| Entry |
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| Name |
carboxyvinyl-carboxyphosphonate phosphorylmutase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
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| Sysname |
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
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| Reaction(IUBMB) |
1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2 [RN: R05165]
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| Reaction(KEGG) |
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| Substrate |
1-carboxyvinyl carboxyphosphonate [CPD: C06367]
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| Product |
3-(hydroxyphosphinoyl)pyruvate;
CO2 [CPD: C00011]
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| Comment |
Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.
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| History |
EC 2.7.8.23 created 1999
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| Pathway |
| ec00440 | Phosphonate and phosphinate metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K12909 | carboxyvinyl-carboxyphosphonate phosphorylmutase |
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| Reference |
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| Authors |
Pollack SJ, Freeman S, Pompliano DL, Knowles JR |
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| Title |
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ |
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| Title |
Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.8.23 |
| ExPASy - ENZYME nomenclature database: | 2.7.8.23 |
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