Entry |
|
Name |
L-serine-phosphatidylethanolamine phosphatidyltransferase;
phosphatidylserine synthase 2;
serine-exchange enzyme II;
PTDSS2 (gene name)
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
|
Sysname |
L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
|
Reaction(IUBMB) |
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine [RN: R07376]
|
Reaction(KEGG) |
|
Substrate |
L-1-phosphatidylethanolamine [CPD: C00350];
L-serine [CPD: C00065]
|
Product |
L-1-phosphatidylserine [CPD: C02737];
ethanolamine [CPD: C00189]
|
Comment |
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
|
History |
EC 2.7.8.29 created 2010
|
Pathway |
ec00564 | Glycerophospholipid metabolism |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K08730 | phosphatidylserine synthase 2 |
|
Genes |
CGE: | 100689448(Ptdss2) 100763873 |
PMUR: | 107291107(PTDSS2) 107300150 |
XLA: | 100190774(ptdss2.L) 108715190(ptdss2.S) |
SANH: | 107673288 107680136 |
CCAR: | 109050607 109050615 |
CAUA: | 113043717 113066680 113066696 113074843 |
CGIB: | 127947305 128014602 |
MASI: | 127436094 127437692 |
PSPA: | 121294898 121330068 |
ARUT: | 117431967 117435009 |
PMRN: | 116939914(PTDSS2) 116945620 |
BBEL: | 109481719 109486878 109486882 |
AFRA: | 136041263 136041662 136042753 136043972 |
LPOL: | 106461777 106466964 |
PMAX: | 117336411 117339202 |
AIRR: | 138330205 138334845 |
OVI: | T265_08340 T265_08342 |
PDAM: | 113667703 113667751 |
CSAT: | 104755819 104773869 |
BNA: | 106377066 106412180 106415915 106439980 |
MINC: | 123214568 123215340 |
GHI: | 107888495 107931303 107946209 121224155 |
HSYR: | 120121952 120142060 120143821 120184248 120197936 120216107 |
DZI: | 111283034 111288443 111317773 |
LANG: | 109334974 109346371 109354405 |
PCIN: | 129284648 129297095 129310938 |
QSA: | O6P43_025781 O6P43_032673 |
MSYL: | 126596505 126608483 |
MCHA: | 111018718 111020081 |
CMAX: | 111467762 111478458 111487009 111489342 |
CMOS: | 111445439 111449822 111458312 111464375 |
CPEP: | 111784319 111784552 111801353 111805286 111808977 |
MESC: | 110600004 110617268 |
PALZ: | 118039880 118057890 |
CILL: | 122309711 122313764 |
SPEN: | 107015927 107018619 |
SSTN: | 125852569 125856675 |
SDUL: | 129870377 129879905 |
CANN: | 107854102 107870662 |
NTA: | 107759508 107768420 107776034 107820856 |
SIND: | 105156339 105160377 |
OEU: | 111383017 111385100 111398987 |
SSPL: | 121769493 121772476 121779774 121782458 |
SHIS: | 125204320 125215583 |
APAN: | 127261744 127264121 |
ECAD: | 122584382 122609710 |
CCAV: | 112525661 112527749 |
MING: | 122080140 122082496 |
PSOM: | 113275442 113282170 |
OSA: | 4326076(PSS1) 4339554(OsJ_19482) 9271420 |
DOSA: | Os01g0118300 Os05g0554400 |
OBR: | 102705851 102712813 102722731 |
OGL: | 127772534 127773095 127784371 |
TDC: | 119274412 119291046 119349438 |
TAES: | 123067183 123068290 123076842 123144567 123182994 |
LPER: | 127327485 127340803 |
ZMA: | 100191625 100216715 100283193 103634768 103647622 |
MFLO: | 136449672 136461887 136511632 |
SITA: | 101767818 101772301 |
PVIR: | 120664703 120675874 120697901 120706184 |
PHAI: | 112885694 112891526 |
PAUA: | 133885239 133895449 133905317 133929372 |
PDA: | 103696139 103705637 103719016 |
EGU: | 105041133 105047235 105048470 |
MUS: | 103979244 103987383 135619477 135625103 |
ZOF: | 121992953 121996948 121999730 122018840 122023489 |
PEQ: | 110033016 110036199 110039580 |
ACAK: | 137936719 137941172 |
NCOL: | 116246902 116264166 |
SMO: | SELMODRAFT_121992 SELMODRAFT_92791 |
ABP: | AGABI1DRAFT74777(AGABI1DRAFT_74777) |
ABV: | AGABI2DRAFT224623(AGABI2DRAFT_224623) |
SCM: | SCHCO_02570286(SCHCODRAFT_02570286) |
EHI: | EHI_009800(4.t00097) |
ACAN: | ACA1_280020 ACA1_295990 |
PLAG: | 39743904(PADL01_1365700) |
BBES: | BESB_007340 BESB_084670 |
TET: | TTHERM_00046230 TTHERM_00190960 |
PTM: | GSPATT00003378001 GSPATT00005991001 GSPATT00011949001 GSPATT00014709001 |
PIF: | PITG_00570 PITG_14699 |
PSOJ: | PHYSODRAFT_474455 PHYSODRAFT_509169 |
BLAC: | 94347576(CCR75_003812) |
SPAR: | SPRG_03478 SPRG_08668 |
» show all
|
Reference |
|
Authors |
Stone SJ, Vance JE |
Title |
Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. |
Journal |
Biochem J 342 ( Pt 1):57-64 (1999) |
Sequence |
|
Reference |
|
Authors |
Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O |
Title |
Purification and characterization of human phosphatidylserine synthases 1 and 2. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.8.29 |
ExPASy - ENZYME nomenclature database: | 2.7.8.29 |
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