KEGG   ENZYME: 2.7.7.84
Entry
EC 2.7.7.84                 Enzyme                                 
Name
2'-5' oligoadenylate synthase;
OAS
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
ATP:ATP adenylyltransferase (2'-5' linkages-forming)
Reaction(IUBMB)
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate [RN:R10909]
Reaction(KEGG)
R10909;
(other) R10910
Substrate
ATP [CPD:C00002]
Product
pppA2'p5'A2'p5'A [CPD:C20936];
diphosphate [CPD:C00013]
Comment
The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity [2].
History
EC 2.7.7.84 created 2013
Orthology
K14216  2'-5'-oligoadenylate synthetase
Genes
HSA4938(OAS1) 4939(OAS2) 4940(OAS3)
PTR452267(OAS3) 739129(OAS1) 739230(OAS2)
PPS100970211(OAS3) 100993699(OAS1) 103783986(OAS2)
GGO101128307(OAS1) 101128904(OAS2) 101129249(OAS3)
PON100172992(OAS1) 100443561(OAS3) 100444286(OAS2)
NLE100587554(OAS1) 100587890(OAS3) 100588209(OAS2)
HMH116477889(OAS3) 116477890(OAS2) 116477891(OAS1)
MCC712265(OAS1) 712342(OAS3) 712401(OAS2)
MCF102131636(OAS1) 102132016(OAS3) 102132392(OAS2)
MTHB126931427 126931448 126931471
MNI105493381(OAS2) 105493382(OAS1) 105493729(OAS3)
CSAB103239154(OAS1) 103239155(OAS3) 103239156(OAS2)
CATY105573163(OAS2) 105573164(OAS3) 105573165(OAS1)
PANU101010277(OAS1) 101010639(OAS2) 101015624(OAS3)
TGE112634074(OAS3) 112634075(OAS2) 112634076(OAS1)
MLEU105552284(OAS1) 105552285(OAS3) 105552286(OAS2)
RRO104666641(OAS1) 104666642(OAS3) 104666645(OAS2)
RBB108540456(OAS3) 108540457(OAS1) 108540462(OAS2)
TFN117089372(OAS2) 117089373(OAS3) 117089374(OAS1)
PTEH111537215(OAS1) 111537227(OAS3) 111537233(OAS2)
CANG105502273(OAS1) 105502274(OAS3) 105502275(OAS2)
CJC100385368(OAS1) 100392459(OAS3) 103795420(OAS2)
SBQ101043239(OAS2) 101043563(OAS3) 101043879(OAS1)
CIMI108314219(OAS1) 108314231(OAS3) 108314247(OAS2)
CSYR103259695 103264095(OAS1) 103264100 103264101 103264102(OAS3)
MMUR105866765(OAS3) 105866766(OAS2) 105866767(OAS1)
LCAT123625980(OAS3) 123626026(OAS2) 123626027(OAS1)
PCOQ105825595(OAS2)
OGA100951039(OAS3) 105886995(OAS2) 105887001(OAS1)
MMU23960(Oas1g) 23961(Oas1b) 246727(Oas3) 246728(Oas2) 246730(Oas1a)
MCAL110293989 110293990 110293991 110293992 110293993 110293994 110294376 110294589(Oas3) 110295017(Oas2)
MPAH110313134(Oas2) 110313135(Oas3) 110313137 110339082 110339083 110339085 110339086 110339087 110339088
RNO192281(Oas1a) 246268(Oas1b) 304507(Oas1i) 363938(Oas2) 494202(Oas3)
MCOC116068327(Oas2) 116068328 116068329 116070696 116070888(Oas3) 116070891 116104629 116104630
ANU117697668(Oas3) 117697784 117697786 117697788 117697969 117698180(Oas2)
MUN110546395 110546404 110546405 132653700
CGE100761048 100767905 100768193 100768468 100768763 100769335 100769624 100769916(Oas3) 100770794 113831143(Oas2)
MAUA101823672 101831783(Oas2) 101832045(Oas3) 101832301 106021986 106021992 121133963 121133964 121134052
PROB127216035(Oas3) 127216036(Oas2) 127216037
PLEU114681897 114681904 114681905 114699623 114699624(Oas3) 114699625(Oas2)
MORG121444679 121445981(Oas3) 121445982(Oas2) 121445994 121446177(Oas1) 121446557
MFOT126511644 126511646 126511713 126511716 126511724 126511729 126511731
AAMP119824522(Oas3) 119824530(Oas1) 119824811(Oas2) 119824866
NGI103745552 103745585 103745586(Oas3) 103745587
HGL101698818(Oas2) 101699903(Oas1)
CPOC100721851(Oas1) 100722126
CCAN109675879 109675880 109681969 109681970
DORD105990722(Oas1)
DSP122098546
PLOP125347736
NCAR124991784
MMMA107158653 107158707
OCU100340530 108178670
OPI101528904
TUP102495865(OAS2) 106735200(OAS1)
GVR103607702(OAS3) 103607703(OAS2) 103610717(OAS1)
CFA477490(OAS3) 608778(OAS1) 611051(OAS2)
CLUD112676583(OAS1) 112676584(OAS3) 112676585(OAS2)
VVP112935202(OAS1) 112935211(OAS3)
VLG121475332(OAS3) 121475809(OAS1)
NPO129508323(OAS3) 129508337(OAS1)
AML100468112(OAS2) 100469118(OAS1) 100469368(OAS3)
UMR103661196(OAS1) 103661290
UAH113266813(OAS3) 113266985
UAR123778492 123778819(OAS1)
ELK111156451 111156463 111156464
LLV125082013 125082014 125082372
MPUF101679851 101693011
MNP132023176 132023746
MLK131811001 131811191(OAS1)
NVS122903410(OAS1) 122903640(OAS2)
ORO101369458(OAS2) 101373749(OAS1) 101374040(OAS3)
EJU114219028(OAS3) 114219029(OAS2) 114219090(OAS1)
ZCA113912618(OAS3) 113912619(OAS2) 113912658(OAS1)
MLX118010160 118011016 118018321(OAS1) 118018489(OAS2) 118018490(OAS3)
NSU110588238(OAS1) 110588261(OAS3) 110588305(OAS2)
LWW102731487(OAS2) 102731794(OAS1) 102733293(OAS3)
FCA101087875(OAS1) 101088116(OAS3) 102902426(OAS2)
PYU121010306(OAS3) 121010310(OAS2) 121010317(OAS1)
PCOO112870096(OAS1) 112870260(OAS2) 112870493(OAS3)
PBG122470243 122470917(OAS3)
LRUF124518197 124518198 124518368
PTG102952232(OAS3) 107179395(OAS2)
PPAD109277626(OAS1) 109277795(OAS3)
PUC125914169 125914170 125914171
AJU106982083 113595144
HHV120222964 120233382(OAS2) 120233460
BTA347699(OAS1X) 519922(OAS1Z) 529660(OAS2) 654488(OAS1Y)
BOM102283231 102283513 102283796(OAS2)
BIU109570926 109571283(OAS2) 109571284
BBUB102407094 102408391
BBIS104980026(OAS2) 104980028 104980029 104993780
CHX102186893 102190983
OAS101109915 101112122 105602911
BTAX128062102(OAS2) 128062104 128062341(OAS1) 128062381
ODA120871127(OAS2) 120871128 120871129
CCAD122422833 122422844 122422848 122422854
SSC397570(OAS1) 595128(OAS2)
CFR102524147(OAS1)
CBAI105080586(OAS1) 105082455
CDK105101979(OAS1)
VPC102530627
BACU102999657 103002522(OAS2) 103002794 103003537(OAS1)
LVE103087433(OAS1) 103087703(OAS2)
OOR101277868(OAS2) 101289192
DLE111162647
PCAD102995339(OAS2) 102995791(OAS1) 102996067
PSIU116765033(OAS2) 116765154
NASI112397262(OAS2) 112397263
ECB100034147(OAS1) 791225(OAS3) 791250(OAS2)
EPZ103542327(OAS2) 103543308(OAS3) 103557130
EAI106842212 106842249(OAS1)
MYB102247108(OAS1) 102251057(OAS2) 102258838
MYD102756142(OAS3) 102756409(OAS2) 102759968(OAS1)
MMYO118673356 118678496(OAS1) 118678600(OAS3)
MLF102419007 102421108 102421409(OAS3) 102421700
MNA107529575 107529617 107545518
PKL118703083 118719718(OAS3) 118719719(OAS2) 118725488
EFUS103287239(OAS1) 103287240(OAS3) 103293910 129148092(OAS2)
HAI109382229 109382257
DRO112310467(OAS3) 112310771 112317826
SHON118977154 118991120 118991332
AJM119040446(OAS3) 119040447(OAS1) 119040463(OAS2) 119056133
PDIC114491969 114509361 114510048
PHAS123806822 123821766(OAS2) 123823259(OAS3) 123823303(OAS1)
MMF118635736 118639793(OAS3) 118640393(OAS2) 118640394(OAS1)
RFQ117017196(OAS1) 117017654(OAS3) 117017655(OAS2)
PPAM129085425 129087190(OAS1) 129087369(OAS3) 129087432(OAS2)
PALE102879074(OAS1) 102879322(OAS3) 102889470(OAS2)
PGIG120606727(OAS3) 120606729(OAS2) 120606731
PVP105289237 105289390(OAS2)
RAY107513228 107513273(OAS1)
MJV108384393(OAS2)
TOD119244963(OAS3) 119245323(OAS2) 119245324(OAS1)
SARA101552816
LAV100659469(OAS2) 104846792(OAS3) 104846793(OAS1)
TMU101344040 101344304 101347429
ETF101643318 101643629(OAS2)
DNM101434635(OAS1)
MDO100028774(OAS3) 100028841 100028903(OAS1)
GAS123244976 123256874 123256875
SHR100928002(OAS3) 100928264 105749342
AFZ127548517 127548527 127548539
PCW110202068 110202070 110202095(OAS2)
AMJ106737542(OAS1)
PSS102447754 102448391
CMY102937233
DCC119843818
CPIC101945210
CABI116817868
MRV120386289
ACS100562806(oas1)
ASAO132769121(OAS1)
PVT110082886
SUND121923507
PBI103053194
PMUR107285479 107297389
TSR106554335
PGUT117659398 117659459 117659752 117660045 117672143
PTEX113450869
NSS113425762
PMUA114586818
PRAF128403870
ZVI118076011 118076012 118076188
HCG128338021 128338124
GJA107122904 107125898
STOW125442469
MUO115479913
GSH117365527
LCM102355743
CMK103184093
RTP109931758 109931761
HOC132827453
BFO118415180 118421963 118421966
BBEL109476677 109484315
APLC110982654 110982655 110982656 110982668 110982703
BCOO119075886 119080484
FCD110850527
LGILOTGIDRAFT_161508 LOTGIDRAFT_233290
PVUL126810515 126811993 126811994 126820496 126821054 126831556 130010284 130010352
PCAN112560500 112576994 112576995 112576996
GAE121374457 121375482 121376033 121384188
HRF124112761 124112762 124112765 124114124 124114125 124146235 124153056 124153057
HRJ124257015 124257041 124265685 124265771 124284019 124284020
CVN111104301
CANU128186242
MMER123525091
RPHI132726019 132732177 132737872
DPOL127845254 127852791 127878910 127880120
LAK106154994 106159596 106172491
NVE5515274
ATEN116287464 116306184 116307279
ADF107334717 107334718 107357250
AMIL114959348 114959349 114959351 114973781
DGT114526963 114529882 114529884 114529910 114529911 114529977 114535094 114535102 114535105 114535124
AQU109580198 109581478
 » show all
Reference
1  [PMID:272640]
  Authors
Kerr IM, Brown RE
  Title
pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.
  Journal
Proc Natl Acad Sci U S A 75:256-60 (1978)
DOI:10.1073/pnas.75.1.256
Reference
2  [PMID:456356]
  Authors
Martin EM, Birdsall NJ, Brown RE, Kerr IM
  Title
Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material.
  Journal
Eur J Biochem 95:295-307 (1979)
DOI:10.1111/j.1432-1033.1979.tb12965.x
Reference
3  [PMID:14636576]
  Authors
Hartmann R, Justesen J, Sarkar SN, Sen GC, Yee VC
  Title
Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase.
  Journal
Mol Cell 12:1173-85 (2003)
DOI:10.1016/S1097-2765(03)00433-7
  Sequence
[ssc:397570]
Reference
4  [PMID:17408844]
  Authors
Hovanessian AG, Justesen J
  Title
The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
  Journal
Biochimie 89:779-88 (2007)
DOI:10.1016/j.biochi.2007.02.003
  Sequence
[hsa:4938 4939 4940]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.84
IUBMB Enzyme Nomenclature: 2.7.7.84
ExPASy - ENZYME nomenclature database: 2.7.7.84
BRENDA, the Enzyme Database: 2.7.7.84

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