Entry |
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Name |
cyclic GMP-AMP synthase;
cGAMP synthase;
cGAS
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Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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Sysname |
ATP:GTP adenylyltransferase (cyclizing)
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Reaction(IUBMB) |
ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') (overall reaction) [RN: R10462];
(1a) ATP + GTP = pppGp(2'-5')A + diphosphate;
(1b) pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate
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Reaction(KEGG) |
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Substrate |
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Product |
diphosphate [CPD: C00013];
cyclic Gp(2'-5')Ap(3'-5') [CPD: C20640];
pppGp(2'-5')A
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Comment |
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
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History |
EC 2.7.7.86 created 2013, modified 2014
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Orthology |
K17834 | cyclic GMP-AMP synthase |
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Genes |
MMUR: | 105858834 105884657(MB21D1) |
PCOQ: | 105807017 105811756(MB21D1) |
MCOC: | 116072532 116073422 |
CGE: | 100754516 100758179(Cgas) |
MAUA: | 101831922(Cgas) 106021433 |
CCAN: | 109694315 109702432 |
ITI: | 101977621(Cgas) 120890696 |
BACU: | 103017021 103017298 |
PHAS: | 123821499 123821692(CGAS) |
OAA: | 100087769(CGAS) 103165103 |
TACU: | 119927246(CGAS) 119938278 |
PPUS: | 135186402 135186494 |
ASN: | 102379168 102388310(CGAS) |
AMJ: | 102565317(MB21D1) 102576030 |
CPOO: | 109311795(MB21D1) 109321596 |
GGN: | 109298553 109299820(MB21D1) |
PSS: | 102447277(CGAS) 112544782 112544783 112544784 112546990 |
CMY: | 102930662 102934779(CGAS) 102936464 |
CCAY: | 125624754 125634772(CGAS) 125638726 |
DCC: | 119845281 119853169(CGAS) |
CPIC: | 101937365(CGAS) 101951637 122172622 |
TST: | 117868382 117875177(CGAS) 117877076 |
CABI: | 116815600(CGAS) 116830189 116835107 |
MRV: | 120389418 120401978(CGAS) 120405307 |
SUND: | 121916199 121919775(CGAS) |
PMUA: | 114593874(CGAS) 114601597 |
PRAF: | 128410255(CGAS) 128418781 |
ZVI: | 118082764(CGAS) 118086762 |
GJA: | 107107013 107123189(MB21D1) |
STOW: | 125432413 125437822 |
XLA: | 108704160(mb21d1.L) 108717996 |
RTEM: | 120937033 120937034 120937377 |
MUO: | 115467235(CGAS) 115467236 |
DRE: | 100536487 557043(cgasa) |
SRX: | 107706136 107718834(mb21d1) |
SANH: | 107654670 107693606(mb21d1) 107696517 |
SGH: | 107588675 107589446 107591657 |
CCAR: | 109112294 109112296 |
CAUA: | 113056938 113112671 113119289 |
CGIB: | 127934967 127970662 127978745 128026636 |
PTET: | 122323294 122356113(cgasa) |
LROH: | 127175618(cgasa) 127182416 |
OMC: | 131526076 131552678(cgasa) |
PPRM: | 120479510(cgas) 120485031 |
RKG: | 130072067(cgasa) 130084207 |
MAMB: | 125275080 125276950(cgasa) |
CIDE: | 127500875 127524368 |
CERY: | 137020074(cgasa) 137037074 |
MASI: | 127412118 127414345 127421380 |
TROS: | 130559752(cgasa) 130567054 |
TDW: | 130415928 130431259(cgasa) |
MANU: | 129415411(cgasa) 129454934 |
IPU: | 108256977 108263730(cgasa) |
IFU: | 128600586 128605703(cgasa) |
PHYP: | 113536320 113545662(cgas) |
SMEO: | 124375754 124395062(cgasa) |
TFD: | 113636304(cgasa) 113661383 |
TVC: | 132837560 132847374(cgasa) |
TRN: | 134301311 134314710(cgasa) |
AMEX: | 103037406(cgasa) 103045125 |
CMAO: | 118805631 118809941(cgas) |
CHAR: | 105911542(cgas) 116223264 |
SPIL: | 134064195(cgasa) 134073195 |
LCO: | 104930807 104930999 109139339(cgas) |
TBEN: | 117478011 117499869(cgas) |
PGEO: | 117455476 117460018(cgas) |
GACU: | 117536638 117542351(cgas) |
ELY: | 117248427(cgas) 117264086 |
EFO: | 125903006(cgasa) 125905116 |
PLEP: | 121954978(cgasa) 121958065 |
SLUC: | 116047115 116061627(cgas) |
ECRA: | 117956958 117960151(cgas) |
ESP: | 116701880 116705125(cgas) |
PFLV: | 114568181 114571773 |
AFB: | 129092545(cgasa) 129097087 |
MSAM: | 119906690 119909717 119917545(cgas) |
SCHU: | 122864465 122884694(cgasa) |
ALAT: | 119015120 119033773(cgas) |
ONL: | 102078106 106097853 109204785 |
OAU: | 116324850 116326666 120443305(cgas) |
CSAI: | 133460830 133463703(cgasa) |
XMA: | 102238245(cgas) 106699738 |
PRET: | 103472993 103476464 |
PFOR: | 103137383(mb21d1) 103143458 |
PLAI: | 106938210(mb21d1) 106951929 |
PMEI: | 106911808 106923428 |
GAF: | 122842438(cgasa) 122843138 |
PPRL: | 129359599(cgasa) 129375921 |
CTUL: | 119774847(cgas) 119790489 |
GMU: | 124859105(cgasa) 124878899 |
AOCE: | 111563935 111586938 |
EJA: | 138195152(cgasa) 138214608 |
BFRE: | 138628920(cgasa) 138631652 |
MCEP: | 125018945 125018951 125019502 |
LCF: | 108873443(cgasa) 108898898 |
SDU: | 111220892 111227407 111227458(cgas) |
SLAL: | 111645593 111646355 111646980 111648681 111649430 |
XGL: | 120786458 120796225(cgasa) |
MALB: | 109954004 109961116 109970716 |
BSPL: | 114865590 114870674(cgasa) |
SJO: | 128373328(cgasa) 128373882 |
SSCO: | 133991535(cgasa) 133995898 |
SASA: | 106570029 106577085(mb21d1) 106606998 |
STRU: | 115153193 115175959 115193802 |
OTW: | 112229902 112253530(cgasa) 112254417 112264864 |
OMY: | 110489275 110496144 110502447 110528533(cgas) |
OGO: | 124037217 124041278(cgasa) 124043619 |
ONE: | 115112699 115128993 115131684 115135136 |
OKI: | 109888967 109899102 109903121 109906931 |
OKE: | 118361302 118369685(cgasa) 118398256 118399243 |
OMM: | 135510120(cgasa) 135512339 135550037 135552296 |
SALP: | 111951600 111955989 112080536 112080849 |
SNH: | 120017425(cgas) 120027447 120045881 |
CCLU: | 121553461 121570526 121585758 |
AANG: | 118218464(cgas) 118232887 |
AROT: | 135244502(cgasa) 135261205 |
CCOG: | 133118487(cgasa) 133137367 |
LOC: | 102683757(mb21d1) 107076494 |
PSPA: | 121308405 121316824(cgasa) |
ARUT: | 117411600(cgas) 117968100 117971567 |
LCM: | 102346272(MB21D1) 102353888 |
PFLL: | 139143284 139143285 |
PTEP: | 107449532 107453297 107453300 |
CRG: | 105322102 105322103 136272497 |
CANU: | 128162093 128162095 |
ATEN: | 116295534 116307849 |
ADF: | 107337790 107349987 107349993 107353078 |
AMIL: | 114948743 114949417 114965664 |
PDAM: | 113670688 113680563 113681850 113681904 |
SPIS: | 111338054 111345036 111345331 111345339 111345504 |
» show all
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Reference |
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Authors |
Sun L, Wu J, Du F, Chen X, Chen ZJ |
Title |
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. |
Journal |
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Sequence |
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Reference |
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Authors |
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V. |
Title |
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.7.86 |
ExPASy - ENZYME nomenclature database: | 2.7.7.86 |
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