KEGG ENZYME: 2.7.7.78

ENZYME: 2.7.7.78

Entry

EC 2.7.7.78                 Enzyme

Name

GDP-D-glucose phosphorylase

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

GDP:alpha-D-glucose 1-phosphate guanylyltransferase

Reaction(IUBMB)

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP [RN:R09752]

Reaction(KEGG)

R09752

Substrate

GDP-alpha-D-glucose [CPD:C00394];
phosphate [CPD:C00009]

Product

alpha-D-glucose 1-phosphate [CPD:C00103];
GDP [CPD:C00035]

Comment

The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.

History

EC 2.7.7.78 created 2011

Orthology

K15630

GDP-D-glucose phosphorylase

Genes

HSA:	390637(GDPGP1)

PTR:	745569(GDPGP1)

PPS:	100982804(GDPGP1)

GGO:	101152503(GDPGP1)

PON:	100444173(GDPGP1)

PPYG:

129013750(GDPGP1)

NLE:	100594834(GDPGP1)

HMH:	116463339 116463656

SSYN:

129482069(GDPGP1)

MCC:	701954(GDPGP1)

MCF:	102121174(GDPGP1)

MTHB:

126958918

MNI:	105488305(GDPGP1)

CSAB:

103231172(GDPGP1)

CATY:

105592385(GDPGP1)

PANU:

101001765(GDPGP1)

TGE:	112628320(GDPGP1)

MLEU:

105534254(GDPGP1)

RRO:	104674333(GDPGP1)

RBB:	108521402(GDPGP1)

TFN:	117070213(GDPGP1)

PTEH:

111522866(GDPGP1)

CANG:

105516194(GDPGP1)

CJC:	100392315(GDPGP1)

SBQ:	101035205(GDPGP1)

CIMI:

108295133(GDPGP1)

ANAN:

110566981(GDPGP1)

CSYR:

103250278(GDPGP1)

MMUR:

109729193(GDPGP1)

LCAT:

123645120(GDPGP1)

PCOQ:

105809851(GDPGP1)

OGA:	100955427(GDPGP1)

MMU:	269952(Gdpgp1)

MCAL:

110284623 110299146(Gdpgp1)

MPAH:

110332879(Gdpgp1)

RNO:	308763(Gdpgp1)

MCOC:

116102452(Gdpgp1)

ANU:	117724545(Gdpgp1)

MUN:	110558670(Gdpgp1)

CGE:	100772319(Gdpgp1)

MAUA:

101825757(Gdpgp1)

PROB:

127238109(Gdpgp1)

PLEU:

114696183(Gdpgp1)

MORG:

121447516(Gdpgp1)

MFOT:

126508646

AAMP:

119803074(Gdpgp1)

NGI:	103749895(Gdpgp1)

HGL:	106010011(Gdpgp1)

CPOC:

100728638(Gdpgp1)

CCAN:

109695080(Gdpgp1)

DORD:

105982483(Gdpgp1)

DSP:	122099985(Gdpgp1)

PLOP:

125367989(Gdpgp1)

NCAR:

124977685

MMMA:

107148418(Gdpgp1)

OCU:	100340539 127486175

OPI:	101525477(GDPGP1)

TUP:	102501837(GDPGP1)

GVR:	103582334(GDPGP1)

CFA:	479045(GDPGP1)

CLUD:

112653199(GDPGP1)

VVP:	112921582(GDPGP1)

VLG:	121489314(GDPGP1)

NPO:	129510280(GDPGP1)

AML:	100473017(GDPGP1)

UMR:	103660194(GDPGP1)

UAH:	113263710(GDPGP1)

UAR:	123802398(GDPGP1)

ELK:

111152581

LLV:

125105671

MPUF:

101677702(GDPGP1)

MNP:	131999037(GDPGP1)

MLK:	131835591(GDPGP1)

NVS:	122893100(GDPGP1)

ORO:	101375354(GDPGP1)

EJU:	114223308(GDPGP1)

ZCA:	113908789(GDPGP1)

MLX:	118023065(GDPGP1)

NSU:	110572299(GDPGP1)

LWW:	102740223(GDPGP1)

FCA:	101082062(GDPGP1)

PYU:	121042375(GDPGP1)

PCOO:

112856434(GDPGP1)

PBG:	122467548(GDPGP1)

PVIV:

125167996(GDPGP1)

LRUF:

124517240

PTG:	102960896(GDPGP1)

PPAD:

109273457(GDPGP1)

PUC:

125910796

AJU:

106965883

HHV:	120248616(GDPGP1)

BTA:	522909(GDPGP1)

BOM:	102288281(GDPGP1)

BIU:	109575519(GDPGP1)

BBUB:

102413903(GDPGP1)

BBIS:

104989390(GDPGP1)

CHX:	102169222(GDPGP1)

OAS:	101105361(GDPGP1)

BTAX:

128066795(GDPGP1)

ODA:	120875604(GDPGP1)

CCAD:

122455246(GDPGP1)

MBEZ:

129550296(GDPGP1)

SSC:	100156697(GDPGP1)

CFR:	102510192(GDPGP1)

CBAI:

105069073(GDPGP1)

CDK:	105094688(GDPGP1)

VPC:	102544623(GDPGP1)

BACU:

102999980(GDPGP1)

BMUS:

118890213(GDPGP1)

LVE:	103071553(GDPGP1)

OOR:	101269491(GDPGP1)

DLE:	111169638(GDPGP1)

PCAD:

102976512(GDPGP1)

PSIU:

116748900(GDPGP1)

NASI:

112414189(GDPGP1)

ECB:	100069039(GDPGP1)

EPZ:	103558648(GDPGP1)

EAI:	106832038(GDPGP1)

MYB:	102240979(GDPGP1)

MYD:	102759603(GDPGP1)

MMYO:

118679198(GDPGP1)

MLF:	102442851(GDPGP1)

MDT:	132222826(GDPGP1)

PKL:	118706316(GDPGP1)

EFUS:

103304347(GDPGP1)

MNA:	107540393(GDPGP1)

DRO:	112305927(GDPGP1)

SHON:

118991957(GDPGP1)

AJM:	119049089(GDPGP1)

PDIC:

114488604(GDPGP1)

PHAS:

123809629(GDPGP1)

MMF:	118640974(GDPGP1)

PPAM:

129073891(GDPGP1)

HAI:	109381493(GDPGP1)

RFQ:	117018794(GDPGP1)

PALE:

102885796(GDPGP1)

PGIG:

120599250(GDPGP1)

PVP:	105305172(GDPGP1)

RAY:	107514142(GDPGP1)

MJV:	108387049(GDPGP1)

TOD:	119245166(GDPGP1)

SARA:

101542172(GDPGP1)

SETR:

126022926(GDPGP1)

LAV:	100673104(GDPGP1)

TMU:

101351913

ETF:	101654620(GDPGP1)

DNM:	101429127(GDPGP1)

MDO:	100015004(GDPGP1)

GAS:	123238103(GDPGP1)

SHR:	100923815(GDPGP1)

AFZ:

127551401

PCW:	110192344(GDPGP1)

TVP:	118828239(GDPGP1)

OAA:	100081924(GDPGP1)

GGA:	100858151(GDPGP1)

PCOC:

116225529(GDPGP1)

MGP:	104912902(GDPGP1)

CJO:	107318942(GDPGP1)

TPAI:

128075663(GDPGP1)

LMUT:

125697986(GDPGP1)

NMEL:

110403483(GDPGP1)

APLA:

113844911(GDPGP1)

ACYG:

125179801(GDPGP1)

CATA:

118259442(GDPGP1)

AFUL:

116493558(GDPGP1)

TGU:	115496640(GDPGP1)

LSR:	110476688(GDPGP1)

PMOA:

120508890(GDPGP1)

OTC:	121343688(GDPGP1)

PRUF:

121352238(GDPGP1)

OMA:	130257322(GDPGP1)

PHI:	102109647(GDPGP1)

PMAJ:

107209304(GDPGP1)

CCW:	120410531(GDPGP1)

ETL:	114064281(GDPGP1)

ZLE:	135452244(GDPGP1)

SVG:	106860100(GDPGP1)

MMEA:

130575741(GDPGP1)

HRT:	120759001(GDPGP1)

SATI:

136366857(GDPGP1)

SHAB:

115612940(GDPGP1)

TALA:

122154562(GDPGP1)

ACHC:

115342064(GDPGP1)

AGEN:

126043872

DPUB:

104297413(GDPGP1)

RTD:	128914636(GDPGP1)

AAM:	106491439(GDPGP1)

AROW:

112963568(GDPGP1)

DNE:	112995336(GDPGP1)

ASN:	102383638(GDPGP1)

AMJ:	102563294(GDPGP1)

PSS:	102450889(GDPGP1)

CMY:	102940662(GDPGP1)

CCAY:

125643394(GDPGP1)

DCC:	119862450(GDPGP1)

CPIC:

101931318(GDPGP1)

TST:	117884505(GDPGP1)

CABI:

116833023(GDPGP1)

MRV:	120372818(GDPGP1)

ASAO:

132762450(GDPGP1)

PVT:	110091453(GDPGP1)

SUND:

121933428(GDPGP1)

PBI:	103057762(GDPGP1)

PMUR:

107283945(GDPGP1)

CTIG:

120316444(GDPGP1)

TSR:	106551043(GDPGP1)

PGUT:

117676218(GDPGP1)

APRI:

131184491(GDPGP1)

PTEX:

113441981(GDPGP1)

NSS:	113423333(GDPGP1)

VKO:	123030721(GDPGP1)

PMUA:

114584049(GDPGP1) 114590319

PRAF:

128401256(GDPGP1)

ZVI:	118092440(GDPGP1)

HCG:	128334902(GDPGP1)

GJA:	107125346(GDPGP1)

STOW:

125424480(GDPGP1)

EMC:	129345763(GDPGP1)

XLA:	100126619(gdpgp1.S)

XTR:	779852(gdpgp1)

NPR:	108799851(GDPGP1)

RTEM:

120931228(GDPGP1)

BBUF:

120985910(GDPGP1)

BGAR:

122929600(GDPGP1)

MUO:	115460667(GDPGP1)

GSH:	117348040(GDPGP1)

DRE:	560896(gdpgp1)

SRX:	107720778 107750735

SANH:

107673239(gdpgp1)

SGH:	107564608 107581860

CCAR:

109051094(gdpgp1)

CAUA:

113043726(gdpgp1)

CGIB:

128014543

PTET:

122331002(gdpgp1)

LROH:

127156872(gdpgp1)

OMC:	131534523(gdpgp1)

PPRM:

120468302(gdpgp1)

RKG:	130073656(gdpgp1)

MAMB:

125247836(gdpgp1)

CIDE:

127507665

CERY:

137015358(gdpgp1)

MASI:

127435945

TROS:

130551934(gdpgp1)

TDW:	130414293(gdpgp1)

MANU:

129434114(gdpgp1)

IPU:

108274456

IFU:	128618344(gdpgp1)

PHYP:

113529577(gdpgp1)

SMEO:

124392675(gdpgp1)

TFD:	113659898(gdpgp1)

TVC:	132856709(gdpgp1)

TRN:	134320257(gdpgp1)

AMEX:

103039909(gdpgp1)

CMAO:

118811579(gdpgp1)

EEE:	113588515(gdpgp1)

CHAR:

105904686(gdpgp1)

TRU:	101072037 101072254

TFS:	130536368 130536369 130536664

TNG:	GSTEN00022830G001

LCO:	104925271(gdpgp1)

NCC:	104944010(gdpgp1)

TBEN:

117491599(gdpgp1)

CGOB:

115009893(gdpgp1)

PGEO:

117448085(gdpgp1)

GACU:

117545686(gdpgp1)

EMAC:

134874207(gdpgp1)

ELY:	117262071(gdpgp1)

EFO:	125887435(gdpgp1)

PLEP:

121950567(gdpgp1)

SLUC:

116038786(gdpgp1)

ECRA:

117948447(gdpgp1)

ESP:	116693662(gdpgp1)

PFLV:

114560491(gdpgp1)

GAT:	120809727(gdpgp1) 120812884

PPUG:

119196381(gdpgp1)

AFB:	129108751(gdpgp1)

CLUM:

117732278(gdpgp1)

PSWI:

130191543(gdpgp1)

MSAM:

119893106(gdpgp1)

SCHU:

122875296(gdpgp1)

CUD:	121515270(gdpgp1)

ALAT:

119024982(gdpgp1)

ASTR:

137594346(gdpgp1)

MZE:	101485114(gdpgp1)

ONL:	100709951(gdpgp1)

OAU:	116334578(gdpgp1)

OLA:	101157128(gdpgp1)

OML:	112152784(gdpgp1)

CSAI:

133444704(gdpgp1)

XMA:	102218616(gdpgp1)

XCO:	114136469(gdpgp1)

XHE:	116711680(gdpgp1)

PRET:

103466114(gdpgp1)

PFOR:

103133662(gdpgp1)

PLAI:

106945054(gdpgp1)

PMEI:

106927563(gdpgp1)

GAF:	122835722(gdpgp1)

PPRL:

129362682(gdpgp1)

CVG:	107103865(gdpgp1)

CTUL:

119793091(gdpgp1)

GMU:	124859451(gdpgp1)

NFU:	107388974(gdpgp1)

KMR:	108239930(gdpgp1)

ALIM:

106515626(gdpgp1)

NWH:	119416201(gdpgp1)

AOCE:

111563211(gdpgp1)

MCEP:

125015000(gdpgp1)

CSEM:

103380517(gdpgp1)

POV:	109624172(gdpgp1)

SSEN:

122776074(gdpgp1)

HHIP:

117762907(gdpgp1)

HSP:	118109092(gdpgp1)

PPLT:

128444196(gdpgp1)

SMAU:

118315811(gdpgp1)

LCF:

108875359

SDU:	111228367(gdpgp1)

SLAL:

111655337(gdpgp1)

XGL:	120792726(gdpgp1)

HCQ:	109530305(gdpgp1)

SSCV:

125970634

SBIA:

133502086(gdpgp1)

PEE:	133403071(gdpgp1)

PTAO:

133477756(gdpgp1)

BPEC:

110165957(gdpgp1)

MALB:

109968722(gdpgp1)

BSPL:

114857720(gdpgp1)

SJO:	128359091(gdpgp1)

SASA:

106573338(gdpgp1)

STRU:

115152139(gdpgp1)

OTW:	112252520(gdpgp1)

OMY:	110522429(gdpgp1)

OGO:	124002222(gdpgp1)

ONE:	115109524(gdpgp1)

OKI:	109889497(gdpgp1)

SALP:

111952815(gdpgp1)

SNH:	120053493(gdpgp1)

CCLU:

121577033

ELS:	105018388(gdpgp1)

SFM:	108942052(gdpgp1)

PKI:	111846654(gdpgp1)

AANG:

118214734(gdpgp1)

LOC:	102691990(gdpgp1)

PSPA:

121294398 121304412

ARUT:

117428563 117429721

PSEX:

120541425(gdpgp1)

LCM:	102348470(GDPGP1)

CMK:	103188517(gdpgp1)

RTP:	109927396(gdpgp1)

CPLA:

122542567(gdpgp1)

HOC:	132834724(gdpgp1)

LERI:

129713513(gdpgp1)

PMRN:

116950847(GDPGP1)

LRJ:	133354200 133354289

BFO:

118427772

BBEL:

109474983

CIN:	100175149 100180071

SCLV:

120336599 120336600 120347485

SPU:	115929696 581869

LPIC:

129264291

APLC:

110981940

AJC:

117104407

SKO:

100367014

DPO:

4812246

DPE:

6599840

DMN:

108151241

DWI:

6645803

DMO:	Dmoj_GI11948

DAZ:

108612989

DNV:

108652377

DHE:

111605679

AGA:

1272333

ACOZ:

120961566

AARA:

120905589

AMER:

121598020

AAG:

5574728

AALB:

109397655 115271003

ASUA:

134210875

CQU:	CpipJ_CPIJ015695

CPII:

120421215

AME:

102655796

ACER:

108003410

ALAB:

122712501

ADR:

102673795

AFLR:

100868601

BIM:

100741522

BBIF:

117214893

BVK:

117241050

BVAN:

117162014

BAFF:

126926082

BPYO:

122577536

BPAS:

132915156 132915890

MGEN:

117227920

NMEA:

116429382

CGIG:

122399628

SOC:

105198366

MPHA:

105830050

AEC:

105143464

ACEP:

105617424

PBAR:

105431382

VEM:

105557187

HST:

105186148

DQU:

106749279

CFO:

105254250

FEX:

115233269

PGC:

109863787

OBO:

105275338

PCF:

106793017

PFUC:

122519643

VPS:

122631723

VCRB:

124427019

VVE:

124952198

NVI:

100678972

CSOL:

105363960

TPRE:

106648467

LBD:

127287374

MDL:

103570636

CGLO:

123266775

FAS:

105269392

DAM:

107044491

AGIF:

122860295

VCAN:

122411928

CCIN:

107264777

DSM:	124404243 124404429

NPT:	124212822 124212988

NFB:	124175522 124176348

NLO:	107221335 107227841

NVG:	124297676 124298652

AROA:

105686670

BMOR:

101737046

BMAN:

114246293

MSEX:

115446077

DPL:	KGM_213251

BANY:

112056784

MJU:

123876545

NIQ:

126776957

VCD:

124537983

MCIX:

123662833

PMAC:

106711096

PPOT:

106105527

PXU:

106120627

PRAP:

110997303

ZCE:

119837479

CCRC:

123701278

AAGE:

121726540

HAW:

110376713

HZE:

124635735

TNL:

113500143

SLIU:

111354393

OFU:

114351687

ATRA:

106138764

GMW:

113512039

PXY:

105394808

PGW:

126375537

LGLY:

125235878

API:

100165161

DNX:

107161738

AGS:	114132837 114132919

RMD:

113552096

ACOO:

126843360

DVT:

126897141

BTAB:

109044281

CLEC:

106666055

HHAL:

106682734

HVI:	124373516 124373924

MQU:	128981888 128987677

FOC:

113208888

TPAL:

117649856

ZNE:

110834328

CSEC:

111870762

SGRE:

126284881

BROR:

134537265

IEL:

124154161

FCD:

110859191

DPX:	DAPPUDRAFT_100309 DAPPUDRAFT_42599

DMK:	116926423 116931567

DPZ:	124327202 124349845

PVM:

113826729

PJA:

122259115

PCHN:

125036189

HAME:

121857389

PCLA:

123764816

CQD:

128689652

PTRU:

123498229

ESN:	126993363 126998527

MNZ:

135207284

MRJ:

136850611

HAZT:

108670309

EAF:	111714904 111714909

LSM:

121128700

TCF:

131886520

PPOI:

119093585 119094114

DSV:

119457516

RSAN:

119375495

RMP:

119166956

TUT:

107365411

DPTE:

113789670

DFR:

124494687

CSCU:

111625557

CVS:

136986879

ABRU:

129959434

UDV:

129218535

SDM:

118197335

LPOL:

106469059

PMEO:

129584913

CEL:	CELE_C10F3.4(mcp-1)

CBR:	CBG_09277(Cbr-mcp-1)

CRQ:	GCK72_017844

NAI:	NECAME_04942

BMY:	BM_BM2136(Bma-mcp-1)

LOA:	LOAG_18387

HRO:	HELRODRAFT_90313

LGI:	LOTGIDRAFT_225290

PVUL:

126821851

PCAN:

112570143

BGT:

106064818

GAE:

121370366

HRF:

124137027

HRJ:

124276128

CRG:

105331436

CANU:

128175015

CVN:

111130481

OED:

125652187

MYI:

110459831

PMAX:

117324275

MCAF:

127738667

MMER:

123525396

RPHI:

132719921 132736207

DPOL:

127870803

MAEA:

128207250

OSN:

115217172

LJP:

135468699

LAK:

106169828

LLON:

135485501

NVE:

5511059

EPA:	110233030 110235795

ATEN:

116295236 116295707

ADF:

107331927

AMIL:

114960700

PDAM:

113680044 113680045

SPIS:

111338205

DGT:

114528863

XEN:

124451432

HMG:

100211520

HSY:

130612752

RES:

135694650

TAD:	TRIADDRAFT_52681

AQU:

109582674

EGR:

108953908

SRE:	PTSG_04213

EHX:	EMIHUDRAFT_108620

» show all

Reference

1 [PMID:21507950]

Authors

Adler LN, Gomez TA, Clarke SG, Linster CL

Title

A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.

Journal

J Biol Chem 286:21511-23 (2011)
DOI:10.1074/jbc.M111.238774

Sequence

[cel:CELE_C10F3.4] [hsa:390637] [mmu:269952]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.78

IUBMB Enzyme Nomenclature:

2.7.7.78

ExPASy - ENZYME nomenclature database:

2.7.7.78

BRENDA, the Enzyme Database:

2.7.7.78

DBGET integrated database retrieval system