KEGG   ENZYME: 2.7.7.83Help
Entry
EC 2.7.7.83                 Enzyme                                 

Name
UDP-N-acetylgalactosamine diphosphorylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase
Reaction(IUBMB)
UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-galactosamine [RN:R10183]
Reaction(KEGG)
Substrate
UTP [CPD:C00075];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]
Product
diphosphate [CPD:C00013];
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203]
Comment
The enzyme from plants and animals also has activity toward N-acetyl-alpha-D-glucosamine 1-phosphate (cf. EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase) [1,2].
History
EC 2.7.7.83 created 2012
Orthology
K00972  UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase
K23144  UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
Genes
HSA: 6675(UAP1) 91373(UAP1L1)
PTR: 457466(UAP1) 464884(UAP1L1)
PPS: 100986482(UAP1) 100986664(UAP1L1)
GGO: 101135679(UAP1L1) 101145360(UAP1)
PON: 100435911(UAP1L1) 100450408(UAP1)
NLE: 100586786(UAP1) 100594334(UAP1L1)
MCC: 100427106(UAP1L1) 720116(UAP1)
MCF: 102118762(UAP1L1) 102130000(UAP1)
CSAB: 103223657(UAP1) 103239583(UAP1L1)
RRO: 104656790(UAP1) 104669772(UAP1L1) 104676993
RBB: 108525180 108535571(UAP1) 108542834(UAP1L1)
CJC: 100392251(UAP1L1) 100409092(UAP1)
SBQ: 101046300(UAP1) 101054466(UAP1L1)
MMU: 107652(Uap1) 227620(Uap1l1)
RNO: 296560(Uap1l1) 498272(Uap1)
CGE: 100768154(Uap1) 100771350(Uap1l1)
NGI: 103741175(Uap1l1) 103746786(Uap1)
HGL: 101710542(Uap1) 101725267(Uap1l1)
CCAN: 109690971(Uap1) 109697992(Uap1l1)
OCU: 100339004(UAP1)
TUP: 102470954(UAP1L1) 102471058(UAP1)
CFA: 488664(UAP1) 491239
AML: 100477861(UAP1L1) 100477971(UAP1)
UMR: 103658240(UAP1) 103675307(UAP1L1)
ORO: 101367554(UAP1) 101375418(UAP1L1)
FCA: 101083738(UAP1) 101101095(UAP1L1)
PTG: 102961155(UAP1) 102969130(UAP1L1)
AJU: 106986770(UAP1) 106989481(UAP1L1)
BTA: 100299558(UAP1L1) 535325(UAP1)
BOM: 102265390(UAP1) 102278095(UAP1L1) 102279063
BIU: 109577931(UAP1)
PHD: 102315392(UAP1) 102322805(UAP1L1)
CHX: 102180172(UAP1) 102182884(UAP1L1)
OAS: 101109315(UAP1) 105606002(UAP1L1) 114117808
SSC: 100156649(UAP1) 110258063(UAP1L1)
CFR: 102513027(UAP1) 102515044 102521245(UAP1L1)
CDK: 105092699(UAP1) 105106187(UAP1L1)
BACU: 103002658(UAP1L1) 103003827(UAP1)
LVE: 103077824(UAP1L1) 103084606(UAP1)
OOR: 101270979(UAP1) 101275413(UAP1L1)
ECB: 100067752(UAP1L1)
EPZ: 103559637(UAP1) 103568016(UAP1L1)
EAI: 106823691(UAP1) 106845497(UAP1L1)
MYB: 102239778(UAP1L1) 102249583(UAP1)
MYD: 102752558(UAP1) 102775206(UAP1L1)
HAI: 109381791(UAP1L1) 109392308(UAP1)
RSS: 109455650(UAP1) 109460943(UAP1L1)
PALE: 102892906(UAP1) 102894165(UAP1L1)
LAV: 100657458(UAP1) 100664908(UAP1L1)
MDO: 100012351(UAP1) 100022709(UAP1L1)
SHR: 100913995(UAP1L1) 100923432(UAP1)
OAA: 100080627(UAP1L1)
GGA: 417295(UAP1L1) 424368(UAP1)
MGP: 100544153(UAP1L1) 100544722(UAP1)
CJO: 107317136(UAP1) 107321675(UAP1L1)
APLA: 101799447(UAP1) 101802927(UAP1L1)
ACYG: 106037121(UAP1L1) 106041625(UAP1)
TGU: 100217671(UAP1L1) 100232443(UAP1)
SCAN: 103819203(UAP1L1) 103824325(UAP1)
GFR: 102031724(UAP1L1) 102042748(UAP1)
FAB: 101811976(UAP1) 101816266(UAP1L1)
PHI: 102104590(UAP1L1) 102107795(UAP1)
PMAJ: 107198633(UAP1) 107212038(UAP1L1)
CCAE: 111932511(UAP1) 111936882(UAP1L1)
CCW: 104695596(UAP1)
FPG: 101914606(UAP1L1) 101919583(UAP1)
FCH: 102051657(UAP1L1) 102059386(UAP1)
CLV: 102083611 102097917(UAP1)
EGZ: 104123975(UAP1L1) 104132129(UAP1)
NNI: 104010458(UAP1) 104018391(UAP1L1)
ACUN: 113483081(UAP1) 113486532(UAP1L1)
AAM: 106494268(UAP1L1) 106499709(UAP1)
ASN: 102372466(UAP1L1) 102379870(UAP1)
AMJ: 102570941(UAP1) 106737208(UAP1L1)
PSS: 102457317(UAP1L1) 102459048(UAP1)
CMY: 102943180(UAP1) 102944856(UAP1L1)
CPIC: 101930917(UAP1) 101947393(UAP1L1)
ACS: 100556659(uap1) 100557994(uap1l1)
PVT: 110078871(UAP1L1) 110081641(UAP1)
PBI: 103049480(UAP1L1) 103067864(UAP1)
PMUR: 107295059(UAP1L1) 107302859(UAP1)
GJA: 107121032(UAP1) 107123272(UAP1L1)
XLA: 100037187(uap1.L) 446803(uap1.S) 494771(uap1l1.L)
XTR: 496559(uap1) 548680(uap1l1)
NPR: 108797123(UAP1L1) 108799768(UAP1)
DRE: 322513(uap1) 393264(uap1l1)
IPU: 108260439 108271881(uap1)
PHYP: 113531036(uap1l1) 113538490(uap1)
AMEX: 103036709(uap1) 103046386(uap1l1)
EEE: 113570474(uap1) 113577557
TRU: 101067772(uap1l1) 101075041(uap1)
LCO: 104930789(uap1) 104936036
NCC: 104948233(uap1) 104967460
MZE: 101476630(uap1)
OLA: 101158685(uap1) 101171264
XMA: 102217070(uap1) 102217567(uap1l1)
PRET: 103463730(uap1) 103474058(uap1l1)
NFU: 107374999(uap1l1) 107393361(uap1)
CSEM: 103376749(uap1) 103389172
SDU: 111221078 111231961(uap1)
HCQ: 109532158(uap1)
BPEC: 110161766 110174038(uap1)
MALB: 109967003(uap1) 109970827
ELS: 105011860(uap1) 105030816
LCM: 102350964(UAP1) 102363974(UAP1L1)
CMK: 103180039(uap1) 103184673(uap1l1)
CIN: 100175591
SPU: 579319
APLC: 110984029
SKO: 102808632
DME: Dmel_CG9535(mmy)
DER: 6542455
DPE: 6593560
DSI: Dsimw501_GD22574(Dsim_GD22574)
DWI: 6646715
MDE: 101890766
AAG: 5571496
AME: 551964
BIM: 100747964
BTER: 100642344
SOC: 105201933
MPHA: 105840616
AEC: 105151716
ACEP: 105618835
PBAR: 105424691
HST: 105191087
DQU: 106741142
CFO: 105256980
LHU: 105675145
PGC: 109859247
OBO: 105277565
PCF: 106789218
NVI: 100118725
MDL: 103578848
NVL: 108557822
BMOR: 101746744
PMAC: 106709113
PRAP: 111002057
HAW: 110380128
TNL: 113492262
PXY: 105387928
API: 100163539
DNX: 107161282
CLEC: 106661195
ZNE: 110834312
FCD: 110850761
TUT: 107367688
DPTE: 113797718
CEL: CELE_C36A4.4(C36A4.4)
BMY: Bm1_39285
TSP: Tsp_05595
CRG: 105331206
MYI: 110446967
OBI: 106878995
LAK: 106173092
SHX: MS3_04133
EPA: 110240169
HMG: 100212797
AQU: 105312538
ATH: AT1G31070(GlcNAc1pUT1) AT2G35020(GlcNAc1pUT2)
CPAP: 110817410
CIT: 102622725
TCC: 18607026
GRA: 105763077
EGR: 104445823
VRA: 106768474
VAR: 108347864
CCAJ: 109812799
CAM: 101512555
LJA: Lj4g3v0243980.1(Lj4g3v0243980.1)
ADU: 107481634
AIP: 107631495
FVE: 101295983
PPER: 18778695
PMUM: 103325488
PAVI: 110767344
ZJU: 107410046
CSV: 101204428
CMO: 103484264
MCHA: 111015829
RCU: 8280391
JCU: 105641840
HBR: 110663551
MESC: 110611338
JRE: 108996252
SLY: 101262173
SPEN: 107011969
SOT: 102596743
CANN: 107858900
NSY: 104222819
NTO: 104094966
INI: 109165115
SIND: 105175890
LSV: 111915424
CCAV: 112511099
DCR: 108205157
BVG: 104898351
NNU: 104599693
DOSA: Os08t0206900-01(Os08g0206900)
ATS: 109782916(LOC109782916)
DCT: 110116189
PEQ: 110022181
ATR: 18443306
CRE: CHLREDRAFT_101274(UAP1)
APRO: F751_5975
SCE: YDL103C(QRI1)
ERC: Ecym_5628
KMX: KLMA_20643(QRI1)
NCS: NCAS_0B05930(NCAS0B05930)
NDI: NDAI_0B03240(NDAI0B03240)
TPF: TPHA_0C03700(TPHA0C03700)
TBL: TBLA_0B07300(TBLA0B07300)
TDL: TDEL_0G02780(TDEL0G02780)
KAF: KAFR_0K02470(KAFR0K02470)
PIC: PICST_61206(UAP1)
CAL: CAALFM_C502530WA(UAP1)
CDU: CD36_52300(UAP1)
CAUR: QG37_04534
SLB: AWJ20_1812(QRI1)
NCR: NCU02109
NTE: NEUTE1DRAFT70531(NEUTE1DRAFT_70531)
MGR: MGG_15671
SSCK: SPSK_00033
MAW: MAC_06193
MAJ: MAA_00708
CMT: CCM_05430
BFU: BCIN_05g00420(Bcqri1)
MBE: MBM_03405
ANI: AN9094.2
ANG: ANI_1_62104(An12g00480)
PBL: PAAG_12288(PAAG_06885)
ABE: ARB_04671
TVE: TRV_03114
PTE: PTT_15553
SPO: SPBC1289.08(uap1)
CNE: CNF01520
CNB: CNBF3190
ABP: AGABI1DRAFT110647(AGABI1DRAFT_110647)
ABV: AGABI2DRAFT189451(AGABI2DRAFT_189451)
MGL: MGL_0007
DDI: DDB_G0290055(uap1)
DFA: DFA_11605(uap1)
EHI: EHI_021200(30.t00023) EHI_039830(138.t00017)
PYO: PY17X_1362300(PY02947)
PCB: PCHAS_136120(PC000356.03.0)
TAN: TA20605
TPV: TP01_0489
BBO: BBOV_I003580(19.m02866)
CPV: cgd4_810
SMIN: v1.2.001128.t1(symbB.v1.2.001128.t1) v1.2.002197.t1(symbB.v1.2.002197.t1) v1.2.006730.t1(symbB.v1.2.006730.t1)
FCY: FRACYDRAFT_209086(UAP1)
GAI: IMCC3135_05880(gtaB_1)
DOL: Dole_2025
DAL: Dalk_0131
DAT: HRM2_25130(glmU)
SAT: SYN_02960
SFU: Sfum_2914
PMW: B2K_33455
RCH: RUM_22100
BPB: bpr_I0191(galU)
BFI: CIY_25470
BHU: bhn_I0192
RIX: RO1_01400
RIM: ROI_41240
COO: CCU_02080
CPY: Cphy_3128
ERT: EUR_25420
ERA: ERE_08640
SLAU: SLA_2433
PAC: PPA0922
PACC: PAC1_04870
PACH: PAGK_1230
CACN: RN83_04970
CGRN: 4412665_01042(glmU_2)
ACIJ: JS278_01917(glmU_1)
KAL: KALB_2025
DEV: DhcVS_470
DMC: btf_492(glmU1)
DMD: dcmb_538(glmU1)
DMG: GY50_0455(rfbA)
CAG: Cagg_2516
TRA: Trad_0907
CTR: CT_715
CTA: CTA_0777
CTY: CTR_7191
CRA: CTO_0777
CTRQ: A363_00769
CTB: CTL0084
CTO: CTL2C_91
CTJ: JALI_7201
CTZ: CTB_7201
CSW: SW2_7271
CES: ESW3_7271
CTRB: BOUR_00764
CTEC: EC599_7451
CFS: FSW4_7271
CFW: FSW5_7271
CTFW: SWFP_7801
CTCH: O173_03965
CTRI: BN197_7251
CTRA: BN442_7251
CTCT: CTW3_03990
CMU: TC_0088
CMUR: Y015_00470
CMX: DNC_00465
CMZ: TAC_00470
CPN: CPn0856
CPA: CP_1013
CPJ: CPj0856(CPj0856)
CPT: CpB0885
CPM: G5S_0185
CPEC: CPE3_0870
CPEO: CPE1_0869
CPER: CPE2_0870
CHB: G5O_0958
CHR: Cpsi_8961
CPSC: B711_1039
CPSN: B712_0978
CPSB: B595_1044
CPSG: B598_0976
CPSM: B602_0979
CPSI: B599_0975
CPSV: B600_1037
CPSW: B603_0982
CPST: B601_0983
CPSD: BN356_9001
CPSA: AO9_04680
CCA: CCA_00911
CAB: CAB879
CABO: AB7_9701
CFE: CF0103(uap)
CHLA: C834K_0938
PCU: pc0016(glmU)
PNL: PNK_2337(glmu3)
PUV: PUV_25530
WCH: wcw_1791(glmU3)
OTE: Oter_3747
AGL: PYTT_1213
RBA: RB6977
PSL: Psta_3921
PLM: Plim_4027
TTF: THTE_2792
GES: VT84_14840 VT84_32030(hddC_4)
IPA: Isop_0382
SACI: Sinac_5178
KST: KSMBR1_2229(uap1)
VBL: L21SP4_00737(glmU)
FSC: FSU_0643
CABY: Cabys_1408
MJA: MJ_1101
MMP: MMP1076
MMD: GYY_06215
MAE: Maeo_0642
MVO: Mvol_0247
MTH: MTH_1589
METC: MTCT_1448
MWO: MWSIV6_0133(glmU)
METE: tca_01538(glmU_3)
MST: Msp_1301
MSI: Msm_0655
MRU: mru_0456(glmU)
MEB: Abm4_0226(glmU)
MMIL: sm9_0316(glmU)
MEYE: TL18_01350
MOL: YLM1_0128
METH: MBMB1_0406(glmU)
MFC: BRM9_1856(glmU)
MCUB: MCBB_0372
MFV: Mfer_0129
MKA: MK0892
FPL: Ferp_2375
GAC: GACE_1114
GAH: GAH_01474
ABI: Aboo_0280
PHO: PH1925(PH1925)
PAB: PAB1115(graD-2)
PFU: PF0235
PFI: PFC_00225
PYN: PNA2_0881
PYS: Py04_0389
TKO: TK1188
TON: TON_0359
TGA: TGAM_0642
TSI: TSIB_1312
THE: GQS_03435
THA: TAM4_697
THM: CL1_0291
TLT: OCC_08739
THS: TES1_0783
TNU: BD01_0352
TEU: TEU_07655
PPAC: PAP_06275
MAC: MA_3025(rfbA)
MBAR: MSBR2_2453
MBAK: MSBR3_2500
MMA: MM_0302
MMAC: MSMAC_2357
METM: MSMTP_2241
MBU: Mbur_2341(glmU)
MMET: MCMEM_0484
MMH: Mmah_0055
MPY: Mpsy_2687
MTP: Mthe_0901
MCJ: MCON_1831 MCON_2572(glmU)
MHI: Mhar_2268
MHU: Mhun_2853
MLA: Mlab_0666
MBG: BN140_1431(glmU2)
MEMA: MMAB1_1836(rfbA)
MBN: Mboo_0254
MPL: Mpal_0314
MPD: MCP_0802
MEZ: Mtc_2010(glmU-2)
RCI: RCIX1438(rfbA-4)
HAL: VNG_0009G(graD2)
HSL: OE_1016R(graD2)
HALH: HTSR_0890(glmU)
HHSR: HSR6_0623(glmU) HSR6_0906(glmU2)
HSU: HLASF_0890(glmU)
HSF: HLASA_0887(glmU)
HMA: rrnAC1081(rffH1)
HHI: HAH_1684(rffH2)
NPH: NP_4276A(graD6) NP_4656A(graD2)
HUT: Huta_2917
HTI: HTIA_2588
HMU: Hmuk_2065
HWA: HQ_2992A(graD4)
HWC: Hqrw_3506(graD4)
HVO: HVO_A0586(graD3)
HME: HFX_2130(rffH1) HFX_6127(rffH1) HFX_6312(rffH1)
HTU: Htur_1202
NMG: Nmag_3048(graD2)
NAT: NJ7G_3629
ACJ: ACAM_0762
SMR: Smar_0849
IHO: Igni_0873
DKA: DKAM_1334
TAG: Tagg_1347
IAG: Igag_1093
HBU: Hbut_1036
STO: STK_04520
SSO: SSO0745
SOL: Ssol_1801
SSOA: SULA_1827
SSOL: SULB_1828
SSOF: SULC_1826
SAI: Saci_0619
SID: M164_1391
SII: LD85_1602
SIH: SiH_1343
SIR: SiRe_1265
SIC: SiL_1256
MSE: Msed_0068
MCN: Mcup_1988
AHO: Ahos_0822
ASC: ASAC_1091
ACIA: SE86_06590
NDV: NDEV_1476
KCR: Kcr_1379
BARC: AOA65_1819(glmU_2)
BARB: AOA66_1497(glmU_3)
LOKI: Lokiarch_02940(glmU_1) Lokiarch_26580(glmU_5) Lokiarch_45000(aglF)
 » show all
Taxonomy
Reference
1  [PMID:9765219]
  Authors
Wang-Gillam A, Pastuszak I, Elbein AD
  Title
A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc.
  Journal
J Biol Chem 273:27055-7 (1998)
DOI:10.1074/jbc.273.42.27055
  Sequence
[hsa:6675]
Reference
2  [PMID:11707391]
  Authors
Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y
  Title
Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture.
  Journal
EMBO J 20:6191-202 (2001)
DOI:10.1093/emboj/20.22.6191
  Sequence
[hsa:6675]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.83
IUBMB Enzyme Nomenclature: 2.7.7.83
ExPASy - ENZYME nomenclature database: 2.7.7.83
BRENDA, the Enzyme Database: 2.7.7.83

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