KEGG   ENZYME: 2.7.8.27
Entry
EC 2.7.8.27                 Enzyme                                 
Name
sphingomyelin synthase;
SM synthase;
SMS1;
SMS2
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
ceramide:phosphatidylcholine cholinephosphotransferase
Reaction(IUBMB)
a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol [RN:R08969]
Reaction(KEGG)
R08969
Substrate
ceramide [CPD:C00195];
phosphatidylcholine [CPD:C00157]
Product
sphingomyelin [CPD:C00550];
1,2-diacyl-sn-glycerol [CPD:C00641]
Comment
The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].
History
EC 2.7.8.27 created 2006
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04714  shingomyelin synthase
Genes
HSA166929(SGMS2) 259230(SGMS1)
PTR100613097(SGMS2) 450460(SGMS1)
PPS100983907(SGMS1) 100993903(SGMS2)
GGO101138449(SGMS2) 101138874(SGMS1)
PON100444992(SGMS1) 100446194(SGMS2)
NLE100593842(SGMS2) 100601656(SGMS1)
HMH116457981(SGMS1) 116479900(SGMS2)
MCC695947(SGMS2) 704027(SGMS1)
MCF101867034(SGMS2) 102126212(SGMS1)
MTHB126954936 126963334
MNI105480969(SGMS1) 105486291(SGMS2)
CSAB103216200(SGMS1) 103236087(SGMS2)
CATY105571409(SGMS2) 105587181(SGMS1)
PANU101011331(SGMS1) 101015814(SGMS2)
TGE112624680(SGMS2) 112631808(SGMS1)
MLEU105546572(SGMS2) 105546952(SGMS1)
RRO104670047(SGMS2) 104675166(SGMS1)
RBB108515885(SGMS2) 108523223 108527547(SGMS1)
TFN117085758(SGMS2) 117085985(SGMS1)
PTEH111548010(SGMS2) 111551301(SGMS1)
CANG105509519(SGMS1) 105514394(SGMS2)
CJC100391389(SGMS1) 100400486(SGMS2)
SBQ101041388(SGMS1) 101049165(SGMS2)
CIMI108289524(SGMS2) 108309815(SGMS1)
CSYR103258321(SGMS2) 103273217(SGMS1)
MMUR105870303(SGMS1) 105872332(SGMS2)
LCAT123627733(SGMS2) 123650393(SGMS1)
PCOQ105818959(SGMS2) 105822727(SGMS1)
OGA100957457(SGMS2) 100957686(SGMS1)
MMU208449(Sgms1) 74442(Sgms2)
MCAL110285283(Sgms1) 110291657(Sgms2)
MPAH110319526(Sgms1) 110320695(Sgms2)
RNO310849(Sgms2) 353229(Sgms1)
MCOC116093796(Sgms2) 116103734(Sgms1)
ANU117705952(Sgms1) 117707767(Sgms2)
MUN110546451(Sgms2) 110558522(Sgms1)
CGE100760913(Sgms2) 100766719(Sgms1)
MAUA101822420(Sgms2) 101825787(Sgms1)
PROB127217268 127223026(Sgms2) 127233484(Sgms1)
PLEU114682862(Sgms2)
MORG121448507(Sgms2) 121453974(Sgms1)
MFOT126504269 126510848
AAMP119801000(Sgms2) 119824048(Sgms1)
NGI103738051(Sgms1) 103742560(Sgms2)
HGL101710267(Sgms1) 101712715(Sgms2)
CPOC100715504(Sgms2) 100730655(Sgms1)
CCAN109681828(Sgms1) 109684300(Sgms2)
DORD105986327(Sgms1) 105991179(Sgms2)
DSP122115733(Sgms1) 122127241(Sgms2)
PLOP125341416(Sgms2) 125346323(Sgms1)
NCAR124984606 124994521
MMMA107141374(Sgms2) 107153343(Sgms1)
OCU100354454 100357932
OPI101525177(SGMS1) 101536125(SGMS2)
TUP102484900(SGMS2) 102485341(SGMS1)
GVR103593300(SGMS1) 103593798(SGMS2)
CFA477582(SGMS1) 478505(SGMS2)
CLUD112656219(SGMS1) 112671615(SGMS2)
VVP112931981(SGMS1) 112934190(SGMS2)
VLG121475421(SGMS1) 121493772(SGMS2)
NPO129507907(SGMS1) 129521142(SGMS2)
AML100466473(SGMS2) 100468555(SGMS1)
UMR103661724(SGMS2) 103661914(SGMS1)
UAH113255540(SGMS2) 113258982(SGMS1)
UAR123793378(SGMS2) 123795556(SGMS1)
ELK111145303 111157064
LLV125085139 125093258
MPUF101689257(SGMS1) 101691106(SGMS2)
MNP132001975(SGMS2) 132016223(SGMS1)
MLK131828965(SGMS1) 131829529(SGMS2)
NVS122889285(SGMS2) 122900673(SGMS1)
ORO101368457(SGMS1) 101371231(SGMS2)
EJU114210244(SGMS1) 114222650(SGMS2)
ZCA113923400(SGMS1) 113924382(SGMS2)
MLX118012974(SGMS1) 118027076(SGMS2)
NSU110575524(SGMS2) 110586030(SGMS1)
LWW102736183(SGMS1) 102736720(SGMS2)
FCA101088574(SGMS2) 101090897(SGMS1)
PYU121016560(SGMS1) 121031520(SGMS2)
PCOO112851478(SGMS1) 112858462(SGMS2)
PBG122477697(SGMS2) 122492662(SGMS1)
LRUF124518706 124520963
PTG102957023(SGMS1) 102970893(SGMS2)
PPAD109247772(SGMS2) 109255389(SGMS1)
PUC125923002 125933184
AJU106980950 106988439
HHV120235951(SGMS1) 120236157(SGMS2)
BTA520954(SGMS2) 533538(SGMS1)
BOM102268543(SGMS2) 102269418(SGMS1)
BIU109553156 109560269(SGMS2) 109579164(SGMS1)
BBUB102400941(SGMS1) 102411175(SGMS2)
BBIS104982767(SGMS1) 105002092(SGMS2)
CHX102184583(SGMS1) 102187660(SGMS2)
OAS101118575(SGMS1) 101123121(SGMS2)
BTAX128049850(SGMS2) 128067714(SGMS1)
ODA120861745(SGMS2) 120873778(SGMS1)
CCAD122422059(SGMS2) 122446202(SGMS1)
MBEZ129555584(SGMS1) 129562211(SGMS2)
SSC100037303(SGMS1) 100518796(SGMS2)
CFR102508365(SGMS1) 102509917(SGMS2)
CBAI105067940(SGMS2) 105081867(SGMS1)
CDK105088962(SGMS1) 105105285(SGMS2)
VPC102529758(SGMS1) 102542154(SGMS2)
BACU103014494(SGMS1) 103016480(SGMS2)
LVE103070270(SGMS2) 103073289(SGMS1)
OOR101278460(SGMS1) 101288900(SGMS2)
DLE111171488(SGMS2) 111172536(SGMS1)
PCAD102978203(SGMS1) 102994661(SGMS2)
PSIU116741663(SGMS1) 116754399(SGMS2)
NASI112397674(SGMS2) 112399573(SGMS1)
ECB100062484(SGMS1) 100072971(SGMS2)
EPZ103546319(SGMS2) 103549843(SGMS1)
EAI106829816(SGMS2) 106845892(SGMS1)
MYB102255621(SGMS1) 102257109(SGMS2)
MYD102752902(SGMS1) 102771993(SGMS2)
MMYO118670007(SGMS1) 118673175(SGMS2)
MLF102430536(SGMS1) 102439892(SGMS2)
MNA107538294(SGMS2) 107543307(SGMS1)
PKL118702959(SGMS2) 118719254(SGMS1)
EFUS103293870(SGMS2) 103296373(SGMS1)
HAI109379483(SGMS2) 109387531(SGMS1)
DRO112296362(SGMS2) 112307416(SGMS1)
SHON118977086(SGMS2) 119001528(SGMS1)
AJM119035368(SGMS2) 119059997(SGMS1)
PDIC114492967(SGMS2) 114496137(SGMS1)
PHAS123806868(SGMS2) 123828750(SGMS1)
MMF118632035(SGMS1) 118638591(SGMS2)
RFQ117022353(SGMS2) 117035945(SGMS1)
PPAM129069985(SGMS1) 129085302(SGMS2)
PALE102883450(SGMS1) 102886439(SGMS2)
PGIG120591200(SGMS2) 120609363(SGMS1)
PVP105293007(SGMS2) 105293117(SGMS1)
RAY107515499(SGMS1) 107518804(SGMS2)
MJV108396674(SGMS1) 108401174(SGMS2)
TOD119234910(SGMS1) 119243647(SGMS2)
SARA101537189(SGMS1) 101547429(SGMS2)
LAV100662186(SGMS1) 100666455(SGMS2)
TMU101344228 101353208
ETF101641498(SGMS1) 101645512(SGMS2)
DNM101430061(SGMS2) 101441610(SGMS1)
MDO100011020(SGMS2) 100013212(SGMS1)
GAS123233050(SGMS1) 123251364(SGMS2)
SHR100928230(SGMS1) 100933601(SGMS2)
AFZ127541302 127552156
PCW110199924(SGMS1) 110218607(SGMS2)
OAA100079264(SGMS2) 100088367(SGMS1)
GGA378907(SGMS1) 422529(SGMS2)
PCOC116234762(SGMS1) 116237975(SGMS2)
MGP100540329(SGMS1) 100541752(SGMS2)
CJO107313258(SGMS2) 107315618(SGMS1)
TPAI128077924(SGMS1) 128079993(SGMS2)
LMUT125692030(SGMS2) 125694040(SGMS1)
NMEL110390482(SGMS1) 110398348(SGMS2)
APLA101791169(SGMS2) 101798673(SGMS1)
ACYG106030221(SGMS1) 106038651(SGMS2)
CATA118247268(SGMS2) 118257373(SGMS1)
AFUL116488781(SGMS2) 116491492(SGMS1)
TGU100218763(SGMS2) 100229900(SGMS1)
LSR110468007(SGMS2) 110474021(SGMS1)
SCAN103814070(SGMS1) 103826010(SGMS2)
PMOA120499694(SGMS1) 120502799(SGMS2)
OTC121336092(SGMS1) 121348414(SGMS2)
PRUF121357029(SGMS1) 121360220(SGMS2)
GFR102035610(SGMS2) 102040343(SGMS1)
FAB101816191(SGMS1) 101821395(SGMS2)
OMA130252144(SGMS2) 130255134(SGMS1)
PHI102106139(SGMS1) 102109103(SGMS2)
PMAJ107203429(SGMS2) 107206882(SGMS1)
CCAE111927765(SGMS2) 111931636(SGMS1)
CCW104695075(SGMS1) 104697118(SGMS2)
CBRC103615259(SGMS1) 103617327(SGMS2)
ETL114057904(SGMS2) 114072037(SGMS1)
ZAB102064438(SGMS1) 102067527(SGMS2)
ACHL103811801(SGMS2)
SVG106854395(SGMS2) 106856716(SGMS1)
MMEA130581146(SGMS2) 130585280(SGMS1)
HRT120753097(SGMS2) 120755749(SGMS1)
FPG101912331(SGMS2) 101914270(SGMS1)
FCH102046789(SGMS2) 102050714(SGMS1)
CLV102093540(SGMS2) 102093853(SGMS1)
EGZ104125134(SGMS1) 104135526(SGMS2)
NNI104013517(SGMS1) 104021167(SGMS2)
PCRI104031847(SGMS1) 104038408(SGMS2)
PLET104615357(SGMS2) 104623953(SGMS1)
EHS104509739(SGMS2)
PCAO104044720(SGMS1) 104048522(SGMS2)
ACUN113479474(SGMS2) 113481877(SGMS1)
TALA104359713(SGMS2) 104369052(SGMS1)
PADL103919537(SGMS2) 103924275(SGMS1)
AFOR103894232(SGMS2) 103895485(SGMS1)
ACHC115340651(SGMS2) 115348159(SGMS1)
HALD104311671(SGMS2) 104314626(SGMS1)
HLE104830795(SGMS1) 104843341(SGMS2)
AGEN126042674 126044962
GCL127015864 127017619
CCRI104164592(SGMS1) 104165830(SGMS2)
CSTI104555642 104555805 104556211(SGMS2)
CMAC104474728(SGMS2) 104480452(SGMS1)
MUI104534563(SGMS2) 104541802(SGMS1)
BREG104630851(SGMS2) 104633298(SGMS1)
FGA104073199(SGMS1) 104077003(SGMS2)
GSTE104260453(SGMS1) 104264577(SGMS2)
LDI104341400(SGMS2) 104349396(SGMS1)
MNB103774572(SGMS1) 103777994(SGMS2)
OHA104327248(SGMS2) 104330378(SGMS1)
NNT104405163(SGMS1) 104412497(SGMS2)
SHAB115607914(SGMS1) 115610747(SGMS2)
DPUB104301799(SGMS2) 104302463(SGMS1)
PGUU104459519 104472045(SGMS2)
ACAR104531322(SGMS2)
CPEA104394493(SGMS2) 104397756(SGMS1)
AVIT104268999(SGMS2) 104281340
CVF104283347(SGMS1) 104286848(SGMS2)
RTD128910440(SGMS2) 128911675(SGMS1)
CUCA104060035(SGMS1) 104062865(SGMS2)
TEO104373429(SGMS2) 104383963(SGMS1)
BRHI104499641(SGMS2)
AAM106489083(SGMS1) 106491991(SGMS2)
AROW112972219(SGMS2) 112973290(SGMS1)
NPD112948428(SGMS1) 112957306(SGMS2)
TGT104578541(SGMS2)
DNE112981611(SGMS1) 112987879(SGMS2)
SCAM104144121(SGMS1) 104153466(SGMS2)
ASN102384963(SGMS2) 102386662(SGMS1)
AMJ102560347(SGMS1) 102561422(SGMS2)
CPOO109309403(SGMS2) 109312529(SGMS1)
GGN109290932(SGMS1) 109301059(SGMS2)
PSS102457944(SGMS2) 102458830(SGMS1)
CMY102929744(SGMS2) 102942050(SGMS1)
CCAY125635698(SGMS2) 125639563(SGMS1)
DCC119855056(SGMS2) 119858305(SGMS1)
CPIC101931755(SGMS1) 101952554(SGMS2)
TST117878335(SGMS2) 117880181(SGMS1)
CABI116827172(SGMS1) 116837676(SGMS2)
MRV120368753(SGMS1) 120406220(SGMS2)
ACS100553259(sgms1) 100556412(sgms2)
ASAO132771130(SGMS1) 132776938(SGMS2)
PVT110080466(SGMS2) 110083115(SGMS1)
SUND121926315(SGMS1) 121931623(SGMS2)
PBI103063562(SGMS1)
PMUR107282562(SGMS2) 107285108(SGMS1)
CTIG120308249(SGMS2) 120318171(SGMS1)
TSR106543016(SGMS2) 106552614(SGMS1)
PGUT117670641(SGMS1) 117679920(SGMS2)
APRI131200843(SGMS1) 131203574(SGMS2)
PTEX113434800(SGMS2) 113449013(SGMS1)
NSS113412823(SGMS2) 113420270(SGMS1)
VKO123018462(SGMS1) 123023107(SGMS2)
PMUA114597274(SGMS1) 114603949 114603950
PRAF128413991(SGMS1) 128421280(SGMS2)
ZVI118083877(SGMS2) 118096113(SGMS1)
HCG128328310(SGMS2) 128347354 128350804(SGMS1)
GJA107108743(SGMS1) 107123168(SGMS2)
STOW125437656(SGMS1) 125440168(SGMS2)
EMC129332118(SGMS1) 129336622(SGMS2)
XLA108696069(sgms1.L) 108706723(sgms2.S) 108710613(sgms2.L) 414566(sgms1.S)
XTR493559(sgms1) 496853(sgms2)
NPR108785425(SGMS2) 108794033(SGMS1)
RTEM120917982(SGMS2) 120947079(SGMS1)
BBUF120989934(SGMS2) 121003445(SGMS1)
BGAR122920475(SGMS2) 122939993(SGMS1)
MUO115461165(SGMS2) 115470141(SGMS1)
GSH117359324(SGMS1) 117365694(SGMS2)
DRE492359(sgms1a) 556193(sgms2a) 566563(sgms1b)
SRX107708931 107715962 107729360 107737971 107739757 107744578 107750186 107750188 107757011
SANH107654047 107670842 107673184 107675923 107684311 107695526 107702172
SGH107553536 107557355 107564763 107568955 107568965 107583242(sgms2) 107583553 107594470 107598611
CCAR109046446 109046449 109061341 109083124 109087247(sgms1) 109108029 109110481
CAUA113041639 113041647 113044745 113044750 113056349 113065791 113076133 113082383 113093188 113111949 113117124 113117404
CGIB127933305 127945883 127948989 127968995 127976272 128025003
PTET122329517 122329700 122348975(sgms2a) 122355592(sgms1b) 122361436(sgms1a)
LROH127168928(sgms2a) 127174090(sgms1b) 127179731(sgms1a)
OMC131522890(sgms1a) 131543491(sgms2a) 131550655(sgms1b)
PPRM120467234(zgc:91976) 120474483(sgms1) 120484081(sgms2b) 120491162(sgms2a)
RKG130080536(sgms1b) 130087326(sgms2a) 130097453(sgms1a)
MAMB125255294(sgms1b) 125260473(sgms2b) 125268755(sgms1a) 125271928(sgms2a)
CIDE127498734 127515380 127523688
MASI127411166 127422885 127426747 127444096 127445106 127455598
TROS130552708(sgms2a) 130560576(sgms1a) 130568992(sgms1b)
TDW130411200(sgms2a) 130436745(sgms1a) 130439048(sgms1b)
MANU129417032(sgms1a) 129420765(sgms1b) 129444127(sgms2a)
IPU108262964(sgms2a) 108269687(sgms1a) 108274297(sgms1b) 108275722(sgms2b)
IFU128606024(sgms2a) 128612728(sgms1a) 128616979(sgms1b)
PHYP113527522(sgms1) 113530982 113543706(sgms2) 113547722
SMEO124376602(sgms2a) 124388621(sgms1b) 124390292(sgms1a) 124399230(sgms2b)
TFD113642482(sgms2a) 113652995(sgms2b) 113653531(sgms1b) 113662054(sgms1a)
TVC132841593(sgms1b) 132846740(sgms2a) 132851942(sgms1a)
AMEX103022236(sgms1) 103032666(sgms2) 103044873 103044881
CMAO118809164(sgms1) 118810860(sgms2a) 118823171(zgc:91976)
EEE113568304 113577008 113591284(sgms2) 113591889
CHAR105891457 105893589(sgms1b) 105898613(sgms2a) 105900833(sgms1a)
TRU101061029(sgms1) 101062959 101064260(sgms2)
TFS130523063 130527751(sgms2a) 130534005(sgms1a)
TNGGSTEN00004027G001 GSTEN00016385G001 GSTEN00033454G001
LCO104927264(sgms2) 104927467(sgms1) 104939615
NCC104953568(sgms2) 104961480(sgms1)
TBEN117480843 117481694(sgms2a) 117499764
CGOB115005747 115011102(sgms2) 115020156
PGEO117454330(sgms2a) 117459715(zgc:91976)
GACU117540930 117555333(sgms2a) 117560769
ELY117246387 117247993(zgc:91976) 117255045(sgms2a)
EFO125883766 125885645(sgms2a) 125903277(sgms1a)
PLEP121941826(sgms2a) 121954572(sgms1a) 121962107
SLUC116034381(sgms2a) 116055160(zgc:91976) 116064548
ECRA117934650 117959948(sgms2a) 117960052(zgc:91976)
ESP116670528(sgms2) 116705374(sgms1)
PFLV114545433(sgms2) 114572166(sgms1) 114574061
GAT120820470(zgc:91976) 120821948 120825744(sgms2a)
PPUG119214153 119218163(sgms2a) 119222978
AFB129092072(sgms1a) 129093440 129096349(sgms2a)
CLUM117734826(sgms2a) 117743933(zgc:91976) 117747947(sgms2b)
MSAM119892990 119898922(sgms2a) 119912285 119916810
SCHU122870189 122873453(sgms2a) 122884083(sgms1a)
CUD121504116 121508632(sgms2a) 121510953(sgms1a)
ALAT119024998(sgms2a) 119027573 119033577
MZE101466244(sgms1) 101466523(sgms2) 101471562
ONL100697094 100698377(sgms1) 102080228(sgms2)
OAU116330068(sgms2a) 116333766 116335897(sgms2b)
OLA101170793 101172470(sgms2) 101173002(sgms1)
OML112155804(sgms2b) 112157255(sgms2a) 112162090(zgc:91976)
XMA102224273 102226501(sgms1) 102235024(sgms2) 111611769
XCO114138291(sgms1) 114145423(sgms2) 114157622
XHE116713534(sgms1) 116719917(sgms2) 116732603
PRET103472709(sgms2) 103476797(sgms1) 103480961
PFOR103133524(sgms1) 103143902(sgms2) 103149064
PLAI106947669(sgms1) 106958168(sgms2) 106958961
PMEI106910479 106929122(sgms1) 106930850(sgms2)
GAF122820822(sgms2b) 122829087(sgms2a) 122842978
PPRL129351053(sgms2a) 129359928(sgms1a) 129376668
CVG107094616(sgms2) 107097429 107099848(sgms1)
CTUL119779060(sgms2a) 119790854(zgc:91976) 119797134(sgms2b)
GMU124859296 124869017(sgms2a) 124881312(sgms2b)
NFU107375265(sgms2) 107376030(sgms1) 107396478
KMR108245812(zgc:91976) 108248702(sgms2a) 108249825(sgms2b)
ALIM106513491(sgms1) 106517063(sgms2)
NWH119410334 119419174 119422645(sgms2a)
AOCE111562752 111570987(sgms2) 111588577(sgms1)
MCEP124999781(sgms2a) 125009461(sgms2b) 125018822
CSEM103383517(sgms2) 103387683(sgms1) 103389486
POV109632771(sgms1) 109634760 109638309(sgms2)
SSEN122765971 122771248(sgms2a) 122782206(sgms1a)
HHIP117751883 117767796(sgms2a) 117775485(zgc:91976)
HSP118102914 118115256(sgms2a) 118118835(sgms1a)
LCF108874529 108888244(sgms2a) 108897294(sgms1a)
SDU111233129 111235272(sgms1) 111236643(sgms2)
SLAL111661049 111670025(sgms1) 111671165(sgms2)
XGL120796380(zgc:91976) 120797273 120800527(sgms2a)
HCQ109508334 109511073(sgms2) 109528787(sgms1)
SSCV125968425 125975167 125978309
SBIA133494412 133505753(sgms2a) 133509526(sgms1a)
PEE133398031 133404559(sgms2a) 133409552
PTAO133472842 133476850(sgms2a) 133486225(sgms1a)
BPEC110157080(sgms1) 110165258(sgms2) 110170302
MALB109955488(sgms2) 109960328(sgms1) 109972936
BSPL114851262(sgms2b) 114854937(sgms2a) 114870404
SJO128373370 128374157(sgms2a) 128384096
SASA106577006 106578226 106578955 106589394 106602292 106610338(sgms2)
STRU115157071 115191728 115193759 115194756 115201170 115202295
OTW112223437 112224281 112240270 112241731(sgms2a) 112253029
OMY110491374 110498629 110498980(sgms1) 110528949 110531313 118941430
OGO124001179 124002283 124008554 124040039 124041255 124048154
ONE115106352 115126800 115135102 115144056 115146705
OKI109865539 109870398 109876657 109885490 109889944 116360046
OKE118368448 118369716 118377356 118383296(sgms2a)
SALP111951930 111967783 111977849 112071964 112079458
SNH120017652 120030069(sgms1) 120034663 120034670 120040811 120046136
CCLU121532937 121547340 121553764 121554420(sgms2a) 121580660
ELS105006231(sgms1) 105009076 105010646 105020992(sgms2)
SFM108924332(sgms2) 108932775 108936681 108939675(sgms1)
PKI111837332(sgms2) 111852109 111853656(sgms1)
AANG118217997 118218480(sgms1) 118227602(sgms2a) 118231890
LOC102683655(sgms1) 102690873(sgms2)
PSPA121296427 121321796(sgms2a) 121321862 121325582
ARUT117409125 117415669 117418036 117421451
PSEX120532817(sgms2a)
LCM102354261(SGMS1) 102360282 106702423
CMK103180856(sgms1b) 103187947
RTP109915826(sgms1) 109931147(sgms2)
CPLA122539260(sgms2a) 122561048(sgms1b)
HOC132826427(sgms1b) 132833355(sgms2a)
LERI129700993(sgms2a) 129704252(sgms1b)
PMRN116956502 116957745
LRJ133362384
BFO118410911
BBEL109485520
CIN100178736
SCLV120347185
ECOE129952858
CLON129606077
HIS119650646
AGA1279896
ACOZ120955126
AARA120900929
AMER121597693
ASTE118509308
AFUN125764524
AMOU128300894
AALI118466715
AAG5565303
AALB109419759 115253700
CQUCpipJ_CPIJ001932
CPII120423470
CNS116344803
BCOO119080637 119082332
AME408766
ACER108000086
ALAB122717449
ADR102673293
AFLR100869473
BIM100743987
BBIF117212177
BVK117240396
BVAN117162768
BTER100646584
BAFF126914346
BPYO122566947
BPAS132909731
FVI122527575
CCAL108623766
OBB114877365
MGEN117223787
NMEA116432833
CGIG122396415
SOC105198487
MPHA105835730
AEC105151108
ACEP105619855
PBAR105424399
VEM105566492
HST105186991
DQU106743028
CFO105253937
FEX115235486
LHU105675772
PGC109859235
OBO105281952
PCF106793971
PFUC122521242
VPS122627627
VCRB124422155
NVI100120614
CSOL105360928
TPRE106659634
LHT122511983
LBD127289467
MDL103575346
CGLO123270388
FAS105268011
DAM107039089
AGIF122855376
CINS118072811
VCAN122408608
CCIN107269033
DSM124416731
NPT124217616
NFB124176837
NLO107221165
NVG124305466
TCA657306
DPA109546370
SOY115883825
AGRG126750301
ATD109595189
CSET123307809
AGB108908290
LDC111513967
NVL108559553
APLN108736654
PPYR116181195
OTU111427269
BMOR101746851
BMAN114241247
MSEX115449998
DPLKGM_215960
BANY112051170
MJU123865960
NIQ126781593
VCD124544114
PMAC106709597
PPOT106104990
PXU106123370
PRAP110998350
PBX123711747
PNAP125058062
ZCE119833244
CCRC123692115
LSIN126975834
HAW110375208
HZE124632667
SLIU111358262
OFU114357749
PGW126366522
CCRN123297627
API100162696
DNX107173732
AGS114131069
RMD113552304
ACOO126839217
DVT126900441
BTAB109042159
DCI103513169
CLEC106669485
HHAL106682167
NLU111054577
HVI124359391
MQU128985442 128987600
PHUPhum_PHUM424420
FOC113205096
TPAL117647618
ZNE110838759
CSEC111871062
IEL124160570
FCD110847378 110853928
DPXDAPPUDRAFT_192074
DMK116930972
DPZ124348979
PVM113816345
PJA122259080
PCHN125041125
PMOO119592057
HAME121867847
PCLA123745757
CQD128685602
PTRU123505893
ESN126980855
HAZT108672627
EAF111704634 111709011
LSM121125127 121129919
TCF131880370 131890556
PPOI119093940
ISC8041314
DSV119437139
RSAN119379541
RMP119161099
VDE111243391
VJA111273721
TUT107361649
DPTE113794756 113799401 113799422
DFR124495892 124495894 124500647
CSCU111631757
PTEP107455859
UDV129226576
SDM118194039
LPOL106458106 106463418 106463666 106471658
PMEO129585639 129586958 129591694
CELCELE_F53H8.4(sms-2) CELE_H21P03.3(sms-1) CELE_Y22D7AL.8(sms-3)
CBRCBG_06147(Cbr-sms-1) CBG_08086(Cbr-sms-2) CBG_11695(Cbr-sms-3)
CRQGCK72_011640 GCK72_014164 GCK72_022236
NAINECAME_01533 NECAME_03184 NECAME_03866 NECAME_07428
BMYBM_BM4329(Bma-sms-2.2) BM_BM4669(Bma-sms-1) BM_BM9313(Bma-sms-2.1)
LOALOAG_03776 LOAG_09340 LOAG_10106 LOAG_11561
TSPTsp_10987
TBRTb09.211.1000 Tb09.211.1010 Tb09.211.1030
TBGTbgDal_IX5300 TbgDal_IX5310 TbgDal_IX5320 TbgDal_IX5330 TbgDal_IX5340 TbgDal_IX5350 TbgDal_IX5360 TbgDal_IX5370
TCR506885.124
LMALMJF_35_4990
LIFLINJ_35_5030
LDOLDBPK_355030
LMILMXM_34_4990
LBZLBRM_34_4930
LPANLPMP_344820
 » show all
Reference
1  [PMID:4817756]
  Authors
Ullman MD, Radin NS.
  Title
The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver.
  Journal
J Biol Chem 249:1506-12 (1974)
Reference
2  [PMID:7093220]
  Authors
Voelker DR, Kennedy EP.
  Title
Cellular and enzymic synthesis of sphingomyelin.
  Journal
Biochemistry 21:2753-9 (1982)
DOI:10.1021/bi00540a027
Reference
3  [PMID:14685263]
  Authors
Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC
  Title
Identification of a family of animal sphingomyelin synthases.
  Journal
EMBO J 23:33-44 (2004)
DOI:10.1038/sj.emboj.7600034
  Sequence
Reference
4  [PMID:16905542]
  Authors
Tafesse FG, Ternes P, Holthuis JC.
  Title
The multigenic sphingomyelin synthase family.
  Journal
J Biol Chem 281:29421-5 (2006)
DOI:10.1074/jbc.R600021200
Reference
5  [PMID:14976195]
  Authors
Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T.
  Title
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.
  Journal
J Biol Chem 279:18688-93 (2004)
DOI:10.1074/jbc.M401205200
  Sequence
[hsa:259230]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.27
IUBMB Enzyme Nomenclature: 2.7.8.27
ExPASy - ENZYME nomenclature database: 2.7.8.27
BRENDA, the Enzyme Database: 2.7.8.27
CAS: 58703-97-2

DBGET integrated database retrieval system