KEGG   ENZYME: 2.7.7.82Help
Entry
EC 2.7.7.82                 Enzyme                                 

Name
CMP-N,N'-diacetyllegionaminic acid synthase;
CMP-N,N'-diacetyllegionaminic acid synthetase;
neuA (gene name);
legF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:N,N'-diacetyllegionaminate cytidylyltransferase
Reaction(IUBMB)
CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate [RN:R10182]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
N,N'-diacetyllegionaminate [CPD:C20418]
Product
CMP-N,N'-diacetyllegionaminate [CPD:C20419];
diphosphate [CPD:C00013]
Comment
Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.
History
EC 2.7.7.82 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K18431  CMP-N,N'-diacetyllegionaminic acid synthase
Genes
PMAI: CF386_03190
LPN: lpg0751(neuA)
LPH: LPV_0877(neuA)
LPO: LPO_0832(neuA)
LPU: LPE509_02460
LPM: LP6_0731(neuA)
LPF: lpl0788(neuA)
LPP: lpp0817(neuA)
LPC: LPC_2541(neuA)
LPA: lpa_01159(neuA)
LPE: lp12_0761
FPH: Fphi_1170
FPI: BF30_1414
FPX: KU46_144
HCP: HCN_1208
SULR: B649_08520
CJE: Cj1331(ptmB)
CJB: BN148_1331(ptmB)
CJI: CJSA_1267(ptmB)
CJS: CJS3_1425
CJEJ: N564_02275
CJEU: N565_02365
CJEN: N755_02425
CJEI: N135_01419
CJER: H730_07610
CJY: QZ67_01467(legF_2)
CJQ: UC78_1274(legF_2)
CJR: CJE1520(ptmB)
CJD: JJD26997_0378(ptmB)
CCO: CCC13826_2299(legF)
CCOC: CCON33237_1634(legF)
CLA: CLA_1229(legF)
CCQ: N149_1294(legF)
CCF: YSQ_02195
CCY: YSS_07220
CCOI: YSU_02230
CCOF: VC76_06680(legF_2)
CCOO: ATE51_00902(legF_2)
CAJ: CIG1485E_0047(legF)
CIS: CINS_1190(legF)
CVO: CVOL_1210(legF)
CSM: CSUB8521_1413(legF)
CSF: CSUB8523_1513(legF)
CHV: CHELV3228_1651(legF)
CLX: CLAN_1245(legF)
CAVI: CAV_1245(legF)
CAMZ: CVIC12175_0318(legF)
CAMY: CSUIS_1332(legF)
ABT: ABED_0623
ARC: ABLL_0815
PPY: PPE_04402
EFU: HMPREF0351_10922(neuA)
CBL: CLK_2102
CBB: CLD_1850
CBN: CbC4_0995
CKL: CKL_2466(neuA)
CKR: CKR_2180
CTH: Cthe_2639
BPB: bpr_I0432(neuA1)
CST: CLOST_0369(neuA)
AWO: Awo_c24820(neuA)
TIT: Thit_0484
TSH: Tsac_2665
LIL: LA_1605(neuA)
LIE: LIF_A1292(neuA)
LIC: LIC_12177(neuA)
 » show all
Taxonomy
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s
  Sequence
[lpn:lpg0751]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039
  Sequence
[cje:Cj1331]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.82
IUBMB Enzyme Nomenclature: 2.7.7.82
ExPASy - ENZYME nomenclature database: 2.7.7.82
BRENDA, the Enzyme Database: 2.7.7.82

DBGET integrated database retrieval system