KEGG   ENZYME: 2.7.8.14
Entry
EC 2.7.8.14                 Enzyme                                 

Name
CDP-ribitol ribitolphosphotransferase;
teichoic-acid synthase (ambiguous);
polyribitol phosphate synthetase (ambiguous);
teichoate synthetase (ambiguous);
poly(ribitol phosphate) synthetase (ambiguous);
polyribitol phosphate polymerase (ambiguous);
teichoate synthase (ambiguous);
CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-ribitol:4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase
Reaction(IUBMB)
n CDP-ribitol + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11621]
Reaction(KEGG)
R11621
Substrate
CDP-ribitol [CPD:C00789];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]
Product
CMP [CPD:C00055];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]
Comment
Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds around 40 ribitol units to the linker molecule.
History
EC 2.7.8.14 created 1972 as EC 2.4.1.55, transferred 1982 to EC 2.7.8.14, modified 2017
Orthology
K18704  CDP-ribitol ribitolphosphotransferase / teichoic acid ribitol-phosphate polymerase
Genes
CCON: AFK62_03185
ESC: Entcl_3738
YMA: DA391_06385
BSUN: A4G13_01115
APJ: APJL_1614(cps3A)
VAQ: FIV01_00150(tagB) FIV01_15895(epsJ)
PPR: PBPRA2702
ALJ: G8D99_14940
COLW: A3Q33_09700
PTN: PTRA_a0500
PPHE: PP2015_409
AAUS: EP12_00250
CJS: CJS3_1521
CJQ: UC78_1376(tagB)
CJR: CJE1613
CCY: YSS_07705
CCOF: VC76_07105(epsJ_2)
CCOO: ATE51_00688(epsJ_1)
CAVI: CAV_0458
NAM: NAMH_1605
DMA: DMR_40290
BSL: A7A1_1140
BSX: C663_3471(tarL)
BSS: BSUW23_17580(tarL)
BST: GYO_3936(tarL)
BMOJ: HC660_34700(tagB)
BACY: QF06_16305
AFL: Aflv_2574(tagB)
SAX: USA300HOU_0264(tagB1) USA300HOU_0268(tagB2)
SUW: SATW20_02550(tarK) SATW20_02590(tarL)
SER: SERP0198
SEP: SE_0321
SEPP: SEB_00243
SEPS: DP17_1631
SSP: SSP0356
SCA: SCA_2404
SSCH: LH95_01800
SARL: SAP2_04720
SSH: NCTC13712_00199(tagF_1) NCTC13712_00203(tagF_3)
SSIM: SAMEA4384339_0090(tagF_1)
LMOG: BN389_11100(tarL)
LMP: MUO_05655
LMOX: AX24_02805
LMQ: LMM7_1109
LMOK: CQ02_05615
LIN: lin1068
LWE: lwe1060
LIV: LIV_1026
LGZ: NCTC10812_01040(tagF_3) NCTC10812_01812(tagF_6) NCTC10812_01814(tagF_7) NCTC10812_02004(kfoC_3)
ESI: Exig_0188
EAN: Eab7_0180(tarL)
LLK: LLKF_0947(ggaB)
LLX: NCDO2118_0939(ggaB)
LLJ: LG36_1406(ggaB)
LLM: llmg_1603(tagB)
LPL: lp_1819(tarL)
LPJ: JDM1_1532(tagB2)
LPT: zj316_1807(tarL)
LPS: LPST_C1461(tagB2)
LPZ: Lp16_1408
PCE: PECL_1837
WCE: WS08_0699
WCT: WS74_0701
CBT: CLH_2994
CBV: U729_1133
RIX: RO1_35060
RIM: ROI_04730
HSD: SD1D_2042
AARG: Aargi30884_26940(tagB)
ABSI: A9CBEGH2_00110(tagB)
LXL: KDY119_02610(tarL)
MOO: BWL13_02197(tarL)
JDE: Jden_1795
XCE: Xcel_2590
IDO: I598_2371(tagF_2)
BBP: BBPR_0698 BBPR_0699(tagB)
BBF: BBB_0690(tarK) BBB_0691
AEQ: AEQU_0651
DDO: I597_2601
TRQ: TRQ2_0300
MRU: mru_1079
MSI: Msm_1327
MEB: Abm4_1699
MMIL: sm9_2259
MEYE: TL18_00335
MOL: YLM1_0599
MCUB: MCBB_1531(tarL)
 » show all
Reference
1  [PMID:5908130]
  Authors
Ishimoto N, Strominger JL.
  Title
Polyribitol phosphate synthetase of Staphylococcus aureus.
  Journal
J Biol Chem 241:639-50 (1966)
Reference
2  [PMID:18215769]
  Authors
Brown S, Zhang YH, Walker S
  Title
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
  Journal
Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011
  Sequence
Reference
3  [PMID:18556787]
  Authors
Pereira MP, D'Elia MA, Troczynska J, Brown ED
  Title
Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases.
  Journal
J Bacteriol 190:5642-9 (2008)
DOI:10.1128/JB.00526-08
Reference
4  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.14
IUBMB Enzyme Nomenclature: 2.7.8.14
ExPASy - ENZYME nomenclature database: 2.7.8.14
BRENDA, the Enzyme Database: 2.7.8.14
CAS: 9076-71-5

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