KEGG   ENZYME: 2.7.8.38Help
Entry
EC 2.7.8.38                 Enzyme                                 

Name
archaetidylserine synthase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-(O-geranylgeranyl)-sn-glycerol phosphotransferase
Reaction(IUBMB)
(1) CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine [RN:R10255];
(2) CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine [RN:R10441]
Reaction(KEGG)
Substrate
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol;
L-serine [CPD:C00065];
CDP-2,3-bis-(O-phytanyl)-sn-glycerol [CPD:C20627]
Product
CMP [CPD:C00055];
2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine;
2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine [CPD:C20628]
Comment
Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.
History
EC 2.7.8.38 created 2013, modified 2013
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K19665  archaetidylserine synthase
Genes
MTH: MTH_1027
MMG: MTBMA_c14090(pssA)
METC: MTCT_0935
MST: Msp_1394
MSI: Msm_0982
MRU: mru_1834(pssA)
MEB: Abm4_1497
MEL: Metbo_2427
MEW: MSWAN_0215
METH: MBMB1_0210
MFC: BRM9_2090(pssA)
 » show all
Taxonomy
Reference
1  [PMID:12562787]
  Authors
Morii H, Koga Y
  Title
CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus.
  Journal
J Bacteriol 185:1181-9 (2003)
DOI:10.1128/JB.185.4.1181-1189.2003
  Sequence
[mth:MTH_1027]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.38
IUBMB Enzyme Nomenclature: 2.7.8.38
ExPASy - ENZYME nomenclature database: 2.7.8.38
BRENDA, the Enzyme Database: 2.7.8.38

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