Entry |
|
Name |
cardiolipin synthase (CMP-forming)
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
|
Sysname |
CDP-diacylglycerol:phosphatidylglycerol diacylglycerolphosphotransferase (CMP-forming)
|
Reaction(IUBMB) |
a CDP-diacylglycerol + a phosphatidylglycerol = a cardiolipin + CMP [RN: R02030]
|
Reaction(KEGG) |
|
Substrate |
CDP-diacylglycerol [CPD: C00269];
phosphatidylglycerol [CPD: C00344]
|
Product |
|
Comment |
The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin. It requires divalent cations for activity.
|
History |
EC 2.7.8.41 created 2014
|
Pathway |
ec00564 | Glycerophospholipid metabolism |
|
Orthology |
K08744 | cardiolipin synthase (CMP-forming) |
|
Genes |
PKL: | 118705782 118708295(CRLS1) |
DNM: | 101424550(CRLS1) 101447986 |
AFUL: | 116488218(CRLS1) 116499914 |
PMUA: | 114593653(CRLS1) 114604220 |
SANH: | 107663140 107678734 |
CCAR: | 109069293 109069295 |
CAUA: | 113060815 113071783 113117753 |
CGIB: | 127975788 128031412 |
MASI: | 127410729 127455233 |
SMEO: | 124389636 124390214(crls1) |
CCLU: | 121544814(crls1) 121559872 |
DSI: | Dsimw501_GD18179(Dsim_GD18179) |
AALB: | 109403482 109433655 115268707 115269334 |
CEL: | CELE_F23H11.9(crls-1) |
CBR: | CBG_15172(Cbr-crls-1) |
CSAT: | 104707641 104716429 104737339 |
LJA: | Lj6g3v1879880.1(Lj6g3v1879880.1) Lj6g3v1879880.2(Lj6g3v1879880.2) |
AHF: | 112705667 112722935 112723257 |
QSU: | 112001311 112007988 112018422 |
PSOM: | 113318823 113331323 113353767 |
DOSA: | Os01t0789100-01(Os01g0789100) |
TAES: | 123062286 123071048 123079419 123129116 |
PVIR: | 120675841 120708329 |
SMO: | SELMODRAFT_405738 SELMODRAFT_415497 |
NCS: | NCAS_0E03780(NCAS0E03780) |
NDI: | NDAI_0A02850(NDAI0A02850) |
TPF: | TPHA_0A03050(TPHA0A03050) |
TBL: | TBLA_0E02000(TBLA0E02000) |
TDL: | TDEL_0C02300(TDEL0C02300) |
KAF: | KAFR_0L01350(KAFR0L01350) |
KNG: | KNAG_0B02760(KNAG0B02760) |
CAL: | CAALFM_C100100CA(CaO19.6100) |
NTE: | NEUTE1DRAFT122183(NEUTE1DRAFT_122183) |
BFU: | BCIN_03g07430(Bccrd1) |
ANG: | ANI_1_1158134(An15g01020) |
PPL: | POSPLDRAFT_26909 POSPLDRAFT_27949 |
ABP: | AGABI1DRAFT114250(AGABI1DRAFT_114250) |
ABV: | AGABI2DRAFT191269(AGABI2DRAFT_191269) |
SCM: | SCHCO_02619624(SCHCODRAFT_02619624) |
EHI: | EHI_035400(17.t00024) |
MICC: | AUP74_00920(pgsA_1) |
LLG: | 44548918_02523(pgsA2) |
LJR: | NCTC11533_02673(pgsA2) |
LCJ: | NCTC11976_00344(pgsA2) |
LWA: | SAMEA4504053_3305(pgsA2) |
LSS: | NCTC12082_01859(pgsA2) |
LADL: | NCTC12735_01591(pgsA2) |
THIP: | N838_14295(pgsA) N838_15040 |
TNI: | TVNIR_3397(pgsA_[C]) |
SEDS: | AAY24_04855 AAY24_08055 |
NMM: | NMBM01240149_0587(pgsA) |
NMS: | NMBM01240355_1520(pgsA) |
NMQ: | NMBM04240196_0634(pgsA) |
NMZ: | NMBNZ0533_1567(pgsA) |
NMX: | NMA510612_2009(pgsA) |
NWE: | SAMEA3174300_1346(pgsA) |
NZO: | SAMEA4504057_0750(pgsA) |
NCI: | NCTC10296_01400(pgsA) |
NCZ: | NCTC10294_01068(pgsA) |
NANI: | NCTC12227_01594(pgsA) |
ECOR: | SAMEA4412678_1735(pgsA) |
REH: | H16_A2546(h16_A2546) |
BMV: | BMASAVP1_A2455(pgsA) |
BML: | BMA10229_A2825(pgsA) |
BPM: | BURPS1710b_2883(pgsA) |
BPL: | BURPS1106A_2828(pgsA) |
BCJ: | BCAL1019(pgsA2) BCAL2853(pgsA1) |
BGL: | bglu_1g09740 bglu_1g19240 |
BGU: | KS03_1907(pgsA) KS03_2772 |
LMIR: | NCTC12852_01960(pgsA) |
BUO: | BRPE64_ACDS19550(pgsA) |
VTR: | MYVALT_G_02920(pgsA) |
BTRM: | SAMEA390648704152(pgsA) |
AXX: | ERS451415_04632(pgsA) |
OUE: | I6G29_05315 I6G29_11900(pgsA) |
LIM: | L103DPR2_02129(pgsA) |
LIH: | L63ED372_01092(pgsA) |
NIT: | NAL212_2508 NAL212_2512 |
NII: | Nit79A3_1924 Nit79A3_2151 |
NUR: | ATY38_00930 ATY38_00965 |
SULF: | CAP31_00845 CAP31_02715 |
SPLB: | SFPGR_24880(pgsA) SFPGR_27260 |
SNIV: | SFSGTM_08410 SFSGTM_25580(pgsA) |
URU: | DSM104443_02372(pgsA) |
UPL: | DSM104440_02115(pgsA) |
APET: | ToN1_09810(pgsA) ToN1_13810 |
AZI: | AzCIB_2780 AzCIB_3484 |
FPHO: | SHINM1_009900(pgsA) |
DDZ: | DSYM_15800 DSYM_18140 |
ERU: | Erum8300(probable_pgsA) |
PACA: | ID47_03140 ID47_03915 |
CAQ: | IM40_01235 IM40_03605 |
NAF: | GQ61_02595 GQ61_08385 |
GAGG: | Gromo_00192 Gromo_00427 |
MLN: | A9174_26600 A9174_26820 |
MCI: | Mesci_4678 Mesci_4714 |
MCIC: | A4R28_03500 A4R28_03670 |
MOP: | Mesop_5167 Mesop_5206 |
MAM: | Mesau_04732 Mesau_04769 |
MAMO: | A6B35_13660 A6B35_13840 |
MESW: | A9K65_025760 A9K65_025940 |
MESM: | EJ066_19280(pgsA) EJ066_19415 |
MESP: | C1M53_26120(pgsA) C1M53_26230 |
MHUA: | MCHK_1329(pgsA) MCHK_1378 |
MJR: | EB229_26845 EB229_27070(pgsA) |
MERD: | EB233_23345 EB233_23545(pgsA) |
MESR: | FGU64_02510(pgsA) FGU64_02575 |
MOH: | IHQ72_25500 IHQ72_25650(pgsA) |
MESO: | BSQ44_10770 BSQ44_10825 |
HOE: | IMCC20628_02409 IMCC20628_02433 |
AAK: | AA2016_4454 AA2016_4499 |
AMIH: | CO731_04170(pgsA_1) CO731_04184(pgsA_2) |
PHT: | BLM14_11140 BLM14_11205 |
PHYL: | HB779_11995(pgsA) HB779_12075 |
RPOD: | E0E05_06635(pgsA) E0E05_06685 |
NIY: | FQ775_11640 FQ775_11710(pgsA) |
NKI: | KW403_15370(pgsA) KW403_15425 |
ORM: | HTY61_07975 HTY61_08040(pgsA) |
PMOB: | HG718_02810(pgsA) HG718_08160 |
KMN: | HW532_04940 HW532_17170(pgsA) |
RBS: | RHODOSMS8_02030(pgsA) |
SMEL: | SM2011_c00601(pgsA) |
SFD: | USDA257_c08920(pgsA) |
SAME: | SAMCFNEI73_Ch1231(pgsA) |
AGR: | AGROH133_05273(pgsA) |
ALF: | CFBP5473_20500(pgsA) |
AVV: | RvVAT039_27790(pgsA) |
AVF: | RvVAR031_14970(pgsA) |
REC: | RHECIAT_CH0001546(pgsAch) |
REL: | REMIM1_CH01491(pgsA) |
REP: | IE4803_CH01480(pgsA) |
REI: | IE4771_CH01531(pgsA) |
RTR: | RTCIAT899_CH06285(pgsA) |
RPUS: | CFBP5875_04360(pgsA) |
RGA: | RGR602_CH01364(pgsA) |
RPHA: | AMC79_CH01498(pgsA) |
RLW: | RlegWSM1455_06185(pgsA) |
LAS: | CLIBASIA_02435(pgsA) |
ABAW: | D5400_15115 D5400_15175(pgsA) |
BIO: | BR141012304_11949(pgsA) |
BJA: | bll4124(bll4124) blr7471(pgsA) |
BJU: | BJ6T_18200 BJ6T_56890 |
BJP: | RN69_08980 RN69_27565 |
BRA: | BRADO3343 BRADO6057(pgsA) |
BRS: | S23_41380 S23_61020(pgsA) |
BRC: | BCCGELA001_06500 BCCGELA001_17190 |
BRAD: | BF49_0938 BF49_3008 |
BIC: | LMTR13_22285 LMTR13_33155 |
BRO: | BRAD285_4003 BRAD285_6027(pgsA) |
BRK: | CWS35_22380 CWS35_37025(pgsA) |
BOT: | CIT37_17840(pgsA) CIT37_33405 |
BRQ: | CIT40_04110(pgsA) CIT40_13325 |
BGQ: | X265_17185 X265_31680(pgsA) |
BGZ: | XH91_20200 XH91_30070(pgsA) |
BSYM: | CIT39_02465(pgsA) CIT39_12495 |
BBET: | F8237_01045 F8237_10080(pgsA) |
BARH: | WN72_22290 WN72_42505(pgsA) |
BVZ: | BRAD3257_1172 BRAD3257_4887 |
BEL: | BE61_61170 BE61_82840(pgsA) |
BDG: | LPJ38_10605(pgsA) LPJ38_22640 |
BSEP: | HAP48_0022325(pgsA) HAP48_0036130 |
BQB: | J4P68_0011870(pgsA) J4P68_0037305 |
BSEI: | KMZ68_12095 KMZ68_21915(pgsA) |
BBAN: | J4G43_008535(pgsA) J4G43_023415 |
BCAN: | BcanWSM471_17930 BcanWSM471_32840(pgsA) |
RPA: | RPA1170(pgsA) RPA3050 |
RPX: | Rpdx1_1340 Rpdx1_2377 |
RBK: | E0H22_06740(pgsA) E0H22_12340 |
OCA: | OCAR_6341 OCAR_7212(pgsA) |
OCG: | OCA5_c09000(pgsA) OCA5_c16990 |
OCO: | OCA4_c08990(pgsA) OCA4_c16990 |
VGO: | GJW-30_1_01771(pgsA) GJW-30_1_03495(pgsA2) |
TRB: | HB776_10120 HB776_29935(pgsA) |
BOS: | BSY19_2801 BSY19_3766(pgsA) |
BVV: | BHK69_18175 BHK69_26755 |
BOI: | BLM15_00555 BLM15_08325 |
BOF: | FQV39_07505 FQV39_26940(pgsA) |
BHS: | BM1374165_00537(pgsA) |
BBK: | BARBAKC583_0515(pgsA) |
BTX: | BM1374166_00776(pgsA) |
BEZ: | NCTC12898_00489(pgsA) |
XDI: | EZH22_03360(pgsA) EZH22_16790 |
STAR: | G3545_05915 G3545_28235(pgsA) |
LNE: | FZC33_14065(pgsA) FZC33_32865 |
MAQU: | Maq22A_c10390(pgsA) Maq22A_c26275(pgsA) |
MEE: | DA075_26570(pgsA) DA075_29665 |
METS: | DK389_20455 DK389_31550(pgsA) |
MMES: | MMSR116_12655(pgsA) |
MTEA: | DK419_11395(pgsA) DK419_16830 |
MIND: | mvi_07810(pgsA) mvi_11170 |
MOC: | BB934_18205 BB934_23315 |
MIV: | C4E04_05165(pgsA) C4E04_12485 |
MICO: | GDR74_08535 GDR74_14215(pgsA) |
MTUN: | MTUNDRAET4_0982 MTUNDRAET4_2197(pgsA) |
MLG: | CWB41_03030(pgsA) CWB41_11940 |
RHJ: | HZY79_09380(pgsA) HZY79_11390 |
CHEL: | AL346_02505 AL346_19810 |
CDQ: | BOQ54_10505 BOQ54_13715 |
HDT: | HYPDE_28443 HYPDE_37773 |
HMC: | HYPMC_2991(pgsA) HYPMC_4116 |
HNI: | W911_06570 W911_06765 |
FIL: | BN1229_v1_0075(pgsA) BN1229_v1_3935 |
FIY: | BN1229_v1_0077(pgsA) BN1229_v1_3922 |
RHZ: | RHPLAN_14650 RHPLAN_44540 |
METG: | HT051_06030(pgsA) HT051_07210 |
BLAG: | BLTE_03900(pgsA) BLTE_19590 |
MROS: | EHO51_04345 EHO51_06605(pgsA) |
MPAR: | F7D14_14440 F7D14_16315(pgsA) |
MTW: | CQW49_02865 CQW49_03695(pgsA) |
PLEO: | OHA_1_00211(pgsA2) OHA_1_02346(pgsA) |
HDI: | HDIA_2780(pgsA2) HDIA_3500(pgsA) |
AUB: | LXB15_10790 LXB15_10850(pgsA) |
JIE: | OH818_03920(pgsA) OH818_15745 |
BRN: | D1F64_11820 D1F64_17250(pgsA) |
PSIN: | CAK95_01635 CAK95_25705 |
NOH: | G5V57_01190(pgsA) G5V57_25110 |
TSO: | IZ6_08640(pgsA) IZ6_16040 |
PHR: | C6569_09650 C6569_18300(pgsA) |
PSTG: | E8M01_00055 E8M01_11725(pgsA) E8M01_34810 |
LIZ: | LGH83_02990 LGH83_12885(pgsA) |
CFH: | C1707_13110(pgsA) C1707_17810 |
BVY: | NCTC9239_00380(pgsA) |
TSV: | DSM104635_03236(pgsA) |
RLI: | RLO149_c003850(pgsA) |
PHP: | PhaeoP97_03070(pgsA) |
PPIC: | PhaeoP14_00207(pgsA) |
SINL: | DSM14862_00608(pgsA) |
SPSE: | SULPSESMR1_02495(pgsA) |
RMM: | ROSMUCSMR3_01765(pgsA) |
AHT: | ANTHELSMS3_00084(pgsA) |
LVS: | LOKVESSMR4R_02971(pgsA) |
CBOT: | ATE48_11540 ATE48_13910 |
SAMI: | SAMIE_1005860 SAMIE_1015550 |
SFLA: | SPHFLASMR4Y_00704(pgsA) |
SMIC: | SmB9_28340 SmB9_36630 |
GBE: | GbCGDNIH1_2036 GbCGDNIH1_2083 |
GBH: | GbCGDNIH2_2036 GbCGDNIH2_2083 |
GBC: | GbCGDNIH3_2036 GbCGDNIH3_2083 |
GBS: | GbCGDNIH4_2036 GbCGDNIH4_2083 |
RGI: | RGI145_04645 RGI145_14055 |
ROS: | CTJ15_12750 CTJ15_22275(pgsA) |
RMUC: | FOB66_06450 FOB66_15680(pgsA) |
RMT: | IAI58_01695 IAI58_09285(pgsA) |
SRF: | LHU95_12830(pgsA) LHU95_17580 |
RAP: | RHOA_1560(pgsA) RHOA_2973 |
SHUM: | STHU_19170 STHU_42210 |
SVC: | STVA_17550 STVA_45930 |
STEL: | STAQ_06080 STAQ_17000 |
AZL: | AZL_013120(pgsA) AZL_015480(pgsA) |
ALI: | AZOLI_1193 AZOLI_1299(pgsA) |
ABS: | AZOBR_130041 AZOBR_p130157 |
ABQ: | ABAZ39_06890 ABAZ39_19590 |
ABF: | AMK58_07955 AMK58_15965 |
ATI: | AL072_12400 AL072_13180 |
AHU: | A6A40_05420 A6A40_05880 |
AZT: | TSH58p_04700(pgsA) TSH58p_28370 |
AZM: | DM194_04860(pgsA) DM194_05315 |
AZZ: | DEW08_04445(pgsA) DEW08_12330 |
AOZ: | HUE56_16790(pgsA) HUE56_17975 |
AARE: | D3093_02320(pgsA) D3093_14290 |
NCB: | C0V82_00710 C0V82_02185(pgsA) |
SKT: | IGS68_06485(pgsA) IGS68_18465 |
SMUC: | JL100_007545 JL100_021115(pgsA) |
SROE: | JL101_007435 JL101_019830(pgsA) |
RCE: | RC1_1549 RC1_1886(pgsA) |
HTQ: | FRZ44_09850 FRZ44_16000 |
HADH: | FRZ61_09810 FRZ61_30710 |
TMO: | TMO_1838 TMO_c0131(pgsA) |
MAGQ: | MGMAQ_0895 MGMAQ_3024(pgsA) |
ELIO: | KO353_08870 KO353_14090(pgsA) |
SNEA: | NBZ79_05220(pgsA) NBZ79_09730 |
THET: | F1847_06005(pgsA) F1847_09020 |
TAV: | G4V39_03525 G4V39_04335 |
TMAI: | FVE67_03415 FVE67_04935 |
PBK: | Back11_52270(pgsA_2) |
COHN: | KCTCHS21_55960(pgsA) |
PABS: | JIR001_30200(pgsA_2) |
EFU: | HMPREF0351_10392(pgsA) |
MARR: | BKP56_06425 BKP56_08615 |
CCB: | Clocel_1089 Clocel_2030 |
CLT: | CM240_2235 CM240_2669 |
CCK: | Ccar_09690 Ccar_24705 |
CCOH: | SAMEA4530647_2460(pgsA_2) |
CRW: | CROST_000010(pgsA_1) CROST_038020 |
CFB: | CLFE_003000(pgsA_1) CLFE_009800 |
CAUN: | CLAUR_029960(pgsA_2) CLAUR_037250 |
GFE: | Gferi_03535 Gferi_04350 |
HHW: | NCTC503_02715(pgsA2) |
EHA: | Ethha_1017 Ethha_1298 |
CAML: | H6X83_01975 H6X83_10535 |
SMAN: | C12CBH8_21520(pgsA_2) |
VFA: | MM35RIKEN_08140(pgsA) |
VCOP: | MM50RIKEN_14640(pgsA_2) |
CFEM: | HCR03_12205 HCR03_17445 |
CCOM: | I6K69_06410 I6K69_12210 |
BPRO: | PMF13cell1_03668(pgsA1) PMF13cell1_05160(pgsA_2) |
CSCI: | HDCHBGLK_00060(pgsA_1) |
DLO: | K5I24_10205 K5I24_15390 |
CBAR: | PATL70BA_0341 PATL70BA_2285 |
CDIA: | CaldiYA01_10600(pgsA) |
HALS: | D7D81_12585 D7D81_12650 |
CAD: | Curi_c05170(pgsA1) Curi_c08180(pgsA2) |
SPOA: | EQM13_00660 EQM13_06700(pgsA) |
FIT: | Fi14EGH31_06120(pgsA_2) Fi14EGH31_12850(pgsA_3) |
AAXA: | NCTC10138_01657(pgsA_2) |
MALA: | NCTC10135_00590(pgsA) |
MBO: | BQ2027_MB1853(pgsA2) |
MMAN: | MMAN_11660(pgsA2_2) |
MMAE: | MMARE11_26200(pgsA2) |
MPSE: | MPSD_27760(pgsA1_2) |
MSHO: | MSHO_40260(pgsA2_1) |
MFJ: | MFLOJ_06490(pgsA2_1) |
MSTO: | MSTO_07750(pgsA2_1) |
MSAK: | MSAS_06980(pgsA2_1) |
MBAI: | MB901379_02496(pgsA) |
MSHJ: | MSHI_13730(pgsA1_1) |
MPHL: | MPHLCCUG_02349(pgsA_1) |
MTHN: | 4412656_02239(pgsA) |
MAUU: | NCTC10437_03035(pgsA_3) |
MFLV: | NCTC10271_02562(pgsA2_1) |
MSAL: | DSM43276_02117(pgsA2_1) |
MTER: | 4434518_01868(pgsA2) |
NFR: | ERS450000_01613(pgsA2_2) |
NAD: | NCTC11293_03723(pgsA2_1) |
RHU: | A3Q40_01819(pgsA1_2) |
RRT: | 4535765_02738(pgsA_2) |
RCR: | NCTC10994_00350(pgsA_1) |
GOM: | D7316_01257(pgsA1_2) |
SAMB: | SAM23877_1447(pgsA) |
SRW: | TUE45_01785(pgsA2_1) |
SLE: | sle_57090(sle_57090) |
SRN: | A4G23_00636(pgsA2_1) |
SSPB: | CP982_08165 CP982_23120 |
AMAU: | DSM26151_12810(pgsA2) |
MALK: | MalAC0309_1270(pgsA) |
PSEV: | USB125703_02031(pgsA1) |
AAGI: | NCTC2676_1_00905(pgsA_1) |
CGA: | Celgi_1702 Celgi_2054 |
CGRN: | 4412665_01261(pgsA_2) |
TLA: | TLA_TLA_00104(pgsA1) |
RAIN: | Rai3103_07555 Rai3103_11140 |
NAQU: | ENKNEFLB_02265(pgsA1) |
NRO: | K8W59_08100 K8W59_14700 |
AER: | AERYTH_08595 AERYTH_16900 |
MMAR: | MODMU_2675 MODMU_4979 |
STP: | Strop_2387 Strop_2928 |
MTEM: | GCE86_08780 GCE86_11395 |
PFLA: | Pflav_035640(pgsA_2) |
ASER: | Asera_46290(pgsA_2) |
DDT: | AAY81_05640 AAY81_09575 |
RTS: | CE91St31_16780(pgsA2) |
PCAT: | Pcatena_07910(pgsA) |
OBG: | Verru16b_02571(pgsA) |
LCRE: | Pla8534_41340(pgsA_1) |
ALUS: | STSP2_03330(pgsA2_2) |
LKB: | LPTSP3_g13450(pgsA_1) |
TPX: | Turpa_2077 Turpa_3868 |
MCOS: | GM418_20080 GM418_23010 GM418_23645 |
RMG: | Rhom172_0692 Rhom172_2372 |
SPHN: | BV902_16800 BV902_24070 |
MGOS: | DIU38_008655 DIU38_030310 |
KOS: | KORDIASMS9_02119(pgsA) |
PROC: | Ptc2401_00519(pgsA_2) |
DTH: | DICTH_0990 DICTH_1746 |
DPB: | BABL1_gene_945(pgsA2) |
CGW: | UR58_C0001G0495(pgsA) |
» show all
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Reference |
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Authors |
Schlame M, Hostetler KY |
Title |
Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement. |
Journal |
J Biol Chem 266:22398-403 (1991) |
Reference |
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Authors |
Nowicki M, Muller F, Frentzen M |
Title |
Cardiolipin synthase of Arabidopsis thaliana. |
Journal |
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Sequence |
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Reference |
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Authors |
Houtkooper RH, Akbari H, van Lenthe H, Kulik W, Wanders RJ, Frentzen M, Vaz FM |
Title |
Identification and characterization of human cardiolipin synthase. |
Journal |
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Sequence |
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Reference |
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Authors |
Sandoval-Calderon M, Geiger O, Guan Z, Barona-Gomez F, Sohlenkamp C |
Title |
A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.8.41 |
ExPASy - ENZYME nomenclature database: | 2.7.8.41 |
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