KEGG   ENZYME: 2.7.7.86
Entry
EC 2.7.7.86                 Enzyme                                 
Name
cyclic GMP-AMP synthase;
cGAMP synthase;
cGAS
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
ATP:GTP adenylyltransferase (cyclizing)
Reaction(IUBMB)
ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') (overall reaction) [RN:R10462];
(1a) ATP + GTP = pppGp(2'-5')A + diphosphate;
(1b) pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate
Reaction(KEGG)
R10462
Substrate
ATP [CPD:C00002];
GTP [CPD:C00044];
pppGp(2'-5')A
Product
diphosphate [CPD:C00013];
cyclic Gp(2'-5')Ap(3'-5') [CPD:C20640];
pppGp(2'-5')A
Comment
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
History
EC 2.7.7.86 created 2013, modified 2014
Orthology
K17834  cyclic GMP-AMP synthase
Genes
HSA115004(CGAS)
PTR462822(CGAS)
PPS100990327(CGAS)
GGO101146170(CGAS)
PON100456001(CGAS)
NLE100583298(CGAS)
MCC717665(CGAS)
MCF102133276(CGAS)
MTHB126952121
MNI105479453(CGAS)
CSAB103243898(MB21D1)
CATY105589206(MB21D1)
PANU100137406(CGAS)
TGE112622071(CGAS)
RRO104669277(CGAS)
RBB108529201(MB21D1)
TFN117087450(CGAS)
PTEH111547444(CGAS)
CANG105513551(MB21D1)
CJC100387233(MB21D1)
SBQ101052976(MB21D1)
CSYR103258632(MB21D1)
MMUR105858834 105884657(MB21D1)
LCAT123632173(CGAS)
PCOQ105807017 105811756(MB21D1)
OGA100960993(CGAS)
MMU214763(Cgas)
MCAL110302572(Mb21d1)
MPAH110328585(Mb21d1)
RNO682147(Cgas)
MCOC116072532 116073422
MUN110560519(Mb21d1)
CGE100754516 100758179(Cgas)
MAUA101831922(Cgas) 106021433
PLEU114686791(Cgas)
MORG121466160(Cgas)
MFOT126491081
AAMP119809822(Cgas)
NGI103744364(Mb21d1)
HGL101717623(Mb21d1)
CPOC100713978(Cgas)
CCAN109694315 109702432
DORD106000092(Mb21d1)
DSP122113960(Cgas)
NCAR124988764
OCU100349407(CGAS)
OPI101520974(CGAS)
TUP102474401(MB21D1)
GVR103595481(MB21D1)
CFA611033(CGAS)
CLUD112658300(CGAS)
VVP112926356(CGAS)
VLG121477532(CGAS)
AML100471590(CGAS)
UMR103657480(MB21D1)
UAH113261117(CGAS)
UAR123796269(CGAS)
ELK111152334
LLV125103240
MPUF101687874(MB21D1)
NVS122899794(CGAS)
ORO101374743(MB21D1)
EJU114204499(CGAS)
ZCA113926618(CGAS)
MLX118000892(CGAS)
NSU110583453(CGAS)
LWW102733539(CGAS)
FCA101098056(CGAS)
PYU121029669(CGAS)
PBG122489692(CGAS)
LRUF124528966
PTG102952381(MB21D1)
PPAD109248226(MB21D1)
AJU106980198(CGAS)
HHV120242942(CGAS)
BTA782472(CGAS)
BOM102285090(MB21D1)
BIU109563704(MB21D1)
BBUB102415629(CGAS)
BBIS104996886(MB21D1)
CHX102187049(MB21D1)
OAS114116050(CGAS)
ODA120862886(CGAS)
CCAD122422632(CGAS)
SSC100516408(MB21D1)
CFR102523852(CGAS)
CBAI105064893(MB21D1)
CDK105099837(CGAS)
VPC102545127(CGAS)
BACU103017021 103017298
LVE103082954(MB21D1)
OOR101289557(MB21D1)
DLE111183240(CGAS)
PCAD102985456(CGAS)
PSIU116763806(CGAS)
ECB100067982(CGAS)
EPZ103562297(MB21D1)
EAI106827075(CGAS)
MYB102243555
MYD102775467(MB21D1)
MMYO118660304(CGAS)
MLF102428890(CGAS)
MNA107531610(MB21D1)
PKL118705992(CGAS)
HAI109387546(MB21D1)
DRO112319268(CGAS)
SHON118978695(CGAS)
AJM119050815(CGAS)
PDIC114495020(CGAS)
PHAS123821499 123821692(CGAS)
MMF118621468(CGAS)
RFQ117020212(CGAS)
PALE102883365(CGAS)
PGIG120594970(CGAS)
PVP105306113(CGAS)
RAY107509280(MB21D1)
TOD119251468(CGAS)
SARA101553412(MB21D1)
LAV100664322(CGAS)
TMU101344880
ETF101644613(CGAS)
MDO100021282(MB21D1)
GAS123246481(CGAS)
SHR100920386(CGAS)
PCW110217669(MB21D1)
OAA100087769(CGAS) 103165103
GGA421864(MB21D1)
PCOC116240629(CGAS)
MGP100549716(CGAS)
CJO107312047(CGAS)
NMEL110396507(MB21D1)
APLA101797757(CGAS)
ACYG106030386(CGAS)
AFUL116487495(CGAS)
TGU100224044(CGAS)
LSR116183447(CGAS)
SCAN103822607(CGAS)
PMOA120511371(CGAS)
OTC121339126(CGAS)
PRUF121358896(CGAS)
GFR102042126(MB21D1)
FAB101809319(MB21D1)
PHI102108130(MB21D1)
PMAJ107201290(CGAS)
CCAE111925811(CGAS)
CCW104694402(CGAS)
CBRC103619163(MB21D1)
ETL114057629(CGAS)
ZAB102069185(CGAS)
ACHL103811171(MB21D1)
FPG101922902(MB21D1)
FCH102047663(CGAS)
CLV102091030(MB21D1)
EGZ104125162(MB21D1)
NNI104022036(MB21D1)
PLET104624433(MB21D1)
PCRI104031956(MB21D1)
PCAO104039501(MB21D1)
ACUN113478379(CGAS)
TALA104360478(CGAS)
PADL103924675(MB21D1)
AFOR103896032(MB21D1)
ACHC115350836(CGAS)
HALD104310548(MB21D1)
HLE104830712(MB21D1)
AGEN126046073
GCL127014782
CCRI104154713(MB21D1)
CSTI104549935(MB21D1)
EHS104502947(MB21D1)
CMAC104479842(MB21D1)
FGA104079823(MB21D1)
GSTE104250724(MB21D1)
LDI104347026(MB21D1)
MNB103773119(MB21D1)
OHA104334473(MB21D1)
NNT104399529(MB21D1)
DPUB104301303(MB21D1)
ACAR104523863(CGAS)
CPEA104393982(MB21D1)
AVIT104268341(MB21D1)
CVF104295951(MB21D1)
CUCA104062712(MB21D1)
TEO104384573(MB21D1)
BRHI104488787(MB21D1)
AAM106492488(MB21D1)
AROW112977541(CGAS)
NPD112957605(CGAS)
TGT104565337(MB21D1)
DNE112984436(CGAS)
ASN102379168 102388310(CGAS)
AMJ102565317(MB21D1) 102576030
CPOO109311795(MB21D1) 109321596
GGN109298553 109299820(MB21D1)
PSS102447277(CGAS) 112544782 112544783 112544784 112546990
CMY102930662 102934779(CGAS) 102936464
CPIC101937365(CGAS) 101951637 122172622
TST117868382 117875177(CGAS) 117877076
CABI116815600(CGAS) 116830189 116835107
MRV120389418 120401978(CGAS) 120405307
ACS100567354(mb21d1)
PVT110075025(MB21D1)
SUND121916199 121919775(CGAS)
CTIG120316881
PGUT117663498
PMUA114593874(CGAS) 114601597
ZVI118082764(CGAS) 118086762
GJA107107013 107123189(MB21D1)
STOW125432413 125437822
XLA108704160(mb21d1.L) 108717996
XTR100488048(cgas)
NPR108795988 108795990
RTEM120937033 120937034 120937377
BBUF120998121(CGAS)
BGAR122934311(CGAS)
DRE100536487 557043(mb21d1)
SRX107706136 107718834(mb21d1)
SANH107654670 107693606(mb21d1) 107696517
SGH107588675 107589446 107591657
CCAR109112294 109112296
CAUA113056938 113112671 113119289
PPRM120479510(cgas) 120485031
MAMB125275080 125276950(cgasa)
IPU108256977 108263730(cgasa)
PHYP113536320 113545662(cgas)
SMEO124375754 124395062(cgasa)
TFD113636304(cgasa) 113661383
AMEX103037406(mb21d1) 103045125
EEE113578442 113580312
LCO104930807 104930999 109139339(cgas)
NCC104953808 104960303
ELY117248427(cgas) 117264086
EFO125903006(cgasa) 125905116
PLEP121954978(cgasa) 121958065
SLUC116047115 116061627(cgas)
ECRA117956958 117960151(cgas)
ESP116701880 116705125(cgas)
PFLV114568181 114571773
GAT120826951
PPUG119218702
MSAM119906690 119909717 119917545(cgas)
CUD121511480(cgasa)
ALAT119015120 119033773(cgas)
MZE101482018 101485826
ONL102078106 106097853 109204785
OAU116324850 116326666 120443305(cgas)
OLA101161502(cgas)
OML112162124(cgas)
XMA102238245(cgas) 106699738
XCO114137781 114156605
XHE116713105 116731906
PRET103472993 103476464
PFOR103137383(mb21d1) 103143458
PLAI106938210(mb21d1) 106951929
PMEI106911808 106923428
GAF122842438(cgasa) 122843138
CVG107098985 107101098
CTUL119774847(cgas) 119790489
GMU124859105(cgasa) 124878899
NFU107375894(mb21d1)
KMR108244627(cgas)
ALIM106533424(mb21d1)
NWH119430509(cgasa)
AOCE111563935 111586938
MCEP125018945 125018951 125019502
POV109631848(mb21d1)
SSEN122786074
HHIP117775272(cgas)
HSP118118935(cgasa)
LCF108873443(cgasa) 108898898
SDU111220892 111227407 111227458(cgas)
SLAL111645593 111646355 111646980 111648681 111649430
XGL120786458 120796225(cgasa)
BPEC110156913(mb21d1)
MALB109954004 109961116 109970716
BSPL114865590 114870674(cgasa)
SASA106570029 106577085(mb21d1) 106606998
STRU115153193 115175959 115193802
OTW112229902 112253530(cgasa) 112254417 112264864
OMY110489275 110496144 110502447 110528533(cgas)
OGO124037217 124041278(cgasa) 124043619
ONE115112699 115128993 115131684 115135136
SALP111951600 111955989 112080536 112080849
SNH120017425(cgas) 120027447 120045881
CCLU121553461 121570526 121585758
ELS105023252 105027914
SFM108927166 108933614
PKI111850720 111854243
AANG118218464(cgas) 118232887
LOC102683757(mb21d1) 107076494
PSPA121308405 121316824(cgasa)
ARUT117411600(cgas) 117968100 117971567
PSEX120516706(cgas)
LCM102346272(MB21D1) 102353888
CMK103172828
RTP109919108(mb21d1)
BFO118419102 118425279
BBEL109470647
SKO100376890 102805563
DPO4812402 6900849
DPE6599088 6601652
DMN108153688
DMODmoj_GI13277
BIM100743943
BTER100644606
BPYO122569612
OBB114876897
MGEN117228555
AEC105145568
HST105183688 112590534
DQU106749942
LHU105675429
PGC109860398
PCF106785405
NVI103315742 103315824
CGLO123267413
DAM107044363
BMOR101736938
BMAN114247162
PMAC106719607
HAW110382810
TNL113492539
TPAL117647679 117653494
PCHN125032947
PPOI119098006
RSAN119406268
CSCU111614518 111640160
PTEP107449532 107453297 107453300
PCAN112564288
HRF124133238 124133248
HRJ124262090 124290754
CRG105322102 105322103 117689519
PMAX117337624
MMER123535881 123537456 123553184 123553746 123559378 123559536 123560041 123560404 123561450 123563286
EPA110240579
ATEN116287623 116295534 116307849
ADF107334028 107337790 107349987 107349993 107353078
AMIL114948743 114949417 114965664
PDAM113665500 113670688 113680563 113681850 113681904
SPIS111338054 111345036 111345331 111345339 111345504
HMG105846279 105850432
 » show all
Reference
1  [PMID:23258413]
  Authors
Sun L, Wu J, Du F, Chen X, Chen ZJ
  Title
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
  Journal
Science 339:786-91 (2013)
DOI:10.1126/science.1232458
  Sequence
[hsa:115004] [mmu:214763]
Reference
2  [PMID:23722158]
  Authors
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V.
  Title
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates  STING.
  Journal
Nature 498:380-4 (2013)
DOI:10.1038/nature12306
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.86
IUBMB Enzyme Nomenclature: 2.7.7.86
ExPASy - ENZYME nomenclature database: 2.7.7.86
BRENDA, the Enzyme Database: 2.7.7.86

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