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Entry
EC 2.7.7.78                 Enzyme                                 

Name
GDP-D-glucose phosphorylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
GDP:alpha-D-glucose 1-phosphate guanylyltransferase
Reaction(IUBMB)
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP [RN:R09752]
Reaction(KEGG)
Substrate
GDP-alpha-D-glucose [CPD:C00394];
phosphate [CPD:C00009]
Product
alpha-D-glucose 1-phosphate [CPD:C00103];
GDP [CPD:C00035]
Comment
The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.
History
EC 2.7.7.78 created 2011
Orthology
K15630  GDP-D-glucose phosphorylase
Genes
HSA: 390637(GDPGP1)
PTR: 745569(GDPGP1)
PPS: 100982804(GDPGP1)
GGO: 101152503(GDPGP1)
PON: 100444173(GDPGP1)
NLE: 100594834(GDPGP1)
MCC: 701954(GDPGP1)
MCF: 102121174(GDPGP1)
CSAB: 103231172(GDPGP1)
RRO: 104674333(GDPGP1)
RBB: 108521402(GDPGP1)
CJC: 100392315(GDPGP1)
SBQ: 101035205(GDPGP1)
MMU: 269952(Gdpgp1)
MCAL: 110284623 110299146(Gdpgp1)
MPAH: 110332879(Gdpgp1)
RNO: 308763(Gdpgp1)
CGE: 100772319(Gdpgp1)
NGI: 103749895(Gdpgp1)
HGL: 106010011(Gdpgp1)
CCAN: 109695080(Gdpgp1)
OCU: 100340539(GDPGP1)
TUP: 102501837(GDPGP1)
CFA: 479045(GDPGP1)
VVP: 112921582(GDPGP1)
AML: 100473017(GDPGP1)
UMR: 103660194(GDPGP1)
UAH: 113263710(GDPGP1)
ORO: 101375354(GDPGP1)
FCA: 101082062(GDPGP1)
PTG: 102960896(GDPGP1)
PPAD: 109273457(GDPGP1)
AJU: 106965883(GDPGP1)
BTA: 522909(GDPGP1)
BOM: 102288281(GDPGP1)
BIU: 109575519(GDPGP1)
BBUB: 102413903(GDPGP1)
CHX: 102169222(GDPGP1)
OAS: 101105361(GDPGP1)
SSC: 100156697(GDPGP1)
CFR: 102510192(GDPGP1)
CDK: 105094688(GDPGP1)
BACU: 102999980(GDPGP1)
LVE: 103071553(GDPGP1)
OOR: 101269491(GDPGP1)
DLE: 111169638(GDPGP1)
PCAD: 102976512(GDPGP1)
ECB: 100069039(GDPGP1)
EPZ: 103558648(GDPGP1)
EAI: 106832038(GDPGP1)
MYB: 102240979(GDPGP1)
MYD: 102759603(GDPGP1)
MNA: 107540393(GDPGP1)
HAI: 109381493(GDPGP1)
DRO: 112305927(GDPGP1)
PALE: 102885796(GDPGP1)
RAY: 107514142(GDPGP1)
MJV: 108387049(GDPGP1)
LAV: 100673104(GDPGP1)
TMU: 101351913
MDO: 100015004(GDPGP1)
SHR: 100923815(GDPGP1)
PCW: 110192344(GDPGP1)
OAA: 100081924(GDPGP1)
GGA: 100858151(GDPGP1)
MGP: 104912902(GDPGP1)
CJO: 107318942(GDPGP1)
NMEL: 110403483(GDPGP1)
APLA: 113844911(GDPGP1)
TGU: 115496640(GDPGP1)
LSR: 110476688(GDPGP1)
PHI: 102109647(GDPGP1)
PMAJ: 107209304(GDPGP1)
ETL: 114064281(GDPGP1)
AAM: 106491439(GDPGP1)
ASN: 102383638(GDPGP1)
AMJ: 102563294(GDPGP1)
PSS: 102450889(GDPGP1)
CMY: 102940662(GDPGP1)
CPIC: 101931318(GDPGP1)
PVT: 110091453(GDPGP1)
PBI: 103057762(GDPGP1)
PMUR: 107283945(GDPGP1)
TSR: 106551043(GDPGP1)
PMUA: 114584049(GDPGP1) 114590319
GJA: 107125346(GDPGP1)
XLA: 100126619(gdpgp1.S)
XTR: 779852(gdpgp1)
NPR: 108799851(GDPGP1)
DRE: 560896(zgc:153343)
SANH: 107673239(gdpgp1)
CCAR: 109051094(gdpgp1)
IPU: 108274456(gdpgp1)
PHYP: 113529577(gdpgp1)
AMEX: 103039909(gdpgp1)
EEE: 113588515(gdpgp1)
LCO: 104925271(gdpgp1)
NCC: 104944010(gdpgp1)
MZE: 101485114(gdpgp1)
ONL: 100709951(gdpgp1)
OLA: 101157128(gdpgp1)
XMA: 102218616(gdpgp1)
XCO: 114136469(gdpgp1)
PRET: 103466114(gdpgp1)
CVG: 107103865(gdpgp1)
NFU: 107388974(gdpgp1)
KMR: 108239930(gdpgp1)
ALIM: 106515626(gdpgp1)
AOCE: 111563211(gdpgp1)
CSEM: 103380517(gdpgp1)
POV: 109624172(gdpgp1)
LCF: 108875359(gdpgp1)
SDU: 111228367(gdpgp1)
SLAL: 111655337(gdpgp1)
HCQ: 109530305(gdpgp1)
BPEC: 110165957(gdpgp1)
MALB: 109968722(gdpgp1)
SASA: 106573338(gdpgp1)
SALP: 111952815(gdpgp1)
ELS: 105018388(gdpgp1)
SFM: 108942052(gdpgp1)
PKI: 111846654(gdpgp1)
LCM: 102348470(GDPGP1)
CMK: 103188517(gdpgp1)
RTP: 109927396(gdpgp1)
CIN: 100175149
SPU: 581869
APLC: 110981940
SKO: 100367014
DPE: 6599840
DWI: 6645803
DAZ: 108612989
DNV: 108652377
DHE: 111605679
MDE: 101897755
AAG: 5574728
AME: 102655796
BIM: 100741522
BTER: 100645275
SOC: 105198366
MPHA: 105830050
AEC: 105143464
ACEP: 105617424
PBAR: 105431382
VEM: 105557187
HST: 105186148
DQU: 106749279
CFO: 105254250
PGC: 109863787
OBO: 105275338
PCF: 106793017
NVI: 100678972
CSOL: 105363960
MDL: 103570636
BMOR: 101737046
PMAC: 106711096
PRAP: 110997303
HAW: 110376713
TNL: 113500143
API: 100165161
DNX: 107161738
RMD: 113552096
BTAB: 109044281
CLEC: 106666055
ZNE: 110834328
FCD: 110859191
PVM: 113826729
TUT: 107365411
DPTE: 113789670
CSCU: 111625557
PTEP: 107446569
CEL: CELE_C10F3.4(mcp-1)
CBR: CBG09277
BMY: Bm1_24620
PCAN: 112570143
MYI: 110459831
OBI: 106880321
LAK: 106169828
SHX: MS3_04850
ADF: 107331927
AMIL: 114960700
DGT: 114528863
HMG: 100211520
AQU: 109582674
 » show all
Taxonomy
Reference
1  [PMID:21507950]
  Authors
Adler LN, Gomez TA, Clarke SG, Linster CL
  Title
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
  Journal
J Biol Chem 286:21511-23 (2011)
DOI:10.1074/jbc.M111.238774
  Sequence
[cel:CELE_C10F3.4] [hsa:390637] [mmu:269952]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.78
IUBMB Enzyme Nomenclature: 2.7.7.78
ExPASy - ENZYME nomenclature database: 2.7.7.78
BRENDA, the Enzyme Database: 2.7.7.78

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