| Entry |
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| Name |
gentamicin 2''-nucleotidyltransferase;
gentamicin 2''-adenylyltransferase;
aminoglycoside adenylyltransferase;
gentamycin 2''-nucleotidyltransferase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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| Sysname |
NTP:gentamicin 2''-nucleotidyltransferase
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| Reaction(IUBMB) |
nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin [RN: R02432]
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| Reaction(KEGG) |
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| Substrate |
nucleoside triphosphate [CPD: C00201];
gentamicin [CPD: C00505]
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| Product |
diphosphate [CPD: C00013];
2''-nucleotidylgentamicin [CPD: C03565]
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| Comment |
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
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| History |
EC 2.7.7.46 created 1976
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| Orthology |
| K17881 | aminoglycoside 2''-adenylyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Angelatou F, Litsas SB, Kontomichalou P. |
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| Title |
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa. |
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| Journal |
J Antibiot (Tokyo) 35:235-44 (1982) |
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| Reference |
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| Authors |
Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H. |
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| Title |
The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B. |
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| Journal |
J Antibiot (Tokyo) 24:913-4 (1971) |
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| Reference |
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| Authors |
Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T. |
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| Title |
Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor. |
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| Journal |
J Antibiot (Tokyo) 24:911-2 (1971) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.7.46 |
| ExPASy - ENZYME nomenclature database: | 2.7.7.46 |
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