KEGG   ENZYME: 2.7.7.92
Entry
EC 2.7.7.92                 Enzyme                                 

Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate cytidylyltransferase
Reaction(IUBMB)
CTP + 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate = diphosphate + CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [RN:R11441]
Reaction(KEGG)
R11441
Substrate
CTP [CPD:C00063];
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
Product
diphosphate [CPD:C00013];
CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
Comment
The enzyme is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 2.7.7.92 created 2016
Orthology
K21749  N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase
K21750  3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase
Genes
HSA: 55907(CMAS)
PTR: 465340(CMAS)
PPS: 100970394(CMAS)
GGO: 101134064(CMAS)
PON: 100173476(CMAS)
NLE: 100588502(CMAS)
MCC: 706604(CMAS)
MCF: 102117955(CMAS)
CSAB: 103218742(CMAS)
RRO: 104660755(CMAS)
RBB: 108541109(CMAS)
CJC: 100406904(CMAS)
SBQ: 101042258(CMAS)
MMU: 12764(Cmas)
MCAL: 110296030(Cmas)
MPAH: 110316174(Cmas)
RNO: 312826(Cmas)
MUN: 110560537(Cmas)
CGE: 100773134(Cmas)
NGI: 103736727(Cmas)
HGL: 101697716(Cmas)
CCAN: 109684205(Cmas) 109700116
OCU: 100351910(CMAS)
TUP: 102484781(CMAS)
CFA: 477673(CMAS)
VVP: 112917221(CMAS)
AML: 100464890(CMAS)
UMR: 103665267(CMAS)
UAH: 113257802(CMAS)
ORO: 101367176(CMAS)
ELK: 111161354
FCA: 101096901(CMAS)
PTG: 102968672(CMAS)
PPAD: 109268728(CMAS)
AJU: 106967979(CMAS)
BTA: 100336710(CMAS)
BOM: 102265983(CMAS)
BIU: 109558556(CMAS)
BBUB: 102410777(CMAS)
CHX: 102171581(CMAS)
OAS: 101115615(CMAS)
SSC: 100520022(CMAS)
CFR: 102512611(CMAS)
CDK: 105096480(CMAS)
BACU: 103009004(CMAS)
LVE: 103076237(CMAS)
OOR: 101286195(CMAS)
PCAD: 102986559(CMAS)
EPZ: 103554940(CMAS)
EAI: 106825570(CMAS)
MYB: 102249530(CMAS)
MYD: 102769445(CMAS)
MNA: 107525267(CMAS)
HAI: 109375147(CMAS)
DRO: 112318410(CMAS)
PALE: 102891934(CMAS)
RAY: 107508579(CMAS)
MJV: 108398365(CMAS)
LAV: 100659502(CMAS)
TMU: 101358724
MDO: 100010366(CMAS)
SHR: 100916925(CMAS)
PCW: 110213797(CMAS)
OAA: 100079158(CMAS)
GGA: 418199(CMAS)
MGP: 100547771(CMAS)
CJO: 107317124(CMAS)
NMEL: 110396222(CMAS)
APLA: 101797002(CMAS)
ACYG: 106038290(CMAS)
TGU: 100225966(CMAS)
LSR: 110475217(CMAS)
SCAN: 103819571(CMAS)
GFR: 102039209(CMAS)
FAB: 101808069(CMAS)
PHI: 102099665(CMAS)
PMAJ: 107205108(CMAS)
CCAE: 111929504(CMAS)
CCW: 104696139(CMAS)
ETL: 114068941(CMAS)
FPG: 101922260(CMAS)
FCH: 102056814(CMAS)
CLV: 102093680(CMAS)
EGZ: 104135092(CMAS)
NNI: 104012728(CMAS)
ACUN: 113488254(CMAS)
PADL: 103924479(CMAS)
AAM: 106488296(CMAS)
ASN: 102377821(CMAS)
AMJ: 102572771(CMAS)
PSS: 102462348(CMAS)
CMY: 102944186(CMAS)
CPIC: 101937923(CMAS)
ACS: 100560058(cmas)
PVT: 110091200(CMAS)
PBI: 103057127(CMAS)
PMUR: 107295787(CMAS)
TSR: 106553370(CMAS)
PMUA: 114605172(CMAS)
GJA: 107106355(CMAS)
XLA: 108710695(cmas.L)
XTR: 100036739(cmas)
NPR: 108789878(CMAS)
DRE: 100885772(cmasb) 561018(cmasa)
AMEX: 103032957(cmas)
TRU: 777966(cmas)
LCO: 104933596(cmas)
OLA: 101175534(cmas)
XCO: 114157354(cmas)
AOCE: 111584516(cmas)
CSEM: 103386081(cmas)
POV: 109642938(cmas)
LCF: 108891965(cmas)
SDU: 111233310(cmas)
SLAL: 111657238(cmas)
HCQ: 109506960(cmas)
SALP: 112068284(cmas) 112077130
ELS: 105009720(cmas)
SFM: 108935968(cmas)
PKI: 111837183(cmas)
LCM: 102354669(CMAS)
CMK: 103181066(cmas)
RTP: 109936007(cmas)
CIN: 100101814(cmas)
SPU: 115923639 588508(cmas)
APLC: 110980233
DME: Dmel_CG32220(Csas)
DER: 6545780
DSE: 6619433
DSI: Dsimw501_GD12235(Dsim_GD12235)
DSR: 110190055
DPE: 6603364
DMN: 108152106
DWI: 6643060
DAZ: 108614625
DNV: 108651686
DHE: 111605622
LCQ: 111687698
AAG: 5576920
NVL: 108564803
PMAC: 106718036
PRAP: 110994754
TNL: 113508728
PXY: 105388536
API: 100161457
DNX: 107172003
AGS: 114128368
RMD: 113556369
BTAB: 109035092
CLEC: 106667611
ZNE: 110839122
FCD: 110861915
PVM: 113806787
TUT: 107359229
CSCU: 111618601
PTEP: 107440108
AMYT: AMYT_2599
ARC: ABLL_2684
HDI: HDIA_0895(kdsC)
MALG: MALG_05057
LABT: FIU93_24280(neuA)
RID: RIdsm_04041(kdsB_1)
MAGX: XM1_0966(neuA)
HLI: HLI_08590
RIX: RO1_19880
MOO: BWL13_02918(neuA)
JDE: Jden_0844
BLIN: BLSMQ_3039
ATM: ANT_06460
BTH: BT_1715
MUC: MuYL_3259
DDO: I597_1524
NDO: DDD_2292
MESQ: C7H62_1953
 » show all
Reference
1  [PMID:8381411]
  Authors
Terada T, Kitazume S, Kitajima K, Inoue S, Ito F, Troy FA, Inoue Y
  Title
Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.
  Journal
J Biol Chem 268:2640-8 (1993)
Reference
2  [PMID:8665905]
  Authors
Terada T, Kitajima K, Inoue S, Koppert K, Brossmer R, Inoue Y
  Title
Substrate specificity of rainbow trout testis CMP-3-deoxy-D-glycero-D-galacto-nonulosonic acid (CMP-Kdn) synthetase: kinetic studies of the reaction of natural and synthetic analogues of nonulosonic acid catalyzed by CMP-Kdn synthetase.
  Journal
Eur J Biochem 236:852-5 (1996)
DOI:10.1111/j.1432-1033.1996.00852.x
Reference
3  [PMID:11479279]
  Authors
Nakata D, Munster AK, Gerardy-Schahn R, Aoki N, Matsuda T, Kitajima K
  Title
Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.
  Journal
Glycobiology 11:685-92 (2001)
DOI:10.1093/glycob/11.8.685
  Sequence
Reference
4  [PMID:17580313]
  Authors
Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Munster-Kuhnel AK
  Title
The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme.
  Journal
Glycobiology 17:945-54 (2007)
DOI:10.1093/glycob/cwm064
  Sequence
[mmu:12764]
Reference
5  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1715]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.92
IUBMB Enzyme Nomenclature: 2.7.7.92
ExPASy - ENZYME nomenclature database: 2.7.7.92
BRENDA, the Enzyme Database: 2.7.7.92

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