Entry
Name
rifampicin phosphotransferase;
rifampin phosphotransferase;
RPH
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with paired acceptors
BRITE hierarchy
Sysname
ATP:rifampicin, water 21-O-phosphotransferase
Reaction(IUBMB)
ATP + rifampicin + H2O = AMP + 21-phosphorifampicin + phosphate [RN:
R11964 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21. The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate-carrying L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis.
History
EC 2.7.9.6 created 2018
Orthology
K22579 rifampicin phosphotransferase
Genes
YMO : HRD69_02435 HRD69_02490
GAI : IMCC3135_00190(pigC)
GSN : YC6258_05101 YC6258_05154 YC6258_05509
CHJ : NCTC10426_00158(ppsA)
AXO : NH44784_041841 NH44784_049541
AXN : AX27061_2362 AX27061_3108
AXX : ERS451415_02356(ppsA_1) ERS451415_03087(ppsA_3)
ACHR : C2U31_17555 C2U31_19150
ACHM : V6V88_10725 V6V88_12045
ACHJ : LN047_10675 LN047_11965
APET : ToN1_07290 ToN1_23230
SPHI : TS85_03975 TS85_03995
ECOM : QTN59_09325 QTN59_17080
EAJ : Q3M24_09515 Q3M24_22505
ELAX : KKHLCK_07845 KKHLCK_14355
ESD : SD837_04975 SD837_17425
CCX : COCOR_03165(pps) COCOR_06506(ppsA1)
SUR : STAUR_0681(ppsA) STAUR_8179
AGE : AA314_05446 AA314_07741
AVM : JQX13_18470 JQX13_45035(ppsA)
MBD : MEBOL_003186 MEBOL_003365 MEBOL_005347 MEBOL_006810 MEBOL_006971
CFUS : CYFUS_002943 CYFUS_004460 CYFUS_005589
PBRU : LZC95_06450 LZC95_15120 LZC95_41285(ppsA)
SCL : sce4177(ppsA1) sce7847(ppsA3) sce7909
SCU : SCE1572_04785 SCE1572_24685 SCE1572_45455
CCRO : CMC5_012370 CMC5_021740 CMC5_047550 CMC5_057100(ppdK) CMC5_075250(ppsA) CMC5_082820(ppsA)
PAUU : E8A73_031260 E8A73_036875 E8A73_038780
LLU : AKJ09_02570 AKJ09_06892
NANN : O0S08_02060(ppsA) O0S08_17740
BDZ : DOM22_00495 DOM22_07185
HAX : BALOs_0906 BALOs_1167(pps)
BSTO : C0V70_07840 C0V70_09540
RUL : UC8_01980(ppsA) UC8_02060(cmdD)
LCRE : Pla8534_16310(ppsA)
PND : Pla175_36850(ppsA_1)
CTM : Cabther_B0172 Cabther_B0809
CHF : KTO58_01375 KTO58_04610(ppsA)
CHIM : CK934_24585 CK934_27845
BLI : BL01065 BL01998(pps) BL05212
BLD : BLi00634(pps1) BLi02172(pps2) BLi02241(pps3)
BLH : BaLi_c07230(pps1) BaLi_c22490(pps2) BaLi_c23230(pps3)
BAY : RBAM_008480 RBAM_017370(ppsA)
BAQ : BACAU_0823 BACAU_1707(ppsA)
BYA : BANAU_0766 BANAU_1861(ppsA)
BQY : MUS_0855(ppsA) MUS_2077(pps)
BAMP : B938_04085 B938_09005
BAML : BAM5036_0758 BAM5036_1683(pps)
BAMA : RBAU_0822 RBAU_1716(pps)
BAMN : BASU_0798 BASU_1696(pps)
BAMB : BAPNAU_0779 BAPNAU_2006(ppsA)
BAMT : AJ82_04735 AJ82_09880
BAMY : V529_07930 V529_17030(pps)
BMP : NG74_00844(cmdD_1) NG74_01810(ppsA_1)
BAMI : KSO_010665 KSO_015575
BAMC : U471_08360 U471_17840
BAMF : U722_04230 U722_09200
BSIA : CWD84_12235 CWD84_17835
BVM : B9C48_04200 B9C48_08900
BSON : S101395_00834(ppsA) S101395_02385(ppdK) S101395_02673
BSTR : QI003_10190(ppsA) QI003_13620(ppsA)
BGY : BGLY_0668 BGLY_2363(pps)
BACP : SB24_00975 SB24_05670
BACB : OY17_06890 OY17_11800
BACS : AUL54_01805 AUL54_06645
BAFC : K3G25_08985(ppsA) K3G25_18545
PERJ : JNUCC41_03620(ppsA)
SCIA : HUG15_07265(ppsA) HUG15_07430 HUG15_12370(ppsA)
PPQ : PPSQR21_025160(ppsA)
PGM : PGRAT_16180 PGRAT_31360
PAEA : R70723_15680 R70723_16590
PAEH : H70357_13825 H70357_17250 H70357_18700
PRI : PRIO_3578(pps1) PRIO_3588(pps3) PRIO_6555
PSON : JI735_24955(ppsA) JI735_25005(ppsA)
PDH : B9T62_13120 B9T62_33230
PKB : B4V02_06275 B4V02_12745
PTJ : JRJ22_12730 JRJ22_13205(ppsA)
PTHI : NDS46_03635 NDS46_14655(ppsA)
PDY : QJQ58_07310(ppsA) QJQ58_14430 QJQ58_18975
PMAE : LMZ02_08175 LMZ02_21170(ppsA)
PSPN : L1F29_17535(ppsA) L1F29_30295
PAUN : MJA45_09290 MJA45_13745(ppsA)
PKP : SK3146_00217(ppsA_1) SK3146_00225(ppsA_2) SK3146_03946(ppsA_3) SK3146_05341(ppsA_4)
PACL : DCC85_11045 DCC85_21510
PAJN : JNUCC32_08465(ppsA)
PLIQ : QWY22_04290(ppsA) QWY22_14140
PSHE : QWY16_04380(ppsA) QWY16_14195
PSHX : QWY21_04750(ppsA) QWY21_14175
LFB : C1X05_07885 C1X05_08980
TVU : AB849_000520 AB849_007725(ppsA)
KEB : GXN75_05380 GXN75_08930(ppsA)
SGO : SGO_0936 SGO_0940(ppsA)
SOI : I872_00955 I872_00975
SFER : NCTC12278_01383(ppsA) NCTC12278_01387(cmdD)
ADC : FOC79_06095 FOC79_06115
CRN : CAR_c23280(pps) CAR_c23320(yvkC)
CAW : Q783_10555 Q783_10575
CAE : SMB_G0546(pps) SMB_G0817
CAY : CEA_G0547(pps) CEA_G0812
CBE : Cbei_2063 Cbei_2066 Cbei_3516 Cbei_3859 Cbei_3862
CBZ : Cbs_2063 Cbs_2066 Cbs_3516 Cbs_3859 Cbs_3862
CBEI : LF65_02232 LF65_03959 LF65_04349 LF65_04354
CKL : CKL_0066(ppsA) CKL_1654 CKL_3749
CKR : CKR_0052 CKR_1538 CKR_2278 CKR_3312
CLJ : CLJU_c14340 CLJU_c38600(ppsA)
CLB : Clo1100_1926 Clo1100_1988
CSQ : CSCA_0950 CSCA_1101 CSCA_2230
CCK : Ccar_03325 Ccar_03775
CDRK : B9W14_08450 B9W14_13265 B9W14_13875
CDY : F3K33_10250(ppsA) F3K33_10265 F3K33_17825(ppsA) F3K33_19700 F3K33_19715
CLOM : AXY43_05665 AXY43_07495 AXY43_25000
CLOO : RCG18_23920(ppsA) RCG18_26665
HSC : HVS_00350(ppsA1) HVS_00370(ppsA2)
DSY : DSY2123(pps) DSY3072 DSY3730(pps) DSY4219(pps)
DHD : Dhaf_1117 Dhaf_1622 Dhaf_3294 Dhaf_4241
DDH : Desde_1478 Desde_1740
DOR : Desor_1583 Desor_1823 Desor_4268 Desor_4320
DAI : Desaci_2107 Desaci_2406
DMI : Desmer_2403 Desmer_3528
PTH : PTH_2376(PpsA) PTH_2377
DRU : Desru_2054 Desru_2195 Desru_2659 Desru_2924 Desru_3297
DAE : Dtox_2649 Dtox_2728 Dtox_3057 Dtox_3844
FWA : DCMF_01170 DCMF_01215 DCMF_13375 DCMF_19530 DCMF_20825
DGI : Desgi_0218 Desgi_1019 Desgi_1072 Desgi_1073 Desgi_4251
CSH : Closa_1338 Closa_4217
LUA : D4A81_01280 D4A81_13050
ANR : Ana3638_11350(ppsA) Ana3638_12680 Ana3638_12695(ppsA) Ana3638_12715(ppsA) Ana3638_13085 Ana3638_13095(ppsA) Ana3638_22680(ppsA)
ACHT : bsdcttw_17080(pps) bsdcttw_26620(yvkC)
ECLF : QMP25_04310 QMP25_08960
VPY : HZI73_03350 HZI73_09660 HZI73_18120
AMIC : Ami3637_14110(ppsA) Ami3637_14570
GFE : Gferi_08025 Gferi_08755 Gferi_21465 Gferi_21865 Gferi_21965 Gferi_22205
GBX : SANA_00770 SANA_14080(ppsA_1) SANA_21310(ppsA_2) SANA_31750
MANA : MAMMFC1_02616(ppsA)
STED : SPTER_29060 SPTER_29070(pigC_1) SPTER_32620 SPTER_46680(pigC_2)
SSPH : SPSPH_025950(rphC) SPSPH_026410(pigC_1) SPSPH_027780(pigC_2)
SOVA : SOV_09660(ppsA_1) SOV_09670(cmdD) SOV_15820(ppsA_2)
SACV : SPACI_023090(pigC) SPACI_035570
EUZ : DVS28_a0222 DVS28_a0820 DVS28_a4889
MFJ : MFLOJ_19580 MFLOJ_55590 MFLOJ_55650 MFLOJ_55770 MFLOJ_56000 MFLOJ_57110 MFLOJ_57160 MFLOJ_57340 MFLOJ_57720
MKY : IWGMT90018_00960 IWGMT90018_44020 IWGMT90018_46670 IWGMT90018_47040 IWGMT90018_48790
MTHN : 4412656_00789(ppsA_1) 4412656_02902(ppsA_4) 4412656_03343(ppsA_5)
MHEV : MHEL_09340 MHEL_48630
MANY : MANY_41910 MANY_41970
MSTE : MSTE_03388 MSTE_03394
MTER : 4434518_01742(ppsA_1)
NCY : NOCYR_1424 NOCYR_3228
NBR : O3I_009070 O3I_015150 O3I_027875
NNO : NONO_c21150 NONO_c58900 NONO_c59210
NSR : NS506_05288 NS506_06812
NTP : CRH09_04675 CRH09_10130
NOZ : DMB37_04070 DMB37_06880 DMB37_29840
NOD : FOH10_13485 FOH10_14915 FOH10_22685 FOH10_23970(ppsA)
NAH : F5544_11650 F5544_14065 F5544_14085
NAD : NCTC11293_03257(ppsA_2)
NWL : NWFMUON74_33870 NWFMUON74_38400 NWFMUON74_54460
NIE : KV110_09605 KV110_14210 KV110_23880(ppsA) KV110_27145
NHU : H0264_11270(ppsA) H0264_24925
NYU : D7D52_10330 D7D52_16655(ppsA)
NVU : V7968_22910 V7968_35660
ROP : ROP_24310 ROP_24430 ROP_pKNR-00990
RRT : 4535765_01581(ppsA_2)
RCR : NCTC10994_00550(ppsA_1)
RPSK : JWS13_27040 JWS13_27370
GPO : GPOL_c15210 GPOL_c20720
SCYE : R2B67_22305 R2B67_33250(rph)
SSX : SACTE_0075 SACTE_2189
SMAL : SMALA_7613 SMALA_8488
SSOI : I1A49_41840 I1A49_47005(ppsA)
STRE : GZL_00479 GZL_01135
SLC : SL103_18720 SL103_22165
SCX : AS200_02640 AS200_05135
SGM : GCM10017557_09840 GCM10017557_62650 GCM10017557_79740(pps)
SLS : SLINC_2286 SLINC_2573
SALU : DC74_1159 DC74_180 DC74_591 DC74_6661
SALL : SAZ_01345 SAZ_03465 SAZ_06290 SAZ_34620
SSIA : A7J05_33555 A7J05_33875
SALF : SMD44_01100 SMD44_04713
SNZ : DC008_00870 DC008_08170 DC008_33345
SDX : C4B68_08170 C4B68_38690
SRIM : CP984_07545 CP984_38940
SCOE : CP976_00750(ppsA) CP976_35740
SBAT : G4Z16_09385(ppsA) G4Z16_15995
STUI : GCM10017668_68180(pps)
SHUN : DWB77_00992(pigC) DWB77_01166(ppsA_2)
SFEU : IM697_12160 IM697_19210(ppsA)
SDW : K7C20_32290(ppsA) K7C20_34900
SAUH : SU9_032300 SU9_033000 SU9_033480(ppsA)
SMOB : J7W19_04605 J7W19_04635(ppsA)
SANU : K7396_01570 K7396_03890(ppsA)
SDD : D9753_01365 D9753_30165(ppsA)
SACT : DMT42_30945 DMT42_35985
SAOV : G3H79_33435 G3H79_40035(ppsA)
SDUR : M4V62_00940(ppsA) M4V62_42160 M4V62_43485
SXT : KPP03845_100210(ppsA_1)
SLON : LGI35_02930 LGI35_04175(ppsA)
STUD : STRTU_000269 STRTU_006053(ppsA)
KBU : Q4V64_04220 Q4V64_16065(rph)
SPRF : K4G22_30255(ppsA) K4G22_30840
SABD : N8I86_36000 N8I86_36410(ppsA)
SPIH : ABXR15_01150 ABXR15_24170(rph)
SSIR : WAB15_02315(rph) WAB15_02780
SEXP : SLV14_000566 SLV14_007525(ppsA)
ART : Arth_0384 Arth_0474 Arth_2857
ARU : ASPU41_06310 ASPU41_07600 ASPU41_08120
ARQ : BWQ92_07940 BWQ92_11920 BWQ92_15925 BWQ92_21695
ACRY : AC20117_10180 AC20117_12625
ARTH : C3B78_02305 C3B78_17385
ARTP : E5206_01200 E5206_01405 E5206_10690 E5206_11270
ASUF : MNQ99_01715 MNQ99_16150
AOD : Q8Z05_01135 Q8Z05_10010 Q8Z05_10380
ARTU : E7Y32_03700 E7Y32_03990
ARTZ : FCN77_02765 FCN77_18410
ARTC : KY499_10315 KY499_14640
PSUL : AU252_05385 AU252_07985
PSNI : NIBR502771_02630 NIBR502771_20500
PSEY : GU243_08600 GU243_09910
PDEL : JCQ34_02230 JCQ34_04815 JCQ34_04830
POK : SMD14_02540 SMD14_04865
PSLS : KTR40_02460 KTR40_04725
PQA : WHH00_01635 WHH00_13915 WHH00_13930 WHH00_16195
SATK : SA2016_0637 SA2016_2847
PSEI : GCE65_09575 GCE65_09810
DCO : SAMEA4475696_0328(ppsA)
MPH : MLP_04570 MLP_04920 MLP_11270 MLP_53260
MIK : FOE78_02790 FOE78_14910
TES : BW730_04805 BW730_15650
RAIN : Rai3103_01850 Rai3103_05135
PSOI : PCC79_00415 PCC79_03920 PCC79_16255
AFUV : AADG42_02520 AADG42_02550 AADG42_17765
MGG : MPLG2_0642 MPLG2_1972
NGV : CDO52_11580 CDO52_21635
NEX : NE857_30885 NE857_32190
NCG : KGD84_02345 KGD84_15675
SAIU : J4H86_00950 J4H86_01830 J4H86_02840(ppsA) J4H86_15130 J4H86_18775
AWS : ACN3XK_37470 ACN3XK_37760
SRO : Sros_0682 Sros_1894 Sros_4939
NOA : BKM31_01095 BKM31_11485 BKM31_32345 BKM31_33035 BKM31_56065
NOW : GBF35_11670 GBF35_12160 GBF35_23280(ppsA) GBF35_31790 GBF35_34945 GBF35_36900
NCX : Nocox_10910(ppsA1) Nocox_11330(ppsA2) Nocox_16350(ppsA4) Nocox_22710(ppsA6) Nocox_29995(ppsA7)
NGN : LCN96_12285 LCN96_12895 LCN96_15225(ppsA) LCN96_26410 LCN96_41210
NFS : OIE67_07795 OIE67_16175 OIE67_18785(ppsA) OIE67_31675(ppsA) OIE67_34145 OIE67_34710
SEN : SACE_0388 SACE_2483 SACE_7324(ppsII)
AAB : A4R43_01915 A4R43_39965
ACOR : LCL61_04760 LCL61_17940 LCL61_28550
AMYS : CVV72_01060 CVV72_03375
PSEE : FRP1_03950 FRP1_13520
PSEQ : AD006_11605 AD006_21200
PECQ : AD017_00780 AD017_19435
PAUT : Pdca_17230 Pdca_45270(pps)
PBRO : HOP40_07000(ppsA) HOP40_12275
PSDS : K1T35_09840 K1T35_13525 K1T35_21325 K1T35_29635(ppsA) K1T35_40470
SSYI : EKG83_13800 EKG83_23240 EKG83_27660
KAL : KALB_1752 KALB_4129 KALB_5806 KALB_6206
KUT : JJ691_07480 JJ691_42190
KPHY : AOZ06_10340 AOZ06_18095
AHM : TL08_03375 TL08_18220
ACTU : Actkin_02314(ppsA_3) Actkin_03269(ppsA_9)
AAUR : V5P93_004919 V5P93_004920 V5P93_007345(ppsA)
CROS : N8J89_08225 N8J89_29140 N8J89_31275
ACTY : OG774_01765(ppsA) OG774_07025 OG774_18360 OG774_22015
UME : RM788_09490 RM788_36410
MICH : FJK98_13765 FJK98_31290(ppsA)
MTEM : GCE86_08815 GCE86_10545(ppsA)
MSAG : GCM10017556_23270(pps) GCM10017556_25840
AMS : AMIS_36040 AMIS_39750
ACTR : Asp14428_11300(pps)
ACTE : ACTI_58500 ACTI_70000(pps)
PLAB : C6361_02300 C6361_03415 C6361_21540
PLAT : C6W10_16465 C6W10_18200 C6W10_19370
CATI : CS0771_27290 CS0771_48740(pps) CS0771_53810
DFU : Dfulv_35450 Dfulv_47145(ppsA)
SNA : Snas_1157 Snas_3169 Snas_5062 Snas_5613
RUB : GBA63_02915 GBA63_09385(ppsA) GBA63_20130 GBA63_22130
SBAE : DSM104329_04458(rphC)
AYM : YM304_23490 YM304_28690
IAM : HC251_07370 HC251_12625
LET : O77CONTIG1_02378(cmdD_2)
BSEN : DP114_02520 DP114_22405
BOX : DP113_02475 DP113_22320
PSUB : Pelsub_P0917 Pelsub_P1365
KBS : EPA93_02960(ppsA) EPA93_10850 EPA93_19960(ppsA) EPA93_21960 EPA93_45745(ppsA) EPA93_46610 EPA93_46735(ppsA)
TBH : Tbon_06430 Tbon_07680
TFLA : O0235_05980 O0235_06995
STR : Sterm_1949 Sterm_3580
MEME : HYG87_08385 HYG87_09445
MHOR : MSHOH_0866 MSHOH_2431
HAAD : MW046_08550 MW046_13760
PSYT : DSAG12_00137 DSAG12_03813
» show all
Taxonomy
Reference
Authors
Spanogiannopoulos P, Waglechner N, Koteva K, Wright GD
Title
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.
Journal
Sequence
Reference
Authors
Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Guarne A, Savchenko A, Wright GD
Title
Rifampin phosphotransferase is an unusual antibiotic resistance kinase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.9.6
ExPASy - ENZYME nomenclature database: 2.7.9.6
BRENDA, the Enzyme Database: 2.7.9.6