KEGG   ENZYME: 2.7.7.91Help
Entry
EC 2.7.7.91                 Enzyme                                 

Name
valienol-1-phosphate guanylyltransferase;
vldB (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
GTP:valienol 1-phosphate guanylyltransferase
Reaction(IUBMB)
GTP + valienol 1-phosphate = diphosphate + GDP-valienol [RN:R11402]
Reaction(KEGG)
R11402;
(other) R11237 R11246
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Substrate
GTP [CPD:C00044];
valienol 1-phosphate [CPD:C21367]
Product
diphosphate [CPD:C00013];
GDP-valienol [CPD:C21368]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.7.7.91 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20427  valienol-1-phosphate guanylyltransferase
Genes
CJA: CJA_3254(glgC)
SUR: STAUR_1375(gacR) STAUR_3141
SHY: SHJG_0277
SHO: SHJGH_0111
SALS: SLNWT_0584
SGU: SGLAU_01015(gacR)
SSIA: A7J05_03480
AMI: Amir_2002
APRE: CNX65_10000
ASE: ACPL_3670(acbR)
ACTS: ACWT_3542
 » show all
Taxonomy
Reference
1  [PMID:20981366]
  Authors
Yang J, Xu H, Zhang Y, Bai L, Deng Z, Mahmud T.
  Title
Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis.
  Journal
Org Biomol Chem 9:438-49 (2011)
DOI:10.1039/c0ob00475h
  Sequence
[shy:SHJG_0277]
Reference
2  [PMID:21766819]
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T.
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.91
IUBMB Enzyme Nomenclature: 2.7.7.91
ExPASy - ENZYME nomenclature database: 2.7.7.91
BRENDA, the Enzyme Database: 2.7.7.91

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