KEGG   ENZYME: 2.7.8.48
Entry
EC 2.7.8.48                 Enzyme                                 
Name
ceramide phosphoethanolamine synthase;
Cpes (gene name);
CPE synthase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-ethanolamine:ceramide phosphoethanolaminyltransferase
Reaction(IUBMB)
CDP-ethanolamine + a ceramide = a ceramide phosphorylethanolamine + CMP [RN:R01503]
Reaction(KEGG)
R01503
Substrate
CDP-ethanolamine [CPD:C00570];
ceramide [CPD:C00195]
Product
ceramide phosphorylethanolamine;
CMP [CPD:C00055]
Comment
The enzyme, studied from the fly Drosophila melanogaster, has homologues among the invertebrates, but not in other animal phyla. Its product, ceramide phosphoethanolamine, is synthesized as the main sphingolipid in cell membranes of arthropods, such as Drosophila and Musca, and is common in worms, bees, spiders, and scorpions. It has also been reported in deep-sea mussels and some sea snails, as well as protozoans and oomycetes. The enzyme requires a Mn(II) cofactor.
History
EC 2.7.8.48 created 2022
Pathway
ec00600  Sphingolipid metabolism
Orthology
K26283  ceramide phosphoethanolamine synthase
Genes
DMEDmel_CG4585(Cpes)
DER6548017
DSE6615787
DSIDsimw501_GD25004(Dsim_GD25004)
DYADyak_GE11520
DAN6494919
DSR110191497
DPO26534028
DPE6590368
DMN108160581 117190958
DWI6641049
DMODmoj_GI20723
DAZ108616641
DNV108652965
DHE111600017
DVI116651094 6625014
CCAT105664470
BOD106626898
BDR109579586
RZE108359268
TDA119661876 119661929 119679379 119683850
MDE101900101
LCQ111677038
HIS119656308
ACOZ120959226
AARA120904060
AMER121598679
AFUN125767051
AMOU128310341
AALI118462767
AAG5563823
AALB109623351
CQUCpipJ_CPIJ017392
CPII120422957
CNS116349052
BCOO119082369
ACER107997556
ALAB122711578
BIM105680864
BBIF117208330
BVK117237731
BVAN117157992
BTER105666543
BAFF126918767
BPYO122577005
BPAS132908421
FVI122527739
CCAL108632699
OBB114871911
MGEN117225071
CGIG122402301
SOC105207917
MPHA105830809 105840354
PBAR105427572
VEM105569516
HST105185092
DQU106744003
CFO105249576
FEX115238445
LHU105670787
PGC109860914
OBO105277222
PCF106793553
PFUC122515659
VPS122632296
VCRB124427225
NVI107980947
CSOL105366345
TPRE106650334
LHT122499655
LBD127278833
CGLO123268518
FAS105266352
AGIF122858141
DSM124414926
NPT124223567
NFB124186325
NLO107222915
NVG124308368
DPA109546868
SOY115887345
AGRG126735409
CSET123322866
AGB108914434
LDC111510677
NVL108563771
PPYR116180598
OTU111417168
BMOR101737048
BMAN114241042
MSEX115453083
DPLKGM_207691
BANY112046696
MJU123878129
NIQ126778522
VCD124540705
MCIX123667545
PMAC106711765
PPOT106108885
PXU106113472
PRAP110992867
PBX123720878
PNAP125052367
ZCE119835982
CCRC123703716
LSIN126976185
HAW110377854
HZE124642903
TNL113505072
SLIU111358046
OFU114350759
PXY105393507
PGW126378143
CFEL113382717 113382933
CCRN123293973
CSEC111873192
IEL124158055 124170790
TCF131881032
DSV119433103
RSAN119405065
RMP119180600
VDE111250463
VJA111261934
TUT107359969
CSCU111634940
PTEP107443179
UDV129227044
SDM118204435
LPOL106471127
LGILOTGIDRAFT_237577
PVUL126829548
PCAN112559354
BGT106057937
GAE121376347
HRF124132655 124134454
HRJ124272727 124274695
CRG105341300
CVN111125476 111125840
CANU128192953
OED125680323
MYI110452410 110452415 110456550 110456553
PMAX117329305 117329306 117329839 117329841
MMER123557088 123557153
RPHI132718310 132729245 132758356
OBI106872238 106883106
OSN115213952 115228066
LAK106181082
NVE5512961 5512969
EPA110238851
ATEN116304526 116304527
ADF107331264
AMIL114977512
PDAM113667155
SPIS111327304
DGT114532928
XEN124440925
HMG101240720
HSY130657730
 » show all
Reference
1  [PMID:19506037]
  Authors
Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC
  Title
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.
  Journal
J Cell Biol 185:1013-27 (2009)
DOI:10.1083/jcb.200903152
Reference
2  [PMID:23449981]
  Authors
Vacaru AM, van den Dikkenberg J, Ternes P, Holthuis JC.
  Title
Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen.
  Journal
J Biol Chem 288:11520-30 (2013)
DOI:10.1074/jbc.M113.460972
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.48
IUBMB Enzyme Nomenclature: 2.7.8.48
ExPASy - ENZYME nomenclature database: 2.7.8.48
BRENDA, the Enzyme Database: 2.7.8.48

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