Entry
Name
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase;
carS (gene name);
CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase;
CTP:2,3-GG-GP ether cytidylyltransferase;
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase;
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase;
CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase;
CDP-unsaturated archaeol synthase;
CDP-archaeol synthase (incorrect)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [RN:
R08966 ]
Reaction(KEGG)
Substrate
CTP [CPD:
C00063 ];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:
C04638 ]
Product
diphosphate [CPD:
C00013 ];
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [CPD:
C18059 ]
Comment
This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1].
History
EC 2.7.7.67 created 2009, modified 2014
Pathway
ec00564 Glycerophospholipid metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K19664 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Genes
SSAI : N0B31_18800 N0B31_20835
TVO : TVG0192666(TVG0192666)
LOKI : Lokiarch_20290 Lokiarch_25840
LOB : NEF87_000385 NEF87_002412
PSYT : DSAG12_00452 DSAG12_02845
» show all
Taxonomy
Reference
Authors
Morii H, Nishihara M, Koga Y
Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
Journal
Reference
Authors
Morii H, Koga Y
Title
CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus.
Journal
Reference
Authors
Jain S, Caforio A, Fodran P, Lolkema JS, Minnaard AJ, Driessen AJ
Title
Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.67
ExPASy - ENZYME nomenclature database: 2.7.7.67