 102808000 |
DSI: | Dsimw501_GD12235(Dsim_GD12235) |
AALB: | 109411850 115259468 115268775 |
ASUA: | 134204040 134227008 |
LSM: | 121121214 121121454 121130036 |
EHX: | EMIHUDRAFT_442878(NANT1) EMIHUDRAFT_445636 |
ECOO: | ECRM13514_2761(nnaC) |
ECOH: | ECRM13516_2629(nnaC) |
ECOI: | ECOPMV1_03251(neuA) |
HIC: | NTHIC486_01386(neuA) |
HHZ: | NCTC10839_01659(neuA) |
HAEG: | NCTC8502_01754(neuA) |
HAP: | HAPS_0040(neuA1) HAPS_2206(neuA3) |
HPAZ: | K756_06940 K756_07665 |
HPAS: | JL26_05910 JL26_06590 |
HPAK: | JT17_03420 JT17_04125 |
PDAG: | 4362423_01163(neuA) |
PATL: | KGI96_01015 KGI96_06055 |
ASI: | ASU2_01190 ASU2_10550 |
ADP: | NCTC12871_01317(neuA) |
NMQ: | NMBM04240196_0081(siaB) |
NMZ: | NMBNZ0533_0075(siaB) |
PBY: | L6471_06300 L6471_06305 |
LGZ: | NCTC10812_01044(neuA) |
GHA: | NCTC10459_01449(neuA) |
SMEN: | SAMEA4412692_0119(cps16V) |
FPOL: | ERS445057_00376(neuA) |
» show all
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Reference |
|
Authors |
Kean EL, Roseman S. |
Title |
The sialic acids. X. Purification and properties of cytidine 5'-monophosphosialic acid synthetase. |
Journal |
J Biol Chem 241:5643-50 (1966) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.7.43 |
ExPASy - ENZYME nomenclature database: | 2.7.7.43 |
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