KEGG   ENZYME: 2.7.8.45Help
Entry
EC 2.7.8.45                 Enzyme                                 

Name
teichoic acid glycerol-phosphate transferase;
tarF (gene name) (ambiguous);
teichoic acid glycerol-phosphate primase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
CDP-glycerol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase
Reaction(IUBMB)
CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11612]
Reaction(KEGG)
Substrate
CDP-glycerol [CPD:C00513];
4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21464]
Product
CDP [CPD:C00112];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]
Comment
Involved in the biosynthesis of teichoic acid linkage units in the cell walls of some bacteria such as Staphylococcus aureus. This enzyme adds a second glycerol unit to the disaccharide linker of the teichoic acid. cf. EC 2.7.8.12, teichoic acid poly(glycerol phosphate) polymerase.
History
EC 2.7.8.45 created 2017
Orthology
K21591  teichoic acid glycerol-phosphate transferase
Genes
VHR: AL538_10705
LAL: AT746_12870
FRX: F7310_06765
ATW: C0099_11620
SAU: SA0244
SAV: SAV0254
SAW: SAHV_0253
SAH: SaurJH1_0245
SAJ: SaurJH9_0239
SAM: MW0230
SAS: SAS0231
SAR: SAR0251
SAC: SACOL0239
SAX: USA300HOU_0265(tagF)
SAE: NWMN_0188
SAD: SAAV_0222
SUE: SAOV_0193
SUJ: SAA6159_00231(tarF)
SUK: SAA6008_00228(tarF)
SUC: ECTR2_215
SUZ: MS7_0244
SUW: SATW20_02560(tarF)
SUG: SAPIG0267
SUF: SARLGA251_02180(tarF)
SAUA: SAAG_00735
SAUE: RSAU_000198(tagF)
SAUS: SA40_0212(tarF)
SAUU: SA957_0227(tarF)
SAUG: SA268_0224(tarF)
SAUF: X998_0230
SAB: SAB0193
SAUB: C248_0242
SAUM: BN843_2530
SAUC: CA347_261
SAUR: SABB_01598(tagF)
SAUI: AZ30_01275
SAUD: CH52_04455
SAMS: NI36_01170
MBAS: ALGA_1633
 » show all
Taxonomy
Reference
1  [PMID:18215769]
  Authors
Brown S, Zhang YH, Walker S
  Title
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
  Journal
Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011
  Sequence
Reference
2  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.45
IUBMB Enzyme Nomenclature: 2.7.8.45
ExPASy - ENZYME nomenclature database: 2.7.8.45
BRENDA, the Enzyme Database: 2.7.8.45

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