KEGG   ENZYME: 2.7.7.96
Entry
EC 2.7.7.96                 Enzyme                                 
Name
ADP-D-ribose pyrophosphorylase;
NUDIX5;
NUDT5 (gene name);
diphosphate---ADP-D-ribose adenylyltransferase;
diphosphate adenylyltransferase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
ATP:D-ribose 5-phosphate adenylyltransferase
Reaction(IUBMB)
ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose [RN:R11553]
Reaction(KEGG)
R11553
Substrate
ATP [CPD:C00002];
D-ribose 5-phosphate [CPD:C00117]
Product
diphosphate [CPD:C00013];
ADP-D-ribose [CPD:C00301]
Comment
The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling. The reaction is dependent on the presence of diphosphate. In its absence the enzyme catalyses the reaction of EC 3.6.1.13, ADP-ribose diphosphatase. cf. EC 2.7.7.35, ADP ribose phosphorylase.
History
EC 2.7.7.96 created 2016
Orthology
K13987  ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase
Genes
HSA11164(NUDT5)
PTR450306(NUDT5)
PPS100977876(NUDT5)
GGO101148720(NUDT5)
PON100172071(NUDT5)
NLE100600434(NUDT5)
MCC694368(NUDT5)
MCF102118162(NUDT5)
CSAB103237893(NUDT5)
CATY105597392(NUDT5)
PANU101022345(NUDT5)
TGE112631906(NUDT5)
RRO104664884(NUDT5)
RBB108538530(NUDT5)
TFN117082492(NUDT5)
PTEH111550058(NUDT5)
CJC100414997(NUDT5)
SBQ101035792(NUDT5)
CSYR103267159(NUDT5)
MMUR105871990(NUDT5)
LCAT123626408(NUDT5)
OGA100959416(NUDT5)
MMU53893(Nudt5)
MCAL110289308(Nudt5)
MPAH110333951(Nudt5)
RNO361274(Nudt5)
MCOC116082462(Nudt5)
MUN110560543(Nudt5)
CGE100772118(Nudt5)
MAUA101841022(Nudt5)
PLEU114708460(Nudt5)
MORG121432709(Nudt5)
AAMP119816502(Nudt5)
NGI103738702(Nudt5)
HGL101722031(Nudt5)
CPOC100723448(Nudt5)
CCAN109682446(Nudt5)
DORD105984516(Nudt5)
DSP122113110(Nudt5)
NCAR124962210
OCU100341885(NUDT5)
OPI101517621(NUDT5)
TUP102481118(NUDT5)
CFA478006(NUDT5)
CLUD112658935(NUDT5)
VVP112933374(NUDT5)
VLG121496799(NUDT5)
AML100482621(NUDT5)
UMR103676270(NUDT5)
UAH113241068(NUDT5)
UAR123789983(NUDT5) 123800652
ELK111155612
LLV125107176
MPUF101679457(NUDT5)
ORO101364423(NUDT5)
EJU114217686(NUDT5)
ZCA113921435(NUDT5)
MLX118021585(NUDT5)
FCA101084635(NUDT5)
PYU121014817(NUDT5)
PBG122472413(NUDT5)
PTG102950979(NUDT5)
PPAD109273729(NUDT5)
AJU106971034(NUDT5)
HHV120241086(NUDT5)
BTA614149(NUDT5)
BOM102283030(NUDT5)
BIU109567873(NUDT5)
BBUB102413034(NUDT5)
CHX102174220(NUDT5)
OAS101117779(NUDT5)
ODA120869271(NUDT5)
CCAD122448976(NUDT5)
SSC100511529(NUDT5)
CFR102506081(NUDT5)
CBAI105067997(NUDT5)
CDK105100309(NUDT5)
VPC102526636(NUDT5)
BACU103014516(NUDT5)
LVE103088541(NUDT5)
OOR101271940(NUDT5)
DLE111178004(NUDT5)
PCAD102986174(NUDT5)
PSIU116749766(NUDT5)
ECB100056812(NUDT5)
EPZ103563355(NUDT5)
EAI106836935(NUDT5)
MYB102243782(NUDT5)
MYD102755333(NUDT5)
MMYO118677371(NUDT5)
MLF102418798(NUDT5)
MNA107530244(NUDT5)
PKL118727251(NUDT5)
HAI109390483(NUDT5)
DRO112322673(NUDT5)
SHON119000849(NUDT5)
AJM119056687(NUDT5)
PDIC114491306(NUDT5)
PHAS123831123(NUDT5)
MMF118615257(NUDT5) 118632073
RFQ117012780 117019138(NUDT5)
PALE102895562(NUDT5)
PGIG120614600(NUDT5)
PVP105291704(NUDT5)
RAY107504857(NUDT5)
MJV108395803(NUDT5)
TOD119244686(NUDT5)
SARA101557689(NUDT5)
LAV100677273(NUDT5)
TMU101350654
DNM101415921(NUDT5)
MDO100013664(NUDT5)
GAS123249109(NUDT5)
SHR100926504(NUDT5)
PCW110217340(NUDT5)
OAA100084986(NUDT5)
GGA426368(NUDT5)
PCOC116242624(NUDT5)
MGP100538350(NUDT5)
CJO107317497(NUDT5)
NMEL110392265(NUDT5)
APLA101792445(NUDT5)
ACYG106046205(NUDT5)
AFUL116491303(NUDT5)
TGU100227819(NUDT5)
LSR110470929(NUDT5)
SCAN103813570(NUDT5)
PMOA120512495(NUDT5)
OTC121340597(NUDT5)
PRUF121362338(NUDT5)
GFR102042579(NUDT5)
FAB101811306(NUDT5)
PHI102100920(NUDT5)
PMAJ107204378(NUDT5)
CCAE111923119(NUDT5)
CCW104694502(NUDT5)
CBRC103619809(NUDT5)
ETL114066636(NUDT5)
ZAB102070954(NUDT5)
ACHL103805777(NUDT5)
FPG101911346(NUDT5)
FCH102058952(NUDT5)
CLV102084865(NUDT5)
EGZ104135774(NUDT5)
NNI104014621(NUDT5)
PLET104619219(NUDT5)
PCRI104035604(NUDT5)
ACUN113475952(NUDT5)
TALA104367680(NUDT5)
PADL103915005(NUDT5)
ACHC115342293(NUDT5)
HALD104316752(NUDT5)
CCRI104158589(NUDT5)
CSTI104551396(NUDT5)
EHS104516721(NUDT5)
CMAC104474571(NUDT5)
MUI104544361
FGA104080831(NUDT5)
GSTE104260292(NUDT5)
LDI104354551(NUDT5)
MNB103775961(NUDT5)
OHA104337624(NUDT5)
AAM106485418(NUDT5)
AROW112978063(NUDT5)
NPD112942378(NUDT5)
DNE112994759(NUDT5)
ASN102373059(NUDT5)
AMJ102562108(NUDT5)
CPOO109315806(NUDT5)
GGN109292219(NUDT5)
PSS102460805(NUDT5)
CMY102941929(NUDT5)
CPIC101938331(NUDT5)
TST117874611(NUDT5)
CABI116835460(NUDT5)
MRV120395231(NUDT5)
ACS100567214(nudt5)
PVT110081210(NUDT5)
SUND121930703(NUDT5)
PBI103064447(NUDT5)
PMUR107297192(NUDT5)
TSR106550928(NUDT5)
PGUT117668316(NUDT5)
VKO123020104(NUDT5)
PMUA114605750(NUDT5)
ZVI118091152(NUDT5)
GJA107111067(NUDT5)
STOW125435403(NUDT5)
XLA108713048(nudt5.S) 432263(nudt5.L)
XTR549367(nudt5)
NPR108784813(NUDT5)
RTEM120931702(NUDT5)
BBUF120983630(NUDT5)
BGAR122925390(NUDT5)
DRE415176(nudt5)
SRX107726016 107743836
SANH107656337 107658859
SGH107580386 107584018(nudt5)
CCAR109066493(nudt5)
CAUA113058729(nudt5)
PPRM120476655(nudt5)
MAMB125245400(nudt5)
IPU100528701(nudt5)
PHYP113532134(nudt5)
SMEO124400931(nudt5)
TFD113635093(nudt5)
AMEX103033374(nudt5)
EEE113584613(nudt5)
TRU115246641(nudt5)
TNGGSTEN00013252G001
LCO104930602(nudt5)
NCC104955336(nudt5)
CGOB115028144(nudt5)
ELY117249003(nudt5)
EFO125882832(nudt5)
PLEP121961712(nudt5)
SLUC116054528(nudt5)
ECRA117938651(nudt5)
ESP116672811(nudt5)
PFLV114550087(nudt5)
GAT120817693(nudt5)
PPUG119211301(nudt5)
MSAM119918013(nudt5)
CUD121505637(nudt5)
ALAT119032273(nudt5)
MZE101470680(nudt5)
ONL100691676(nudt5)
OAU116317027(nudt5)
OLA101161229(nudt5)
OML112138286(nudt5)
XMA102224507(nudt5)
XCO114161063(nudt5)
XHE116736820(nudt5)
PRET103459674(nudt5)
PFOR103151529(nudt5)
PLAI106939907(nudt5)
PMEI106910230(nudt5)
GAF122826518(nudt5)
CVG107096229(nudt5)
CTUL119794458(nudt5)
GMU124882691(nudt5)
NFU107382591(nudt5)
KMR108245546(nudt5)
ALIM106524598(nudt5)
NWH119428608(nudt5)
AOCE111579133(nudt5)
MCEP125000364(nudt5)
CSEM103383109(nudt5)
POV109632774(nudt5)
SSEN122766261(nudt5)
HHIP117756994(nudt5)
HSP118101933(nudt5)
LCF108874307(nudt5) 108891412
SDU111224766(nudt5)
SLAL111667281(nudt5)
XGL120799818(nudt5)
HCQ109528866(nudt5)
BPEC110161767(nudt5)
MALB109960917(nudt5)
BSPL114861381(nudt5)
SASA100196024(nudt5) 106609278(NUDT5)
OTW112215017 112216934(nudt5)
OMY110490345 110500138
OGO123994568 124014450
ONE115119431 115133094
SALP111949778 111951434
SNH120032181 120050062
CCLU121543580 121559076
ELS105028521(nudt5)
SFM108931529(nudt5)
PKI111842369(nudt5)
AANG118231645(nudt5)
LOC102682917(nudt5)
PSPA121319847(nudt5)
ARUT117415728 117419430
LCM102359306(NUDT5)
CMK103187912(nudt5)
BFO118415934
BBEL109477274
SCLV120347350
SPU580253
APLC110987738
SKO100371378
BTAB109039647
FOC113206125
TPAL117645005
ZNE110831927
CSEC111866312
FCD110850781
PVM113820552
HAME121857297
ISCIscW_ISCW021976
DSV119465892
RSAN119371980
RMP119163799
TUT107360643
DPTE113789553
DFR124499901
CSCU111621324
PTEP107436389
SDM118202731
LOALOAG_03218
LGILOTGIDRAFT_204741
PCAN112571706
GAE121390067
HRF124136284
HRJ124281969
CRG117683170
MYI110448861
PMAX117331692
MMER123528667
OBI106881854
OSN115210667
LAK106166567
AQU100632790
OLUOSTLU_38092
OTAOT_ostta10g00760
PANPODANSg4001
ACANACA1_131000 ACA1_177470
FCYFRACYDRAFT_162205
GTTGUITHDRAFT_166567
 » show all
Reference
1  [PMID:27257257]
  Authors
Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, Nacht AS, Samino S, Font-Mateu J, Vicent GP, Wierer M, Trabado MA, Schelhorn C, Carolis C, Macias MJ, Yanes O, Oliva B, Beato M
  Title
ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.
  Journal
Science 352:1221-5 (2016)
DOI:10.1126/science.aad9335
  Sequence
[hsa:11164]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.96
IUBMB Enzyme Nomenclature: 2.7.7.96
ExPASy - ENZYME nomenclature database: 2.7.7.96
BRENDA, the Enzyme Database: 2.7.7.96

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