KEGG   ENZYME: 2.7.8.47
Entry
EC 2.7.8.47                 Enzyme                                 

Name
teichoic acid ribitol-phosphate polymerase;
Tar polymerase (ambiguous);
tarL (gene name) (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-ribitol:4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase
Reaction(IUBMB)
n CDP-ribitol + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11614]
Reaction(KEGG)
R11614
Substrate
CDP-ribitol [CPD:C00789];
4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21503]
Product
CMP [CPD:C00055];
4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21504]
Comment
Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the 25-35 ribitol units to the linker molecule.
History
EC 2.7.8.47 created 2017
Orthology
K18704  CDP-ribitol ribitolphosphotransferase / teichoic acid ribitol-phosphate polymerase
Genes
CCON: AFK62_03185
ESC: Entcl_3738
YMA: DA391_06385
BSUN: A4G13_01115
APJ: APJL_1614(cps3A)
VAQ: FIV01_00150(tagB) FIV01_15895(epsJ)
PPR: PBPRA2702
ALJ: G8D99_14940
COLW: A3Q33_09700
PTN: PTRA_a0500
PPHE: PP2015_409
AAUS: EP12_00250
CJS: CJS3_1521
CJQ: UC78_1376(tagB)
CJR: CJE1613
CCY: YSS_07705
CCOF: VC76_07105(epsJ_2)
CCOO: ATE51_00688(epsJ_1)
CAVI: CAV_0458
NAM: NAMH_1605
DMA: DMR_40290
BSL: A7A1_1140
BSX: C663_3471(tarL)
BSS: BSUW23_17580(tarL)
BST: GYO_3936(tarL)
BMOJ: HC660_34700(tagB)
BACY: QF06_16305
AFL: Aflv_2574(tagB)
SAX: USA300HOU_0264(tagB1) USA300HOU_0268(tagB2)
SUW: SATW20_02550(tarK) SATW20_02590(tarL)
SER: SERP0198
SEP: SE_0321
SEPP: SEB_00243
SEPS: DP17_1631
SSP: SSP0356
SCA: SCA_2404
SSCH: LH95_01800
SARL: SAP2_04720
SSH: NCTC13712_00199(tagF_1) NCTC13712_00203(tagF_3)
SSIM: SAMEA4384339_0090(tagF_1)
LMOG: BN389_11100(tarL)
LMP: MUO_05655
LMOX: AX24_02805
LMQ: LMM7_1109
LMOK: CQ02_05615
LIN: lin1068
LWE: lwe1060
LIV: LIV_1026
LGZ: NCTC10812_01040(tagF_3) NCTC10812_01812(tagF_6) NCTC10812_01814(tagF_7) NCTC10812_02004(kfoC_3)
ESI: Exig_0188
EAN: Eab7_0180(tarL)
LLK: LLKF_0947(ggaB)
LLX: NCDO2118_0939(ggaB)
LLJ: LG36_1406(ggaB)
LLM: llmg_1603(tagB)
LPL: lp_1819(tarL)
LPJ: JDM1_1532(tagB2)
LPT: zj316_1807(tarL)
LPS: LPST_C1461(tagB2)
LPZ: Lp16_1408
PCE: PECL_1837
WCE: WS08_0699
WCT: WS74_0701
CBT: CLH_2994
CBV: U729_1133
RIX: RO1_35060
RIM: ROI_04730
HSD: SD1D_2042
AARG: Aargi30884_26940(tagB)
ABSI: A9CBEGH2_00110(tagB)
LXL: KDY119_02610(tarL)
MOO: BWL13_02197(tarL)
JDE: Jden_1795
XCE: Xcel_2590
IDO: I598_2371(tagF_2)
BBP: BBPR_0698 BBPR_0699(tagB)
BBF: BBB_0690(tarK) BBB_0691
AEQ: AEQU_0651
DDO: I597_2601
TRQ: TRQ2_0300
MRU: mru_1079
MSI: Msm_1327
MEB: Abm4_1699
MMIL: sm9_2259
MEYE: TL18_00335
MOL: YLM1_0599
MCUB: MCBB_1531(tarL)
 » show all
Reference
1  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.47
IUBMB Enzyme Nomenclature: 2.7.8.47
ExPASy - ENZYME nomenclature database: 2.7.8.47
BRENDA, the Enzyme Database: 2.7.8.47

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