Entry
Name
2'-5' oligoadenylate synthase;
OAS
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:ATP adenylyltransferase (2'-5' linkages-forming)
Reaction(IUBMB)
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate [RN:
R10909 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity [2].
History
EC 2.7.7.84 created 2013
Orthology
K14216 2'-5'-oligoadenylate synthetase
Genes
HSA : 4938(OAS1) 4939(OAS2) 4940(OAS3)
PTR : 452267(OAS3) 739129(OAS1) 739230(OAS2)
PPS : 100970211(OAS3) 100993699(OAS1) 130540460(OAS2)
GGO : 101128307(OAS1) 101128904(OAS2) 101129249(OAS3)
PON : 100172992(OAS1) 100443561(OAS3) 100444286(OAS2)
PPYG : 129009683(OAS3) 129009684(OAS2) 129010118(OAS1)
NLE : 100587554(OAS1) 100587890(OAS3) 100588209(OAS2)
HMH : 116477889(OAS3) 116477890(OAS2) 116477891(OAS1)
SSYN : 129459335(OAS3) 129459336(OAS2) 129459337(OAS1)
MCC : 712265(OAS1) 712342(OAS3) 712401(OAS2)
MCF : 102131636(OAS1) 102132016(OAS3) 102132392(OAS2)
MTHB : 126931427 126931448 126931471
MNI : 105493381(OAS2) 105493382(OAS1) 105493729(OAS3)
CSAB : 103239154(OAS1) 103239155(OAS3) 103239156(OAS2)
CATY : 105573163(OAS2) 105573164(OAS3) 105573165(OAS1)
PANU : 101010277(OAS1) 101010639(OAS2) 101015624(OAS3)
TGE : 112634074(OAS3) 112634075(OAS2) 112634076(OAS1)
MLEU : 105552284(OAS1) 105552285(OAS3) 105552286(OAS2)
RRO : 104666641(OAS1) 104666642(OAS3) 104666645(OAS2)
RBB : 108540456(OAS3) 108540457(OAS1) 108540462(OAS2)
TFN : 117089372(OAS2) 117089373(OAS3) 117089374(OAS1)
PTEH : 111537215(OAS1) 111537227(OAS3) 111537233(OAS2)
CANG : 105502273(OAS1) 105502274(OAS3) 105502275(OAS2)
CJC : 100385368(OAS1) 100392459(OAS3) 103795420(OAS2)
SBQ : 101043239(OAS2) 101043563(OAS3) 101043879(OAS1)
CIMI : 108314219(OAS1) 108314231(OAS3) 108314247(OAS2)
ANAN : 105728833(OAS2) 105728835(OAS3) 105728836(OAS1)
CSYR : 103259695 103264095(OAS1) 103264100 103264101 103264102(OAS3)
MMUR : 105866765(OAS3) 105866766(OAS2) 105866767(OAS1)
LCAT : 123625980(OAS3) 123626026(OAS2) 123626027(OAS1)
OGA : 100951039(OAS3) 105886995(OAS2) 105887001(OAS1)
MMU : 23960(Oas1g) 23961(Oas1b) 246727(Oas3) 246728(Oas2) 246730(Oas1a)
MCAL : 110293989 110293990 110293991 110293992 110293993 110293994 110294376 110294589(Oas3) 110295017(Oas2)
MPAH : 110313134(Oas2) 110313135(Oas3) 110313137 110339082 110339083 110339085 110339086 110339087 110339088
RNO : 192281(Oas1a) 246268(Oas1b) 304507(Oas1i) 363938(Oas2) 494202(Oas3)
MCOC : 116068327(Oas2) 116068328 116068329 116070696 116070888(Oas3) 116070891 116104629 116104630
ANU : 117697668(Oas3) 117697784 117697786 117697788 117697969 117698180(Oas2)
ASYL : 127672977 127672978 127672979 127673314(Oas3) 127673315(Oas2)
MUN : 110546395 110546404 110546405 132653700
CGE : 100761048 100767905 100768193 100768468 100768763 100769335 100769624 100769916(Oas3) 100770794 113831143(Oas2)
MAUA : 101823672 101831783(Oas2) 101832045(Oas3) 101832301 106021986 106021992 121133963 121133964 121134052
PROB : 127216035(Oas3) 127216036(Oas2) 127216037
PLEU : 114681897 114681904 114681905 114699623 114699624(Oas3) 114699625(Oas2)
MORG : 121444679 121445981(Oas3) 121445982(Oas2) 121445994 121446177(Oas1) 121446557
MFOT : 126511644 126511646 126511713 126511716 126511724 126511729 126511731
AAMP : 119824522(Oas3) 119824530(Oas1) 119824811(Oas2) 119824866
NGI : 103745552 103745585 103745586(Oas3) 103745587
HGL : 101698818(Oas2) 101699903(Oas1)
CPOC : 100721851(Oas1) 100722126
CCAN : 109675879 109675880 109681969 109681970
MMMA : 107158653 107158707
ITI : 101966357(Oas3) 120891307
TUP : 102495865(OAS2) 106735200(OAS1)
GVR : 103607702(OAS3) 103607703(OAS2) 103610717(OAS1)
CFA : 477490(OAS3) 608778(OAS1) 611051(OAS2)
CLUD : 112676583(OAS1) 112676584(OAS3) 112676585(OAS2)
VVP : 112935202(OAS1) 112935211(OAS3)
VLG : 121475332(OAS3) 121475809(OAS1)
NPO : 129508323(OAS3) 129508337(OAS1)
AML : 100468112(OAS2) 100469118(OAS1) 100469368(OAS3)
UMR : 103661196(OAS1) 103661290
UAH : 113266813 113266985(OAS1)
UAR : 123778492 123778819(OAS1)
ELK : 111156451 111156463 111156464
LLV : 125082013 125082014 125082372
MPUF : 101679851 101693011
MLK : 131811001 131811191(OAS1)
NVS : 122903410(OAS1) 122903640(OAS2)
ORO : 101369458(OAS2) 101373749(OAS1) 101374040(OAS3)
EJU : 114219028(OAS3) 114219029(OAS2) 114219090(OAS1)
ZCA : 113912618(OAS3) 113912619(OAS2) 113912658(OAS1)
MLX : 118010160 118011016 118018321(OAS1) 118018489(OAS2) 118018490(OAS3)
NSU : 110588238(OAS1) 110588261(OAS3) 110588305(OAS2)
LWW : 102731487(OAS2) 102731794(OAS1) 102733293(OAS3)
FCA : 101087875(OAS1) 101088116(OAS3) 102902426(OAS2)
PYU : 121010306(OAS3) 121010310(OAS2) 121010317(OAS1)
PCOO : 112870096(OAS1) 112870260(OAS2) 112870493(OAS3)
PBG : 122470243 122470917(OAS3)
PVIV : 125148827(OAS3) 125148828(OAS2) 125149587(OAS1)
LRUF : 124518197 124518198 124518368
PTG : 102952232(OAS3) 107179395(OAS2)
PPAD : 109277626(OAS1) 109277795(OAS3)
PUC : 125914169 125914170 125914171
HHV : 120222964 120233382(OAS2) 120233460
BTA : 347699(OAS1X) 519922(OAS1Z) 529660(OAS2) 654488(OAS1Y)
BOM : 102283231 102283513(OAS1) 102283796(OAS2)
BIU : 109570926 109571283(OAS2) 109571284
BBUB : 102407094 102408391
BBIS : 104980026(OAS2) 104980028 104980029 104993780
OAS : 101109915 101112122 105602911
BTAX : 128062102(OAS2) 128062104 128062341(OAS1) 128062381
ODA : 120871127(OAS2) 120871128 120871129
CCAD : 122422833 122422844 122422848 122422854
MREE : 136145802 136145803 136145804 136145868 136146099 136146100
OVR : 110144275(OAS2) 139037797(OAS1)
SSC : 397570(OAS1) 595128(OAS2)
CBAI : 105080586(OAS1) 105082455
BACU : 102999657 103002522(OAS2) 103002794 103003537(OAS1)
BMUS : 118879885(OAS2) 118879886 118879887
LVE : 103087433(OAS1) 103087703(OAS2)
OOR : 101277868(OAS2) 101289192
PCAD : 102995339(OAS2) 102995791(OAS1) 102996067
PSIU : 116765033(OAS2) 116765154
NASI : 112397262(OAS2) 112397263
ECB : 100034147(OAS1) 791225(OAS3) 791250(OAS2)
EPZ : 103542327(OAS3) 103557130(OAS1)
EAI : 106842212 106842249(OAS1)
MYB : 102247108(OAS1) 102251057(OAS2) 102258838
MYD : 102756142(OAS3) 102756409(OAS2) 102759968(OAS1)
MMYO : 118673356 118678496(OAS1) 118678600(OAS3)
MLF : 102419007 102421108 102421409(OAS3) 102421700
MDT : 132214450 132222135 132222200(OAS2)
PKL : 118703083 118719718(OAS3) 118719719(OAS2) 118725488
EFUS : 103287239(OAS1) 103287240(OAS3) 103293910 129148092(OAS2)
MNA : 107529575 107529617 107545518
DRO : 112310467(OAS3) 112310771 112317826
SHON : 118977154 118991120 118991332
AJM : 119040446(OAS3) 119040447(OAS1) 119040463(OAS2) 119056133
PDIC : 114491969 114509361 114510048
PHAS : 123806822 123821766(OAS2) 123823259(OAS3) 123823303(OAS1)
MMF : 118635736 118639793(OAS3) 118640393(OAS2) 118640394(OAS1)
PPAM : 129085425 129087190(OAS1) 129087369(OAS3) 129087432(OAS2)
RFQ : 117017196(OAS1) 117017654(OAS3) 117017655(OAS2)
PALE : 102879074(OAS1) 102879322(OAS3) 102889470(OAS2)
PGIG : 120606727(OAS3) 120606729(OAS2) 120606731
PVP : 105289237 105289390(OAS2)
RAY : 107513228 107513273(OAS1)
TOD : 119244963(OAS3) 119245323(OAS2) 119245324(OAS1)
SETR : 126029500(OAS3) 126030705(OAS1)
LAV : 100659469(OAS2) 104846792(OAS3) 104846793(OAS1)
TMU : 101344040 101344304 101347429
ETF : 101643318 101643629(OAS2)
MDO : 100028774(OAS3) 100028841 100028903(OAS1)
GAS : 123244976 123256874 123256875
SHR : 100928002(OAS3) 100928264 105749342
AFZ : 127548517 127548527 127548539
PCW : 110202068 110202070 110202095(OAS2)
TVP : 118848195 118848211 118853324 118853468
PMUR : 107285479 107297389
ZVI : 118076011 118076012 118076188
BFO : 118415180 118421963 118421966
BBEL : 109476677 109484315
APLC : 110982654 110982655 110982656 110982668 110982703
ARUN : 117302114 117302115 117302116 117302137 117302142 117302601 117302602 117302623 117302657
PFLL : 139145124 139145320
BCOO : 119075886 119080484
LGI : LOTGIDRAFT_161508 LOTGIDRAFT_233290
PVUL : 126810515 126811993 126811994 126820496 126821054 126831556 130010284 130010352
PCAN : 112560500 112576994 112576995 112576996
LSAX : 138962552 138963214 138963215
GAE : 121374457 121375482 121376033 121384188
HRF : 124112761 124112762 124112765 124114124 124114125 124146235 124153056 124153057
HRJ : 124257015 124257041 124265685 124265771 124284019 124284020
HASI : 137265829 137266100 137290532 137290533 137290856 137290874 137291057
RPHI : 132726019 132732177 132737872
DPOL : 127845254 127852791 127878910 127880120
MAEA : 128218834 128220155 128236816
LAK : 106154994 106159596 106172491
ATEN : 116287464 116306184 116307279
ADF : 107334717 107334718 107357250
AMIL : 114959348 114959349 114959351 114973781
MFOO : 137999160 138000563
DGT : 114526963 114529884 114529910 114529911 114529977 114535094 114535102 114535105 114535124
» show all
Taxonomy
Reference
Authors
Kerr IM, Brown RE
Title
pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.
Journal
Reference
Authors
Martin EM, Birdsall NJ, Brown RE, Kerr IM
Title
Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material.
Journal
Reference
Authors
Hartmann R, Justesen J, Sarkar SN, Sen GC, Yee VC
Title
Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase.
Journal
Sequence
Reference
Authors
Hovanessian AG, Justesen J
Title
The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.84
ExPASy - ENZYME nomenclature database: 2.7.7.84