Entry
Name
tRNAHis guanylyltransferase;
histidine tRNA guanylyltransferase;
Thg1p (ambiguous);
Thg1 (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
p-tRNAHis:GTP guanylyltransferase (ATP-hydrolysing)
Reaction(IUBMB)
p-tRNAHis + ATP + GTP + H2O = pGp-tRNAHis + AMP + 2 diphosphate (overall reaction);
(1a) p-tRNAHis + ATP = App-tRNAHis + diphosphate;
(1b) App-tRNAHis + GTP = pppGp-tRNAHis + AMP;
(1c) pppGp-tRNAHis + H2O = pGp-tRNAHis + diphosphate
Substrate
p-tRNAHis;
ATP [CPD:
C00002 ];
GTP [CPD:
C00044 ];
H2O [CPD:
C00001 ];
App-tRNAHis;
pppGp-tRNAHis
Product
pGp-tRNAHis;
AMP [CPD:
C00020 ];
diphosphate [CPD:
C00013 ];
App-tRNAHis;
pppGp-tRNAHis
Comment
In eukarya an additional guanosine residue is added post-transcriptionally to the 5'-end of tRNAHis molecules. The addition occurs opposite a universally conserved adenosine73 and is thus the result of a non-templated 3'-5' addition reaction. The additional guanosine residue is an important determinant for aminoacylation by EC
6.1.1.21 , histidine---tRNA ligase.The enzyme requires a divalent cation for activity [2]. ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNAHis) [3].
History
EC 2.7.7.79 created 2011
Orthology
K10761 tRNA(His) guanylyltransferase
Genes
PANU : 101023046(THG1L) 116273266
ANAN : 105716558 105719487(THG1L)
RTEM : 120932585(THG1L) 120946740
SGH : 107551452(thg1l) 107580781 107587123
CCAR : 109066864 109102429
CAUA : 113057666 113078452 113098246
CGIB : 127971848 128027027
PTET : 122357321 122357791(thg1l)
MASI : 127412728 127417614
MSAM : 119882146 119888307
PFOR : 103154062 103154066
PMEI : 106912891 106912903
SASA : 100195605(thg1) 106604278
OKE : 118372983(thg1l) 118381557
CCLU : 121536730(thg1l) 121539421
PSPA : 121297291 121323830(thg1l)
ARUT : 117413410 117431376
DSI : Dsimw501_GD21976(Dsim_GD21976)
CCAT : 101462141 111591800
TDA : 119671222 119671231 119672674
PPAP : 129805379 129805380
PPYR : 116171280 116171374
CFEL : 113366709 113390979
BTAB : 109036128 109036130
PMAX : 117319880 117339410
DPOL : 127841809 127842884
AMIL : 114958174 114958205
TAD : TRIADDRAFT_32525 TRIADDRAFT_55308
CRB : 17889197 17889432 17889503
CSAT : 104700225 104700306 104749634 104749738 104786351 104786354 104786461
BNA : 106391044 106392395 106437722 106445690
RSZ : 108807291 108813816 108827686 108828391 108845426 130504187 130509169
RARG : 115727821 125314150
GMX : 100802539 100810659 100817433
GSJ : 114372276 114389412 114405598
VAR : 108324927 108339100 128193637 128196577
VVO : 131603230 131610670 131632109
LANG : 109326607 109329221
PCIN : 129290336 129296318
QSA : O6P43_028649 O6P43_031237
PAVI : 110754953 110765697
MSYL : 126584884 126620985
HBR : 110664462 110664493 110666869
CILL : 122295349 122304564
CAVE : 132165241 132173585
SSTN : 125855207 125856629 125860497
NTA : 107788909 107800326 107816514
ITR : 116016130 116027252 116027354
SSPL : 121748281 121767258 121770937 121789395 121790126 121791829
SHIS : 125200830 125201700 125202562 125210589
CQI : 110682550 110706826 110718765
PSOM : 113286460 113292611 113298353 113302343
TDC : 119267754 119275627 119293367 119299358 119307540
TAES : 123058199 123069455 123077969 123102336 123110529 123119525 123158120
LPER : 127321797 127342139
PVIR : 120664812 120673520 120698011
MSIN : 131223439 131243943
SMO : SELMODRAFT_105392 SELMODRAFT_232047
CGR : 2889888(GVI51_J00099)
NDI : NDAI_0D03900(NDAI0D03900)
TPF : TPHA_0F00940(TPHA0F00940)
TBL : TBLA_0G01180(TBLA0G01180)
TDL : TDEL_0D02910(TDEL0D02910)
KAF : KAFR_0F03760(KAFR0F03760)
KNG : KNAG_0D03850(KNAG0D03850)
LBG : 92211023(LODBEIA_P58270)
CAL : CAALFM_C700560CA(THG1)
YLI : 2912569(YALI2_E01566g)
NTE : NEUTE1DRAFT70540(NEUTE1DRAFT_70540)
SMP : 10810541(SMAC4_05003)
FPOA : FPOAC1_000972(RGT1)
NHE : NECHADRAFT_30739 NECHADRAFT_87153
TATV : 25783741(TrAtP1_006458)
PLJ : 28891182(PLICBS_004522)
CDET : 87948819(CDEST_12319)
BFU : BCIN_05g04330(Bcthg1)
CIM : CIMG_13693(CIMG03241)
PNO : SNOG_06471 SNOG_14258
ADAC : 96082265(ACET3X_001943) 96087195(ACET3X_006873)
TML : GSTUM_00002202001 GSTUM_00004516001
CDEP : 91088663(L203_104453)
KMG : 30166896(I203_100509)
KNE : 92181774(IAR55_004516)
CCAC : CcaHIS019_0203610(THG1)
PPL : POSPLDRAFT_87675 POSPLDRAFT_88866
ADL : AURDEDRAFT_107511 AURDEDRAFT_146700
ABP : AGABI1DRAFT121643(AGABI1DRAFT_121643)
ABV : AGABI2DRAFT200849(AGABI2DRAFT_200849)
SCM : SCHCO_02501794(SCHCODRAFT_02501794)
DPP : DICPUDRAFT_152806 DICPUDRAFT_83062
PLAG : 39741136(PADL01_0721000)
PBRS : 92369094(MKS88_001004)
TET : TTHERM_00085230 TTHERM_00373760
SPAR : SPRG_05518 SPRG_16419
» show all
Taxonomy
Reference
Authors
Jahn D, Pande S
Title
Histidine tRNA guanylyltransferase from Saccharomyces cerevisiae. II. Catalytic mechanism.
Journal
J Biol Chem 266:22832-6 (1991)
Reference
Authors
Pande S, Jahn D, Soll D
Title
Histidine tRNA guanylyltransferase from Saccharomyces cerevisiae. I. Purification and physical properties.
Journal
J Biol Chem 266:22826-31 (1991)
Reference
Authors
Gu W, Jackman JE, Lohan AJ, Gray MW, Phizicky EM
Title
tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis.
Journal
Sequence
Reference
Authors
Placido A, Sieber F, Gobert A, Gallerani R, Giege P, Marechal-Drouard L
Title
Plant mitochondria use two pathways for the biogenesis of tRNAHis.
Journal
Sequence
Reference
Authors
Jackman JE, Phizicky EM
Title
Identification of critical residues for G-1 addition and substrate recognition by tRNA(His) guanylyltransferase.
Journal
Reference
Authors
Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublie S
Title
tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.79
ExPASy - ENZYME nomenclature database: 2.7.7.79