Entry |
|
Name |
gentamicin 2''-nucleotidyltransferase;
gentamicin 2''-adenylyltransferase;
aminoglycoside adenylyltransferase;
gentamycin 2''-nucleotidyltransferase
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
|
Sysname |
NTP:gentamicin 2''-nucleotidyltransferase
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Reaction(IUBMB) |
nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin [RN: R02432]
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Reaction(KEGG) |
|
Substrate |
nucleoside triphosphate [CPD: C00201];
gentamicin [CPD: C00505]
|
Product |
diphosphate [CPD: C00013];
2''-nucleotidylgentamicin [CPD: C03565]
|
Comment |
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
|
History |
EC 2.7.7.46 created 1976
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Orthology |
K17881 | aminoglycoside 2''-adenylyltransferase |
|
Genes |
» show all
|
Reference |
|
Authors |
Angelatou F, Litsas SB, Kontomichalou P. |
Title |
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa. |
Journal |
|
Reference |
|
Authors |
Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H. |
Title |
The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B. |
Journal |
|
Reference |
|
Authors |
Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T. |
Title |
Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.7.46 |
ExPASy - ENZYME nomenclature database: | 2.7.7.46 |
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