KEGG   ENZYME: 2.7.8.46
Entry
EC 2.7.8.46                 Enzyme                                 

Name
teichoic acid ribitol-phosphate primase;
Tar primase;
tarK (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-ribitol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitylphosphotransferase
Reaction(IUBMB)
CDP-ribitol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CMP + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11613]
Reaction(KEGG)
R11613
Substrate
CDP-ribitol [CPD:C00789];
4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21464]
Product
CMP [CPD:C00055];
4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21503]
Comment
Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the first ribitol unit to the disaccharide linker of the teichoic acid.
History
EC 2.7.8.46 created 2017
Orthology
K21592  teichoic acid ribitol-phosphate primase
Genes
BSL: A7A1_1141
BSY: I653_17455
BSUS: Q433_19605
BSS: BSUW23_17575(tarK)
BST: GYO_3935(tarK)
BSX: C663_3470(tarK)
BHT: DIC78_13175
BJS: MY9_3632
BACY: QF06_16300
BGI: BGM20_12055
ESI: Exig_0191
EAN: Eab7_0183(tarK)
CBV: U729_1136
 » show all
Reference
1  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.46
IUBMB Enzyme Nomenclature: 2.7.8.46
ExPASy - ENZYME nomenclature database: 2.7.8.46
BRENDA, the Enzyme Database: 2.7.8.46

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