KEGG   ENZYME: 2.7.7.43
Entry
EC 2.7.7.43                 Enzyme                                 
Name
N-acylneuraminate cytidylyltransferase;
CMP-sialate pyrophosphorylase;
CMP-sialate synthase;
cytidine 5'-monophosphosialic acid synthetase;
CMP-Neu5Ac synthetase;
CMP-NeuAc synthetase;
acylneuraminate cytidyltransferase;
CMP-N-acetylneuraminate synthetase;
CMP-N-acetylneuraminate synthase;
CMP-N-acetylneuraminic acid synthase;
CMP-NANA synthetase;
CMP-sialate synthetase;
CMP-sialic synthetase;
cytidine 5'-monophospho-N-acetylneuraminic acid synthetase;
cytidine 5-monophosphate N-acetylneuraminic acid synthetase;
cytidine monophosphosialic acid synthetase;
cytidine monophosphoacetylneuraminic synthetase;
cytidine monophosphosialate pyrophosphorylase;
cytidine monophosphosialate synthetase;
acetylneuraminate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:N-acylneuraminate cytidylyltransferase
Reaction(IUBMB)
CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate [RN:R02599]
Reaction(KEGG)
R02599 > R01117 R04215
Substrate
CTP [CPD:C00063];
N-acylneuraminate [CPD:C00591]
Product
diphosphate [CPD:C00013];
CMP-N-acylneuraminate [CPD:C01064]
Comment
Acts on N-acetyl- and N-glycolyl- derivatives.
History
EC 2.7.7.43 created 1972
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K00983  N-acylneuraminate cytidylyltransferase
K21749  N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase
Genes
HSA55907(CMAS)
PTR465340(CMAS)
PPS100970394(CMAS)
GGO101134064(CMAS)
PON100173476(CMAS)
NLE100588502(CMAS)
MCC706604(CMAS)
MCF102117955(CMAS)
CSAB103218742(CMAS)
CATY105585058(CMAS)
PANU101009685(CMAS)
TGE112634866(CMAS)
RRO104660755(CMAS)
RBB108541109(CMAS)
TFN117090398(CMAS)
PTEH111540639(CMAS)
CJC100406904(CMAS)
SBQ101042258(CMAS)
CSYR103255168
MMUR105882803(CMAS)
LCAT123639935(CMAS)
OGA100950112(CMAS)
MMU12764(Cmas)
MCAL110296030(Cmas)
MPAH110316174(Cmas)
RNO312826(Cmas)
MCOC116099768(Cmas)
MUN110560537(Cmas)
CGE100773134(Cmas)
MAUA101834722(Cmas)
PLEU114700283(Cmas)
MORG121439415(Cmas)
MFOT126497321
AAMP119806711(Cmas)
NGI103736727(Cmas)
HGL101697716(Cmas)
CPOC100715137(Cmas)
CCAN109684205(Cmas) 109700116
DORD105992240(Cmas)
DSP122102254(Cmas)
NCAR124984040
OCU100351910(CMAS)
OPI101531831(CMAS)
TUP102484781(CMAS)
CFA477673(CMAS)
CLUD112665512(CMAS)
VVP112917221(CMAS)
VLG121480099(CMAS)
AML100464890(CMAS)
UMR103665267(CMAS)
UAH113257802(CMAS)
UAR123801662(CMAS)
ELK111161354
LLV125107288
MPUF101692809(CMAS)
ORO101367176(CMAS)
EJU114216635(CMAS)
ZCA113922763(CMAS)
MLX118025583(CMAS)
NSU110580831(CMAS)
FCA101096901(CMAS)
PYU121038821(CMAS)
PBG122474063(CMAS)
LRUF124501645
PTG102968672(CMAS)
PPAD109268728(CMAS)
AJU106967979(CMAS)
HHV120236000(CMAS)
BTA100336710(CMAS)
BOM102265983(CMAS)
BIU109558556(CMAS)
BBUB102410777(CMAS)
CHX102171581(CMAS)
OAS101115615(CMAS)
ODA120858933(CMAS)
CCAD122423658(CMAS)
SSC100520022(CMAS)
CFR102512611(CMAS)
CBAI105062286(CMAS)
CDK105096480(CMAS)
VPC102526239(CMAS)
BACU103009004(CMAS)
LVE103076237(CMAS)
OOR101286195(CMAS)
DLE111176838 111176839
PCAD102986559(CMAS)
PSIU116760945(CMAS)
ECB100064384(CMAS) 111767497 111772031 111772222
EPZ103554940(CMAS)
EAI106825570(CMAS)
MYB102249530(CMAS)
MYD102769445(CMAS)
MMYO118651200(CMAS)
MLF102437190(CMAS)
MNA107525267(CMAS)
PKL118729455(CMAS)
HAI109375147(CMAS)
DRO112318410(CMAS)
SHON118978367(CMAS)
AJM119048977(CMAS)
PDIC114513143(CMAS)
PHAS123813106(CMAS)
MMF118624507(CMAS)
RFQ117029190(CMAS)
PALE102891934(CMAS)
PGIG120618364(CMAS)
PVP105306531(CMAS)
RAY107508579(CMAS)
MJV108398365(CMAS)
TOD119247641(CMAS)
SARA101537210(CMAS)
LAV100659502(CMAS)
TMU101358724
DNM101445069(CMAS)
MDO100010366(CMAS)
GAS123249156(CMAS)
SHR100916925(CMAS)
PCW110213797(CMAS)
OAA100079158(CMAS)
GGA418199(CMAS)
PCOC116231408(CMAS)
MGP100547771(CMAS)
CJO107317124(CMAS)
NMEL110396222(CMAS)
APLA101797002(CMAS)
ACYG106038290(CMAS)
AFUL116493389(CMAS)
TGU100225966(CMAS)
LSR110475217(CMAS)
SCAN103819571(CMAS)
PMOA120507577(CMAS)
OTC121332067(CMAS)
PRUF121352112(CMAS)
GFR102039209(CMAS)
FAB101808069(CMAS)
PHI102099665(CMAS)
PMAJ107205108(CMAS)
CCAE111929504(CMAS)
CCW104696139(CMAS)
CBRC103623398(CMAS)
ETL114068941(CMAS)
ZAB102069251(CMAS)
ACHL103809183(CMAS)
FPG101922260(CMAS)
FCH102056814(CMAS)
CLV102093680(CMAS)
EGZ104135092(CMAS)
NNI104012728(CMAS)
PLET104614354(CMAS)
PCRI104029073(CMAS)
ACUN113488254(CMAS)
TALA104360103(CMAS)
PADL103924479(CMAS)
AFOR103898736(CMAS)
ACHC115352604(CMAS)
HALD104319173(CMAS)
CCRI104165180(CMAS)
CSTI104562286(CMAS)
EHS104510454(CMAS)
CMAC104480002(CMAS)
MUI104534845(CMAS)
FGA104070353(CMAS)
GSTE104262592(CMAS)
LDI104346311(CMAS)
MNB103773097(CMAS)
OHA104327195(CMAS)
NNT104399858(CMAS)
DPUB104299428(CMAS)
PGUU104464829(CMAS)
ACAR104521373(CMAS)
AVIT104270825(CMAS)
AAM106488296(CMAS)
AROW112966587(CMAS)
NPD112944383(CMAS)
TGT104578996(CMAS)
DNE112978899(CMAS)
SCAM104154120(CMAS)
ASN102377821(CMAS)
AMJ102572771(CMAS)
CPOO109316393(CMAS)
GGN109296300(CMAS)
PSS102462348(CMAS)
CMY102944186(CMAS)
CPIC101937923(CMAS)
TST117883383(CMAS)
CABI116835473(CMAS)
MRV120391308(CMAS)
ACS100560058(cmas)
PVT110091200(CMAS)
SUND121931412(CMAS)
PBI103057127(CMAS)
PMUR107295787(CMAS)
CTIG120309795(CMAS)
TSR106553370(CMAS)
PGUT117679859(CMAS)
VKO123034669(CMAS)
PMUA114605172(CMAS)
ZVI118091426(CMAS)
GJA107106355(CMAS)
STOW125434317(CMAS)
XLA108710695(cmas.L)
XTR100036739(cmas)
NPR108789878(CMAS)
RTEM120932767(CMAS)
BBUF121005137(CMAS)
DRE100885772(cmasb) 561018(cmasa)
SRX107725656 107729858 107754376
SANH107676932 107686963 107686964 107690429
SGH107561146 107566237 107583561 107587160
CCAR109050865 109055284 109078903 109079913 109087566
CAUA113060713 113063685 113066549 113066552 113066554 113066638 113085421
PPRM120475374(cmasb) 120475382 120475383 120476870(cmasa)
MAMB125246406(cmasa) 125247715 125247764 125247863 125247900 125247934 125251691
IPU108260153 108279965(cmasa)
PHYP113531521 113532112
SMEO124378729 124400965 124401283 124401284 124401666
TFD113647288(cmasa)
AMEX103032957(cmas)
EEE113569165 113569273 113571272 113587611
TRU777966(cmas)
TNGGSTEN00036152G001
LCO104933596(cmas)
CGOB115024037(cmas)
ELY117246230(cmasa)
EFO125884435(cmasa)
PLEP121962198 121966280
SLUC116053150(cmasa)
ECRA117935047(cmasa)
ESP116669510(cmas)
PFLV114573918(cmas)
GAT120823098(cmasa)
PPUG119222965(cmasa)
MSAM119912402
CUD121504755(cmasa)
ALAT119027006(cmasa)
MZE106676701 111501613
ONL100690888 100691152 100691690
OAU116317091 116329280 116334504
OLA101175534(cmas)
OML112156064(cmasa)
XMA102216878 102216980 111610925 111610926
XCO114157354(cmas)
XHE116733436 116733437 116733438
PRET103480600 103480601
PFOR103156678 103156685(cmas) 103156781
PLAI106956934 106956935 106956936
PMEI106907823 106907824
GAF122820263 122820265
CVG107083409 107095092 107104871 107104876
CTUL119779748 119787166
GMU124880206 124880382 124880383 124880384 124880385 124880456
NFU107376910 107376911
KMR108228449 108250897
ALIM106519069 106519070
NWH119411792 119411887
AOCE111584516(cmas)
MCEP125020788(cmasa)
CSEM103386081(cmas)
POV109642938(cmas)
SSEN122765919(cmasa)
HHIP117751875(cmasa)
HSP118102620(cmasa)
LCF108891965(cmasa)
SDU111233310(cmas)
SLAL111657238(cmas)
XGL120797656(cmasa)
HCQ109506960(cmas)
BPEC110172765 110174880
MALB109974198 109974201
BSPL114847429(cmasa)
SASA100194895(neua) 106576595 106578766 106590764 106590838 106593487 106596479(NEUA) 106597166 106597185 106597441 106597467 106597528 106597536
STRU115180552 115180553 115199177 115199178 115202177
OTW112240998 112241039 112245012 121845714
OMY100135794(cmas) 110490643 110497426 118936248 118942883
OGO124002066 124017676(cmasa) 124027201 124028462 124028543
ONE115146547(cmas)
SALP112068284(cmas) 112077130
SNH120031773 120031774 120035099 120035151 120049417 120050104
CCLU121535763 121557235 121557236 121561191
ELS105009720(cmas)
SFM108935968(cmas)
PKI111837183(cmas)
AANG118219286(cmasa)
LOC102697163(cmas)
PSPA121318009 121320279
ARUT117414820 117419575
LCM102354669(CMAS)
CMK103181066(cmasa)
RTP109936007(cmas)
BFO118406623 118406756 118407224 118421524
BBEL109463567 109463577 109471768 109471775
CIN100101814(cmas)
SCLV120331504 120331505
SPU115923639 588508(cmas)
APLC110980233
SKO100378063 100378406 102808000
DMEDmel_CG32220(Csas)
DER6545780
DSE6619433
DSIDsimw501_GD12235(Dsim_GD12235)
DYADyak_GE22447
DAN6493701
DSR110190055
DPO6900890
DPE6603364
DMN108152106
DWI6643060
DGR6557117
DMODmoj_GI13380
DAZ108614625
DNV108651686
DHE111605622
DVI6622652
CCAT101454971
BOD106617956
RZE108362028
SCAC106080898
LCQ111687698
LSQ119612161
HIS119649316
AGAAgaP_AGAP004527
ACOZ120948298
AARA120903006
ASTE118503037
AAG5576920
AALB109411850 115259468 115268775
CQUCpipJ_CPIJ000558
CPII120417068
CNS116349105
BCOO119074977
NVL108564803
APLN108741878
PPYR116178086
OTU111417161
DPLKGM_200278
BANY112056558
PMAC106718036
PPOT106107405
ZCE119832208
TNL113508728
OFU114363071
PXY105388536
API100161457
DNX107172003
AGS114128368
RMD113556369
BTAB109035092
DCI103508411
CLEC106667611
HHAL106687600
PHUPhum_PHUM094730
TPAL117649570
ZNE110839122
CSEC111868098
FCD110861915
DPXDAPPUDRAFT_310334
DMK116924342
PVM113806787
PJA122263570
PCHN125039821
HAME121855760
PCLA123763938
PTRU123503078
EAF111713760
LSM121121214 121121454 121130036
PPOI119095530
ISCIscW_ISCW021121
DSV119453111 119453112
RSAN119400028
RMP119179616
VDE111252968
VJA111260555
TUT107359229
CSCU111618601
PTEP107440108
SDM118183334
MMER123529943 123530395 123530487
AAFAURANDRAFT_22362
EHXEMIHUDRAFT_442878(NANT1) EMIHUDRAFT_445636
ECOOECRM13514_2761(nnaC)
ECOHECRM13516_2629(nnaC)
ESLO3K_09235
ESOO3O_16385
ESMO3M_09200
ECKEC55989_2294
ECVAPECO1_3472(neuA)
ECMEcSMS35_3231(neuA)
ECTECIAI39_3442(neuA)
ECIUTI89_C3371(neuA)
EIHECOK1_3368(neuA)
ECZECS88_3329(neuA)
ELUUM146_01625
ECOIECOPMV1_03251(neuA)
SBZA464_2221
SBVN643_09310
PTTVY86_07615
EICNT01EI_1317
ETRETAE_1208(neuA)
ETDETAF_1123
ETEETEE_3152(neuA)
ETCETAC_05750
EDWQY76_14235
EDLAAZ33_06220
EHOA9798_10690
HINHI_1279
HITNTHI1891(siaB)
HIPCGSHiEE_04135
HIQCGSHiGG_01585
HIFHIBPF_06650(siaB)
HILHICON_15140(siaB)
HIUHIB_14310
HIER2846_0799(neuA)
HIZR2866_0861(neuA)
HIKHifGL_000977(neuA)
HIAH733_0891
HIHNF38_06255
HIWNTHI477_00380(neuA)
HICNTHIC486_01386(neuA)
HIXNTHI723_00291(neuA)
HPRPARA_02840(nnaC)
HDUHD_0685(neuA)
HAYC3V42_00575
HHZNCTC10839_01659(neuA)
HAEGNCTC8502_01754(neuA)
HPAAE5Q53_08230
HSEML3077_07260
HAPHAPS_0040(neuA1) HAPS_2206(neuA3)
HPAZK756_06940 K756_07665
HPASJL26_05910 JL26_06590
HPAKJT17_03420 JT17_04125
GLECJD39_01130
PMUPM0187(neuA)
PMVPMCN06_1113(neuA)
PULNT08PM_1145
PMPPmu_11260(neuA)
PMULDR93_1879(neuA)
PDAG4362423_01163(neuA)
PATLKGI96_01015 KGI96_06055
PCAIK7G93_001109
MHTD648_18130
MHQD650_8030
MHATB824_18210
MHXMHH_c26660(nnaC)
MHAEF382_04085
MHAMJ450_03115
MHAOJ451_04325
MHALN220_10185
MHAQWC39_04020
MHAYVK67_04020
MVRX781_6000
MVIX808_15560
MVGX874_14500
MVEX875_5520
MANNGM695_10185
MGRAA4G16_01265
MBOSICJ55_05340
MPEGHV560_09840
ASIASU2_01190 ASU2_10550
ASSASU1_01195
AEUACEE_01050
AIOEXH44_08930
ADPNCTC12871_01317(neuA)
GANUMN179_00299
BTOWQG_15700
BTREF542_6360
BTRHF543_7540
BTRAF544_16050
APAGEIA51_04605
RHEYFEE42_11165
FCLA4G17_09125
BHUDA6A11_03425
VSAVSAL_I3012(neuA)
PGBH744_2c2919
NMENMB0069(siaB)
NMPNMBB_0073A(siaB)
NMHNMBH4476_0069
NMDNMBG2136_0074
NMMNMBM01240149_0068
NMSNMBM01240355_0071
NMQNMBM04240196_0081(siaB)
NMZNMBNZ0533_0075(siaB)
NMCNMC0053(siaB)
NMNNMCC_0077(siaB)
NMTNMV_0070(siaB)
NBLGJV52_06950
SMURBWP33_01880
RPJN234_26960
BPSIIX83_06870
CJECj1143(neuA1)
CJBBN148_1143(neuA1)
CJICJSA_1085(neuA1)
CJPA911_05540
CJEJN564_01109
CJEUN565_01152
CJENN755_01147
CJEIN135_01180
CMUCCMCT_1130(neuA)
CNVCNZW441b_1141(neuA)
DBKDGMP_13680(neuA_2)
LGZNCTC10812_01044(neuA)
GHANCTC10459_01449(neuA)
SAGSAG1158(neuA)
SANneuA
SAKSAK_1247(neuA)
SGCA964_1131(neuA)
SAGSSaSA20_0980(neuA)
SAGLGBS222_0990(neuA)
SAGMBSA_12360
SAGIMSA_12780
SAGRSAIL_12780
SAGPV193_05410
SAGCDN94_05410
SAGTGBSCOH1_1064
SAGEEN72_06440
SAGGEN73_05975
SAGNW903_1241
SSBSSUBM407_1277(neuA)
SSUSSU05_0581
SSVSSU98_0585
SSISSU0538(neuA)
SSSSSUSC84_0520(neuA)
SSFSSUA7_0541(neuA)
SSWSSGZ1_0574
SUPYYK_02550
SSUSNJAUSS_0546
SUISSUJS14_0545(neuA)
SUOSSU12_0542(neuA)
SRPSSUST1_1224(neuA)
SSUTTL13_1185(cps16V)
SSUIT15_1398(neuA)
SRQSR187_6410
SGWD7D53_08705
SMENSAMEA4412692_0119(cps16V)
AUHAWM75_07805
RGNRGna_11990
LILLA_1615(neuA)
LIELIF_A1302(neuA)
LICLIC_12167
FNTHMPREF0405_00112
FVAFV113G1_31670
PBYL6471_06300 L6471_06305
 » show all
Reference
1  [PMID:4288894]
  Authors
Kean EL, Roseman S.
  Title
The sialic acids. X. Purification and properties of cytidine 5'-monophosphosialic acid synthetase.
  Journal
J Biol Chem 241:5643-50 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.43
IUBMB Enzyme Nomenclature: 2.7.7.43
ExPASy - ENZYME nomenclature database: 2.7.7.43
BRENDA, the Enzyme Database: 2.7.7.43
CAS: 9067-82-7

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