Entry
Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate cytidylyltransferase
Reaction(IUBMB)
CTP + 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate = diphosphate + CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [RN:
R11441 ]
Reaction(KEGG)
Substrate
CTP [CPD:
C00063 ];
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [CPD:
C20934 ]
Product
diphosphate [CPD:
C00013 ];
CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [CPD:
C21384 ]
Comment
The enzyme is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 2.7.7.92 created 2016
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
K21749 N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase
K21750 3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase
Genes
CJC : 100406904 118144192(CMAS)
CCAN : 109684205(Cmas) 109700116
ECB : 100064384(CMAS) 111767497 111772031 111772222
PBRV : 138175777 138176099
DRE : 100885772(cmasb) 561018(cmasa)
SRX : 107725656 107729858 107754376
SANH : 107676932 107686963 107686964 107690429
SGH : 107561146 107566237 107583561 107587160
CCAR : 109050865 109055284 109078903 109079913 109087566
CAUA : 113060713 113063685 113066549 113066552 113066554 113066638 113085421
CGIB : 127946851 127946852 127956849
LROH : 127156355(cmasb) 127163846 127164428
OMC : 131524839 131534810(cmasb) 131538692(cmasa)
PPRM : 120475374(cmasb) 120475382 120475383 120476870(cmasa)
RKG : 130071122(cmasa) 130106465 130106506
MAMB : 125246406(cmasa) 125247715 125247764 125247863 125247900 125247934 125251691
CERY : 137014594 137014770 137014859 137014938 137023896(cmasa)
MASI : 127434850 127436916
TDW : 130414207(cmasb) 130421002(cmasa)
MANU : 129432594(cmasa) 129433134 129433748 129445959
IPU : 108260153 108279965(cmasa)
IFU : 128603811 128623380(cmasa)
PHYP : 113531521 113532112
SMEO : 124378729 124400965 124401283 124401284 124401666
AMEX : 103032957(cmasa) 125798997(cmasb)
CMAO : 118811158(cmasb) 118812198(cmasa)
EEE : 113569165 113569273 113571272 113587611
SPIL : 134062239 134062611(cmasa)
PLEP : 121962198 121966280
ONL : 100690888 100691152 100691690
OAU : 116317091 116329280 116334504
XMA : 102216878 102216980 111610925 111610926
XHE : 116733436 116733437 116733438
PRET : 103480600 103480601
PFOR : 103156678 103156685(cmas) 103156781
PLAI : 106956934 106956935 106956936
PMEI : 106907823 106907824
PPRL : 129356659 129379873
CVG : 107083409 107095092 107104871 107104876
CTUL : 119779748 119787166
GMU : 124880206 124880382 124880383 124880384 124880385 124880456
ALIM : 106519069 106519070
BPEC : 110172765 110174880
MALB : 109974198 109974201
SASA : 100194895(neua) 106576595 106578766 106590764 106590838 106593487 106596479(NEUA) 106597166 106597185 106597441 106597467 106597528 106597536
STRU : 115180552 115180553 115199177 115199178 115202177
OTW : 112240998 112241039 112245012 121845714
OMY : 100135794(cmas) 110490643 110497426 118936248 118942883
OGO : 124002066 124017676(cmasa) 124027201 124028462 124028543
OKI : 109876841 109877423 109893843 116366308
OKE : 118362102 118377932 118377933 118377934
OMM : 135507746 135515659 135515660
SALP : 112068284(cmas) 112077130
SNH : 120031773 120031774 120035099 120035151 120049417 120050104
CCLU : 121535763 121557235 121557236 121561191
PSPA : 121318009 121320279
ARUT : 117414820 117419575
BFO : 118406623 118406756 118407224 118421524
BBEL : 109463567 109463577 109471768 109471775
SCLV : 120331504 120331505
SPU : 115923639 588508(cmas)
ARUN : 117292241 117292429
SKO : 100378063 100378406 102808000
PFLL : 139151869 139151881
DSI : Dsimw501_GD12235(Dsim_GD12235)
AALB : 109411850 115259468 115268775
ASUA : 134204040 134227008
LSM : 121121214 121121454 121130036
EHX : EMIHUDRAFT_442878(NANT1) EMIHUDRAFT_445636
» show all
Taxonomy
Reference
Authors
Terada T, Kitazume S, Kitajima K, Inoue S, Ito F, Troy FA, Inoue Y
Title
Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.
Journal
J Biol Chem 268:2640-8 (1993)
Reference
Authors
Terada T, Kitajima K, Inoue S, Koppert K, Brossmer R, Inoue Y
Title
Substrate specificity of rainbow trout testis CMP-3-deoxy-D-glycero-D-galacto-nonulosonic acid (CMP-Kdn) synthetase: kinetic studies of the reaction of natural and synthetic analogues of nonulosonic acid catalyzed by CMP-Kdn synthetase.
Journal
Reference
Authors
Nakata D, Munster AK, Gerardy-Schahn R, Aoki N, Matsuda T, Kitajima K
Title
Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.
Journal
Sequence
Reference
Authors
Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Munster-Kuhnel AK
Title
The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme.
Journal
Sequence
Reference
Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.92
ExPASy - ENZYME nomenclature database: 2.7.7.92