Entry
Name
CMP-N,N'-diacetyllegionaminic acid synthase;
CMP-N,N'-diacetyllegionaminic acid synthetase;
neuA (gene name);
legF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:N,N'-diacetyllegionaminate cytidylyltransferase
Reaction(IUBMB)
CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate [RN:
R10182 ]
Reaction(KEGG)
Substrate
Product
CMP-N,N'-diacetyllegionaminate [CPD:
C20419 ];
diphosphate [CPD:
C00013 ]
Comment
Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.
History
EC 2.7.7.82 created 2012
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
K18431 CMP-N,N'-diacetyllegionaminic acid synthase
Genes
SOF : NCTC11214_05338(neuA)
PSYC : DABAL43B_0735(neuA)
ILI : K734_02595 K734_02775
LCD : clem_09295(neuA_1) clem_09325(neuA_2) clem_09390(neuA_3) clem_09460(neuA_4)
LWA : SAMEA4504053_1065(neuA)
LCAD : PXX05_08085 PXX05_08230
TSE : THMIRHAS_08980(neuA)
GAI : IMCC3135_21680(neuA_1) IMCC3135_22670(neuA_2)
HAHE : ENC22_08715 ENC22_10840
THO : SP60_02300 SP60_02365
RBS : RHODOSMS8_01664(legF)
BRC : BCCGELA001_25440 BCCGELA001_25505
BOT : CIT37_24310 CIT37_24405
BRQ : CIT40_21835 CIT40_21930
BSYM : CIT39_21125 CIT39_21220
RBZ : B9057_08970 B9057_15025
LVS : LOKVESSMR4R_02195(legF)
ALI : AZOLI_p60076 AZOLI_p60140(neuA)
AZZ : DEW08_29930 DEW08_30030
MAGQ : MGMAQ_3695 MGMAQ_3718
HCP : HCN_1207 HCN_1208 HCN_1209 HCN_1214
HCB : HCBAA847_0752 HCBAA847_0757 HCBAA847_0758 HCBAA847_0759
HCL : NCTC13205_00836(siaB)
CJY : QZ67_01222 QZ67_01467(legF)
CJL : PJ17_05855 PJ17_07040 PJ17_07460
CJW : PJ18_05665 PJ18_06840
CJZ : M635_01415 M635_02350
CCOC : CCON33237_1634(legF)
CCOL : BN865_08050c BN865_09870c
CCC : G157_01710 G157_02165
CCY : YSS_06180 YSS_07220 YSS_07635
CCOO : ATE51_00902(legF_2)
CAJ : CIG1485E_0045 CIG1485E_0047(legF)
CIS : CINS_1190(legF) CINS_1203(neuA)
CHV : CHELV3228_1651(legF)
CAMZ : CVIC12175_0318(legF)
CUX : CUP3940_0188(legF) CUP3940_0882(neuA)
GSUB : KP001_18470 KP001_19695
GPL : M1B72_02000 M1B72_03385
DFL : DFE_2596 DFE_2600 DFE_2854
PSEL : GM415_02260 GM415_04205
SBF : JCM31447_25320 JCM31447_25510
OBG : Verru16b_02057(neuA)
LAJ : A0128_07325 A0128_07405
COPR : Cop2CBH44_22050(neuA)
FOK : KK2020170_01080(neuA)
POLA : BXQ17_03855 BXQ17_13945
PPEC : H9W90_01225 H9W90_03860
KOS : KORDIASMS9_03605(neuA)
KAN : IMCC3317_05770(neuA)
CJG : NCTC13459_02718(neuA)
CANT : NCTC13489_01538(neuA)
PROC : Ptc2401_00369(neuA)
DTP : JZK55_12510 JZK55_23620
EFU : HMPREF0351_10922(neuA)
HHW : NCTC503_01055(neuA_1)
ANR : Ana3638_07750 Ana3638_07860
HALS : D7D81_05085 D7D81_17920
MANA : MAMMFC1_02390(neuA)
DSL : Dacsa_0260 Dacsa_2196
MPRO : BJP34_15945 BJP34_26760 BJP34_35260
CGW : UR58_C0001G0067(neuA)
» show all
Taxonomy
Reference
Authors
Glaze PA, Watson DC, Young NM, Tanner ME
Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
Journal
Sequence
Reference
Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.82
ExPASy - ENZYME nomenclature database: 2.7.7.82