KEGG   ENZYME: 2.7.7.91
Entry
EC 2.7.7.91                 Enzyme                                 
Name
valienol-1-phosphate guanylyltransferase;
vldB (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
GTP:valienol 1-phosphate guanylyltransferase
Reaction(IUBMB)
GTP + valienol 1-phosphate = diphosphate + GDP-valienol [RN:R11402]
Reaction(KEGG)
R11402;
(other) R11237 R11246
Substrate
GTP [CPD:C00044];
valienol 1-phosphate [CPD:C21367]
Product
diphosphate [CPD:C00013];
GDP-valienol [CPD:C21368]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.7.7.91 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20427  valienol-1-phosphate guanylyltransferase
Genes
THAT: H3N35_23245
TVD: SG34_025405
PAEW: KIH87_05090
CJA: CJA_3254(glgC)
SUR: STAUR_1375(gacR) STAUR_3141
SHY: SHJG_0277
SHO: SHJGH_0111
SALS: SLNWT_0584
SGU: SGLAU_01015(gacR)
SSIA: A7J05_03480
SRJ: SRO_6638
SCYA: EJ357_02055
SNQ: CP978_00075
SSPO: DDQ41_30795
SGF: HEP81_06981(glgC)
SPAC: B1H29_04405
STRV: EZV63_03175
STRH: GXP74_26590
ACTQ: OG417_31665
APRE: CNX65_10000
AMI: Amir_2002
UME: RM788_17730
MCAB: HXZ27_14340
ASE: ACPL_3670(acbR)
ACTS: ACWT_3542
PRY: Prubr_33370
 » show all
Reference
1  [PMID:20981366]
  Authors
Yang J, Xu H, Zhang Y, Bai L, Deng Z, Mahmud T
  Title
Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis.
  Journal
Org Biomol Chem 9:438-49 (2011)
DOI:10.1039/c0ob00475h
  Sequence
[shy:SHJG_0277]
Reference
2  [PMID:21766819]
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.91
IUBMB Enzyme Nomenclature: 2.7.7.91
ExPASy - ENZYME nomenclature database: 2.7.7.91
BRENDA, the Enzyme Database: 2.7.7.91

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Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG REACTION (3)   
   KEGG RCLASS (1)   
Gene (62)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (27)   
   KEGG MGENES (34)   
Protein sequence (5)   
   UniProt (3)   
   SWISS-PROT (2)   
Protein domain (3)   
   InterPro (3)   
All databases (90)   

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