Entry
Name
CCA tRNA nucleotidyltransferase;
CCA-adding enzyme;
tRNA adenylyltransferase;
tRNA cytidylyltransferase;
tRNA CCA-pyrophosphorylase;
tRNA-nucleotidyltransferase;
transfer-RNA nucleotidyltransferase;
transfer ribonucleic acid nucleotidyl transferase;
CTP(ATP):tRNA nucleotidyltransferase;
transfer ribonucleate adenylyltransferase;
transfer ribonucleate adenyltransferase;
transfer RNA adenylyltransferase;
transfer ribonucleate nucleotidyltransferase;
ATP (CTP):tRNA nucleotidyltransferase;
ribonucleic cytidylic cytidylic adenylic pyrophosphorylase;
transfer ribonucleic adenylyl (cytidylyl) transferase;
transfer ribonucleic-terminal trinucleotide nucleotidyltransferase;
transfer ribonucleate cytidylyltransferase;
ribonucleic cytidylyltransferase;
-C-C-A pyrophosphorylase;
ATP(CTP)-tRNA nucleotidyltransferase;
tRNA adenylyl(cytidylyl)transferase;
CTP:tRNA cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP,CTP,ATP:tRNA cytidylyl,cytidylyl,adenylyltransferase
Reaction(IUBMB)
a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate (overall reaction) [RN:
R09382 ];
(1a) a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate [RN:
R09383 ];
(1b) a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate [RN:
R09384 ];
(1c) a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate [RN:
R09386 ]
Reaction(KEGG)
Substrate
Product
tRNA with a 3' CCA end [CPD:
C19085 ];
diphosphate [CPD:
C00013 ];
tRNA with a 3' cytidine end;
tRNA with a 3' CC end [CPD:
C19080 ]
Comment
The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition [5].
History
EC 2.7.7.72 created 1965 as EC 2.7.7.21 and EC 2.7.7.25, both transferred 2010 to EC 2.7.7.72
Orthology
K00974 tRNA nucleotidyltransferase (CCA-adding enzyme)
K07558 tRNA nucleotidyltransferase (CCA-adding enzyme)
Genes
PON : 100449831(TRNT1) 100460729
PPYG : 129032604(TRNT1) 129036811
RNO : 100911093 312616(Trnt1)
PROB : 127214541 127236089 127236091(Trnt1)
HGL : 101701523(Trnt1) 101721883
MLX : 118005749(TRNT1) 118021035
NSU : 110584854(TRNT1) 110589013
MYB : 102242809 102252750(TRNT1)
TVP : 118831940(TRNT1) 118838425
NNI : 104016861 104016943(TRNT1)
XLA : 398421(trnt1.S) 734914(trnt1.L)
BGAR : 122920437 122943350(TRNT1)
SANH : 107667021 107680704
SGH : 107584501 107599420(trnt1)
CCAR : 109075086 109091084(trnt1)
CAUA : 113050474 113096011
CGIB : 127960018 128015842
MASI : 127445880 127449116
GACU : 117543768 117543807
SLAL : 111648065 111653184(trnt1)
PSPA : 121298336 121328212
ARUT : 117411743 117412332
PMRN : 116939268 116951104(TRNT1)
LPIC : 129272809 129273182
DSI : Dsimw501_GD19587(Dsim_GD19587)
AALB : 109413928 109621289 115254236
CQU : CpipJ_CPIJ013325 CpipJ_CPIJ013326
CNS : 116345120 116345121 116345143
BCOO : 119073545 119084128
CFEL : 113372254 113372506
AFRA : 136030776 136038697
PPOI : 119113413 119114391
CEL : CELE_F55B12.4(hpo-31)
CBR : CBG_11474(Cbr-hpo-31)
BMY : BM_BM4409(Bma-hpo-31)
AQU : 100634325 100634448 100636807
NCS : NCAS_0B04830(NCAS0B04830)
NDI : NDAI_0B02240(NDAI0B02240)
TPF : TPHA_0B03380(TPHA0B03380)
TBL : TBLA_0E04200(TBLA0E04200)
TDL : TDEL_0A01310(TDEL0A01310)
KAF : KAFR_0A02390(KAFR0A02390) KAFR_0B02540(KAFR0B02540)
KNG : KNAG_0G01860(KNAG0G01860)
LBG : 92210016(LODBEIA_P48200)
CAL : CAALFM_C400880WA(CaO19.4705)
YLI : 2910568(YALI2_D01066g)
NTE : NEUTE1DRAFT109031(NEUTE1DRAFT_109031)
SMP : 10805147(SMAC4_03810)
FVR : FVEG_08912 FVEG_16808
TATV : 25780144(TrAtP1_005864)
TASP : 36608657(TrAFT101_005180)
PLJ : 28891032(PLICBS_004651)
CDET : 87944897(CDEST_08394)
BFU : BCIN_12g01580(Bccca1)
ADAC : 96083349(ACET3X_003027)
CDEP : 91084702(L203_100486)
KMG : 30164959(I203_108255)
KNE : 92177608(IAR55_000348)
CCAC : CcaHIS019_0304780(CCA1)
ABP : AGABI1DRAFT117129(AGABI1DRAFT_117129)
ABV : AGABI2DRAFT176078(AGABI2DRAFT_176078)
PGR : PGTG_09736 PGTG_09750
PLAG : 39742432(PADL01_1118600)
PBRS : 92370893(MKS88_002805)
TVA : TVAG_2v0422020 TVAG_2v0587420 TVAG_2v0940540 TVAG_2v1022920
ECOO : ECRM13514_3951(cca)
ECOH : ECRM13516_3819(cca)
ELR : ECO55CA74_18010(cca)
EDJ : ECDH1ME8569_2953(cca)
SEEH : SEEH1578_02165(cca)
SENJ : CFSAN001992_17515(cca)
REE : electrica_00625(cca)
RTG : NCTC13098_00879(cca)
SENM : TRABTM_A_00240(cca)
RIP : RIEPE_0583 RIEPE_0591
RIG : AOQ88_02210 AOQ88_02240
CLAP : NCTC11466_03967(cca)
KIE : NCTC12125_04558(cca)
AHN : NCTC12129_00802(cca)
METY : MRY16398_07230(cca)
PSHI : SAMEA2665130_0459(cca)
YPI : YpsIP31758_0560(cca)
SERS : SERRSCBI_20500(cca)
SFJ : SAMEA4384070_4256(cca)
SOF : NCTC11214_02390(cca)
EHD : ERCIPSTX3056_286(cca)
BAPF : BUMPF009_CDS00529(cca)
BAPG : BUMPG002_CDS00530(cca)
BAPU : BUMPUSDA_CDS00528(cca)
BAPW : BUMPW106_CDS00529(cca)
TPTY : NCTC11468_00589(cca_1)
PHEI : NCTC12003_03131(cca)
LRI : NCTC12151_02790(cca)
HPIT : NCTC13334_01521(cca)
HHZ : NCTC10839_01257(cca)
HAEG : NCTC8502_01394(cca)
ADP : NCTC12871_00232(cca)
ALIG : NCTC10568_00376(cca)
ASEG : NCTC10977_01075(cca)
RPNE : NCTC8284_01772(cca_1)
PAET : NCTC13378_00496(cca)
XFU : XFF4834R_chr07250(cca)
XPH : XppCFBP6546_08015(XppCFBP6546P_08015)
VAU : VANGNB10_cI2210(cca)
VPL : SA104470976_00380(cca)
VIB : VspSTUT11_25880(cca)
VIS : VspSTUT16_26950(cca)
PPRC : PFLCHA0_c56090(cca)
PMUD : NCTC8068_04858(cca)
PFW : PF1751_v1c50100(cca)
PTAE : NCTC10697_00450(cca)
ACUM : C9E88_016290 C9E88_17530
MCUN : NCTC10297_00962(cca)
SCAA : TUM17387_10870(cca)
PPHE : PP2015_3269 PP2015_734
CBS : COXBURSA331_A2026(cca)
LLO : LLO_0310(cca) LLO_3217(cca)
LSH : CAB17_02640 CAB17_05650
LJR : NCTC11533_02416(cca)
LCJ : NCTC11976_00293(cca_1) NCTC11976_02511(cca_2)
LWA : SAMEA4504053_3248(cca)
LSS : NCTC12082_02300(cca)
LANT : TUM19329_32090(cca)
MCA : MCA0022(cca) MCA2306
MMEO : OOT43_04475 OOT43_12635 OOT43_17120
MEEF : JWZ97_16295 JWZ97_17550
MSZE : MSZNOR_2985(cca) MSZNOR_4710
MISZ : MishRS11D_01880(cca)
ALV : Alvin_1212 Alvin_2457
EPS : L0Y14_00145 L0Y14_03715
SEDS : AAY24_15515(cca) AAY24_17415
HAAH : HALA3H3_680014(cca)
AEL : NCTC12917_03682(cca)
CHJ : NCTC10426_00533(cca)
GBI : PG2T_00360 PG2T_10685(cca)
NMQ : NMBM04240196_0963(cca)
NWE : SAMEA3174300_0742(cca)
NZO : SAMEA4504057_1854(cca)
NCI : NCTC10296_01938(cca)
NCZ : NCTC10294_00702(cca)
NANI : NCTC12227_00785(cca)
VFF : VITFI_CDS1455 VITFI_CDS1663
ECOR : SAMEA4412678_1343(cca)
AQL : BXU06_07625 BXU06_16730
BPM : BURPS1710b_0457(cca)
BPL : BURPS1106A_0272(cca)
PSPW : BJG93_11935 BJG93_13660
PLG : NCTC10937_04945(cca)
LMIR : NCTC12852_00336(cca)
BUO : BRPE64_ACDS26620(cca)
BUE : BRPE67_ACDS26060(cca)
BTRM : SAMEA390648701413(cca)
AXX : ERS451415_05966(cca)
SMIO : CATMQ487_07550(cca)
SPLB : SFPGR_06810(cca) SFPGR_21410
URU : DSM104443_03560(cca)
UPL : DSM104440_03073(cca)
FLE : KI610_07400 KI610_19545
AZO : azo0493(cca1) azo2549(cca2)
AZR : CJ010_03335 CJ010_16120
THAG : CKCBHOJB_03246(cca)
AFE : Lferr_0396 Lferr_1450
AFI : Acife_2043 Acife_2808
AFJ : AFERRID_11900 AFERRID_25640
ATX : GCD22_00309(cca) GCD22_01161(cca)
AFP : K1Y48_07395 K1Y48_10350
HCL : NCTC13205_00644(cca)
CCOC : CCON33237_1247(cca)
CPIN : CPIN18020_0870(cca)
CAMZ : CVIC12175_1497(cca)
GEF : FO488_01735 FO488_09475
GEV : GSVR_05800(ccaA) GSVR_26750
GEO : Geob_3012(ccaA) Geob_3306(cca)
GLO : Glov_0285 Glov_0878 Glov_2360
TAMM : GEAMG1_0620 GEAMG1_0953
GBM : Gbem_2294(ccaA) Gbem_2894(cca)
GBN : GEOBRER4_13040 GEOBRER4_21470(ccaA)
GER : KP004_06270 KP004_10425
GSUB : KP001_04780 KP001_09285
GNT : KP003_05790 KP003_09850
GPL : M1B72_10215 M1B72_14645
DVE : DESUT3_20430(ccaC) DESUT3_22320(ccaA)
DFI : AXF13_06375 AXF13_06515
DPG : DESPIGER_0652 DESPIGER_0876
PSYF : N1030_04575 N1030_04760
DSB : LN040_02425 LN040_02620
DCB : C3Y92_10580 C3Y92_12900
DMS : E8L03_03835 E8L03_04535
DSA : Desal_1954 Desal_2042
DHY : DESAM_22205 DESAM_22302
DAF : Desaf_3035 Desaf_3136
DEJ : AWY79_12035 AWY79_12285 AWY79_17940
PPRF : DPRO_0410 DPRO_0653
PSEL : GM415_14030 GM415_14685
DDN : DND132_0413 DND132_0462
PPOR : JCM14722_01650 JCM14722_02270
PTHE : LF599_08770 LF599_09495
PMEN : V8V93_11420 V8V93_12170
DSX : GD604_09100 GD604_09270
DSD : GD606_03695 GD606_05035
PBIZ : LWC08_04790 LWC08_05045
DVG : Deval_1469 Deval_1638
CLIH : KPS_000462 KPS_000538
DBA : Dbac_0636 Dbac_1254 Dbac_1458
DOA : AXF15_00120 AXF15_00215
DESU : NLA06_03360 NLA06_06465
THEW : TDMWS_13410 TDMWS_13590
DPR : Despr_2890 Despr_2911
DEO : CAY53_05640 CAY53_09635
DOG : HP555_06145 HP555_06245
DAT : HRM2_21820 HRM2_22310 HRM2_45970
DTO : TOL2_C20080 TOL2_C24950 TOL2_C37610(cca)
DOV : DSCO28_08940 DSCO28_19600(ccaA)
DWD : DSCW_07970 DSCW_13340(ccaA) DSCW_19870
DALK : DSCA_04020(ccaA) DSCA_10530
DML : Dmul_11400 Dmul_23720
DMM : dnm_047240 dnm_054190
DEK : DSLASN_07040(ccaA) DSLASN_20560
DAX : FDQ92_01395 FDQ92_04285
CFUS : CYFUS_004493 CYFUS_007210
VIN : AKJ08_1202 AKJ08_2587 AKJ08_2588
SAMY : DB32_001216 DB32_004064
BAFH : BafHLJ01_0774(papS)
TPI : TREPR_1615 TREPR_2687
TRC : DYE49_03655 DYE49_05740
SSM : Spirs_1890 Spirs_3960
SPER : EW093_10485 EW093_14590
OCK : EXM22_05900 EXM22_14985
TAZ : TREAZ_1438 TREAZ_3326
BHC : JFL75_09165 JFL75_14510
LKB : LPTSP3_g05980(pcnB_1)
TPX : Turpa_1406 Turpa_3172
EPL : P4G45_10345 P4G45_13960
ADIN : H7849_01920 H7849_07420
TGI : RBB81_02260 RBB81_15375
TEMP : RBB75_10570 RBB75_18125
TPSC : RBB77_15245 RBB77_22735
FOK : KK2020170_15340(cca)
CPO : COPRO5265_0444 COPRO5265_0793
GTL : EP073_01580 EP073_07370
MSCH : N508_000144 N508_001224
TYE : THEYE_A0458 THEYE_A1552
TOB : V4D31_07785 V4D31_07980
TAUT : V4D30_09485 V4D30_09665
DTP : JZK55_04960 JZK55_08540
NMV : NITMOv2_1028 NITMOv2_3747
NIO : NITINOP_0008 NITINOP_2618
NKF : Nkreftii_002022 Nkreftii_002970
NVA : G3M78_09560 G3M78_13895
BSTR : QI003_11145 QI003_14575
BTG : BTB_502p05190(cca) BTB_c15770(cca)
BTN : BTF1_05385 BTF1_30957
BSHI : LGQ02_06645 LGQ02_08690
BCO : Bcell_1555 Bcell_1901
BKW : BkAM31D_11140(cca_1) BkAM31D_17495(cca_2)
BCL : ABC2069(cca) ABC2543
BLE : BleG1_2003 BleG1_2539
SHUA : PQ477_00735 PQ477_18895
BPF : BpOF4_02070 BpOF4_15585(pcnB)
RUE : DT065_01995 DT065_06350
SALE : EPH95_01325 EPH95_06620
SCIB : HUG20_08310 HUG20_13490
SCIA : HUG15_11045 HUG15_16105
AIA : AWH56_000625 AWH56_024735
BLEN : NCTC4824_01962(cca)
BBEV : BBEV_1179(cca-1) BBEV_1469(cca-2)
PSUA : FLK61_29245 FLK61_30865
ALKL : MM271_13745 MM271_18495
AHAL : FTX54_006795 FTX54_008130
SAX : USA300HOU_1395(pcnB)
SUX : SAEMRSA15_13180(papS)
SUF : SARLGA251_13710(papS)
SAUT : SAI1T1_2010520(cca)
SAUJ : SAI2T2_1010540(cca)
SAUK : SAI3T3_1010530(cca)
SAUQ : SAI4T8_1010530(cca)
SAUV : SAI7S6_1010540(cca)
SAUW : SAI5S5_1010490(cca)
SAUX : SAI6T6_1010500(cca)
SAUY : SAI8T7_1010530(cca)
SDP : NCTC12225_01548(cca)
SPIC : SAMEA4384060_1480(pap)
SSH : NCTC13712_01448(cca)
SSIM : SAMEA4384339_1354(cca)
SSTE : SAMEA4384403_1322(cca)
LMOC : LMOSLCC5850_1967(cca)
LMW : LMOSLCC2755_1965(cca)
LMX : LMOSLCC2372_1971(cca)
LMZ : LMOSLCC2482_1966(cca)
LMON : LMOSLCC2376_1867(cca)
LMOS : LMOSLCC7179_1877(cca)
LMOO : LMOSLCC2378_1928(cca)
LMOY : LMOSLCC2479_1968(cca)
LMOT : LMOSLCC2540_1986(cca)
LMOA : LMOATCC19117_1923(cca)
LGZ : NCTC10812_00906(cca)
GMO : NCTC11323_00916(cca)
GHA : NCTC10459_00908(cca)
PPQ : PPSQR21_028740(pcnB)
COHN : KCTCHS21_26330(cca)
JEO : JMA_19640 JMA_41330 JMA_43250
SPOP : SporoP37_04790 SporoP37_15555
SURE : SporoP32a_04665 SporoP32a_15870
SPOS : DV702_03555 DV702_08515
SOW : QWT69_08260 QWT69_13280