KEGG   ENZYME: 2.7.8.44
Entry
EC 2.7.8.44                 Enzyme                                 
Name
teichoic acid glycerol-phosphate primase;
Tag primase;
CDP-glycerol:glycerophosphate glycerophosphotransferase;
tagB (gene name);
tarB (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-glycerol:N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase
Reaction(IUBMB)
CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11558 R12860]
Reaction(KEGG)
R11558 R12860(G)
Substrate
CDP-glycerol [CPD:C00513];
N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C04881]
Product
CDP [CPD:C00112];
4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21464]
Comment
Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. This enzyme adds the first glycerol unit to the disaccharide linker of the teichoic acid.
History
EC 2.7.8.44 created 2016
Pathway
ec00552  Teichoic acid biosynthesis
Orthology
K21285  teichoic acid glycerol-phosphate primase
Genes
SLOShew_3696
SJASJ2017_0061
SMAVCFF01_18305
THTE2K93_04605
PDVFFU37_13135
TCYThicy_0930
KGETQ33_2188
CFTCFF04554_1615
CFVCFVI03293_1637
CFXCFV97608_1740
CFZCSG_17470
SDOSD1155_05970
BSUBSU35760(tagB)
BSRI33_3705
BSLA7A1_1144
BSHBSU6051_35760(tagB)
BSYI653_17440
BSUTBSUB_03809(tagB)
BSULBSUA_03809(tagB)
BSUSQ433_19590
BSOBSNT_10220(tagB)
BSNBSn5_08795
BSQB657_35760(tagB)
BSXC663_3467(tarB)
BSPU712_17950
BSSBSUW23_17560(tarB)
BSTGYO_3932(tarB)
BLIBL02433(tagB)
BLDBLi03820(tagB)
BLHBaLi_c38320(tagB)
BAYRBAM_032890
BAQBACAU_3319(tagB)
BYABANAU_3478(tagB)
BAMPB938_16890
BQYMUS_3917(tagB)
BAMLBAM5036_3213(tagB)
BAMARBAU_3429(tagB)
BAMNBASU_3207(tagB)
BAMBBAPNAU_3486(tagB)
BAMTAJ82_18570
BAMYV529_35570(tagB)
BMPNG74_03465(tagB)
BAOBAMF_3415(tagB)
BAZBAMTA208_18095(tagB)
BQLLL3_03710(tagB)
BXHBAXH7_03699(tagB)
BAMIKSO_002625
BAMCU471_34160
BAMFU722_17635
BSIACWD84_02610
BAEBATR1942_15770
BVMB9C48_16875
BSONS101395_00593(tarL)
BHTDIC78_13190
BMOJHC660_34660
BTEQG4P54_18365
BIQAN935_18020
BMYOBG05_726
BMYCDJ92_2373
BPUBPUM_3232
BPUMBW16_17250
BPUSUP12_16740
BGYBGLY_4217
BXIBK049_10710
BALTCFN77_17160
BSAFBSL056_17875
BITBIS30_07530
BFDNCTC4823_03769(tagF_4)
BSHILGQ02_18320
BCABEFK13_18405
BRYM0696_18125
BJSMY9_3629
BACWQR42_16245
BACPSB24_12250
BACBOY17_00125
BACYQF06_16285
BACLBS34A_38890(tagB)
BALMBsLM_3592
BACSAUL54_13150
BCIRC2I06_14140
BCKBCO26_0718
BAGBcoa_0457
BCOABF29_3239 BF29_3251
BGIBGM20_12040
BKOCKF48_13440
GEAGARCT_03218(tagB)
AXLAXY_20290(tagB)
TAIDKS242_14100
VIRX953_16995 X953_17010
VHLBME96_16485 BME96_16495
VIGBKP57_07935
VILCFK37_08170
VNECFK40_03410
VPNA21D_00863(tagB)
VIMGWK91_11405
VPTKBP50_19475
BSJUP17_23880
BMURABE28_022565
PBUTDTO10_10375
PASABAOM_4717
PPSRI6J18_15985
PFRIL8956_17900 L8956_25340
PRDF7984_17495
NMKCHR53_23540
BLENNCTC4824_03836(tagF_4)
SEDDERJ70_16910
RMFD5E69_20535
BVJI5776_05250
BOUI5818_06580
STEAC0679_05935
SAUSA0595(tagB)
SAVSAV0639(tagB)
SAWSAHV_0636(tagB)
SAHSaurJH1_0677
SAJSaurJH9_0662
SAMMW0601(tagB)
SASSAS0605
SARSAR0649(tagB)
SACSACOL0696(tagB)
SAXUSA300HOU_0659(tagB3)
SAASAUSA300_0626(tagB)
SAOSAOUHSC_00643
SAENWMN_0609(tagB)
SADSAAV_0602(tagB)
SUUM013TW_0627
SUVSAVC_02830
SUESAOV_0674
SUJSAA6159_00594(tagB)
SUKSAA6008_00656(tagB)
SUCECTR2_591
SUTSAT0131_00708
SUQHMPREF0772_12548
SUZMS7_0690
SUDST398NM01_0718
SUXSAEMRSA15_05650(tagB)
SUWSATW20_07140(tagB)
SUGSAPIG0718
SUFSARLGA251_05730(tagB)
SAUASAAG_01062
SAUERSAU_000595(tagB)
SAUNSAKOR_00633
SAUSSA40_0580(tagB)
SAUUSA957_0595(tagB)
SAUGSA268_0593(tagB)
SAUZSAZ172_0651(tagB)
SAUTSAI1T1_2004930
SAUJSAI2T2_1004950
SAUKSAI3T3_1004940
SAUQSAI4T8_1004930
SAUVSAI7S6_1004940
SAUWSAI5S5_1004900
SAUXSAI6T6_1004910
SAUYSAI8T7_1004940
SAUFX998_0687
SABSAB0589(tagB)
SUYSA2981_0615(tagB)
SAUBC248_0721(tagB)
SAUMBN843_6410
SAUCCA347_653
SAURSABB_06074
SAUIAZ30_03350
SAUDCH52_02565
SAMSNI36_03200
SUHSAMSHR1132_05850
SERSERP0298
SEPSE_0413
SEPPSEB_00334
SEPSDP17_1717
SHASH2257(tagB)
SHHShL2_02107(tagB)
SSPSSP2080
SCASCA_0288(tagB)
SLGSLGD_02185
SLNSLUG_21590(tagB)
SSDSPSINT_0348
SDTSPSE_2110(tagB)
SDPNCTC12225_02327(tagB)
SWAA284_10130
SPASSTP1_1725
SXYBE24_00955
SXLSXYLSMQ121_2057
SXOSXYL_02210(tagB)
SHUSHYC_10505(tagB)
SCAPAYP1020_0008(tagB)
SSCHLH95_10100
SSCZRN70_10835
SAGQEP23_11665
SEQOSE1039_04680
SSIFAL483_08410
SCVA4G25_06235
SPETCEP67_10185
SLZB5P37_07655
SCOHBZ166_02355
SNLBJD96_11675
SKLC7J89_12250
SFQC7J90_01525
SHOMEGX58_03025
SMUSC7J88_08660
SCARDWB96_11030
SARLSAP2_21290
SPICSAMEA4384060_2231(tagB)
SSHNCTC13712_00601
SSIMSAMEA4384339_0582(tagF_5)
SDBCNQ82_12560
SLLOISP08_10515
SAULI6G39_09520
SSACI6I31_05980
SRAILN051_09770
SPSDJMB28_11195
SSCUCEP64_08370
SFFFOB90_09365
SSTESAMEA4384403_1805(tagB)
MLENH3V22_13600
MVTI6J10_02330
MCLMCCL_0653
MARYLAU42_03810
SHVAAT16_03995
JEAJEM45_04385
NAMPKPF49_02125
LMOlmo1088(tagB)
LMNLM5578_1171(tagB)
LMYLM5923_1125(tagB)
LMTLMRG_00550
LMOCLMOSLCC5850_1094(tagB)
LMOEBN418_1306
LMOBBN419_1303
LMODLMON_1098(tagB)
LMOWAX10_14020
LMOQLM6179_1408
LMRLMR479A_1116
LMOMIJ09_04845
LMFLMOf2365_1104
LMCLm4b_01103
LMOGBN389_11170(tagB)
LMPMUO_05690
LMOLLMOL312_1084(tagB)
LMOJLM220_18775
LMOZLM1816_14237
LMOXAX24_02840
LMHLMHCC_1543
LMQLMM7_1114(tagB)
LMLlmo4a_1092(tagB)
LMGLMKG_01832
LMSLMLG_2571
LMJLMOG_00630
LMWLMOSLCC2755_1086(tagB)
LMXLMOSLCC2372_1102(tagB)
LMZLMOSLCC2482_1132(tagB)
LMONLMOSLCC2376_1055(tagB)
LMOSLMOSLCC7179_1069(tagB)
LMOOLMOSLCC2378_1101(tagB)
LMOYLMOSLCC2479_1102(tagB)
LMOTLMOSLCC2540_1085(tagB)
LMOALMOATCC19117_1106(tagB)
LMOKCQ02_05650
LMVY193_10315
LINlin1075
LWElwe1065(tagB)
LSGlse_0978(tagB)
LIVLIV_1031
LIIJL52_05480
LIWAX25_05570
LIAJL58_05700
LIOJL53_06190
LWIUE46_11725
LGZNCTC10812_01809(tagF_5)
LMARLAX80_005015
BTHSCNY62_01040
ESIExig_0594
EANEab7_0568
EXMU719_03105
EXUESP131_05545
EACEKKI46_03305
PLNPlano_2228
PLLI858_011695
PDGBCM40_04110
PHCBBI08_08395
PGQFK545_02145
KURASO14_2495
KZONCTC404_00414(tagF_2)
SPAEE2C16_11345
RSTATY39_17045
PANCE2636_12050
PLAYDNR44_008290
VIJJNUCC6_17780
LDELDBND_0395(tarB)
LPXASU28_08650
LPGBB562_07725
LSNLSA_07850
LLEAYR59_05205
LFVLF543_03650
LBHLbuc_1007
LBNLBUCD034_1141(tagB)
LPARFAM21731_02458
LCUPL11_009435
LKFDNL43_09525
LHILG8J22_01371(tagB)
LBRLVIS_0739
LBKLVISKB_1240
LKOABN16_12145
LZYLZ3411_1119
LSUAH3M12_08800
LJIELX58_02170
LAGLBEN83_04750
LACALAC1533_1167
LKUAPS55_06025
ABOMD7I45_03070
LPDAYR62_05195
LMAEFGL90_09010
PPEPEPE_1113
PPENT256_05475
PCEPECL_957
PDMADU72_2183
PACIA4V11_02385
PIOPI20285_04425
ECASECBG_01909
ETHCK496_09740
ESGEsVE80_09540(tagB3)
EIEENLAB_28960(tagB)
THLTEH_16240(tagB) TEH_16360(tagB)
TEYGLW17_02030
TOOC7K38_10615
TKRC7K43_04375
VTEBHY08_07885
VPIBW732_01940
VACE4Z98_08055
VAOFA707_08745
VAHG7081_00365
VCPH9L18_03815
VHYG7082_02265
CHYCHY_2587
TBMBK010_09645
PCUPC_RS08980
PNLPNK_2242
PUVPUV_00330
SNGSNE_A00890
RPORRHAB15C_0000041
CPOCOPRO5265_1091
TPRFA3L09_01825
 » show all
Reference
1  [PMID:16150696]
  Authors
Bhavsar AP, Truant R, Brown ED
  Title
The TagB protein in Bacillus subtilis 168 is an intracellular peripheral membrane protein that can incorporate glycerol phosphate onto a membrane-bound acceptor in vitro.
  Journal
J Biol Chem 280:36691-700 (2005)
DOI:10.1074/jbc.M507154200
Reference
2  [PMID:17163636]
  Authors
Ginsberg C, Zhang YH, Yuan Y, Walker S
  Title
In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis.
  Journal
ACS Chem Biol 1:25-8 (2006)
DOI:10.1021/cb0500041
Reference
3  [PMID:18215769]
  Authors
Brown S, Zhang YH, Walker S
  Title
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
  Journal
Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.44
IUBMB Enzyme Nomenclature: 2.7.8.44
ExPASy - ENZYME nomenclature database: 2.7.8.44
BRENDA, the Enzyme Database: 2.7.8.44

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