KEGG   ENZYME: 2.7.7.47
Entry
EC 2.7.7.47                 Enzyme                                 
Name
streptomycin 3''-adenylyltransferase;
streptomycin adenylate synthetase;
streptomycin adenyltransferase;
streptomycin adenylylase;
streptomycin adenylyltransferase;
streptomycin-spectinomycin adenylyltransferase;
AAD (3'');
aminoglycoside 3''-adenylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
ATP:streptomycin 3''-adenylyltransferase
Reaction(IUBMB)
ATP + streptomycin = diphosphate + 3''-adenylylstreptomycin [RN:R02226]
Reaction(KEGG)
R02226
Substrate
ATP [CPD:C00002];
streptomycin [CPD:C00413]
Product
diphosphate [CPD:C00013];
3''-adenylylstreptomycin [CPD:C03462]
Comment
Also acts on spectinomycin.
History
EC 2.7.7.47 created 1976
Orthology
K00984  streptomycin 3"-adenylyltransferase
Genes
CSAB103247768
HHV120227784
NSY104236379
EUNpUMNK88_130(aadA) pUMNK88_133(aadA2)
ECOSEC958_A0109(aadA5)
ECVAPECO1_O1R89(aadA)
ECMEcSMS35_A0135(aadA)
EUMECUMN_4816(aadA)
ELOEC042_4093(aadA1)
ELNNRG857_30102
STYSTY1857(aadA)
STTt1142(aadA)
SEXSTBHUCCB_12250
SENTTY21A_05790
STMSTM1264(aadA)
SEOSTM14_1525(aadA)
SEVSTMMW_12701
SEYSL1344_1199(aadA)
SEMSTMDT12_C12800 STMDT12_C39240 STMDT12_L00640
SEJSTMUK_1231(aadA)
SEBSTM474_1265(aadA)
SEFUMN798_1312(aadA)
SETUSTU288_02640 STU288_1p00740 STU288_1p00750
SETCCFSAN001921_10840
SENRSTMDT2_11961(aadA)
SENDDT104_12401(aadA) DT104_38561
SENICY43_06435 CY43_20060
SEENSE451236_12180
SPTSPA1582(aadA)
SEKSSPA1470
SPQSPAB_02095
SEISPC_2479(aadA)
SECSCH_032(aadA2) SCH_051(aadA2) SCH_053(aadA2) SCH_1275(aadA)
SEHSeHA_C1385
SHBSU5_01885
SENHCFSAN002069_02690 CFSAN002069_23195
SEEHSEEH1578_00460 SEEH1578_15545
SEESNSL254_A1370 SNSL254_p_0144(aadA)
SENNSN31241_23340 SN31241_6930
SEWSeSA_A1354 SeSA_B0063 SeSA_B0065(aadA)
SEASeAg_B1916
SENSQ786_08935
SEGSG1860(aadA)
SELSPUL_1067(aadA)
SEGASPUCDC_1067(aadA)
SETSEN1788(aadA)
SENAAU38_09260
SENOAU37_09265
SENVAU39_09270
SENQAU40_10340
SENLIY59_09475
SENJCFSAN001992_05275
SEECCFSAN002050_12715
SEEBSEEB0189_013255
SEEPI137_04900
SENBBN855_12930
SENEIA1_06235
SENCSEET0819_12965
SBGSBG_1109(aadA)
SBZA464_1205
SBVN643_05265
SALZEOS98_13170(aadA) EOS98_23490
SFESFxv_1143 SFxv_4143
SFNSFy_1440
SFSSFyv_1489
SSNSSON_3896(aadA)
ENLA3UG_21725
ECLYLI62_012770
EHMAB284_00830
ECLSLI67_024955
ESHC1N69_21695
KPNKPN_pKPN4p07059(aadA)
KPMKPHS_p300690
KPHKPNIH24_17325 KPNIH24_26870 KPNIH24_27460 KPNIH24_27470
KPVKPNIH29_26630
KPWKPNIH30_26930
KPGKPNIH32_27930 KPNIH32_28355
KPCKPNIH10_10970 KPNIH10_26705
KPJN559_5186
KPAKPNJ1_05669 KPNJ1_05817
KPXPMK1_ndm00221(ant1)
KPBFH42_25795 FH42_26820
KPNEKU54_01020 KU54_01030 KU54_01515
KPNULI86_15200 LI86_26840 LI86_28235 LI86_28245
KOEA225_R1p0440 A225_R1p0760
KOKKONIH1_31115 KONIH1_32185
KOCAB185_00175 AB185_01225 AB185_02720 AB185_03260
KQUAVR78_27115
EARCCG28765
KLWDA718_21680
KGRJJJ10_29165(aadA1) JJJ10_29400(aadA1)
CFDCFNIH1_06155 CFNIH1_14270
CYOCD187_15820
CPOTFOB25_03520
CFQC2U38_08315 C2U38_21215 C2U38_26810(aadA1)
CSEDJY391_23190(aadA1) JY391_23580(aadA1)
CAFAL524_13660
CIFAL515_08750
CFARCI104_25625
CIRC2U53_00295(aadA1) C2U53_23740
CIEAN232_22170 AN232_27640(aadA) AN232_27685
CPARCUC49_03955
CTELGBC03_15875
CARSE1B03_09345
LEIC2U54_25010(aadA1) C2U54_26545(aadA1)
LEHC3F35_26160(aadA1)
METYMRY16398_p20070(aadA2)
YREHEC60_24125(aadA1)
KINAB182_03100
PDZHHA33_25990
EBCC2U52_00370(aadA1) C2U52_01465
SMARSM39_pSMC1_34(aadA)
SMWSMWW4_v1c36970
SMAFD781_3902
SERFL085_10150
SRZAXX16_1244
SERMCLM71_20005
SOFNCTC11214_04436(ant1)
SURIJ0X03_05455
SRHZFO014_13500
BIZHC231_08325
PANTPSNIH1_20585
PANPPSNIH2_21630 PSNIH2_21665
PCIBF9282_19600(aadA1)
PSIS70_21070
PSXDR96_3112
PRQCYG50_00660 CYG50_16055(aadA1)
PVCG3341_10330
PMAGJI723_10140
MWIMNY66_17445
PMPPmu_03420(aadA25)
AIOEXH44_00950(aadA1)
PSUPsesu_2826
PMEXH4W19_04340
PJPLAG73_10975
VCQEN18_05755
PNCNCGM2_1759(aadA1)
PAEBNCGM1900_3708(aadA6)
PMKMDS_2542
PPUHB479_26984
PJUL1P09_25575
PSAPST_2171
PSZPSTAB_2058
PSRPSTAA_2202
PSJPSJM300_03550
SDEGGOM96_02055
ACBA1S_0131
ABMABSDF0145
ABYABAYE3570(aadA1) ABAYE3618(aadA1) ABAYE3739
ABCACICU_00156
ABNAB57_0171 AB57_0293(aadA1)
ABBABBFA_03356(ant1)
ABXABK1_0164 ABK1_1143
ABZABZJ_00158(ant(3'')-II) ABZJ_01289(aadA1) ABZJ_05070(aadA1)
ABRABTJ_01327 ABTJ_02579 ABTJ_03672
ABDABTW07_0156 ABTW07_3885(aadA1) ABTW07_3901(aadA1)
ABADABD1_01350(aadA)
ABJBJAB07104_00166 BJAB07104_p0090
ABABBJAB0715_00178
ABAJBJAB0868_00173 BJAB0868_p0101
ABAZP795_16505
ABKLX00_00825
ABAUIX87_15250
ABAAIX88_02960
ABWBL01_01055
ABALABLAC_36340
ACCBDGL_003056(ant)
AJNBVL33_11240
AUGURS_0862
ADSFPL17_13585(ant(3'')-II)
ACHICDG60_00125(ant(3'')-II)
ATGJ4G44_12750
AGYLFPL18_06190(ant(3'')-II)
AVZHWI77_18570(aadA1)
MBLAAX09_10140
SHFCEQ32_08445 CEQ32_19865
LPPplpp0092
RHHE0Z06_09360 E0Z06_15160(aadA1)
HSXHNO51_03535
HTXEKK97_04260
HPROLMS44_05805
APACS7S_01185
VCWGJQ55_09870(aadA1)
AHHRY45_02925
AAJBOQ57_11180 BOQ57_11320
ASAASA_P4G100(aadA)
AEAC2U39_10275 C2U39_22035 C2U39_23830
AESC2U30_02790
ASIMFE240_15575(aadA1)
IGNMMG00_04760
NBLGJV52_06020(aadA)
PTESJQU52_07645
BURBcep18194_B2105
BCMBcenmc03_3549
BCJBCAM1013a
BCEOI35_4932
BCEDDM42_4074
BCEPAPZ15_19365
BPYRABD05_16735
BCONNL30_07300
BSEMWJ12_25325
BSTLBBJ41_18345
BURKDM992_30780(aadA)
BPARBN117_3644(aadA4)
BPABPP1010(aadA4)
BBHBN112_2235(aadA4)
BBRBB1224(aadA4)
BBMBN115_1180(aadA4)
BBXBBS798_1186(aadA4)
PUSCKA81_11630
AFAUZ73_19160
CKEB5M06_08275
COFFOZ74_01865
CODOLAD35_00045
DRGH9K76_07195
SIMPC6571_18320
MELAC6568_16815(aadA1)
MJELVC68_14640
STHMIS481_17930
NSTNstercoris_00876
NMUNmul_A0161
THUAC731_003650
APOCAPORC_0768 APORC_1871
ATHRATH_1371
MXAMXAN_1698
MSDMYSTI_05831
MFULILAB_34765
MMASMYMAC_005253
AVMJQX13_24570
SMESMa2315 SMa2317
RIRBN877_II1271(aadA)
PDEPden_4803
VPTKBP50_17155(ant(9))
SCIBHUG20_01380(ant(9))
SCIAHUG15_19065(ant(9))
SPABKQ224_02185
EFAEF1076
ERAFJ9537_20475
VLUM2919_04215
MVMMJO54_06225
SCOSCO4355(SCD19.10)
ASOIMTP13_01100
GPRJQN66_18130
NAEBHE16_08500
SYOC7I86_08920(aadA1)
MGOSDIU38_018140
MOAI6I89_09680 I6I89_10565
DINSelin_0013
 » show all
Reference
1  [PMID:4887506]
  Authors
Harwood JH, Smith DH.
  Title
Resistance factor-mediated streptomycin resistance.
  Journal
J Bacteriol 97:1262-71 (1969)
DOI:10.1128/JB.97.3.1262-1271.1969
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.47
IUBMB Enzyme Nomenclature: 2.7.7.47
ExPASy - ENZYME nomenclature database: 2.7.7.47
BRENDA, the Enzyme Database: 2.7.7.47
CAS: 52660-23-8

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