KEGG   ENZYME: 2.7.8.27Help
Entry
EC 2.7.8.27                 Enzyme                                 

Name
sphingomyelin synthase;
SM synthase;
SMS1;
SMS2
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
ceramide:phosphatidylcholine cholinephosphotransferase
Reaction(IUBMB)
a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol [RN:R08969]
Reaction(KEGG)
Substrate
ceramide [CPD:C00195];
phosphatidylcholine [CPD:C00157]
Product
sphingomyelin [CPD:C00550];
1,2-diacyl-sn-glycerol [CPD:C00641]
Comment
The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].
History
EC 2.7.8.27 created 2006
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04714  shingomyelin synthase
Genes
HSA: 166929(SGMS2) 259230(SGMS1)
PTR: 100613097(SGMS2) 450460(SGMS1)
PPS: 100983907(SGMS1) 100993903(SGMS2)
GGO: 101138449(SGMS2) 101138874(SGMS1)
PON: 100444992(SGMS1) 100446194(SGMS2)
NLE: 100593842(SGMS2) 100601656(SGMS1)
MCC: 695947(SGMS2) 704027(SGMS1)
MCF: 101867034(SGMS2) 102126212(SGMS1)
CSAB: 103216200(SGMS1) 103236087(SGMS2)
RRO: 104670047(SGMS2) 104675166(SGMS1)
RBB: 108515885(SGMS2) 108523223 108527547(SGMS1)
CJC: 100391389(SGMS1) 100400486(SGMS2)
SBQ: 101041388(SGMS1) 101049165(SGMS2)
MMU: 208449(Sgms1) 74442(Sgms2)
MCAL: 110285283(Sgms1) 110291657(Sgms2)
MPAH: 110319526(Sgms1) 110320695(Sgms2)
RNO: 310849(Sgms2) 353229(Sgms1)
MUN: 110546451(Sgms2) 110558522 110558523
CGE: 100760913(Sgms2) 100766719(Sgms1)
NGI: 103738051(Sgms1) 103742560(Sgms2)
HGL: 101710267(Sgms1) 101712715(Sgms2)
CCAN: 109681828(Sgms1) 109684300(Sgms2)
OCU: 100354454(SGMS2) 100357932(SGMS1)
TUP: 102484900(SGMS2) 102485341(SGMS1)
CFA: 477582(SGMS1) 478505(SGMS2)
VVP: 112931981(SGMS1) 112934190(SGMS2)
AML: 100466473(SGMS2) 100468555(SGMS1)
UMR: 103661724(SGMS2) 103661995(SGMS1)
UAH: 113255540(SGMS2) 113258982(SGMS1)
ORO: 101368457(SGMS1) 101371231(SGMS2)
ELK: 111145303 111157064
FCA: 101088574(SGMS2) 101090897(SGMS1)
PTG: 102957023(SGMS1) 102970893(SGMS2)
PPAD: 109247772(SGMS2) 109255389(SGMS1)
AJU: 106980950(SGMS1) 106988439(SGMS2)
BTA: 520954(SGMS2) 533538(SGMS1)
BOM: 102268543(SGMS2) 102269418(SGMS1)
BIU: 109553156 109560269(SGMS2) 109579164(SGMS1)
BBUB: 102400941(SGMS1) 102411175(SGMS2)
CHX: 102184583(SGMS1) 102187660(SGMS2)
OAS: 101118575(SGMS1) 101123121(SGMS2)
SSC: 100037303(SGMS1) 100518796(SGMS2)
CFR: 102508365(SGMS1) 102509917(SGMS2)
CDK: 105088962(SGMS1) 105105285(SGMS2)
BACU: 103014494(SGMS1) 103016480(SGMS2)
LVE: 103070270(SGMS2) 103073289(SGMS1)
OOR: 101278460(SGMS1) 101288900(SGMS2)
DLE: 111171488(SGMS2) 111172536(SGMS1)
PCAD: 102978203(SGMS1) 102994661(SGMS2)
ECB: 100062484(SGMS1) 100072971(SGMS2)
EPZ: 103546319(SGMS2) 103549843(SGMS1)
EAI: 106829816(SGMS2) 106845892(SGMS1)
MYB: 102255621(SGMS1) 102257109(SGMS2)
MYD: 102752902(SGMS1) 102771993(SGMS2)
MNA: 107538294(SGMS2) 107543307(SGMS1)
HAI: 109379483(SGMS2) 109387531(SGMS1)
DRO: 112296362(SGMS2) 112307416(SGMS1)
PALE: 102883450(SGMS1) 102886439(SGMS2)
RAY: 107515499(SGMS1) 107518804(SGMS2)
MJV: 108396674(SGMS1) 108401174(SGMS2)
LAV: 100662186(SGMS1) 100666455(SGMS2)
TMU: 101344228 101353208
MDO: 100011020(SGMS2) 100013212(SGMS1)
SHR: 100928230(SGMS1) 100933601(SGMS2)
PCW: 110199924(SGMS1) 110218607(SGMS2)
OAA: 100079264(SGMS2) 100088367(SGMS1)
GGA: 378907(SGMS1) 422529(SGMS2)
MGP: 100540329(SGMS1) 100541752(SGMS2)
CJO: 107313258(SGMS2) 107315618(SGMS1)
NMEL: 110390482(SGMS1) 110398348(SGMS2)
APLA: 101791169(SGMS2) 101798673(SGMS1)
ACYG: 106030221(SGMS1) 106038651(SGMS2)
TGU: 100218763(SGMS2) 100229900(SGMS1)
LSR: 110468007(SGMS2) 110474021(SGMS1)
SCAN: 103814070(SGMS1) 103826010(SGMS2)
GFR: 102035610(SGMS2) 102040343(SGMS1)
FAB: 101816191(SGMS1) 101821395(SGMS2)
PHI: 102106139(SGMS1) 102109103(SGMS2)
PMAJ: 107203429(SGMS2) 107206882(SGMS1)
CCAE: 111927765(SGMS2) 111931636(SGMS1)
CCW: 104695075(SGMS1) 104697118(SGMS2)
ETL: 114057904(SGMS2) 114072037(SGMS1) 114072038
FPG: 101912331(SGMS2) 101914270(SGMS1)
FCH: 102046789(SGMS2) 102050714(SGMS1)
CLV: 102093540(SGMS2) 102093853(SGMS1)
EGZ: 104125134(SGMS1) 104135526(SGMS2)
NNI: 104013517(SGMS1) 104021167(SGMS2)
ACUN: 113479474(SGMS2) 113481877(SGMS1)
PADL: 103919537(SGMS2) 103924275(SGMS1)
AAM: 106489083(SGMS1) 106491991(SGMS2)
ASN: 102384963(SGMS2) 102386662(SGMS1)
AMJ: 102560347(SGMS1) 102561422(SGMS2)
PSS: 102457944(SGMS2) 102458830(SGMS1)
CMY: 102929744(SGMS2) 102942050(SGMS1)
CPIC: 101931755(SGMS1) 101952554(SGMS2)
ACS: 100553259(sgms1) 100556412(sgms2)
PVT: 110080466(SGMS2) 110083115(SGMS1)
PBI: 103054795 103063562(SGMS1)
PMUR: 107282562(SGMS2) 107285108(SGMS1)
TSR: 106543016(SGMS2) 106552614(SGMS1)
PMUA: 114597274(SGMS1) 114603949 114603950
GJA: 107108743(SGMS1) 107123168(SGMS2)
XLA: 108696069(sgms1.L) 108706723(sgms2.S) 108710613(sgms2.L) 414566(sgms1.S)
XTR: 493559(sgms1) 496853(sgms2)
NPR: 108785425(SGMS2) 108794033(SGMS1)
DRE: 556193(sgms2a) 566563(sgms1)
SRX: 107708931 107715962 107729360 107737971 107739757 107744578 107750186 107750188 107757011
SANH: 107654047 107670842 107673184 107675923 107684311 107695526 107702172
SGH: 107553536 107557355 107564763 107568955 107568965 107583242(sgms2) 107583553 107594470 107598611
CCAR: 109046446 109046449 109058326 109061341 109083124 109087247(sgms1) 109087589 109099488 109108029 109110481
IPU: 108262964(sgms2) 108269687(SGMS1) 108274297(sgms1) 108275722
PHYP: 113527522(sgms1) 113530982 113543706(sgms2) 113547722
AMEX: 103022236(sgms1) 103032666(sgms2) 103044873 103044881
EEE: 113568304 113577008 113591284(sgms2) 113591889
TRU: 101061029(sgms1) 101062959 101064260(sgms2)
TNG: GSTEN00004027G001 GSTEN00016385G001 GSTEN00033454G001
LCO: 104927264(sgms2) 104927467(sgms1) 104939615
NCC: 104953568(sgms2) 104961480(sgms1)
MZE: 101466244(sgms1) 101466523(sgms2) 101471562
ONL: 100697094 100698377(sgms1) 102080228(sgms2)
OLA: 101170793 101172470(sgms2) 101173002(sgms1)
XMA: 102224273 102226501(sgms1) 102235024(sgms2) 111611769
XCO: 114138291(sgms1) 114145423(sgms2) 114157622
PRET: 103472709(sgms2) 103476797(sgms1) 103480961
CVG: 107094616(sgms2) 107097429 107099848(sgms1)
NFU: 107375265(sgms2) 107376030(sgms1) 107396478
KMR: 108245812(sgms1) 108248702(sgms2) 108249825
ALIM: 106513491(sgms1) 106517063(sgms2)
AOCE: 111562752 111570987(sgms2) 111576123 111588001 111588577(sgms1)
CSEM: 103383517(sgms2) 103387683(sgms1) 103389486
POV: 109632771(sgms1) 109634760 109638309(sgms2)
LCF: 108874529 108888244(sgms2) 108897294(sgms1)
SDU: 111233129 111235272(sgms1) 111236643(sgms2)
SLAL: 111657553 111661049 111670025(sgms1) 111671165(sgms2)
HCQ: 109508334 109511073(sgms2) 109528787(sgms1)
BPEC: 110157080(sgms1) 110165258(sgms2) 110170302
MALB: 109955488(sgms2) 109960328(sgms1) 109972936
SASA: 106577006 106578226 106578955 106589394 106602292 106610338(sgms2)
OTW: 112223437 112224281 112240270 112253029
SALP: 111951930 111967783 111977849 112071964 112079458
ELS: 105006231(sgms1) 105009076 105010646 105020992(sgms2)
SFM: 108924332(sgms2) 108932775 108936681 108939675(sgms1)
PKI: 111837332(sgms2) 111852109 111853656(sgms1)
LCM: 102354261(SGMS1) 102360282 106702423
CMK: 103180856(sgms1) 103187947(sgms2)
RTP: 109915826(sgms1) 109931147(sgms2)
BFO: BRAFLDRAFT_104157
CIN: 100178736
AGA: AgaP_AGAP008926
AAG: 5565303
AALB: 109419759 115253700
CQU: CpipJ_CPIJ001932
AME: 408766
BIM: 100743987
BTER: 100646584
CCAL: 108623766
OBB: 114877365
SOC: 105198487
MPHA: 105835730
AEC: 105151108
ACEP: 105619855
PBAR: 105424399
VEM: 105566492
HST: 105186991
DQU: 106743028
CFO: 105253937
LHU: 105675772
PGC: 109859235
OBO: 105281952
PCF: 106793971
NVI: 100120614
CSOL: 105360928
MDL: 103575346
TCA: 657306
DPA: 109546370
ATD: 109595189
NVL: 108559553
BMOR: 101746851
BMAN: 114241247
DPL: KGM_215960
PMAC: 106709597
PRAP: 110998350
HAW: 110375208
API: 100162696
DNX: 107173732
AGS: 114131069
RMD: 113552304
BTAB: 109042159
CLEC: 106669485
PHU: Phum_PHUM424420
ZNE: 110838759
FCD: 110847378 110853928
DPX: DAPPUDRAFT_192074
PVM: 113816345
ISC: IscW_ISCW014927
TUT: 107361649
DPTE: 113794756 113799401 113799422
CSCU: 111631757
PTEP: 107455859
CEL: CELE_F53H8.4(sms-2) CELE_H21P03.3(sms-1) CELE_Y22D7AL.8(sms-3)
CBR: CBG06147(Cbr-sms-1) CBG08086(Cbr-sms-2) CBG11695(Cbr-sms-3)
BMY: Bm1_25335 Bm1_37870 Bm1_44615
LOA: LOAG_03776 LOAG_09340 LOAG_10106 LOAG_11561
NAI: NECAME_01533 NECAME_03184 NECAME_03866 NECAME_07428
TSP: Tsp_10987 Tsp_14919
TBR: Tb09.211.1000 Tb09.211.1010
TCR: 506885.124
LMA: LMJF_35_4990
LIF: LINJ_35_5030
LDO: LDBPK_355030
LMI: LMXM_34_4990
LBZ: LBRM_34_4930
 » show all
Taxonomy
Reference
1  [PMID:4817756]
  Authors
Ullman MD, Radin NS.
  Title
The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver.
  Journal
J Biol Chem 249:1506-12 (1974)
Reference
2  [PMID:7093220]
  Authors
Voelker DR, Kennedy EP.
  Title
Cellular and enzymic synthesis of sphingomyelin.
  Journal
Biochemistry 21:2753-9 (1982)
Reference
3  [PMID:14685263]
  Authors
Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC.
  Title
Identification of a family of animal sphingomyelin synthases.
  Journal
EMBO J 23:33-44 (2004)
DOI:10.1038/sj.emboj.7600034
  Sequence
Reference
4  [PMID:16905542]
  Authors
Tafesse FG, Ternes P, Holthuis JC.
  Title
The multigenic sphingomyelin synthase family.
  Journal
J Biol Chem 281:29421-5 (2006)
DOI:10.1074/jbc.R600021200
Reference
5  [PMID:14976195]
  Authors
Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T.
  Title
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.
  Journal
J Biol Chem 279:18688-93 (2004)
DOI:10.1074/jbc.M401205200
  Sequence
[hsa:259230]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.27
IUBMB Enzyme Nomenclature: 2.7.8.27
ExPASy - ENZYME nomenclature database: 2.7.8.27
BRENDA, the Enzyme Database: 2.7.8.27
CAS: 58703-97-2

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (5094)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (458)   
   KEGG MGENES (414)   
   RefGene (4221)   
Protein sequence (123)   
   UniProt (58)   
   SWISS-PROT (16)   
   RefSeq(pep) (49)   
DNA sequence (112)   
   RefSeq(nuc) (61)   
   GenBank (28)   
   EMBL (23)   
All databases (5339)   

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