KEGG   ENZYME: 2.7.8.29
Entry
EC 2.7.8.29                 Enzyme                                 
Name
L-serine-phosphatidylethanolamine phosphatidyltransferase;
phosphatidylserine synthase 2;
serine-exchange enzyme II;
PTDSS2 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
Reaction(IUBMB)
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine [RN:R07376]
Reaction(KEGG)
R07376
Substrate
L-1-phosphatidylethanolamine [CPD:C00350];
L-serine [CPD:C00065]
Product
L-1-phosphatidylserine [CPD:C02737];
ethanolamine [CPD:C00189]
Comment
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
History
EC 2.7.8.29 created 2010
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08730  phosphatidylserine synthase 2
Genes
HSA81490(PTDSS2)
PTR739066(PTDSS2)
PPS100994862(PTDSS2)
GGO101132603(PTDSS2)
PON100458699(PTDSS2)
NLE100603636(PTDSS2)
MCC114669774 698582
MCF102117045(PTDSS2)
MTHB126935819
CSAB103242751(PTDSS2)
CATY105577196(PTDSS2)
PANU101002066(PTDSS2)
TGE112606078(PTDSS2)
RRO104654944(PTDSS2)
RBB108543520(PTDSS2)
TFN117080297(PTDSS2)
PTEH111520627(PTDSS2)
CJC100412047(PTDSS2)
SBQ101035880(PTDSS2)
CSYR103255567(PTDSS2)
MMUR105874065(PTDSS2)
LCAT123642972(PTDSS2)
OGA100964126(PTDSS2)
MMU27388(Ptdss2)
MCAL110298796(Ptdss2)
MPAH110322252(Ptdss2)
RNO293620(Ptdss2)
MCOC116103204(Ptdss2)
MUN110553910(Ptdss2)
CGE100689448(Ptdss2) 100763873
MAUA101839781(Ptdss2)
PLEU114693553(Ptdss2)
MORG121457980(Ptdss2)
MFOT126498278
AAMP119810117(Ptdss2)
NGI103751073(Ptdss2)
HGL101716975(Ptdss2)
CPOC100735593(Ptdss2)
CCAN109698239(Ptdss2)
DORD105998572(Ptdss2)
DSP122095003(Ptdss2)
NCAR124960393
OPI101517456(PTDSS2)
TUP102474211(PTDSS2)
GVR103609096(PTDSS2)
CFA483401(PTDSS2)
CLUD112663538(PTDSS2)
VVP112914605(PTDSS2)
VLG121501694(PTDSS2)
AML100475601(PTDSS2)
UMR103671087(PTDSS2)
UAH113249903 113249905
UAR123775467(PTDSS2)
ELK111150188
LLV125078619
MPUF101671435(PTDSS2)
ORO101363533(PTDSS2)
EJU114201557(PTDSS2)
ZCA113914144(PTDSS2)
MLX118016224(PTDSS2)
NSU110582221(PTDSS2)
LWW102735838(PTDSS2)
FCA101085320(PTDSS2)
PYU121022787(PTDSS2)
PBG122484177(PTDSS2)
LRUF124527511
PTG102951536(PTDSS2)
PPAD109259777(PTDSS2)
AJU106987937(PTDSS2)
HHV120223398(PTDSS2)
BTA100336649(PTDSS2)
BOM102283385(PTDSS2)
BBIS105003734(PTDSS2)
CHX106503774(PTDSS2)
OAS101107006(PTDSS2)
ODA120874207(PTDSS2)
CCAD122430583(PTDSS2)
SSC110259207(PTDSS2)
CFR106731055
CBAI105062446(PTDSS2)
CDK105106485
VPC102534340(PTDSS2)
BACU103000053(PTDSS2)
LVE103072335(PTDSS2)
OOR101278674(PTDSS2)
DLE111170339(PTDSS2)
PCAD102994437(PTDSS2)
PSIU116757434(PTDSS2)
ECB100054404(PTDSS2)
EPZ103561334(PTDSS2)
EAI106826306(PTDSS2)
MYB102245359(PTDSS2)
MYD102762251(PTDSS2)
MMYO118649026(PTDSS2)
MLF102426380(PTDSS2)
MNA107542344(PTDSS2)
PKL118717948(PTDSS2)
HAI109375658(PTDSS2)
DRO112317446(PTDSS2)
SHON118982221(PTDSS2)
AJM119062197(PTDSS2)
PDIC114499184(PTDSS2)
PHAS123807358(PTDSS2)
MMF118643158(PTDSS2)
RFQ117029894(PTDSS2)
PALE102895742(PTDSS2)
PGIG120584653(PTDSS2)
PVP105305929(PTDSS2)
RAY107507002(PTDSS2)
MJV108397343(PTDSS2)
TOD119249821(PTDSS2)
SARA101550825(PTDSS2)
LAV100657791(PTDSS2)
TMU101351025
ETF101646133(PTDSS2)
DNM101419042(PTDSS2)
MDO103096840(PTDSS2)
GAS123255880
SHR100921197(PTDSS2)
PCW110202978(PTDSS2)
OAA103166516(PTDSS2)
GGA422997(PTDSS2)
PCOC116237923(PTDSS2)
MGP100540844(PTDSS2)
CJO107314266(PTDSS2)
NMEL110401132(PTDSS2)
APLA101801482(PTDSS2)
ACYG106047059(PTDSS2)
AFUL116489681(PTDSS2)
TGU100229553(PTDSS2)
LSR110484969(PTDSS2)
SCAN103826812(PTDSS2)
PMOA120500998(PTDSS2)
OTC121334791(PTDSS2)
PRUF121352280(PTDSS2)
GFR102035529(PTDSS2)
FAB101807502(PTDSS2)
PHI102106200(PTDSS2)
PMAJ107205772(PTDSS2)
CCAE111930577(PTDSS2)
CCW104684527(PTDSS2)
CBRC103614563(PTDSS2)
ETL114063288(PTDSS2)
ZAB102068176(PTDSS2)
ACHL103803727(PTDSS2)
FPG101915281(PTDSS2)
FCH102049262(PTDSS2)
CLV102088455(PTDSS2)
EGZ104125116(PTDSS2)
NNI104011400(PTDSS2)
PLET104618264(PTDSS2)
PCRI104037049(PTDSS2)
PCAO104047552(PTDSS2)
ACUN113481175(PTDSS2)
TALA104366653(PTDSS2)
PADL103925320(PTDSS2)
AFOR103906280(PTDSS2)
ACHC115351728(PTDSS2)
HALD104311355(PTDSS2)
HLE104832098(PTDSS2)
AGEN126046997
GCL127016818
CCRI104164243(PTDSS2)
CSTI104555459(PTDSS2)
EHS104508164(PTDSS2)
CMAC104476282(PTDSS2)
MUI104548340(PTDSS2)
FGA104076122(PTDSS2)
GSTE104259187(PTDSS2)
LDI104352924(PTDSS2)
MNB103775057(PTDSS2)
OHA104336355(PTDSS2)
NNT104405267(PTDSS2)
DPUB104297513(PTDSS2)
PGUU104468031(PTDSS2)
ACAR104530364(PTDSS2)
CPEA104392095(PTDSS2)
AVIT104274807(PTDSS2)
CVF104292998
CUCA104057225(PTDSS2)
TEO104373649(PTDSS2)
BRHI104495082(PTDSS2)
AAM106489130(PTDSS2)
AROW112973781(PTDSS2)
NPD112948049(PTDSS2)
TGT104574664(PTDSS2)
DNE112991577(PTDSS2)
SCAM104149784(PTDSS2)
ASN102384840(PTDSS2)
AMJ102568801(PTDSS2)
CPOO109318177(PTDSS2)
GGN109299410(PTDSS2)
PSS102450192(PTDSS2)
CMY102929824(PTDSS2)
CPIC101951300(PTDSS2)
TST117877378(PTDSS2)
CABI116820555(PTDSS2)
MRV120403852(PTDSS2)
ACS100567634(ptdss2)
PVT110074163(PTDSS2)
SUND121929467(PTDSS2)
PBI103058382(PTDSS2)
PMUR107291107(PTDSS2) 107300150
CTIG120312482(PTDSS2)
TSR106552076(PTDSS2)
PGUT117665155(PTDSS2)
VKO123021151(PTDSS2)
PMUA114600254(PTDSS2)
ZVI118088741(PTDSS2)
GJA107118380(PTDSS2)
STOW125426169(PTDSS2)
XLA100190774(ptdss2.L) 108715190(ptdss2.S)
XTR780129(ptdss2)
NPR108797710(PTDSS2)
RTEM120917227(PTDSS2)
BBUF120980647(PTDSS2)
BGAR122920997(PTDSS2)
DRE100004136(ptdss2)
SRX107720803 107740889
SANH107673288 107680136
SGH107559963 107573150
CCAR109050607 109050615
CAUA113043717 113066680 113066696 113074843
PPRM120477838(ptdss2)
MAMB125247089(ptdss2)
IPU108274776(ptdss2)
PHYP113529441
SMEO124392677(ptdss2)
TFD113654023(ptdss2)
AMEX103034186(ptdss2)
EEE113573672(ptdss2)
TRU101080052(ptdss2)
TNGGSTEN00016109G001
LCO109140081(ptdss2)
CGOB115010082(ptdss2)
ELY117262780(ptdss2)
EFO125887035(ptdss2)
PLEP121950042(ptdss2)
SLUC116038269(ptdss2)
ECRA117948530(ptdss2)
ESP116693327(ptdss2)
PFLV114559946(ptdss2)
GAT120809238(ptdss2)
PPUG119196563(ptdss2)
MSAM119893609(ptdss2)
CUD121515088(ptdss2)
ALAT119025023(ptdss2)
MZE101475089(ptdss2)
ONL100711828(ptdss2)
OAU116312035(ptdss2)
OLA101164977(ptdss2)
OML112152792(ptdss2)
XMA102221675(ptdss2)
XCO114157187(ptdss2)
XHE116737569(ptdss2)
PFOR103134501(ptdss2)
PLAI106958704(ptdss2)
PMEI106917100(ptdss2)
GAF122835925(ptdss2)
CVG107081022(ptdss2)
CTUL119773754(ptdss2)
GMU124884865(ptdss2)
NFU107388401(ptdss2)
KMR108246989(ptdss2)
ALIM106534361(ptdss2)
NWH119416532(ptdss2)
AOCE111582802(ptdss2)
MCEP125014398(ptdss2)
CSEM103379957(ptdss2)
POV109624492(ptdss2)
SSEN122776019(ptdss2)
HHIP117763237(ptdss2)
HSP118109617(ptdss2)
LCF108883055
SDU111229645(ptdss2)
SLAL111650416(ptdss2)
XGL120793815(ptdss2)
HCQ109529832(ptdss2)
BPEC110164269(ptdss2)
MALB109973948(ptdss2)
BSPL114857038(ptdss2)
SASA106560699(ptdss2)
STRU115197204(ptdss2)
OTW112218382(ptdss2)
OMY110490806(ptdss2)
OGO124040706(ptdss2)
ONE115134620(ptdss2)
SALP111962000(ptdss2)
SNH120066030(ptdss2)
CCLU121532009(ptdss2)
ELS105026605(ptdss2)
SFM108942184(ptdss2)
PKI111859468(ptdss2)
AANG118215578(ptdss2)
LOC102682545(ptdss2)
PSPA121294898 121330068
ARUT117431967 117435009
PSEX120523457(ptdss2)
LCM102358962(PTDSS2)
CMK103186012(ptdss2)
RTP109914215(ptdss2)
BFO118413246 118414660
BBEL109481719 109486878 109486882
CIN100183272 100184878
SCLV120342387
SPU100890899
APLC110975411
AJC117108247
SKO100366968
RZE108355289
ZNE110839981
CSEC111867184
SGRE126266803
FCD110846538
DPXDAPPUDRAFT_40255
DMK116924944
DPZ124334731
PVM113828849
PJA122245087
PCHN125041160
HAME121868701
PCLA123770675
PTRU123498819
HAZT108667978
EAF111703037
LSM121114194 121130660
DPTE113793977
DFR124492676
CSCU111639283
HROHELRODRAFT_150062
LGILOTGIDRAFT_103737
PCAN112559188
BGT106072336
GAE121381286
HRF124138182
HRJ124268674
CRG105343224
MYI110452045 110458923
PMAX117336411 117339202
MMER123537226 123544278
OBI106879554
OSN115225338
LAK106168753 106176668
SMMSmp_125780
OVIT265_08340 T265_08342
NVE5520913
EPA114574153
ATEN116290160
ADF107353714
AMIL114956887
PDAM113667703 113667751
SPIS111325394
AQU100636278 100636405
ATHAT1G15110(PSS1)
ALY9328912
CRB17897196
CSAT104755819 104773869
EUSEUTSA_v10007726mg
BRP103842918 103872302
BNA106367054 106377066 106412180 106413585 106415915 106439980
BOE106292796 106307944
RSZ108806457 108806495 108821957
THJ104805051 104824158
CPAP110813354
CIT102618383
CICCICLE_v10015341mg
PVY116123945
MINC123214568 123215340
TCC18609079
GRA105764255 105798059
GHI107888495 107931303 107946209 121224155
GAB108454295 108476666
DZI111283034 111288443 111317773
EGR104433168
GMX100787048 100802199
GSJ114372352 114403482
PVUPHAVU_007G034000g
VRA106772597
VAR108322074
VUN114191630
CCAJ109814886
APRC113872112
MTR25485448
CAM101502644
PSAT127092458
LJALj5g3v2169530.1(Lj5g3v2169530.1) Lj5g3v2169530.2(Lj5g3v2169530.2) Lj5g3v2169530.3(Lj5g3v2169530.3)
ADU107467458
AIP107618369
AHF112712020 112775326
LANG109334974 109346371 109354405
FVE101309739
RCN112197466
PPER18791823
PMUM103341672
PAVI110765458
PDUL117634493
MDM103402640 103452265
PXB103947074 103948159
ZJU107413347
MNT21408531
CSV101205141 101208533
CMO103489325 103504584
BHJ120081483 120092998
MCHA111018718 111020081
CMAX111467762 111478458 111487009 111489342
CMOS111445439 111449822 111458312 111464375
CPEP111784319 111784552 111801353 111805286 111808977
RCU8275111
HBR110663430 110663583
MESC110600004 110617268
POP7475554 7482863
PEU105124449 105135517
PALZ118039880 118057890
JRE109007794 109012506
QSU112004669
QLO115974711
TWL119991875 120014683
VVI100261188 100266447
VRI117912448 117934377
SLY101251081 101264518
SPEN107015927 107018619
SOT102585428 102596511
SSTN125852569 125856675
CANN107854102 107870662
NTA107759508 107768420 107776034 107820856
NSY104212450 104228931
NTO104110642 104113662
NAU109208557 109235210
INI109160991 109166049
ITR116005364 116017771
SIND105156339 105160377
OEU111383017 111385100 111398987
EGT105966180
SSPL121769493 121772476 121779774 121782458
APAN127261744 127264121
HAN110904860 110921798
ECAD122584382 122609710
LSV111911270 111912596
CCAV112525661 112527749
DCR108200328
CSIN114282104
BVG104895498
SOE110784857
CQI110714278 110715005
NNU104613331
MING122080140 122082496
TSS122645877 122652971
PSOM113275442 113282170
OSA4326076 4339554 9271420
DOSAOs01t0683550-00(Os01g0683550) Os05t0554400-01(Os05g0554400)
OBR102705851 102712813 102722731
BDI100833489 100836759
ATS109744623 109783523
TDC119274412 119291046 119349438
TAES123067183 123068290 123076842 123144567 123182994
TUA125528268 125542335
LPER127327485 127340803
SBI8074565 8079060
ZMA100191625 100216715 100283193 103634768 103647622
SITA101767818 101772301
SVS117849844 117858207
PVIR120664703 120675874 120697901 120706184
PHAI112885694 112891526
PDA103696139 103705637 103719016
EGU105041133 105047235 105048470
MUS103968743 103974222 103979244 103987383
ZOF121992953 121996948 121999730 122018840 122023489
DCT110097883 110109854
PEQ110033016 110036199 110039580
AOF109829079
NCOL116246902 116264166
ATR18433852
SMOSELMODRAFT_121992 SELMODRAFT_92791
PPP112278017 112281293
MNGMNEG_10285
CSLCOCSUDRAFT_34906
CVRCHLNCDRAFT_30982
APROF751_6371
OLUOSTLU_3295
OTAOT_ostta11g01160
BPGBathy13g02220
MISMICPUN_103532
MPPMICPUCDRAFT_51318
GSLGasu_10430
TVSTRAVEDRAFT_166615
DSQDICSQDRAFT_160494
PCOPHACADRAFT_212696
SHSSTEHIDRAFT_124987
PSQPUNSTDRAFT_141403
ADLAURDEDRAFT_182424
FMEFOMMEDRAFT_170750
GTRGLOTRDRAFT_77251
LBCLACBIDRAFT_312044
CCICC1G_08005
ABPAGABI1DRAFT74777(AGABI1DRAFT_74777)
ABVAGABI2DRAFT224623(AGABI2DRAFT_224623)
MRRMoror_5898
MOREE1B28_011979
SCMSCHCO_02570286(SCHCODRAFT_02570286)
CPUTCONPUDRAFT_85797
SLASERLADRAFT_479838
PGRPGTG_02227
MLRMELLADRAFT_35829
SREPTSG_07276
DDIDDB_G0278159(pssA)
DPPDICPUDRAFT_37736
DFADFA_00831(pssA)
EHIEHI_009800(4.t00097)
EDIEDI_100190
EIVEIN_314450
ACANACA1_280020 ACA1_295990
PFAPF3D7_1366800
PFHPFHG_03563
PGABPGSY75_1366800
PYOPY17X_1144000
PCBPCHAS_1142200
PBEPBANKA_1142700
PVVPVVCY_1104370
PKNPKNH_1104500
PVXPVX_115300
PCYPCYB_111370
TGOTGME49_273540
TETTTHERM_00046230 TTHERM_00190960
PTMGSPATT00003378001 GSPATT00005991001 GSPATT00011949001 GSPATT00014709001
PIFPITG_00570 PITG_14699
PSOJPHYSODRAFT_474455 PHYSODRAFT_509169
SPARSPRG_03478 SPRG_08668
GTTGUITHDRAFT_113850
NGRNAEGRDRAFT_82113
 » show all
Reference
1  [PMID:10432300]
  Authors
Stone SJ, Vance JE
  Title
Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2.
  Journal
Biochem J 342 ( Pt 1):57-64 (1999)
  Sequence
[mmu:27388]
Reference
2  [PMID:19014349]
  Authors
Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O
  Title
Purification and characterization of human phosphatidylserine synthases 1 and 2.
  Journal
Biochem J 418:421-9 (2009)
DOI:10.1042/BJ20081597
  Sequence
[hsa:81490]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.29
IUBMB Enzyme Nomenclature: 2.7.8.29
ExPASy - ENZYME nomenclature database: 2.7.8.29
BRENDA, the Enzyme Database: 2.7.8.29

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