KEGG ENZYME: 2.7.7.47

ENZYME: 2.7.7.47

Entry

EC 2.7.7.47                 Enzyme

Name

streptomycin 3''-adenylyltransferase;
streptomycin adenylate synthetase;
streptomycin adenyltransferase;
streptomycin adenylylase;
streptomycin adenylyltransferase;
streptomycin-spectinomycin adenylyltransferase;
AAD (3'');
aminoglycoside 3''-adenylyltransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

ATP:streptomycin 3''-adenylyltransferase

Reaction(IUBMB)

ATP + streptomycin = diphosphate + 3''-adenylylstreptomycin [RN:R02226]

Reaction(KEGG)

R02226

Substrate

ATP [CPD:C00002];
streptomycin [CPD:C00413]

Product

diphosphate [CPD:C00013];
3''-adenylylstreptomycin [CPD:C03462]

Comment

Also acts on spectinomycin.

History

EC 2.7.7.47 created 1976

Orthology

K00984

streptomycin 3"-adenylyltransferase

Genes

CSAB:

103247768

HHV:

120227784

ECOC:

C3026_04245 C3026_04565 C3026_04885

EUN:	pUMNK88_130(aadA) pUMNK88_133(aadA2)

ECOS:

EC958_A0109(aadA5)

ECV:	APECO1_O1R89(aadA)

ECM:	EcSMS35_A0135(aadA)

EUM:	ECUMN_4816(aadA)

ECOB:

C3029_07780 C3029_08100

ELO:	EC042_4093(aadA1)

ELN:	NRG857_30102

STY:	STY1857(aadA)

STT:	t1142(aadA)

SEX:	STBHUCCB_12250

SENT:

TY21A_05790

STM:	STM1264(aadA)

SEO:	STM14_1525(aadA)

SEV:	STMMW_12701

SEY:	SL1344_1199(aadA)

SEM:	STMDT12_C12800 STMDT12_C39240 STMDT12_L00640

SEJ:	STMUK_1231(aadA)

SEB:	STM474_1265(aadA)

SEF:	UMN798_1312(aadA)

SETU:

STU288_02640 STU288_1p00740 STU288_1p00750

SETC:

CFSAN001921_10840

SENR:

STMDT2_11961(aadA)

SEND:

DT104_12401(aadA) DT104_38561

SENI:

CY43_06435 CY43_20060

SEEN:

SE451236_12180

SPT:	SPA1582(aadA)

SEK:

SSPA1470

SPQ:	SPAB_02095

SEI:	SPC_2479(aadA)

SEC:	SCH_032(aadA2) SCH_051(aadA2) SCH_053(aadA2) SCH_1275(aadA)

SEH:	SeHA_C1385

SHB:

SU5_01885

SENH:

CFSAN002069_02690 CFSAN002069_23195

SEEH:

SEEH1578_00460 SEEH1578_15545

SEE:	SNSL254_A1370 SNSL254_p_0144(aadA)

SENN:

SN31241_23340 SN31241_6930

SEW:	SeSA_A1354 SeSA_B0063 SeSA_B0065(aadA)

SEA:	SeAg_B1916

SENS:

Q786_08935

SEG:	SG1860(aadA)

SEL:	SPUL_1067(aadA)

SEGA:

SPUCDC_1067(aadA)

SET:	SEN1788(aadA)

SENA:

AU38_09260

SENO:

AU37_09265

SENV:

AU39_09270

SENQ:

AU40_10340

SENL:

IY59_09475

SENJ:

CFSAN001992_05275

SEEC:

CFSAN002050_12715

SEEB:

SEEB0189_013255

SEEP:

I137_04900

SENB:

BN855_12930

SENE:

IA1_06235

SENC:

SEET0819_12965

SBG:	SBG_1109(aadA)

SBZ:

A464_1205

SBV:	N643_05265

SALZ:

EOS98_13170(aadA) EOS98_23490

SFE:	SFxv_1143 SFxv_4143

SFN:

SFy_1440

SFS:

SFyv_1489

SSN:	SSON_3896(aadA)

ENL:	A3UG_21725

ECLY:

LI62_012770

EHM:	AB284_00830

ECLS:

LI67_024955

ESH:	C1N69_21695

KPN:	KPN_pKPN4p07059(aadA)

KPM:	KPHS_p300690

KPH:	KPNIH24_17325 KPNIH24_26870 KPNIH24_27460 KPNIH24_27470

KPV:	KPNIH29_26630

KPW:	KPNIH30_26930

KPG:	KPNIH32_27930 KPNIH32_28355

KPC:	KPNIH10_10970 KPNIH10_26705

KPJ:

N559_5186

KPA:	KPNJ1_05669 KPNJ1_05817

KPX:	PMK1_ndm00221(ant1)

KPB:	FH42_25795 FH42_26820

KPNE:

KU54_01020 KU54_01030 KU54_01515

KPNU:

LI86_15200 LI86_26840 LI86_28235 LI86_28245

KQU:	AVR78_27115

KOE:	A225_R1p0440 A225_R1p0760

KOK:	KONIH1_31115 KONIH1_32185

KOC:	AB185_00175 AB185_01225 AB185_02720 AB185_03260

EAR:

CCG28765

KLW:	DA718_21680

KGR:	JJJ10_29165(aadA1) JJJ10_29400(aadA1)

CFD:	CFNIH1_06155 CFNIH1_14270

CYO:	CD187_15820

CPOT:

FOB25_03520

CFQ:	C2U38_08315 C2U38_21215 C2U38_26810(aadA1)

CSED:

JY391_23190(aadA1) JY391_23580(aadA1)

CAF:	AL524_13660

CIF:	AL515_08750

CFAR:

CI104_25625

CIR:	C2U53_00295(aadA1) C2U53_23740

CIE:	AN232_22170 AN232_27640(aadA) AN232_27685

CPAR:

CUC49_03955

CTEL:

GBC03_15875

CARS:

E1B03_09345

CIX:	M4I31_15465

CIB:	HF677_015625

CITR:

GUC46_15720

LEI:	C2U54_25010(aadA1) C2U54_26545(aadA1)

LEH:	C3F35_26160(aadA1)

YRE:	HEC60_24125(aadA1)

KIN:	AB182_03100

PDZ:	HHA33_25990

METY:

MRY16398_p20070(aadA2)

EBC:	C2U52_00370(aadA1) C2U52_01465

SMAR:

SM39_pSMC1_34(aadA)

SMW:	SMWW4_v1c36970

SMAF:

D781_3902

SERF:

L085_10150

SRZ:	AXX16_1244

SERM:

CLM71_20005

SOF:	NCTC11214_04436(ant1)

SURI:

J0X03_05455

SRHZ:

FO014_13500

BIZ:	HC231_08325

PANT:

PSNIH1_20585

PANP:

PSNIH2_21630 PSNIH2_21665

PCIB:

F9282_19600(aadA1)

PSI:

S70_21070

PSX:

DR96_3112

PSTA:

BGK56_03010

PTHA:

OI982_02260

PRQ:	CYG50_00660 CYG50_16055(aadA1)

PVC:	G3341_10330

PMAG:

JI723_10140

MWI:	MNY66_17445

PMP:	Pmu_03420(aadA25)

AIO:	EXH44_00950(aadA1)

SFOE:

K5L94_08040

PSU:	Psesu_2826

PMEX:

H4W19_04340

PJP:	LAG73_10975

VCQ:	EN18_05755

PNC:	NCGM2_1759(aadA1)

PAEB:

NCGM1900_3708(aadA6)

PPUH:

B479_26984

PJU:	L1P09_25575

PPHN:

HU825_15055

PTRL:

OU419_17775

PMY:

Pmen_2178

PMK:

MDS_2542

PHF:	NLY38_13110

PSA:

PST_2171

PSZ:	PSTAB_2058

PSR:	PSTAA_2202

PSJ:	PSJM300_03550

SDEG:

GOM96_02055

PBAU:

OS670_09015

ACB:

A1S_0131

ABM:

ABSDF0145

ABY:	ABAYE3570(aadA1) ABAYE3618(aadA1) ABAYE3739

ABC:	ACICU_00156

ABN:	AB57_0171 AB57_0293(aadA1)

ABB:	ABBFA_03356(ant1)

ABX:

ABK1_0164

ABZ:	ABZJ_00158(ant(3'')-II) ABZJ_01289(aadA1) ABZJ_05070(aadA1)

ABR:	ABTJ_01327 ABTJ_02579 ABTJ_03672

ABD:	ABTW07_0156 ABTW07_3885(aadA1) ABTW07_3901(aadA1)

ABAD:

ABD1_01350(aadA)

ABJ:	BJAB07104_00166 BJAB07104_p0090

ABAB:

BJAB0715_00178

ABAJ:

BJAB0868_00173 BJAB0868_p0101

ABAZ:

P795_16505

ABK:	LX00_00825

ABAU:

IX87_15250

ABAA:

IX88_02960

ABW:	BL01_01055

ABAL:

ABLAC_36340

ACC:	BDGL_003056(ant)

AJN:	BVL33_11240

AUG:

URS_0862

ADS:	FPL17_13585(ant(3'')-II)

ACHI:

CDG60_00125(ant(3'')-II)

ATG:	J4G44_12750

AGYL:

FPL18_06190(ant(3'')-II)

AVZ:	HWI77_18570(aadA1)

APRL:

PY247_04750 PY247_21700

ACOI:

NQU59_02720

AVIV:

LF296_17755

MBL:	AAX09_10140

MORA:

NGM44_03830

SHF:	CEQ32_08445 CEQ32_19865

SHEJ:

MZ182_20570

RHH:	E0Z06_09360 E0Z06_15160(aadA1)

HPRO:

LMS44_05805

HASO:

B2G49_00405

HAAH:

HALA3H3_30231(ant)

HABD:

OM794_12300

HSX:	HNO51_03535

HTX:	EKK97_04260

APAC:

S7S_01185

VCW:	GJQ55_09870(aadA1)

AHH:	RY45_02925

AAJ:	BOQ57_11180 BOQ57_11320

ASA:	ASA_P4G100(aadA)

AEA:	C2U39_10275 C2U39_22035 C2U39_23830

AES:	C2U30_02790

ASIM:

FE240_15575(aadA1)

NBL:	GJV52_06020(aadA)

PTES:

JQU52_07645

CCAX:

KZ686_00295(ant(3'')-Ib)

BUR:	Bcep18194_B2105

BCM:	Bcenmc03_3549

BCJ:

BCAM1013a

BCEO:

I35_4932

BCED:

DM42_4074

BCEP:

APZ15_19365

BPYR:

ABD05_16735

BCON:

NL30_07300

BSEM:

WJ12_25325

BSTL:

BBJ41_18345

BARI:

NLX30_33360

BAEN:

L3V59_34875

BSER:

R0290_24710

BURK:

DM992_30780(aadA)

BURM:

GJG85_29305(aadA)

BPAR:

BN117_3644(aadA4)

BPA:	BPP1010(aadA4)

BBH:	BN112_2235(aadA4)

BBR:	BB1224(aadA4)

BBM:	BN115_1180(aadA4)

BBX:	BBS798_1186(aadA4)

AXY:	AXYL_03722(aadA)

ACHO:

H4P35_14885

AMUI:

PE062_11610

APES:

FOC84_26915

AAEG:

RA224_14710

PUS:	CKA81_11630

AFA:	UZ73_19160

NARM:

N7E01_00125

CKE:	B5M06_08275

COF:	FOZ74_01865

CODO:

LAD35_00045

CRJ:	QMY55_12300

DRG:	H9K76_07195

SIMP:

C6571_18320

MELA:

C6568_16815(aadA1)

MJE:	LVC68_14640

STHM:

IS481_17930

ETB:	N7L95_29350

NST:	Nstercoris_00876

NMU:	Nmul_A0161

THU:	AC731_003650

RIR:	BN877_II1271(aadA)

PALP:

JHW40_14870

ATHR:

ATH_1371

APOC:

APORC_0768 APORC_1871

MXA:

MXAN_1698

MSD:	MYSTI_05831

MYX:	QEG98_09670

MLAN:

JY572_37770

MFU:	LILAB_34765

MMAS:

MYMAC_005253

AVM:	JQX13_24570

MOA:	I6I89_09680 I6I89_10565

PROW:

OO006_07580

PROI:

OO005_07015

DIN:	Selin_0013

VPT:	KBP50_17155(ant(9))

VIK:	KFZ58_12740(ant(9))

SCIB:

HUG20_01380(ant(9))

SCIA:

HUG15_19065(ant(9))

BRUM:

NDK47_11445(ant(9))

PSPN:

L1F29_18155

SPAB:

KQ224_02185

SACY:

O6R09_07140(ant(9))

ERAF:

J9537_20475

VLU:	M2919_04215

DINC:

QNK01_11415

ANV:	RBQ60_07650

TIZ:	RBU61_05980(ant(9))

MINV:

T9R20_00720

LARI:

KI794_14560

GPR:	JQN66_18130

NAE:	BHE16_08500

SYO:	C7I86_08920(aadA1)

» show all

Reference

1 [PMID:4887506]

Authors

Harwood JH, Smith DH.

Title

Resistance factor-mediated streptomycin resistance.

Journal

J Bacteriol 97:1262-71 (1969)
DOI:10.1128/JB.97.3.1262-1271.1969

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.47

IUBMB Enzyme Nomenclature:

2.7.7.47

ExPASy - ENZYME nomenclature database:

2.7.7.47

BRENDA, the Enzyme Database:

2.7.7.47

CAS:	52660-23-8

DBGET integrated database retrieval system