KEGG   ENZYME: 2.7.7.47
Entry
EC 2.7.7.47                 Enzyme                                 

Name
streptomycin 3''-adenylyltransferase;
streptomycin adenylate synthetase;
streptomycin adenyltransferase;
streptomycin adenylylase;
streptomycin adenylyltransferase;
streptomycin-spectinomycin adenylyltransferase;
AAD (3'');
aminoglycoside 3''-adenylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
ATP:streptomycin 3''-adenylyltransferase
Reaction(IUBMB)
ATP + streptomycin = diphosphate + 3''-adenylylstreptomycin [RN:R02226]
Reaction(KEGG)
R02226
Substrate
ATP [CPD:C00002];
streptomycin [CPD:C00413]
Product
diphosphate [CPD:C00013];
3''-adenylylstreptomycin [CPD:C03462]
Comment
Also acts on spectinomycin.
History
EC 2.7.7.47 created 1976
Orthology
K00984  streptomycin 3"-adenylyltransferase
Genes
CSAB: 103247768
NSY: 104236379
EUN: pUMNK88_130(aadA) pUMNK88_133(aadA2)
ECOS: EC958_A0109(aadA5)
ECV: APECO1_O1R89(aadA)
ECM: EcSMS35_A0135(aadA)
EUM: ECUMN_4816(aadA)
ELO: EC042_4093(aadA1)
ELN: NRG857_30102
STY: STY1857(aadA)
STT: t1142(aadA)
STM: STM1264(aadA)
SEO: STM14_1525(aadA)
SEY: SL1344_1199(aadA)
SEJ: STMUK_1231(aadA)
SEB: STM474_1265(aadA)
SEF: UMN798_1312(aadA)
SENR: STMDT2_11961(aadA)
SPT: SPA1582(aadA)
SEK: SSPA1470
SEI: SPC_2479(aadA)
SEC: SCH_032(aadA2) SCH_051(aadA2) SCH_053(aadA2) SCH_1275(aadA)
SHB: SU5_01885
SENS: Q786_08935
SEG: SG1860(aadA)
SEL: SPUL_1067(aadA)
SEGA: SPUCDC_1067(aadA)
SET: SEN1788(aadA)
SENA: AU38_09260
SENO: AU37_09265
SENV: AU39_09270
SENQ: AU40_10340
SENL: IY59_09475
SEEP: I137_04900
SENE: IA1_06235
SBG: SBG_1109(aadA)
SBZ: A464_1205
SFN: SFy_1440
SFS: SFyv_1489
SSN: SSON_3896(aadA)
KPN: KPN_pKPN4p07059(aadA)
KPJ: N559_5186
KPX: PMK1_ndm00221(ant1)
EAR: CCG28765
LEI: C2U54_25010(aadA1) C2U54_26545(aadA1)
LEH: C3F35_26160(aadA1)
METY: MRY16398_p20070(aadA2)
YRE: HEC60_24125(aadA1)
SMAR: SM39_pSMC1_34(aadA)
SMAF: D781_3902
SERF: L085_10150
SOF: NCTC11214_04436(ant1)
PCIB: F9282_19600(aadA1)
PSI: S70_21070
PSX: DR96_3112
PMP: Pmu_03420(aadA25)
AIO: EXH44_00950(aadA1)
PNC: NCGM2_1759(aadA1)
PAEB: NCGM1900_3708(aadA6)
PMK: MDS_2542
PPUH: B479_26984
PSA: PST_2171
ACB: A1S_0131
ABM: ABSDF0145
ABY: ABAYE3570(aadA1) ABAYE3618(aadA1) ABAYE3739
ABN: AB57_0171 AB57_0293(aadA1)
ABB: ABBFA_03356(ant1)
ABZ: ABZJ_00158(ant(3'')-II) ABZJ_01289(aadA1) ABZJ_05070(aadA1)
ABD: ABTW07_0156 ABTW07_3885(aadA1) ABTW07_3901(aadA1)
ABAD: ABD1_01350(aadA)
ABAZ: P795_16505
ABAU: IX87_15250
ABAA: IX88_02960
ACC: BDGL_003056(ant)
AUG: URS_0862
ADS: FPL17_13585(ant(3'')-II)
ACHI: CDG60_00125(ant(3'')-II)
LPP: plpp0092
APAC: S7S_01185
ASA: ASA_P4G100(aadA)
NBL: GJV52_06020(aadA)
BCJ: BCAM1013a
BCEO: I35_4932
BCED: DM42_4074
BSEM: WJ12_25325
BPAR: BN117_3644(aadA4)
BPA: BPP1010(aadA4)
BBH: BN112_2235(aadA4)
BBR: BB1224(aadA4)
BBM: BN115_1180(aadA4)
BBX: BBS798_1186(aadA4)
MELA: C6568_16815(aadA1)
MXA: MXAN_1698
RIR: BN877_II1271(aadA)
PDE: Pden_4803
EFA: EF1076
SCO: SCO4355(SCD19.10)
SYO: C7I86_08920(aadA1)
 » show all
Reference
1  [PMID:4887506]
  Authors
Harwood JH, Smith DH.
  Title
Resistance factor-mediated streptomycin resistance.
  Journal
J Bacteriol 97:1262-71 (1969)
DOI:10.1128/JB.97.3.1262-1271.1969
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.47
IUBMB Enzyme Nomenclature: 2.7.7.47
ExPASy - ENZYME nomenclature database: 2.7.7.47
BRENDA, the Enzyme Database: 2.7.7.47
CAS: 52660-23-8

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