Entry
Name
gentamicin 2''-nucleotidyltransferase;
gentamicin 2''-adenylyltransferase;
aminoglycoside adenylyltransferase;
gentamycin 2''-nucleotidyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
NTP:gentamicin 2''-nucleotidyltransferase
Reaction(IUBMB)
nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin [RN:
R02432 ]
Reaction(KEGG)
Substrate
nucleoside triphosphate [CPD:
C00201 ];
gentamicin [CPD:
C00505 ]
Product
diphosphate [CPD:
C00013 ];
2''-nucleotidylgentamicin [CPD:
C03565 ]
Comment
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
History
EC 2.7.7.46 created 1976
Orthology
K17881 aminoglycoside 2''-adenylyltransferase
Genes
ECLE : ECNIH2_24600 ECNIH2_25855
KPZ : KPNIH27_26410 KPNIH27_27275
CFD : CFNIH1_06100 CFNIH1_25705
EBC : C2U52_00390(aadB) C2U52_01405(aadB)
» show all
Taxonomy
Reference
Authors
Angelatou F, Litsas SB, Kontomichalou P.
Title
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa.
Journal
Reference
Authors
Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H.
Title
The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B.
Journal
Reference
Authors
Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T.
Title
Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.46
ExPASy - ENZYME nomenclature database: 2.7.7.46