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Entry
EC 2.7.8.29                 Enzyme                                 

Name
L-serine-phosphatidylethanolamine phosphatidyltransferase;
phosphatidylserine synthase 2;
serine-exchange enzyme II;
PTDSS2 (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
Reaction(IUBMB)
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine [RN:R07376]
Reaction(KEGG)
Substrate
L-1-phosphatidylethanolamine [CPD:C00350];
L-serine [CPD:C00065]
Product
L-1-phosphatidylserine [CPD:C02737];
ethanolamine [CPD:C00189]
Comment
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
History
EC 2.7.8.29 created 2010
Pathway
ec00564  Glycerophospholipid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08730  phosphatidylserine synthase 2
Genes
HSA: 81490(PTDSS2)
PTR: 739066(PTDSS2)
PPS: 100994862(PTDSS2)
GGO: 101132603(PTDSS2)
PON: 100458699(PTDSS2)
NLE: 100603636(PTDSS2)
MCC: 698582(PTDSS2)
MCF: 102117045(PTDSS2)
CSAB: 103242751(PTDSS2)
RRO: 104654944(PTDSS2)
RBB: 108543520(PTDSS2)
CJC: 100412047(PTDSS2)
SBQ: 101035880(PTDSS2)
MMU: 27388(Ptdss2)
RNO: 293620(Ptdss2)
CGE: 100689448(Ptdss2) 100763873
NGI: 103751073(Ptdss2)
HGL: 101716975(Ptdss2)
CCAN: 109698239(Ptdss2)
OCU: 103347505(PTDSS2)
TUP: 102474211(PTDSS2)
CFA: 483401(PTDSS2)
AML: 100475601(PTDSS2)
UMR: 103671087(PTDSS2)
ORO: 101363533(PTDSS2)
FCA: 101085320(PTDSS2)
PTG: 102951536(PTDSS2)
AJU: 106987937(PTDSS2)
BOM: 102283385(PTDSS2)
CHX: 106503774(PTDSS2)
OAS: 101107006(PTDSS2)
SSC: 110259207(PTDSS2)
CFR: 106731055
CDK: 105106485(PTDSS2)
BACU: 103000053(PTDSS2)
LVE: 103072335(PTDSS2)
OOR: 101278674(PTDSS2)
ECB: 100054404(PTDSS2)
EPZ: 103561334(PTDSS2)
EAI: 106826306(PTDSS2)
MYB: 102245359(PTDSS2)
MYD: 102762251(PTDSS2)
HAI: 109375658(PTDSS2)
RSS: 109436283(PTDSS2)
PALE: 102895742(PTDSS2)
LAV: 100657791(PTDSS2)
TMU: 101351025
MDO: 103096840(PTDSS2)
SHR: 100921197(PTDSS2)
GGA: 422997(PTDSS2)
MGP: 100540844(PTDSS2)
CJO: 107314266(PTDSS2)
APLA: 101801482(PTDSS2)
ACYG: 106047059(PTDSS2)
TGU: 100229553(PTDSS2)
GFR: 102035529(PTDSS2)
FAB: 101807502(PTDSS2)
PHI: 102106200(PTDSS2)
PMAJ: 107205772(PTDSS2)
CCW: 104684527(PTDSS2)
FPG: 101915281(PTDSS2)
FCH: 102049262(PTDSS2)
CLV: 102088455(PTDSS2)
EGZ: 104125116(PTDSS2)
AAM: 106489130(PTDSS2)
ASN: 102384840(PTDSS2)
AMJ: 102568801(PTDSS2)
PSS: 102450192(PTDSS2)
CMY: 102929824(PTDSS2)
CPIC: 101951300(PTDSS2)
ACS: 100567634(ptdss2)
PVT: 110074163(PTDSS2)
PBI: 103058382(PTDSS2)
GJA: 107118380(PTDSS2)
XLA: 100190774(ptdss2.L) 108715190
XTR: 780129(ptdss2)
NPR: 108797710(PTDSS2)
DRE: 100004136(ptdss2)
IPU: 108274776(ptdss2)
AMEX: 103034186(ptdss2)
TRU: 101080052(ptdss2)
LCO: 104921024(ptdss2) 109140081
MZE: 101475089(ptdss2)
OLA: 101164977(ptdss2)
XMA: 102221675(ptdss2)
PRET: 103465929
NFU: 107388401(ptdss2)
CSEM: 103379957(ptdss2)
LCF: 108883055(ptdss2)
HCQ: 109529832(ptdss2)
BPEC: 110164269(ptdss2)
SASA: 106560699(ptdss2)
ELS: 105026605(ptdss2)
SFM: 108942184(ptdss2)
LCM: 102358962(PTDSS2)
CMK: 103186012(ptdss2)
SPU: 100890899
APLC: 110975411
SKO: 100366968
ZNE: 110839981
FCD: 110846538
CRG: 105343224
OBI: 106879554
SHX: MS3_09375
EPA: 110238286
ADF: 107353714
ATH: AT1G15110(PSS1)
CRB: 17897196
CPAP: 110813354
TCC: 18609079
EGR: 104433168
VRA: 106772597
VAR: 108322074
CAM: 101502644
ADU: 107467458
AIP: 107618369
LJA: Lj5g3v2169530.1(Lj5g3v2169530.1) Lj5g3v2169530.2(Lj5g3v2169530.2) Lj5g3v2169530.3(Lj5g3v2169530.3)
FVE: 101309739
PPER: 18791823
PMUM: 103341672
PAVI: 110765458
ZJU: 107413347
RCU: 8275111
JCU: 105636911
DCR: 108200328
BVG: 104895498
SOE: 110784857
NNU: 104613331
DOSA: Os01t0118300-01(Os01g0118300) Os01t0683550-00(Os01g0683550) Os05t0554400-01(Os05g0554400)
ATS: 109744623(LOC109744623) 109783523(LOC109783523)
AOF: 109829079
ATR: 18433852
APRO: F751_6371
ABP: AGABI1DRAFT74777(AGABI1DRAFT_74777)
ABV: AGABI2DRAFT224623(AGABI2DRAFT_224623)
DDI: DDB_G0278159(pssA)
DFA: DFA_00831(pssA)
EHI: EHI_009800(4.t00097)
PYO: PY17X_1144000(PY06104)
PCB: PCHAS_114220(PC000559.02.0)
TCR: 506795.40
 » show all
Taxonomy
Reference
1  [PMID:10432300]
  Authors
Stone SJ, Vance JE
  Title
Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2.
  Journal
Biochem J 342 ( Pt 1):57-64 (1999)
  Sequence
[mmu:19210 27388]
Reference
2  [PMID:19014349]
  Authors
Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O
  Title
Purification and characterization of human phosphatidylserine synthases 1 and 2.
  Journal
Biochem J 418:421-9 (2009)
DOI:10.1042/BJ20081597
  Sequence
[hsa:9791 81490]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.29
IUBMB Enzyme Nomenclature: 2.7.8.29
ExPASy - ENZYME nomenclature database: 2.7.8.29
BRENDA, the Enzyme Database: 2.7.8.29

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