KEGG   ENZYME: 2.7.8.45
Entry
EC 2.7.8.45                 Enzyme                                 
Name
teichoic acid glycerol-phosphate transferase;
tarF (gene name) (ambiguous);
teichoic acid glycerol-phosphate primase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-glycerol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase
Reaction(IUBMB)
CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11612 R12868]
Reaction(KEGG)
R11612 R12868(G)
Substrate
CDP-glycerol [CPD:C00513];
4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21464]
Product
CDP [CPD:C00112];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]
Comment
Involved in the biosynthesis of teichoic acid linkage units in the cell walls of some bacteria such as Staphylococcus aureus. This enzyme adds a second glycerol unit to the disaccharide linker of the teichoic acid. cf. EC 2.7.8.12, teichoic acid poly(glycerol phosphate) polymerase.
History
EC 2.7.8.45 created 2017
Pathway
ec00552  Teichoic acid biosynthesis
Orthology
K21591  teichoic acid glycerol-phosphate transferase
Genes
ECQECED1_2383
YFRAW19_2176
YKRCH54_3610
XPOXPG1_3611
ASYAUT07_00140(tagF)
MSUMS0659(tagB)
SACZAOT14_19650
VHRAL538_10705
VAQFIV01_00160(tagF1) FIV01_00165(tagF2)
PPRPBPRA2683 PBPRA2700
PGBH744_2c2863 H744_2c2866
GHOAL542_04975
PPUUPputUW4_03542
SSESsed_2954
SJASJ2017_1421
SPSWSps_03695
SMAIEXU30_17220
COZA3Q34_09475
COVEKO29_15330
CBERB5D82_09540
LALAT746_12870
FPHFphi_1473
FPIBF30_1738
FPXKU46_1834
TZOTHMIRHAT_08400
HCSFF32_16315
HCAMI4484_00940
HSXHNO51_00805
HSVHNO53_00800
ATWC0099_11620
DVMDvMF_1840
DDEDde_0439
BSYI653_17405
BSXC663_3460(ggaB1)
BHTDIC78_13225
BMOJHC660_34590
BTHUYBT1518_29660
BVJI5776_16315
SAUSA0244
SAVSAV0254
SAWSAHV_0253
SAHSaurJH1_0245
SAJSaurJH9_0239
SAMMW0230
SASSAS0231
SARSAR0251
SACSACOL0239
SAXUSA300HOU_0265(tagF)
SAASAUSA300_0248
SAOSAOUHSC_00223
SAENWMN_0188
SADSAAV_0222
SUUM013TW_0235
SUVSAVC_01010
SUESAOV_0193
SUJSAA6159_00231
SUKSAA6008_00228(tarF)
SUCECTR2_215
SUTSAT0131_00247
SUQHMPREF0772_10248
SUZMS7_0244
SUDST398NM01_0267
SUXSAEMRSA15_02130
SUWSATW20_02560(tarF)
SUGSAPIG0267
SUFSARLGA251_02180(tarF)
SAUASAAG_00735
SAUERSAU_000198(tagF)
SAUNSAKOR_00233
SAUSSA40_0212(tarF)
SAUUSA957_0227(tarF)
SAUGSA268_0224(tarF)
SAUZSAZ172_0257
SAUTSAI1T1_2001950
SAUJSAI2T2_1001950
SAUKSAI3T3_1001950
SAUQSAI4T8_1001950
SAUVSAI7S6_1001950
SAUWSAI5S5_1001940
SAUXSAI6T6_1001950
SAUYSAI8T7_1001950
SAUFX998_0230
SABSAB0193
SUYSA2981_0254
SAUBC248_0242
SAUMBN843_2530
SAUCCA347_261
SAURSABB_01598(tagF)
SAUIAZ30_01275
SAUDCH52_04455
SAMSNI36_01170
SUHSAMSHR1132_02220
SSHNCTC13712_00200(tagF_2)
SSIMSAMEA4384339_0215(tagF_4)
PRTAUC31_12615
LPBSH83_04920
LPXASU28_00370
LRUHMPREF0538_20101
LSALCA_1576(tagB)
VHYG7082_02250
VFVK5K99_13420
SMANC12CBH8_18810
PHXKGNDJEFE_00744(tarF)
HALSD7D81_02040
ERHERH_1440
ERSK210_05635
LEOAMK43_07405
MPWMPR_1602
SHYRLA303_09580
CABYCabys_1821 Cabys_1831
METCMTCT_0287
NPHNP_1920A
NSALHWV07_10640
 » show all
Reference
1  [PMID:18215769]
  Authors
Brown S, Zhang YH, Walker S
  Title
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
  Journal
Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011
  Sequence
Reference
2  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.45
IUBMB Enzyme Nomenclature: 2.7.8.45
ExPASy - ENZYME nomenclature database: 2.7.8.45
BRENDA, the Enzyme Database: 2.7.8.45

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