Entry
Name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;
MEP cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [RN:
R05633 ]
Reaction(KEGG)
Substrate
CTP [CPD:
C00063 ];
2-C-methyl-D-erythritol 4-phosphate [CPD:
C11434 ]
Product
diphosphate [CPD:
C00013 ];
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [CPD:
C11435 ]
Comment
The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
History
EC 2.7.7.60 created 2001
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00991 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
K12506 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Genes
CSAT : 104710168 104779591 104790032
BNA : 106380674 106396261 125580067
VVO : 131605410 131626045 131626084
AHF : 112706805 112722754 112722760
QSA : O6P43_012105 O6P43_031429
MSYL : 126601509 126633453
MESC : 110600407 110630951
CILL : 122312524 122312834
SSPL : 121805771 121808317
SMIL : 131002917 131023665
AEW : 130774476 130779093 130784646
TAES : 123062915 123071780 123080105
MFLO : 136450969 136456962
PVIR : 120672828 120708918
SMO : SELMODRAFT_117940 SELMODRAFT_73567
CVR : CHLNCDRAFT_141910(CMS)
FCY : FRACYDRAFT_205256(CMS)
ECOO : ECRM13514_3599(ispD)
ECOH : ECRM13516_3464(ispD)
ELR : ECO55CA74_16165(ispD)
ECW : EcE24377A_3048(ispD)
ECOA : APECO78_17325(ispD)
EBR : ECB_02597(ispD) ECB_02825
EBL : ECD_02597(ispD) ECD_02825
EBE : B21_02562(ispD) B21_02774(ybl129)
EDJ : ECDH1ME8569_2657(ispD)
ECOI : ECOPMV1_03007(ispD)
SEM : STMDT12_C29790(ispD)
SEEH : SEEH1578_00655(ispD)
SENJ : CFSAN001992_18890(ispD)
REE : electrica_00950(ispD)
RTG : NCTC13098_01436(ispD_1)
CLAP : NCTC11466_00748(ispD)
KIE : NCTC12125_04938(ispD)
AHN : NCTC12129_03948(ispD)
METY : MRY16398_10520(ispD)
PTF : PROFFT_A_03000(ispD)
PSHI : SAMEA2665130_2347(ispD)
YPG : YpAngola_A0964(ispD)
YPI : YpsIP31758_3299(ispD)
SMW : SMWW4_v1c08050(ispD)
SFJ : SAMEA4384070_0854(ispD)
SOF : NCTC11214_00674(ispD)
SSAR : SSARUM_000748(ispD)
PAQU : DMB82_0004630(ispD)
PARL : PEC302110_31170(ispD)
DIC : Dpoa569_000801(ispD)
EHD : ERCIPSTX3056_610(ispD)
BAPF : BUMPF009_CDS00179(ispd)
BAPG : BUMPG002_CDS00179(ispd)
BAPU : BUMPUSDA_CDS00179(ispd)
BAPW : BUMPW106_CDS00179(ispd)
TPTY : NCTC11468_00920(ispD)
PHEI : NCTC12003_00950(ispD)
PRJ : NCTC6933_03101(ispD)
LRI : NCTC12151_01111(ispD)
HIC : NTHIC486_00323(ispD)
HPIT : NCTC13334_00824(ispD)
HHZ : NCTC10839_00533(ispD)
HAEG : NCTC8502_00532(ispD)
HSEM : L3077_02415(ispD) L3077_03420
PDAG : 4362423_01685(ispD)
ADP : NCTC12871_00380(ispD)
ALIG : NCTC10568_00553(ispD_1)
AAZ : ADJ80_02385 ADJ80_07400
ASEG : NCTC10977_00426(ispD)
AVT : NCTC3438_00935(ispD)
RPNE : NCTC8284_00489(ispD)
PAET : NCTC13378_01738(ispD_2)
XFU : XFF4834R_chr27900(ispD)
XPH : XppCFBP6546_18890(XppCFBP6546P_18890)
XHD : LMG31886_25880(ispD)
LLZ : LYB30171_01946(ispD)
THES : FHQ07_04175 FHQ07_10575
TCN : H9L16_02765 H9L16_09940
XBA : C7S18_13520 C7S18_22720
VAU : VANGNB10_cI0434(ispD)
VPL : SA104470976_02199(ispD)
PAEB : NCGM1900_2643(ispD)
PPUD : DW66_1159 DW66_1493
PVD : CFBP1590__4023(ispD)
PPRC : PFLCHA0_c12190(ispD)
PMUD : NCTC8068_01205(ispD)
PFW : PF1751_v1c12390(ispD)
PFF : PFLUOLIPICF701915(ispD)
PPUU : PputUW4_01110(ispD)
PTRT : HU722_0007520(ispD)
PTK : EXN22_07520 EXN22_16535
PTW : TUM18999_46050(ispD)
PTAE : NCTC10697_03436(ispD)
MSHE : MAALD49_24010(ispD)
PSYC : DABAL43B_2149(ispD)
MCAT : MC25239_01279(ispD)
MCUN : NCTC10297_01059(ispD)
SCAA : TUM17387_12440(ispD)
SALH : HMF8227_00533(ispD)
MISZ : MishRS11D_13490(ispD)
TFRI : Thiofri_01940(ispD)
TNI : TVNIR_1886(ispD_[H])
GAI : IMCC3135_23790(ispD)
THIC : TspCOW1_06000(ispD)
HAXI : HAALTHF_22260n(ispD)
HAAH : HALA3H3_670007(ispD)
ALCA : ASALC70_00475(ispD)
AEL : NCTC12917_03571(ispD)
CDIZ : CEDIAZO_01110(ispD)
NMM : NMBM01240149_0655(ispD)
NMS : NMBM01240355_1435(ispD)
NMQ : NMBM04240196_0707(ispD)
NMZ : NMBNZ0533_1488(ispD)
NMX : NMA510612_1926(ispD)
NWE : SAMEA3174300_1165(ispD)
NZO : SAMEA4504057_0803(ispD)
NCI : NCTC10296_00017(ispD)
NCZ : NCTC10294_00990(ispD)
NANI : NCTC12227_01187(ispD)
ECOR : SAMEA4412678_0286(ispD)
REH : H16_A1456(h16_A1456)
BMV : BMASAVP1_A1987(ispD)
BML : BMA10229_A3319(ispD)
BPM : BURPS1710b_2512(ispD)
BPL : BURPS1106A_2401(ispD)
BUE : BRPE67_ACDS12410(ispD)
PLG : NCTC10937_01489(ispD)
LMIR : NCTC12852_01843(ispD)
BUO : BRPE64_ACDS13440(ispD)
VTR : MYVALT_F_02800(ispD)
BTRM : SAMEA390648702504(ispD)
AXX : ERS451415_01390(ispD)
PACR : FXN63_10495 FXN63_24555
LIM : L103DPR2_02079(ispD)
LIH : L63ED372_01100(ispD)
SMIO : CATMQ487_33870(ispD)
SUTT : SUTMEG_07090(ispDF)
URU : DSM104443_02592(ispD)
UPL : DSM104440_02323(ispD)
THAG : CKCBHOJB_01942(ispD)
FPHO : SHINM1_010300(ispD)
ERU : Erum1030(probable_ispD)
ERW : ERWE_CDS_01000(ispD)
ERG : ERGA_CDS_00960(ispD)
MESW : A9K65_019910(ispDF)
RBS : RHODOSMS8_00938(ispF)
SMEL : SM2011_c01040(ispDF)
SFD : USDA257_c34930(ispDF)
SAME : SAMCFNEI73_Ch1586(ispD)
AGR : AGROH133_05946(ispF)
AVV : RvVAT039_31940(ispDF)
AVF : RvVAR031_18900(ispDF)
REC : RHECIAT_CH0002043(ispDF)
REL : REMIM1_CH02004(ispDF)
REP : IE4803_CH02004(ispDF)
REI : IE4771_CH02079(ispDF)
RGA : RGR602_CH01839(ispDF)
RHN : AMJ98_CH02008(ispDF)
RPHA : AMC79_CH02126(ispDF)
RHX : AMK02_CH02016(ispDF)
REZ : AMJ99_CH02086(ispDF)
NEN : NCHU2750_19860(ispD)
BSV : BSVBI22_A1116(ispDF)
BVL : BF3285c1_1932(ispDF)
BIO : BR141012304_11720(ispDF)
BRC : BCCGELA001_18915(ispDF)
BVZ : BRAD3257_4530(ispDF)
VGO : GJW-30_1_02992(ispDF)
BHS : BM1374165_00568(ispDF)
BBK : BARBAKC583_0540(ispDF)
BTX : BM1374166_00809(ispDF)
BEZ : NCTC12898_00518(ispDF)
APOL : K9D25_01265 K9D25_15235
MAQU : Maq22A_c17520(ispF)
MTUN : MTUNDRAET4_1116(ispDF)
FIL : BN1229_v1_2799(ispDF)
FIY : BN1229_v1_3114(ispDF)
BVY : NCTC9239_01631(ispDF)
TSV : DSM104635_01993(ispDF)
RLI : RLO149_c017900(ispD)
KVL : KVU_0798(ispDF) KVU_1312(ispD)
KVU : EIO_1299 EIO_1847(ispD)
PHP : PhaeoP97_01473(ispDF)
PPIC : PhaeoP14_01380(ispDF)
SINL : DSM14862_01391(ispF)
SPSE : SULPSESMR1_01634(ispD)
RMM : ROSMUCSMR3_00179(ispF)
AHT : ANTHELSMS3_02797(ispDF)
LALG : LentiSH36_01197(ispDF)
RMAI : MACH21_12900(ispDF)
RCP : RCAP_rcc01795(ispDF)
LVS : LOKVESSMR4R_01530(ispDF)
SDH : H9L15_10550 H9L15_10555(ispF)
SBIN : SBA_ch1_23490(ispDF)
SSY : SLG_18000(ispD_ispF)
SPAG : sphantq_03519(ispDF)
SFLA : SPHFLASMR4Y_00766(ispDF)
EBLA : JGUZn3_17530(ispDF)
SHUM : STHU_25830(ispDF) STHU_41050(ispD)
STEL : STAQ_23660(ispDF) STAQ_25520(ispD)
ABS : AZOBR_p110006(ispDF)
MGY : MGMSRv2__1153(ispDF)
THAC : CSC3H3_09655(ispDF)
HHP : HPSH112_02410(ispDF)
HHQ : HPSH169_02330(ispDF)
HHR : HPSH417_02135(ispDF)
HPO : HMPREF4655_20672(ispD)
HPX : HMPREF0462_0488(ispD)
HEP : HPPN120_02170(ispDF)
HEU : HPPN135_02190(ispDF)
HPYA : HPAKL117_02085(ispDF)
HPYK : HPAKL86_03210(ispDF)
HPYO : HPOK113_0435(ispDF)
HPYL : HPOK310_0430(ispDF)
HCB : HCBAA847_1800(ispD_ispF)
HCL : NCTC13205_00024(ispDF)
HSH : NHP194022_15370(ispDF)
HPUL : NCTC13154_01087(ispDF)
CJV : MTVDSCj20_1564(ispDF)
CFT : CFF04554_0408(ispDF)
CFV : CFVI03293_0407(ispDF)
CFX : CFV97608_0410(ispDF)
CAMP : CFT03427_0418(ispDF)
CCV : CCV52592_0202(ispDF)
CCO : CCC13826_1467(ispDF)
CCOC : CCON33237_1231(ispDF)
CLR : UPTC16701_0252(ispDF)
CLM : UPTC16712_0256(ispDF)
CLQ : UPTC4110_0247(ispDF)
CLN : UPTC3659_0264(ispDF)
CAJ : CIG1485E_0468(ispDF)
CAMR : CAQ16704_0254(ispDF)
CSM : CSUB8521_0256(ispDF)
CSF : CSUB8523_0250(ispDF)
CHV : CHELV3228_1535(ispDF)
CPIN : CPIN18020_0977(ispDF)
CLX : CLAN_0125(ispD) CLAN_1607(ispDF)
CAMZ : CVIC12175_1628(ispDF)
CINF : CINF_1118(ispDF) CINF_1601(ispD)
CNV : CNZW441b_0294(ispDF)
SMAB : LN246_02545 LN246_15190
GEC : GEO60473_28050(ispD)
GBN : GEOBRER4_36880(ispD)
DMA : DMR_23150(ispD_ispF)
PSEF : PSDVSF_26180(ispDF)
PPOR : JCM14722_21800(ispDF)
BAZ : BAMTA208_00455(ispD)
BAE : BATR1942_19060(ispD)
BSON : S101395_00123(ispD)
BTHR : YBT1520_00400(ispD)
BTHU : YBT1518_00410(ispD)
BFD : NCTC4823_04122(ispD)
BACI : B1NLA3E_00410(ispD)
PARG : PspKH34_00840(ispD)
BLEN : NCTC4824_00113(ispD_1)
SDP : NCTC12225_02467(ispD)
SSTE : SAMEA4384403_2332(ispD)
LMOC : LMOSLCC5850_0230(ispD)
LMW : LMOSLCC2755_0233(ispD)
LMX : LMOSLCC2372_0237(ispD)
LMZ : LMOSLCC2482_0235(ispD)
LMON : LMOSLCC2376_0205(ispD)
LMOS : LMOSLCC7179_0230(ispD)
LMOO : LMOSLCC2378_0248(ispD)
LMOY : LMOSLCC2479_0236(ispD)
LMOT : LMOSLCC2540_0241(ispD)
LMOA : LMOATCC19117_0243(ispD)
LGZ : NCTC10812_00244(ispD)
EXI : A0126_00400(ispD) A0126_15960(ispD)
PPQ : PPSQR21_045600(ispD)
PCHI : PC41400_29275(ispD)
PCEL : HUB94_26540(ispD) HUB94_26930
LCAR : BHS00_02030 BHS00_06070
SPSU : NCTC13786_02012(ispD2)
SPOC : NCTC10925_01126(ispD2)
FPEN : KIW23_01595 KIW23_09530(ispD)
CLOS : DMR38_02305 DMR38_20465(ispD)
CGEL : psyc5s11_01440(ispD)
CLO : HMPREF0868_0720(ispD)
RUK : A4V00_01745 A4V00_12725
RGV : NQ502_12290(ispD) NQ502_13605
VFA : MM35RIKEN_10370(ispD)
AMUR : ADH66_07330 ADH66_15650
BPEN : NQ488_09015 NQ488_12170(ispD)
RRK : H8S51_004210(ispD) H8S51_015555
CEV : LK421_05845 LK421_10540(ispD)
BLAU : DQQ01_03195(ispD) DQQ01_13315
BPRO : PMF13cell1_05312(tarI)
BWX : NQ550_03570(ispD) NQ550_08350
BLAR : LC508_24905(ispD) LC508_26880
BLUI : Blut17040_05960(ispD)
BCOC : BLCOC_40520(tarI) BLCOC_43830(ispD)
CSCI : HDCHBGLK_00450(ispD) HDCHBGLK_03643(tarI)
CHYL : CE91St63_05890(ispD)
LXA : OW255_00765 OW255_03460(ispD)
ACEL : acsn021_05200 acsn021_41650(ispD)
ACHT : bsdcttw_04360(ispD)
DLO : K5I24_03870(ispD) K5I24_06515(ispD)
SINT : K5I26_00040(ispD) K5I26_14320
WCP : H9Q76_00890 H9Q76_01745(ispD) H9Q76_02880
CBIL : EUBC25_03850 EUBC25_08140(ispD)
CBAR : PATL70BA_0999(ispD)
ABUT : Ami103574_01960 Ami103574_13585
ETM : CE91St48_38370(ispDF)
PDF : CD630DERM_00470(ispD)
PHX : KGNDJEFE_00084(ispD)
TEM : JW646_04335 JW646_08920(ispD) JW646_10250
EAC : EAL2_c01300(ispD1) EAL2_c19020(ispD2) EAL2_c19040(ispD3)