Entry
Name
citrate lyase holo-[acyl-carrier protein] synthase;
2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase;
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase;
CitX;
holo-ACP synthase (ambiguous);
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase;
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase;
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate-lyase adenylyltransferase;
holo-citrate lyase synthase (incorrect);
2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate-lyase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-[citrate (pro-3S)-lyase] 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase
Reaction(IUBMB)
2'-(5-triphosphoribosyl)-3'-dephospho-CoA + apo-[citrate (pro-3S)-lyase] = diphosphate + holo-[citrate (pro-3S)-lyase] [RN:
R10706 ]
Reaction(KEGG)
Substrate
2'-(5-triphosphoribosyl)-3'-dephospho-CoA [CPD:
C19771 ];
apo-[citrate (pro-3S)-lyase]
Product
diphosphate [CPD:
C00013 ];
holo-[citrate (pro-3S)-lyase] [CPD:
C04298 ]
Comment
The gamma-subunit of EC
4.1.3.6 , citrate (pro-3S) lyase, serves as an acyl-carrier protein (ACP) and contains the cofactor 2'-(5-triphosphoribosyl)-3'-dephospho-CoA [1,3]. Synthesis and attachment of the cofactor requires the concerted action of this enzyme and EC
2.4.2.52 , triphosphoribosyl-dephospho-CoA synthase [1]. In the enzyme from Escherichia coli, the cofactor is attached to serine-14 of the ACP via a phosphodiester bond.
History
EC 2.7.7.61 created 2002, modified 2008, modified 2023
Orthology
K13927 holo-ACP synthase / triphosphoribosyl-dephospho-CoA synthase
Genes
ECD : ECDH10B_0574(citX) ECDH10B_0682(citX)
ECOO : ECRM13514_0638(citX)
ECOH : ECRM13516_0583(citX)
ELR : ECO55CA74_03815(citX)
ECW : EcE24377A_0636(citX)
EDJ : ECDH1ME8569_0584(citX)
STY : STY0071(citX2) STY0669(citX)
STT : t0064(citX) t2247(citX)
SEX : STBHUCCB_23780 STBHUCCB_730
SENT : TY21A_00330 TY21A_11395(citX)
STM : STM0062(citX2) STM0620(citX)
SEO : STM14_0073(citX2) STM14_0721(citX)
SEV : STMMW_00631 STMMW_06851
SEY : SL1344_0063(citX2) SL1344_0608(citX)
SEM : STMDT12_C00630 STMDT12_C06820(citX)
SEJ : STMUK_0063(citX2) STMUK_0625(citX)
SEB : STM474_0065(citX2) STM474_0641(citx)
SEF : UMN798_0070(citX2) UMN798_0670(citX)
SETU : STU288_00310 STU288_11275(citX)
SETC : CFSAN001921_13935 CFSAN001921_17110
SENR : STMDT2_00631(citX2) STMDT2_06111(citX)
SEND : DT104_00621(citX2) DT104_06491(citX)
SENI : CY43_00305 CY43_03385
SEEN : SE451236_06320 SE451236_09125
SPT : SPA0063 SPA2114(citX)
SPQ : SPAB_00074 SPAB_02940
SEI : SPC_0066(citX2) SPC_0633(citX)
SEC : SCH_0056(citX2) SCH_0649(citX)
SEH : SeHA_C0066(citX) SeHA_C0733(citX)
SENH : CFSAN002069_05745 CFSAN002069_08915
SEEH : SEEH1578_09345 SEEH1578_12530(citX)
SEE : SNSL254_A0067(citX) SNSL254_A0674(citX)
SENN : SN31241_10420 SN31241_16250
SEW : SeSA_A0068(citX) SeSA_A0779(citX)
SEA : SeAg_B0069(citX) SeAg_B0660(citX)
SENS : Q786_00310 Q786_03030
SED : SeD_A0067(citX) SeD_A0720(citX)
SEG : SG0066(citX2) SG0624(citX)
SEL : SPUL_0066(citX2) SPUL_2344(citX)
SEGA : SPUCDC_0066(citX2) SPUCDC_2330(citX)
SET : SEN0063(citX2) SEN0589(citX)
SENA : AU38_00310 AU38_03015
SENO : AU37_00310 AU37_03010
SENV : AU39_00310 AU39_03015
SENQ : AU40_00335 AU40_03315
SENL : IY59_00325 IY59_03065
SENJ : CFSAN001992_08230(citX) CFSAN001992_10720
SEEC : CFSAN002050_06765 CFSAN002050_09710
SEEB : SEEB0189_016185 SEEB0189_019075
SEEP : I137_00295 I137_10690
SENB : BN855_6130(citX) BN855_630(citX2)
SENE : IA1_00315 IA1_03250
SENC : SEET0819_07205 SEET0819_10065
SALZ : EOS98_16020(citX) EOS98_18930(citX)
ENL : A3UG_11845 A3UG_19005
ECLS : LI67_014035 LI67_019830
ESH : C1N69_11760(citX) C1N69_19060(citX)
LNI : CWR52_00510(citX) CWR52_16400(citX)
EDY : F0320_11290(citX) F0320_17975(citX)
KOY : J415_20970 J415_26985
KOM : HR38_09465 HR38_15105
KOC : AB185_25575 AB185_31710
KPAS : LUW96_11010(citX) LUW96_17210(citX)
KLC : K7H21_17650(citX) K7H21_23665(citX)
REE : electrica_00726(citX_1) electrica_04279(citX_2)
KLP : GUC22_16890(citX) GUC22_22750(citX)
ROR : RORB6_14935 RORB6_22485
RON : TE10_06060 TE10_13735
RPLN : B1209_03710 B1209_22885
RAO : DSD31_03940(citX) DSD31_21590(citX)
CFD : CFNIH1_01330 CFNIH1_13240
CYO : CD187_06135(citX) CD187_17150(citX)
CFAR : CI104_07430(citX) CI104_19390(citX)
CIE : AN232_09035(citX) AN232_23245(citX)
CIX : M4I31_04315(citX) M4I31_16495(citX)
KOR : AWR26_03865(citX) AWR26_12470(citX)
KRD : A3780_11640 A3780_20200
BFT : MNO13_16205(citX) MNO13_18060(citX)
AHN : NCTC12129_03712(citX)
KIN : AB182_03490 AB182_18880
PDZ : HHA33_06385(citX) HHA33_21440(citX)
METY : MRY16398_08530 MRY16398_42950
MPHG : MPHASIOC01_003042(citX) MPHASIOC01_005044(citX)
EBC : C2U52_13400(citX) C2U52_30135(citX)
SMW : SMWW4_v1c32150(citX)
SSAR : SSARUM_003089(citX)
GQU : AWC35_01470 AWC35_07840
SERA : Ser39006_011315(citX) Ser39006_015630(citX)
SERQ : CWC46_11310(citX) CWC46_15625(citX)
PROD : PCO85_09365(citX) PCO85_13180(citX)
PAQU : DMB82_0009060(citX)
PARL : PEC302110_17510(citX)
DDC : Dd586_2258 Dd586_2560
DZC : W909_07520 W909_08740
MINT : C7M51_04151(citX_1) C7M51_04165(citX_2)
LRI : NCTC12151_00770 NCTC12151_02913
LGB : V8L73_04140(citX) V8L73_15215(citX)
LAG : N175_08930 N175_08975
VAU : VANGNB10_cI1184c(citX_1) VANGNB10_cI1192(citX_2)
VZI : G5S32_08615(citX) G5S32_08660(citX)
VIB : VspSTUT11_32070(citX)
CDIZ : CEDIAZO_02597(citX)
SPYM : M1GAS476_0964(citX)
SPH : MGAS10270_Spy1022(citX)
SPI : MGAS10750_Spy1058(citX)
STG : MGAS15252_0906(citX)
STZ : SPYALAB49_000899(citX)
SMC : SmuNN2025_1001(citX)
SDG : SDE12394_05500(citX)
SMEN : SAMEA4412692_1177(citX)
SPSU : NCTC13786_01464(citX)
SPOC : NCTC10925_01692(citX)
LCHI : KG086_05640(citX) KG086_08230(citX)
LRU : HMPREF0538_20647(citG)
LFF : LBFF_1031(citXG-1) LBFF_1724(citXG-2)
LGAS : LG045_04745 LG045_04750 LG045_07485(citX)
EMS : P3T75_01675(citX) P3T75_03265(citX)
CSR : Cspa_c19320 Cspa_c37380(citX1) Cspa_c44170(citX2)
CCK : Ccar_16860 Ccar_19580
CEU : A7L45_03615 A7L45_07990
CCOH : SAMEA4530647_2252(citX)
PETR : QKW49_09185(citX) QKW49_11025(citX)
DOR : Desor_4455 Desor_5267
BPRS : CK3_12420 CK3_28390
BPRO : PMF13cell1_03167(citG)
EAC : EAL2_808p05990(citXG)
MANA : MAMMFC1_01290(citG)
ERH : ERH_0503 ERH_0749(citX)
ERS : K210_00480 K210_01580
ERL : AOC36_05875 AOC36_09210
ERI : EEI45_06390(citX) EEI45_07290
ERD : G7062_04490(citX) G7062_08970
EIO : H9L01_06300(citX) H9L01_09615
SERI : SERIO_v1c06490(citX)
PPIO : CE91St28_10980(citXG)
» show all
Taxonomy
Reference
Authors
Schneider K, Dimroth P, Bott M.
Title
Biosynthesis of the prosthetic group of citrate lyase.
Journal
Sequence
Reference
Authors
Schneider K, Dimroth P, Bott M
Title
Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group.
Journal
Sequence
Reference
Authors
Schneider K, Kastner CN, Meyer M, Wessel M, Dimroth P, Bott M.
Title
Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.61
ExPASy - ENZYME nomenclature database: 2.7.7.61