KEGG   ENZYME: 2.7.8.23
Entry
EC 2.7.8.23                 Enzyme                                 
Name
carboxyvinyl-carboxyphosphonate phosphorylmutase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
Reaction(IUBMB)
1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2 [RN:R05165]
Reaction(KEGG)
R05165;
(other) R08868 R08869
Substrate
1-carboxyvinyl carboxyphosphonate [CPD:C06367]
Product
3-(hydroxyphosphinoyl)pyruvate;
CO2 [CPD:C00011]
Comment
Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.
History
EC 2.7.8.23 created 1999
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K12909  carboxyvinyl-carboxyphosphonate phosphorylmutase
Reference
1  [PMID:1330557]
  Authors
Pollack SJ, Freeman S, Pompliano DL, Knowles JR
  Title
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.
  Journal
Eur J Biochem 209:735-43 (1992)
DOI:10.1111/j.1432-1033.1992.tb17342.x
  Sequence
[ag:CAA48139]
Reference
2  [PMID:3611020]
  Authors
Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ
  Title
Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus.
  Journal
J Bacteriol 169:3482-8 (1987)
DOI:10.1128/JB.169.8.3482-3488.1987
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.23
IUBMB Enzyme Nomenclature: 2.7.8.23
ExPASy - ENZYME nomenclature database: 2.7.8.23
BRENDA, the Enzyme Database: 2.7.8.23
CAS: 122799-57-9

  All links  
Protein sequence (546)   
   UniProt (506)   
   SWISS-PROT (2)   
   RefSeq(pep) (36)   
   PDBSTR (2)   
DNA sequence (1052)   
   RefSeq(nuc) (53)   
   GenBank (511)   
   EMBL (488)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   InterPro (5)   
   PROSITE(DOC) (1)   
All databases (1605)   

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