KEGG   ENZYME: 2.7.8.17
Entry
EC 2.7.8.17                 Enzyme                                 
Name
UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase;
N-acetylglucosaminylphosphotransferase;
UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase;
uridine diphosphoacetylglucosamine-lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase;
uridine diphosphoacetylglucosamine-glycoprotein acetylglucosamine-1-phosphotransferase;
lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase;
N-acetylglucosaminyl phosphotransferase;
UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase;
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase;
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose [RN:R04291]
Reaction(KEGG)
R04291
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
lysosomal-enzyme D-mannose [CPD:C03706]
Product
UMP [CPD:C00105];
lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose [CPD:C04789]
Comment
Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes.
History
EC 2.7.8.17 created 1984
Orthology
K08239  UDP-N-acetylglucosamine-lysosomal-enzyme
Genes
HSA79158(GNPTAB)
PTR452176(GNPTAB)
PPS100986324(GNPTAB)
GGO101124301(GNPTAB)
PON100441852(GNPTAB)
NLE100606002(GNPTAB)
MCC697307(GNPTAB)
MCF102121493(GNPTAB)
MTHB126931766
CSAB103238949(GNPTAB)
CATY105573316(GNPTAB)
PANU101012528(GNPTAB)
TGE112634278(GNPTAB)
RRO104657408(GNPTAB)
RBB108543135(GNPTAB)
TFN117089538(GNPTAB)
PTEH111522870(GNPTAB)
CJC100394765(GNPTAB)
SBQ101034734(GNPTAB)
CSYR103258830(GNPTAB)
MMUR105875558(GNPTAB)
LCAT123639381(GNPTAB)
OGA100961486(GNPTAB)
MMU432486(Gnptab)
MCAL110303855(Gnptab)
MPAH110326364(Gnptab)
RNO362865(Gnptab)
MCOC116075767(Gnptab)
MUN110550289(Gnptab)
CGE100774953(Gnptab)
MAUA101830846(Gnptab)
PLEU114700625(Gnptab)
MORG121459254(Gnptab)
MFOT126503848
AAMP119803598(Gnptab)
NGI103733731(Gnptab)
HGL101710539(Gnptab)
CPOC100716394(Gnptab)
CCAN109690295(Gnptab)
DORD105987699(Gnptab)
DSP122119119(Gnptab)
NCAR124983165
OCU100340567(GNPTAB)
OPI101529623(GNPTAB)
TUP102486510(GNPTAB)
CFA475443(GNPTAB)
CLUD112654528(GNPTAB)
VVP112930646(GNPTAB)
VLG121481192(GNPTAB)
AML100483884(GNPTAB)
UMR103676570(GNPTAB)
UAH113256088(GNPTAB)
UAR123780943(GNPTAB)
ELK111142162
LLV125106764
MPUF101677824(GNPTAB)
ORO101376907(GNPTAB)
EJU114222949(GNPTAB)
ZCA113921984(GNPTAB)
MLX117998822(GNPTAB)
NSU110578048(GNPTAB)
FCA101100231(GNPTAB)
PYU121040534(GNPTAB)
PBG122472592(GNPTAB)
LRUF124501263
PTG102962249(GNPTAB)
PPAD109265406(GNPTAB)
AJU106971899(GNPTAB)
HHV120245435(GNPTAB)
BTA509610(GNPTAB)
BOM102269745(GNPTAB)
BIU109559441(GNPTAB)
BBUB102390456(GNPTAB)
CHX102186936(GNPTAB)
OAS101122348(GNPTAB)
ODA120858668(GNPTAB)
CCAD122423277(GNPTAB)
SSC100523554(GNPTAB)
CFR102511319(GNPTAB)
CBAI105075044(GNPTAB)
CDK105097459(GNPTAB)
VPC102533919(GNPTAB)
BACU103017866(GNPTAB)
LVE103075123(GNPTAB)
OOR101271916(GNPTAB)
DLE111187783(GNPTAB)
PCAD102977484(GNPTAB)
PSIU116760494(GNPTAB)
ECB100067011(GNPTAB)
EPZ103555699(GNPTAB)
EAI106827262(GNPTAB)
MYB102257362(GNPTAB)
MYD102766549(GNPTAB)
MMYO118650111(GNPTAB)
MLF102427082(GNPTAB)
MNA107545143(GNPTAB)
PKL118730822(GNPTAB)
HAI109387783(GNPTAB)
DRO112321707(GNPTAB)
SHON119002254(GNPTAB)
AJM119060473(GNPTAB)
PDIC114512842(GNPTAB)
PHAS123810621(GNPTAB)
MMF118623581(GNPTAB)
RFQ117028719(GNPTAB)
PALE102892520(GNPTAB)
PGIG120614963(GNPTAB)
PVP105310616(GNPTAB)
RAY107501162(GNPTAB)
MJV108400322(GNPTAB)
TOD119247377(GNPTAB)
SARA101540086(GNPTAB)
LAV100668883(GNPTAB)
DNM101445799(GNPTAB)
MDO100021000(GNPTAB)
GAS123249623(GNPTAB)
SHR100917351(GNPTAB)
PCW110205645(GNPTAB)
OAA100075585(GNPTAB)
GGA418096(GNPTAB)
PCOC116226789(GNPTAB)
MGP100546740(GNPTAB)
CJO107316196(GNPTAB)
NMEL110393985(GNPTAB)
APLA101792400(GNPTAB)
ACYG106031028(GNPTAB)
AFUL116497841(GNPTAB)
TGU100225345(GNPTAB)
LSR110473676(GNPTAB)
SCAN103819648(GNPTAB)
PMOA120501617(GNPTAB)
OTC121332745(GNPTAB)
PRUF121363579(GNPTAB)
GFR102032997(GNPTAB)
FAB101807127(GNPTAB)
PHI102114373(GNPTAB)
PMAJ107204412(GNPTAB)
CCAE111931335(GNPTAB)
CCW104696224(GNPTAB)
CBRC103619548(GNPTAB)
ETL114056141(GNPTAB)
ZAB102065149(GNPTAB)
ACHL103809887
FPG101921963(GNPTAB)
FCH102059391(GNPTAB)
CLV102091116(GNPTAB)
EGZ104135578(GNPTAB)
NNI104013363(GNPTAB)
PLET104626726(GNPTAB)
PCRI104024405(GNPTAB)
ACUN113491601(GNPTAB)
TALA104365817(GNPTAB)
PADL103924423(GNPTAB)
AFOR103906462(GNPTAB)
ACHC115352300(GNPTAB)
HALD104311159(GNPTAB)
CCRI104162583(GNPTAB)
CSTI104558924(GNPTAB)
EHS104513219(GNPTAB)
CMAC104477757(GNPTAB)
MUI104538817(GNPTAB)
FGA104081372
GSTE104258959(GNPTAB)
LDI104350101(GNPTAB)
MNB103774366(GNPTAB)
OHA104338297(GNPTAB)
NNT104402056(GNPTAB)
DPUB104296557(GNPTAB)
PGUU104462220(GNPTAB)
ACAR104532149(GNPTAB)
AVIT104270242(GNPTAB)
CVF104288586(GNPTAB)
AAM106488838(GNPTAB)
AROW112974673(GNPTAB)
NPD112946613(GNPTAB)
TGT104578353(GNPTAB)
DNE112995038(GNPTAB)
SCAM104147342(GNPTAB)
ASN102381964(GNPTAB)
AMJ102569913(GNPTAB)
CPOO109316551(GNPTAB)
GGN109296134(GNPTAB)
PSS102458343(GNPTAB)
CMY102933760(GNPTAB)
CPIC101937487(GNPTAB)
TST117881499(GNPTAB)
CABI116825717(GNPTAB)
MRV120369846(GNPTAB)
ACS100561961(gnptab)
PVT110082687(GNPTAB)
SUND121931370(GNPTAB)
PBI103063690(GNPTAB)
PMUR107289471(GNPTAB)
CTIG120305859(GNPTAB)
TSR106549829(GNPTAB)
PGUT117655764(GNPTAB)
VKO123028890(GNPTAB)
PMUA114605356(GNPTAB)
ZVI118090717(GNPTAB)
GJA107119577
STOW125434905(GNPTAB)
XLA108711016(gnptab.L) 108713209(gnptab.S)
XTR100036684(gnptab)
NPR108787158(GNPTAB)
RTEM120932134(GNPTAB)
BBUF120979102(GNPTAB)
BGAR122928136(GNPTAB)
DRE553365(gnptab)
SRX107725515 107725516 107744940
SANH107664853 107695880
SGH107578483 107590216(gnptab) 107593561
CCAR109052697(gnptab)
CAUA113048152 113062700
PPRM120477024(gnptab)
MAMB125245517(gnptab)
IPU108274741(gnptab)
PHYP113529818(gnptab)
SMEO124392217(gnptab)
TFD113653994(gnptab)
AMEX103033431(gnptab)
EEE113587996(gnptab)
TRU101073922(gnptab)
TNGGSTEN00021551G001
LCO104926728(gnptab)
NCC104950103(gnptab)
CGOB115028529(gnptab)
ELY117249483(gnptab)
EFO125882938(gnptab)
PLEP121961361(gnptab)
SLUC116060191(gnptab)
ECRA117938722(gnptab)
ESP116673281(gnptab)
PFLV114549950(gnptab)
GAT120817672(gnptab)
PPUG119210337(gnptab)
MSAM119917979(gnptab)
CUD121505565(gnptab)
ALAT119032654(gnptab)
MZE101475826(gnptab)
ONL100693179(gnptab)
OAU116334737(gnptab)
OLA101160613(gnptab)
OML112154151(gnptab)
XMA102234905(gnptab)
XCO114160852(gnptab)
XHE116736477(gnptab)
PRET103459179(gnptab)
PFOR103156924(gnptab)
PLAI106937965
PMEI106914464(gnptab)
GAF122826198(gnptab)
CVG107085887(gnptab)
CTUL119776899(gnptab)
GMU124882859(gnptab)
NFU107386129(gnptab)
KMR108233168(gnptab)
ALIM106534107
NWH119428546(gnptab)
AOCE111582871(gnptab)
MCEP124999963(gnptab)
CSEM103382686(gnptab)
POV109647166
SSEN122765715(gnptab)
HHIP117757181(gnptab)
HSP118101279(gnptab)
LCF108890213
SDU111225004(gnptab)
SLAL111656504(gnptab)
XGL120799856(gnptab)
HCQ109520445 109523683(gnptab) 109531035
BPEC110161776(gnptab)
MALB109959884(gnptab)
BSPL114861717(gnptab)
SASA106576272 106609432
STRU115180191 115198933
OTW112214208 112217000
OMY110490418(gnptab) 110500058
OGO123994493 124013741
ONE115107059 115133039(gnptab)
SALP111949335(gnptab) 111951374
SNH120032069 120049940
CCLU121543525 121548952
ELS105030154(gnptab)
SFM108931544(gnptab)
PKI111846561(gnptab)
AANG118218692(gnptab)
LOC102690544(gnptab)
PSPA121318430(gnptab)
ARUT117419810(gnptab)
LCM102357933(GNPTAB)
CMK103179873(gnptab)
RTP109935929
BFO118419938
BBEL109467924
CIN100175423
SCLV120338836
SPU100891240
APLC110975033
SKO102800521
DMEDmel_CG8027(CG8027)
DER6540631
DSE6608323
DSIDsimw501_GD10091(Dsim_GD10091)
DYADyak_GE22445
DAN6495935
DSR110176269
DPO4804592
DPE6592343
DMN108160549
DWI6646162
DMODmoj_GI19208
DAZ108617543
DNV108653552
DHE111604105
DVI6625684
CCAT101451009
BOD106619812
RZE108373929
MDE105262536
SCAC106092261
LCQ111675955
LSQ119615591
HIS119661752
AGAAgaP_AGAP012336
ACOZ120955677
AARA120901355
ASTE118508395
AAG5569134
AALB109407546 115253452
CQUCpipJ_CPIJ005729
CPII120423893
AME552725
ACER107998891
ALAB122721041
BIM100750026
BBIF117210195
BVK117241731
BVAN117157073
BTER100644736
BPYO122573334
CCAL108631356
OBB114883021 114883038
MGEN117219831
NMEA116424785
CGIG122403286
SOC105200650
MPHA105831784
AEC105149757
ACEP105620156
PBAR105432088
VEM105558455
HST105181322
DQU106745239
CFO105259355
FEX115242761
LHU105671433
PGC109858480
OBO105282929
PCF106784009
PFUC122524776
VPS122628219
NVI100121219
CSOL105360226
TPRE106657864
MDL103578445
CGLO123260397
FAS105266468
DAM107041642
AGIF122858826
CCIN107263777
TCA658742
DPA109543779
ATD109603709
CSET123320233
AGB108908014
LDC111507569
NVL108561151
APLN108735861
PPYR116161012
CLEC106663634
HHAL106689519
NLU111058841
PHUPhum_PHUM365660
FOC113207711
TPAL117640951
ZNE110832957
CSEC111873081
PVM113810960
PJA122256758
PCHN125042478
HAME121876923
PCLA123746530
PTRU123499905
HAZT108673148
PPOI119094497
ISCIscW_ISCW000548
DSV119448884
RSAN119383888
RMP119169837
TUT107361970
DPTE113792887
DFR124493161
CSCU111638304
PTEP107456786
SDM118183519
HROHELRODRAFT_85704
LGILOTGIDRAFT_238796
PCAN112559231
BGT106051917
GAE121382338
HRF124141048
HRJ124281882
CRG105336164
MYI110450047
PMAX117335468
MMER123536730 123550858
OBI106867695
OSN115214114
LAK106178212
NVE116618049 5511923
EPA110243799
ATEN116287560
ADF107352997
AMIL114953565
PDAM113681410
SPIS111319225
DGT114532361
XEN124443043
HMG100199845
TADTRIADDRAFT_51611
AQU100632364
MBRMONBRDRAFT_26647
SREPTSG_12554
DDIDDB_G0285815(gpt1)
DPPDICPUDRAFT_158811
DFADFA_06347(gpt1)
PIFPITG_00725
PSOJPHYSODRAFT_302006
SPARSPRG_00375 SPRG_00376 SPRG_00377 SPRG_15088 SPRG_18839
NGRNAEGRDRAFT_77790
 » show all
Reference
1  [PMID:6452459]
  Authors
Reitman ML, Kornfeld S.
  Title
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes.
  Journal
J Biol Chem 256:4275-81 (1981)
Reference
2  [PMID:6457829]
  Authors
Reitman ML, Kornfeld S.
  Title
Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes.
  Journal
J Biol Chem 256:11977-80 (1981)
Reference
3  [PMID:6288715]
  Authors
Waheed A, Hasilik A, von Figura K.
  Title
UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme.
  Journal
J Biol Chem 257:12322-31 (1982)
Reference
4  [PMID:6260788]
  Authors
Waheed A, Pohlmann R, Hasilik A, von Figura K.
  Title
Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes.
  Journal
J Biol Chem 256:4150-2 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.17
IUBMB Enzyme Nomenclature: 2.7.8.17
ExPASy - ENZYME nomenclature database: 2.7.8.17
BRENDA, the Enzyme Database: 2.7.8.17
CAS: 84012-69-1

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