Entry
Name
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase;
D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase;
D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase;
hldE (gene name);
rfaE (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Reaction(IUBMB)
D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate [RN:
R05644 ]
Reaction(KEGG)
Substrate
D-glycero-beta-D-manno-heptose 1-phosphate [CPD:
C07838 ];
ATP [CPD:
C00002 ]
Product
ADP-D-glycero-beta-D-manno-heptose [CPD:
C06397 ];
diphosphate [CPD:
C00013 ]
Comment
The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC
2.7.1.167 ). The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.
History
EC 2.7.7.70 created 2010
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K03272 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase
K21345 D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Genes
ECW : EcE24377A_3515(hldE)
EDJ : ECDH1ME8569_2949(rfaE)
ECOI : ECOPMV1_03369(hldE)
REE : electrica_00629(hldE)
RTG : NCTC13098_00883(hldE)
RIP : RIEPE_0585 RIEPE_0589
CLAP : NCTC11466_03963(hldE)
KIE : NCTC12125_04562(hldE)
BAGE : BADSM9389_35320(hldE)
METY : MRY16398_07270(hldE)
PTF : PROFFT_A_01130(hldE)
PSHI : SAMEA2665130_0471(hldE)
MPHG : MPHASIOC01_003519(hldE)
YPG : YpAngola_A0292(hldE)
YPI : YpsIP31758_0564(hldE)
SMW : SMWW4_v1c42130(rfaE)
SFJ : SAMEA4384070_4252(hldE)
SOF : NCTC11214_02397(hldE)
SSAR : SSARUM_004109(hldE)
PAQU : DMB82_0004420(hldE)
PARL : PEC302110_31690(hldE)
EHD : ERCIPSTX3056_281(hldE)
PHEI : NCTC12003_03127(hldE)
PRJ : NCTC6933_03230(hldE)
LRI : NCTC12151_02771(hldE)
HIC : NTHIC486_01179(hldE)
HPIT : NCTC13334_01260(hldE)
HHZ : NCTC10839_01336(hldE)
HAEG : NCTC8502_01552(hldE)
PDAG : 4362423_00581(hldE)
ADP : NCTC12871_01672(hldE)
ALIG : NCTC10568_01117(waaE)
ASEG : NCTC10977_01595(hldE)
AVT : NCTC3438_01160(hldE)
PAET : NCTC13378_01088(hldE)
VAU : VANGNB10_cI2201c(rfaE)
VPL : SA104470976_00389(hldE)
VIB : VspSTUT11_25780(hldE)
VIS : VspSTUT16_26840(hldE)
PAEB : NCGM1900_5748(rfaE)
PVD : CFBP1590__4801(hldE)
PPRC : PFLCHA0_c05390(hldE)
PMUD : NCTC8068_00484(hldE)
PFW : PF1751_v1c04520(hldE)
PPUU : PputUW4_00413(rfaE)
PTRT : HU722_0003330(hldE)
PTW : TUM18999_55440(hldE)
PTAE : NCTC10697_04108(hldE)
MSHE : MAALD49_07730(hldE)
SCAA : TUM17387_31730(hldE)
SALH : HMF8227_02392(gmhC)
CBS : COXBURSA331_A1838(hldE)
MSZE : MSZNOR_0510(hldE) MSZNOR_3944(hldE)
MISZ : MishRS11D_00750(hldE_1) MishRS11D_16880(hldE_2)
TIB : THMIRHAM_04650(hldE)
TSE : THMIRHAS_20000(hldE)
TZO : THMIRHAT_05880(hldE)
TFRI : Thiofri_04185(hldE)
TNI : TVNIR_2697(hldE_[H])
HAAH : HALA3H3_360023(hldE)
ALCA : ASALC70_02818(hldE)
AEL : NCTC12917_00461(hldE)
ACII : C4901_03255(rfaE2) C4901_13985
ATY : A9R16_002880(rfaE2) A9R16_013060(rfaE2)
CDIZ : CEDIAZO_00912(hldE)
NMQ : NMBM04240196_2016(hldE_C)
NMZ : NMBNZ0533_2007(hldE_C)
NWE : SAMEA3174300_2025(hldE)
NZO : SAMEA4504057_0114(hldE)
NCI : NCTC10296_02409(hldE)
NCZ : NCTC10294_01399(hldE)
NANI : NCTC12227_00086(hldE)
ECOR : SAMEA4412678_1182(hldE_1)
CCAH : DWG20_06060 DWG20_06320(rfaE2)
CUPP : CTP10_R00830(rfaE2)
BML : BMA10229_A1355(rfaE_2)
BMN : BMA10247_3207(rfaE_2)
BPM : BURPS1710b_0607(rfaE)
BPL : BURPS1106A_0444(rfaE_2)
BPR : GBP346_A0353(rfaE_1)
PAZZ : PBP221_02360(rfaE2)
PLG : NCTC10937_00715(hldE)
BUE : BRPE67_ACDS01550(rfaE)
BTRM : SAMEA390648700822(aut)
AXX : ERS451415_00502(hldE_1)
ODH : DHf2319_01710(rfaE2)
RHOF : AB3G31_00215(rfaE2)
RDP : RD2015_2043 RD2015_723
RBH : B4966_11490 B4966_13470
THK : CCZ27_01465(rfaE2) CCZ27_22030(rfaE1)
ZPA : C3497_10580(rfaE2) C3497_12845(rfaE1)
MESU : LHFGNBLO_002633(rfaE1)
RPUS : CFBP5875_22080(rfaE1)
BSEP : HAP48_0047280(rfaE1)
BQB : J4P68_0006470(rfaE1)
BBAN : J4G43_035480(rfaE1)
BCAN : BcanWSM471_26295(rfaE1)
VGO : GJW-30_1_01782(hldE)
BVY : NCTC9239_01317(hldE)
BSTA : ACETK8_11195(rfaE2)
SPHI : TS85_08255 TS85_23845
RAP : RHOA_2616(hldE) RHOA_3110(hldE)
SRF : LHU95_11445(rfaE1) LHU95_23195
ABS : AZOBR_40288(rfaE) AZOBR_p60111(rfaE)
NAO : Y958_28115 Y958_29415
SMUC : JL100_016370(rfaE2)
HPO : HMPREF4655_20738(rfaE)
HPX : HMPREF0462_0550(rfaE)
HCL : NCTC13205_00422(waaE)
HSH : NHP194022_13470(hldE)
HPUL : NCTC13154_00047(hldE)
CJV : MTVDSCj20_1157(waaE)
CFV : CFVI03293_1452(waaE)
CAMP : CFT03427_1376(waaE)
CCOC : CCON33237_0838(waaE)
CLR : UPTC16701_0475(waaE)
CLM : UPTC16712_0483(waaE)
CAMR : CAQ16704_0498(waaE)
CHV : CHELV3228_0618(waaE)
CPIN : CPIN18020_0875(waaE)
CAMZ : CVIC12175_0217(waaE)
GEC : GEO60473_15300(rfaE1)
GBN : GEOBRER4_32680(hldE)
DEP : AOP6_1888(hldE_1) AOP6_1893(hldE_2)
DEF : CNY67_09115(rfaE2) CNY67_12975(rfaE2)
PBIZ : LWC08_00155(rfaE2) LWC08_15080(rfaE2)
DML : Dmul_08940 Dmul_39030(hldE)
DMM : dnm_056430 dnm_098060(hldE)
DAO : Desac_1301 Desac_2006
DAW : HS1_000697 HS1_002161
TMV : OH491_09865 OH491_16245(rfaE2)
MTAR : DF168_01099(hldE_1)
ABIW : Abiwalacus_14370(hldE)
GIM : F1728_11020 F1728_24510(rfaE2)
SDYN : Mal52_56790(hldE_2)
PVAR : SH412_004390(rfaE2)
GES : VT84_12315(hldE_1) VT84_29035(hldE_4)
LRS : PX52LOC_03499(rfaE2) PX52LOC_08097
SACI : Sinac_4782 Sinac_6232
AGV : OJF2_33180(hldE_2) OJF2_34390(hldE_3)
TPLA : ElP_40830(hldE_1) ElP_41890(hldE_2)
JET : L3J17_05250 L3J17_05255
MCAD : Pan265_00520(hldE_1)
ALUS : STSP2_02128(hldE_2)
PBAP : Pla133_40370(hldE_2) Pla133_40620(hldE_4)
VBL : L21SP4_01291(hldE_2)
LPRO : PQO03_06970 PQO03_12375
ABA : Acid345_3788 Acid345_3810
CTM : Cabther_A0425 Cabther_A0586
CVL : J8C06_02785(rfaE2) J8C06_07935(rfaE2)
CHLO : J8C02_02055(rfaE2) J8C02_02850(rfaE2)
ABAC : LuPra_05051(hldE_2) LuPra_06306(hldE_4)
LUB : TBR22_A39830 TBR22_A53430
PSPC : Strain318_001399(rfaE2)
BLQ : L21SP5_02367(hldE_2)
NIA : A8C56_10015 A8C56_13705
ARAC : E0W69_012945(rfaE2)
PCM : AY601_0245 AY601_2842
PEDO : AB3G38_11255(rfaE2)
STHA : NCTC11429_04546(hldE)
MUH : HYN43_005110(rfaE2) HYN43_008145(rfaE2)
MRUB : DEO27_005320(rfaE2)
MGOS : DIU38_005085(rfaE2)
MMAB : HQ865_06475(rfaE1) HQ865_12425(rfaE2)
MGIK : GO620_004425(rfaE2)
MDJ : LLH06_08255(rfaE1) LLH06_15360(rfaE2)
MSAB : SNE25_24125(rfaE2) SNE25_24735(rfaE2)
AGD : FRZ59_02920(rfaE2) FRZ59_11310(rfaE2)
PSEZ : HME7025_00875(gmhC)
ALEN : G9X62_03525(rfaE2) G9X62_06370(rfaE1)
PPSV : PEPS_25410 PEPS_25460
PROC : Ptc2401_00323(hldE_1)
NMV : NITMOv2_2851(rfaE) NITMOv2_4626(rfaEb)
AMIC : Ami3637_06355(rfaE2)
VRM : 44547418_00765(hldE)
VDN : NCTC11831_01192(hldE)
DHO : Dia5BBH33_11420(hldE)
SELM : TAMA11512_18150 TAMA11512_18180(rfaE2)
MANA : MAMMFC1_02279(hldE_2)
SOVA : SOV_08450(hldE_2) SOV_40870(hldE_3)
SSID : SPSIL_012130 SPSIL_043040(hldE_2)
PFAC : PFJ30894_00059(hldE)
MAVM : MAA44156_03531(hldE)
MNV : MNVI_29030(hldE) MNVI_32420
MFLV : NCTC10271_03893(hldE)
CHN : A605_05485 A605_05505
CSTA : CSTAT_10495 CSTAT_10515
NFR : ERS450000_01687(hldE_1)
NWL : NWFMUON74_17460 NWFMUON74_43000 NWFMUON74_43780
NGP : LTT66_21630 LTT66_23975
NSPU : IFM12276_16610 IFM12276_25540
SAMB : SAM23877_5918(hldE)
SLE : sle_14910(sle_14910)
SGM : GCM10017557_15180(hldE)
SGRS : V9K83_06245(rfaE2) V9K83_15280
SAST : CD934_01780(rfaE2) CD934_05560
SCOE : CP976_34445(rfaE2) CP976_40825(rfaE2)
STUI : GCM10017668_56760(hldE)
SVD : CP969_05260(rfaE2) CP969_29910(rfaE2)
SMOB : J7W19_00345(rfaE2) J7W19_01800(rfaE2)
SGOB : test1122_07605(rfaE2)
SRUG : F0345_02475 F0345_26095(rfaE2)
SLUO : PS467_06155(rfaE2) PS467_34380(rfaE2)
STRI : C7M71_027485(rfaE2)
CMH : VO01_13820 VO01_13905
CCAP : AES38_12970 AES38_13045
CPHA : FGI33_14495(rfaE2) FGI33_14600
CCAF : FGD68_00680 FGD68_00750(rfaE2)
MOJ : D7D94_02820(rfaE2) D7D94_02840(rfaE2)
MHOT : PU630_02705 PU630_02720(rfaE2)
RTX : TI83_04215 TI83_04250
RTC : APU90_02220 APU90_02255
RTN : A6122_0937 A6122_0942
RRY : C1O28_03860(rfaE2) C1O28_03885(rfaE2)
RIA : C7V51_01350(rfaE2) C7V51_01380
RFS : C1I64_10200 C1I64_10265(rfaE2)
RTE : GSU10_05280(rfaE2) GSU10_05305
RATH : GSU68_06260(rfaE2) GSU68_06295
CUM : NI26_07895 NI26_07915
CUB : BJK06_17395 BJK06_17415
CQF : GBG65_15785 GBG65_15805(rfaE2)
CCIT : QPK07_08205(rfaE2) QPK07_08225
CUF : KM842_05425 KM842_05445(rfaE2)
CUY : I8920_07715(rfaE2) I8920_07735
CPOI : OE229_11470(rfaE2) OE229_11490
CURT : LCG91_07785(rfaE2) LCG91_07805
CURZ : LQK89_08240(rfaE2) LQK89_08260
LTN : KVY00_14825 KVY00_14840
ARR : ARUE_c01140(hldE1) ARUE_c01170(hldE2)
ARQ : BWQ92_08045 BWQ92_08065
ARN : CGK93_00785 CGK93_00800(rfaE2)
ARX : ARZXY2_3794 ARZXY2_3797
ACRY : AC20117_03410 AC20117_03430
ARTH : C3B78_02155 C3B78_02170(rfaE2)
AAGI : NCTC2676_1_01792(hldE_1) NCTC2676_1_01796(hldE_2)
AJG : KKR91_16600 KKR91_16620(rfaE2)
ASUF : MNQ99_03355(rfaE2) MNQ99_03375(rfaE2)
AOD : Q8Z05_09860 Q8Z05_09880(rfaE2)
AZX : N2K95_15760 N2K95_15940(rfaE2)
AJR : N2K98_16790(rfaE2) N2K98_16920(rfaE2)
ARTM : MN0502_20350(hldE) MN0502_20390
AAU : AAur_0116(rfaE) AAur_0119
PUE : FV140_00460(rfaE2) FV140_00475(rfaE2)
PAYJ : HMI59_20575(rfaE2) HMI59_20590(rfaE2)
PAGO : IRJ34_00505 IRJ34_00520(rfaE2)
PAYN : HMI60_00705 HMI60_00720(rfaE2)
PHRZ : QN084_11285(rfaE2) QN084_11300(rfaE2)
ARZ : AUT26_00470 AUT26_00485
APN : Asphe3_04650 Asphe3_04680
PSNI : NIBR502771_02810(rfaE2) NIBR502771_02825
PDEL : JCQ34_02035 JCQ34_02050(rfaE2)
POK : SMD14_02385 SMD14_02400(rfaE2)
PSLS : KTR40_02315 KTR40_02330(rfaE2)
GCR : GcLGCM259_2540 GcLGCM259_2545
RAIN : Rai3103_14165(rfaE2)
PROP : QQ658_11715(rfaE2) QQ658_11735
THAO : NI17_001780(rfaE2) NI17_013640
TALX : FOF52_01135 FOF52_11005
STRR : EKD16_13615(hldE) EKD16_17960
ACTQ : OG417_11975(rfaE2) OG417_12035(rfaE2)
NOA : BKM31_06230 BKM31_27005 BKM31_47610
NOW : GBF35_19315 GBF35_32270 GBF35_49780(rfaE2)
NCX : Nocox_17170 Nocox_26265(hldE1) Nocox_40560(hldE2)
NGN : LCN96_19570 LCN96_35380 LCN96_54500(rfaE2)
NFS : OIE67_13110(rfaE2) OIE67_26730 OIE67_45565(rfaE2)
BMON : ABDB74_01835(rfaE2)
AMQ : AMETH_2578 AMETH_5618
AACD : LWP59_11485(rfaE2) LWP59_32465(rfaE2)
ATHM : L1857_15660(rfaE2) L1857_31005(rfaE2)
ACYN : ORV05_03590(rfaE2) ORV05_21675(rfaE2)
PBRO : HOP40_26095(rfaE2) HOP40_26140
PSDS : K1T35_25000 K1T35_25010(rfaE2)
ACTA : C1701_21510 C1701_21555(rfaE2)
ACTU : Actkin_03546(hldE_2)
ACTY : OG774_29610 OG774_29625(rfaE2)
STP : Strop_1764 Strop_3975
MAU : Micau_0472 Micau_2224
MICB : MicB006_0485 MicB006_5289
MTUA : CSH63_13645 CSH63_14505(rfaE2)
MTEM : GCE86_03790 GCE86_04550 GCE86_27940(rfaE2)
MCAB : HXZ27_02435(rfaE2) HXZ27_11540
MSAG : GCM10017556_30440 GCM10017556_45700(hldE)
VMA : VAB18032_06470 VAB18032_14350
MCRA : ID554_02655 ID554_10675(rfaE2)
MENO : Jiend_07850(hldE) Jiend_23680
MCHL : PVK74_01925 PVK74_23465(rfaE2)
MFEU : H1D33_09155(rfaE2) H1D33_17155
MPRN : Q3V37_04790(rfaE2) Q3V37_27305
MHAW : RMN56_00940 RMN56_01765 RMN56_09270(rfaE2)
ACTR : Asp14428_09620(hldE)
PLK : CIK06_02550(rfaE2) CIK06_27580
PLAB : C6361_07540 C6361_19270(rfaE2)
PLAT : C6W10_04125 C6W10_28955(rfaE2) C6W10_32635
PFLA : Pflav_026370(hldE_1) Pflav_050250(hldE_2)
PSUU : Psuf_007790(hldE_1) Psuf_081700(hldE_2)
PRY : Prubr_20530 Prubr_48080(hldE)
RMAR : GBA65_13850(rfaE2) GBA65_19700
SBAE : DSM104329_02167(hldE)
LEPT : JVX88_05110(rfaE1) JVX88_05145 JVX88_18025(rfaE2)
ARP : NIES39_K03440 NIES39_K03510
PRUN : PCC7821_02104(hldE)
LIX : H2674_23245 H2674_23285
KBS : EPA93_20970(rfaE2) EPA93_26795 EPA93_46405
PPIO : CE91St28_16150(hldE)
FPOL : ERS445057_01298(hldE_2)
SCHV : BRCON_0039 BRCON_1254 BRCON_1443
TMG : US01_C0001G0014(hldE)
GBG : HYW15_01375 HYW15_01760
» show all
Taxonomy
Reference
Authors
Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD
Title
The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose.
Journal
Sequence
Reference
Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
Journal
Sequence
Reference
Authors
Valvano MA, Messner P, Kosma P
Title
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
Journal
Reference
Authors
Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D
Title
Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.70
ExPASy - ENZYME nomenclature database: 2.7.7.70