KEGG   ENZYME: 2.7.7.93Help
Entry
EC 2.7.7.93                 Enzyme                                 

Name
phosphonoformate cytidylyltransferase;
phpF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:phosphonoformate cytidylyltransferase
Reaction(IUBMB)
CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate [RN:R08867]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
phosphonoformate [CPD:C06456]
Product
CMP-5'-phosphonoformate [CPD:C17945];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase.
History
EC 2.7.7.93 created 2016
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01130  Biosynthesis of antibiotics
Orthology
K12908  phosphonoformate cytidylyltransferase
Reference
1  [PMID:17632514]
  Authors
Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW
  Title
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
  Journal
Nat Chem Biol 3:480-5 (2007)
DOI:10.1038/nchembio.2007.9
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.93
IUBMB Enzyme Nomenclature: 2.7.7.93
ExPASy - ENZYME nomenclature database: 2.7.7.93
BRENDA, the Enzyme Database: 2.7.7.93

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