Entry
Name
molybdopterin synthase;
MPT synthase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
thiocarboxylated molybdopterin synthase:cyclic pyranopterin phosphate sulfurtransferase
Reaction(IUBMB)
cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + H2O = molybdopterin + 2 molybdopterin-synthase sulfur-carrier protein [RN:
R09395 ]
Reaction(KEGG)
Substrate
cyclic pyranopterin phosphate [CPD:
C18239 ];
[molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH [CPD:
C15814 ];
H2O [CPD:
C00001 ]
Product
molybdopterin [CPD:
C05924 ];
molybdopterin-synthase sulfur-carrier protein [CPD:
C15810 ]
Comment
Catalyses the synthesis of molybdopterin from cyclic pyranopterin monophosphate. Two sulfur atoms are transferred to cyclic pyranopterin monophosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur-carrier proteins) that are thiocarboxylated at the C-terminus by EC
2.8.1.11 , molybdopterin synthase sulfurtransferase. The reaction occurs in prokaryotes and eukaryotes.
History
EC 2.8.1.12 created 2011
Pathway
Orthology
K03635 molybdopterin synthase catalytic subunit
K21142 MoaE-MoaD fusion protein
Genes
MCF : 102117396 135971287(MOCS2)
MTHB : 126943597 126956861
MAUA : 101835876(Mocs2) 121143293
HGL : 101697470 101701123(Mocs2)
BBIS : 105001057(MOCS2) 105001432
BTAX : 128057688 128066137(MOCS2)
ODA : 120879298(MOCS2) 120883174
BMUS : 118891346 118892662(MOCS2)
SANH : 107685191 107686431(mocs2)
TNG : GSTEN00000931G001 GSTEN00003926G001
MSAM : 119914871 119914872
PPRL : 129356185 129356953
AOCE : 111568821 111569351
ARUT : 117403503 117403817
LPIC : 129260373 129260375
DME : Dmel_CG10238(Mocs2B)
DSI : Dsimw501_GD18232(Dsim_GD18232)
RZE : 108365858 108375909 108376508
MDE : 101891455 101893976 131800354
SCAC : 106091941 106092984
ASUA : 134204910 134206069
CPII : 120423724 120425566
OBO : 105284290 113561764 113561765
AGIF : 122855937 122855941
MSEX : 115449507 119191236 119192102
BTAB : 109038502 109044046
CLEC : 106661395 106670777
PHU : Phum_PHUM458240 Phum_PHUM458250
BROR : 134538217 134538218
RSAN : 119377951 119385129 119389749 119401772
CEL : CELE_T27A3.6(nmrk-1)
BMY : BM_BM6035(Bma-nmrk-1)
CSAT : 104782911 104784962 104793315
BNA : 106360892 106391819 106429292 106447136
HSYR : 120136580 120170314
DZI : 111301195 111303899 111303958
GMX : 100781775 100786918 100793056
GSJ : 114403884 114419904 114419905
VVO : 131656733 131656857 131662457
PCIN : 129300396 129318071
QSA : O6P43_014682 O6P43_020934
PMUM : 103326907 103326908
MEAN : 126686626 126686627
VRI : 117915773 117915783 117926205
SSPL : 121740949 121789837
APAN : 127259415 127260138
CSIN : 114273606 114322202
PSOM : 113284095 113316394
TAES : 123101328 123116104 123121368
MFLO : 136455580 136462377 136462698 136475647
PVIR : 120646579 120654628
ZOF : 121982127 122012504 122014695 122038154
MSIN : 131216954 131217593
SMO : SELMODRAFT_104759 SELMODRAFT_89901 SELMODRAFT_89945
MPP : MICPUCDRAFT_53761(CNX6B)
NTE : NEUTE1DRAFT126117(NEUTE1DRAFT_126117)
SMP : 10805856(SMAC4_02895)
TATV : 25781370(TrAtP1_012810)
TASP : 36613502(TrAFT101_009941)
MAW : 19249200(J3458_019726)
PLJ : 28888101(PLICBS_003314)
CDET : 87944389(CDEST_07886)
ALUC : AKAW2_11113S(MOCS2)
TRG : TRUGW13939_01693 TRUGW13939_11003
PTRR : 90954730(PtrM4_042600)
DDI : DDB_G0271864(mocs2l)
SPAR : SPRG_11363 SPRG_17371
ECOO : ECRM13514_0860(moaE)
ECOH : ECRM13516_0815(moaE)
ELR : ECO55CA74_04915(moaE)
ECW : EcE24377A_0848(moaE)
ECOA : APECO78_07595(moaE)
EDJ : ECDH1ME8569_0738(moaE)
ECOI : ECOPMV1_00788(moaE)
SEM : STMDT12_C08590(moaE)
SETC : CFSAN001921_13000(moaE)
SEEN : SE451236_10055(moaE)
SENH : CFSAN002069_04815(moaE)
SEEH : SEEH1578_13425(moaE)
SENJ : CFSAN001992_07400(moaE)
SEEC : CFSAN002050_10580(moaE)
SEEB : SEEB0189_015325(moaE)
SENC : SEET0819_10965(moaE)
REE : electrica_03528(moaE)
RTG : NCTC13098_05214(moaE)
CLAP : NCTC11466_03189(moaE)
KIE : NCTC12125_02196(moaE)
BAGE : BADSM9389_28660(moaE)
AHN : NCTC12129_03422(moaE)
METY : MRY16398_39820(moaE)
PSHI : SAMEA2665130_1314(moaE)
YPG : YpAngola_A1437(moaE)
YPI : YpsIP31758_2833(moaE)
SMW : SMWW4_v1c12930(moaE)
SRR : SerAS9_1291 SerAS9_3707
SRL : SOD_c11930(moaE2) SOD_c34330(moaE)
SRY : M621_06665(moaE) M621_18655(moaE)
SRS : SerAS12_1291 SerAS12_3708
SRA : SerAS13_1291 SerAS13_3709
SMAF : D781_1249 D781_2830
SERS : SERRSCBI_06100(moaE)
SRZ : AXX16_2240 AXX16_3844
SFJ : SAMEA4384070_1378(moaE)
SOF : NCTC11214_05579(moaE)
SSAR : SSARUM_001241(moaE)
PAQU : DMB82_0012665(moaE)
PARL : PEC302110_15530(moaE)
DIC : Dpoa569_002256(moaE)
TPTY : NCTC11468_01268(moaE)
PHEI : NCTC12003_02885(moaE)
PRJ : NCTC6933_01162(moaE)
LRI : NCTC12151_02144(moaE)
HIC : NTHIC486_01462(moaE)
HPIT : NCTC13334_01586(moaE)
HHZ : NCTC10839_01604(moaE)
HAEG : NCTC8502_01841(moaE)
PDAG : 4362423_00760(moaE)
ADP : NCTC12871_00110(moaE)
ALIG : NCTC10568_00741(moaE)
ASEG : NCTC10977_01481(moaE)
AVT : NCTC3438_01367(moaE)
RPNE : NCTC8284_02155(moaE)
PAET : NCTC13378_00643(moaE)
XFU : XFF4834R_chr10820(moaE)
XPH : XppCFBP6546_06055(XppCFBP6546P_06055)
THES : FHQ07_03215 FHQ07_06990
THEH : G7079_05960 G7079_09860
VAU : VANGNB10_cI0907(moaE)
VPL : SA104470976_01743(moaE)
PHOT : L4174_005930(moaE) L4174_011540(moaE)
PAEB : NCGM1900_1056(moaE)
PCQ : PcP3B5_31990(moaE_1) PcP3B5_50630(moaE_2)
PVD : CFBP1590__4271(moaE)
PFL : PFL_1040(moaE_1) PFL_3725(moaE_2)
PPRC : PFLCHA0_c10600(moaE1) PFLCHA0_c37700(moaE2)
PPRO : PPC_1078(moaE_1) PPC_3868
PFO : Pfl01_0966 Pfl01_2145(moaE)
PMUD : NCTC8068_04314(moaE)
PFW : PF1751_v1c09550(moaE)
PPUU : PputUW4_03066(moaE1) PputUW4_04465(moaE2)
PCH : EY04_04550 EY04_19170
PCP : JM49_12050 JM49_25095
PCHP : C4K32_1109 C4K32_3880
PSEC : CCOS191_4435(moaE2)
PSOS : POS17_1038(moaE_1) POS17_3883(moaE_2)
PKE : DLD99_05190 DLD99_11365
PGY : AWU82_18100 AWU82_19050 AWU82_29040
PZE : HU754_006305(moaE) HU754_012385(moaE)
PSEP : C4K39_1050 C4K39_5681
PPII : QL104_05215(moaE) QL104_19625(moaE)
PTRT : HU722_0006200(moaE)
PAZE : KSS91_16930(moaE) KSS91_23815(moaE)
PTW : TUM18999_50040(moaE)
PTAE : NCTC10697_03566(moaE_1) NCTC10697_03854(moaE2)
PIZ : LAB08_R33160(moaE) LAB08_R50350(moaE)
PFIT : KJY40_05965(moaE) KJY40_12540(moaE)
PSHS : JJN09_02510(moaE) JJN09_11550(moaE)
PLIS : NN484_01420(moaE) NN484_08045(moaE)
PKH : JLK41_05250(moaE) JLK41_12920
MSHE : MAALD49_05380(moaE)
PSPG : AK823_10250 AK823_10430
PSYG : AK825_10490 AK825_10670
PSYC : DABAL43B_0834(moaE)
ATT : AMQ28_03500 AMQ28_13585
MCAT : MC25239_00734(moaE)
MOW : RNZ41_10135 RNZ41_11325
SCAA : TUM17387_37290(moaE)
AMC : MADE_1013520 MADE_1019325
AMH : I633_12200 I633_19925
CEG : D0C16_04610 D0C16_05145(moaE)
TIB : THMIRHAM_01530(moaE)
TSE : THMIRHAS_01580(moaE)
TZO : THMIRHAT_20810(moaE)
TFRI : Thiofri_03548(moaE)
TNI : TVNIR_3594(moaE_[H])
GAI : IMCC3135_02330(moaE)
THIC : TspCOW1_19340(moaE)
HAAH : HALA3H3_830136(moaE)
HAXI : HAALTHF_35100n(moaE)
ALCA : ASALC70_04437(moaE)
ADI : B5T_00605(moaE) B5T_02843(moaE)
TWAN : HUF19_16460(moaE) HUF19_16820(moaE)
AEL : NCTC12917_01452(moaE)
CHJ : NCTC10426_02150(moaE)
CDIZ : CEDIAZO_01940(moaE)
NZO : SAMEA4504057_1754(moaE)
NCI : NCTC10296_02116(moaE)
NANI : NCTC12227_00630(moaE)
ECOR : SAMEA4412678_1482(moaE)
VOX : LCH97_05165 LCH97_16070
RIN : ACS15_2036 ACS15_4255
CCUP : BKK81_13345 BKK81_23625
CUP : BKK80_14275 BKK80_32685
CUU : BKK79_18725 BKK79_23650
BMV : BMASAVP1_A1870(moaE)
BML : BMA10229_A0026(moaE)
BPM : BURPS1710b_2392(moaE)
BPL : BURPS1106A_2265(moaE)
BUR : Bcep18194_A5151 Bcep18194_C6964
BCM : Bcenmc03_1874 Bcenmc03_7062
BCH : Bcen2424_1850 Bcen2424_6403
BCEN : DM39_1812 DM39_6959
BCEW : DM40_2447 DM40_5252
BCEO : I35_1842(moaE) I35_7671
BAC : BamMC406_1760 BamMC406_6447
BMJ : BMULJ_01820(moaE) BMULJ_06102(moaE)
BMUL : NP80_1910 NP80_5461
BCED : DM42_3250 DM42_7189
BCEP : APZ15_14205 APZ15_36875
BPYR : ABD05_15410 ABD05_31780
BCON : NL30_13580 NL30_37915
BDF : WI26_08765 WI26_27110
BLAT : WK25_08955 WK25_16930
BTEI : WS51_19645 WS51_26725
BSEM : WJ12_09275 WJ12_17330
BPSL : WS57_15200 WS57_27565
BMEC : WJ16_09480 WJ16_17860
BSTG : WT74_09010 WT74_09685
BSTL : BBJ41_02740 BBJ41_36045
BARI : NLX30_10890 NLX30_38550
BAEN : L3V59_10485 L3V59_35690
BSER : R0290_09315 R0290_28780
BUE : BRPE67_ACDS16280(moaE)
BURK : DM992_11375 DM992_37525
PCAF : DSC91_001151 DSC91_007062
PTRO : G5S35_07825 G5S35_24585
PCOM : NTU39_08205 NTU39_11920(moaE)
PLG : NCTC10937_04277(moaE)
LMIR : NCTC12852_02160(moaE)
BUO : BRPE64_ACDS16230(moaE)
BTRM : SAMEA390648702123(moaE)
AXX : ERS451415_05020(moaE)
BOZ : DBV39_10640 DBV39_17465
ODH : DHf2319_03460 DHf2319_03710(moaE)
LIM : L103DPR2_02017(moaE)
LIH : L63ED372_01519(moaE)
SMIO : CATMQ487_24490(moaE)
SULF : CAP31_09105 CAP31_10735
URU : DSM104443_02054(moaE)
UPL : DSM104440_01886(moaE)
THAG : CKCBHOJB_01767(moaE)
RBS : RHODOSMS8_02032(moaE)
SMEL : SM2011_c00599(moaE)
SFD : USDA257_c08900(moaE)
SAME : SAMCFNEI73_Ch1229(moaE)
AGR : AGROH133_05271(moaE)
AVV : RvVAT039_27770(moaE)
AVF : RvVAR031_14950(moaE)
REC : RHECIAT_CH0001544(moaE)
REL : REMIM1_CH01489(moaE)
REP : IE4803_CH01478(moaE)
REI : IE4771_CH01529(moaE)
RTR : RTCIAT899_CH06275(moaE)
RGA : RGR602_CH01362(moaE)
RPHA : AMC79_CH01496(moaE)
NEN : NCHU2750_10410(moaE)
BIO : BR141012304_11951(moaE)
VGO : GJW-30_1_01769(moaE)
MAQU : Maq22A_c20960(moaE)
MTUN : MTUNDRAET4_2199(moaE)
FIL : BN1229_v1_0073(moaE)
FIY : BN1229_v1_0075(moaE)
BVY : NCTC9239_01330(moaE)
BALB : M8231_08670 M8231_14565
RLI : RLO149_c003870(moaE)
PHP : PhaeoP97_03068(moaE)
PPIC : PhaeoP14_00209(moaE)
SINL : DSM14862_00610(moaE)
SPSE : SULPSESMR1_02493(moaE)
RMM : ROSMUCSMR3_01763(moaE)
AHT : ANTHELSMS3_00086(moaE)
LALG : LentiSH36_00415(moaE)
PTP : RCA23_c05540(moaE1) RCA23_c22970(moaE2)
LVS : LOKVESSMR4R_02969(moaE)
HNE : HNE_1067(moaE1) HNE_1550(moaE2)
SPAG : sphantq_02997(moaE)
SFLA : SPHFLASMR4Y_00706(moaE)
SPHS : ETR14_19955 ETR14_25030
AEP : AMC99_00136 AMC99_00579
QSO : IRL76_03260 IRL76_10085
ERYT : KDC96_06870 KDC96_07820
KNA : B0W47_02030 B0W47_03025
KSC : CD178_02251(moaE) CD178_03057(moaE1)
AACE : A0U92_09595 A0U92_13230
PBR : PB2503_11664 PB2503_13639
HCL : NCTC13205_00325(moaE)
HSH : NHP194022_05270(moaE)
HPUL : NCTC13154_00994(moaE)
CJV : MTVDSCj20_1482(moaE)
CFV : CFVI03293_0193(moaE)
CAMP : CFT03427_0202(moaE)
CCOC : CCON33237_0324(moaE)
CLR : UPTC16701_0346(moaE)
CLM : UPTC16712_0348(moaE)
CAMR : CAQ16704_0362(moaE)
CHV : CHELV3228_0131(moaE)
CPIN : CPIN18020_0995(moaE)
CAMZ : CVIC12175_1575(moaE)
CRX : CRECT_0331(moaE) CRECT_1613
HCJ : HCR_11410(moaE_1) HCR_12580(moaE_2)
GEF : FO488_12935 FO488_15235
AORY : AMOR_09980(moaX) AMOR_45500
BAZ : BAMTA208_09995(moaE)
BSON : S101395_03309(moaE)
BAN : BA_2136(moaE1) BA_3622(moaE2) BA_4972(moaE3)
BAR : GBAA_2136(moaE1) GBAA_3622(moaE2) GBAA_4972(moaE3)
BAT : BAS1988 BAS3359 BAS4616
BAH : BAMEG_1010(moaE2) BAMEG_2455(moaE1) BAMEG_5003(moaE3)
BAI : BAA_2202(moaE1) BAA_3649(moaE2) BAA_4982(moaE3)
BAX : H9401_2029 H9401_3443 H9401_4747
BANT : A16_21710 A16_36270 A16_49650
BANR : A16R_21990 A16R_36730 A16R_50280
BANS : BAPAT_2043 BAPAT_3468 BAPAT_4768
BANH : HYU01_10685 HYU01_17715 HYU01_24220
BANV : DJ46_2340 DJ46_3634 DJ46_938
BCE : BC2126 BC3565 BC4719
BCA : BCE_3580(moaE) BCE_4862(moaE)
BCZ : BCE33L1940(moaE) BCE33L3273(moaE) BCE33L4470(moaE)
BCR : BCAH187_A2283(moaE1) BCAH187_A3590(moaE2) BCAH187_A4856(moaE3)
BCB : BCB4264_A2143(moaE1) BCB4264_A3673(moaE2) BCB4264_A4832(moaE3)
BCU : BCAH820_2169(moaE1) BCAH820_3573(moaE2) BCAH820_4838(moaE3)
BCG : BCG9842_B0404(moaE3) BCG9842_B1644(moaE2) BCG9842_B3172(moaE1)
BCQ : BCQ_2110(moaE) BCQ_3359(moaE) BCQ_4533(moaE)
BCX : BCA_2221(moaE1) BCA_3659(moaE2) BCA_4843(moaE3)
BAL : BACI_c20970(moaE1) BACI_c35090(moaE2) BACI_c47170(moaE3)
BNC : BCN_2095 BCN_3375 BCN_4629
BCF : bcf_10545 bcf_17670 bcf_23685
BCER : BCK_11580 BCK_17435 BCK_23950
BCEF : BcrFT9_02718 BcrFT9_03751
BTK : BT9727_1962(moaE) BT9727_3323(moaE) BT9727_4452(moaE)
BTL : BALH_1898(moaE) BALH_3204 BALH_4293(moaE)
BTB : BMB171_C1912(moaE1) BMB171_C3240(moaE2) BMB171_C4357(moaE3)
BTT : HD73_2381 HD73_3837 HD73_5029
BTHR : YBT1520_11610 YBT1520_18940 YBT1520_24940
BTHI : BTK_11785 BTK_18875 BTK_24795
BTC : CT43_CH2075(moaE1) CT43_CH3509(moaE2) CT43_CH4742(moaE3)
BTF : YBT020_11030 YBT020_17460 YBT020_23245
BTM : MC28_1348 MC28_2714 MC28_3999
BTG : BTB_c21890(moaE1) BTB_c36410(moaE2) BTB_c48740(moaE3)
BTI : BTG_01555 BTG_09255 BTG_25250
BTN : BTF1_08125 BTF1_15580 BTF1_22160
BTHT : H175_ch2105 H175_ch3567 H175_ch4820
BTHU : YBT1518_11755 YBT1518_19550 YBT1518_26145
BTW : BF38_3355 BF38_4739 BF38_482
BTHY : AQ980_06230 AQ980_12135 AQ980_19125
BWE : BcerKBAB4_1979 BcerKBAB4_4551
BWW : bwei_0169(moaE) bwei_2897 bwei_3317(moaE2)
BTY : Btoyo_0777 Btoyo_1960 Btoyo_4705
BMYC : DJ92_1811 DJ92_4468
BBY : CY96_09765 CY96_16820 CY96_22760
BWD : CT694_11500 CT694_18960 CT694_25265
BTRO : FJR70_08925(moaE) FJR70_10720(moaE) FJR70_17445(moaE)
BMOB : MLA2C4_18505 MLA2C4_24555
BNT : GSN03_08345(moaE) GSN03_10435 GSN03_22465(moaE)
BPAC : LMD38_03310(moaE) LMD38_09275(moaE)
BPAN : NLJ82_10505 NLJ82_16840(moaE) NLJ82_23140(moaE)
BALU : QRY64_12890 QRY64_20440(moaE) QRY64_26550(moaE)
BFD : NCTC4823_00381(moaE)
BACI : B1NLA3E_19130 B1NLA3E_21795
BCIR : C2I06_17135 C2I06_18245
GWC : GWCH70_0733 GWCH70_1350
PTB : DER53_08330 DER53_11295
PARG : PspKH34_29750(moaE)
BMUR : ABE28_002920 ABE28_023155
BVJ : I5776_14635 I5776_20245
SAX : USA300HOU_2253(moaE)
SUQ : HMPREF0772_10927(moaE)
SUX : SAEMRSA15_21690(moaE)
SUF : SARLGA251_20550(moaE)
SDP : NCTC12225_00630(moaE)
SPIC : SAMEA4384060_0769(moaE)
SSH : NCTC13712_02218(moaE)
SSIM : SAMEA4384339_2100(moaE)
SSTE : SAMEA4384403_0505(moaE)
LMOC : LMOSLCC5850_1050(moaE)
LMW : LMOSLCC2755_1046(moaE)
LMX : LMOSLCC2372_1058(moaE)
LMZ : LMOSLCC2482_1091(moaE)
LMON : LMOSLCC2376_1017(moaE)
LMOS : LMOSLCC7179_1025(moaE)
LMOO : LMOSLCC2378_1062(moaE)
LMOY : LMOSLCC2479_1057(moaE)
LMOT : LMOSLCC2540_1044(moaE)
LMOA : LMOATCC19117_1066(moaE)
LGZ : NCTC10812_00175(moaE1)
BAYD : BSPP4475_05035(moaD)
PPM : PPSC2_17360(moaE1) PPSC2_17965(moaE3)
PPO : PPM_3502(moaE1) PPM_3615(moaE3)
PPOL : X809_33400 X809_34040
PPQ : PPSQR21_034990(moaE) PPSQR21_036170
PPOY : RE92_19235 RE92_19740
PTA : HPL003_25970 HPL003_26555
POD : PODO_08870 PODO_21370
PAEN : P40081_08840 P40081_10935
PAEQ : R50912_08020 R50912_10445
PPEO : ABE82_17460 ABE82_17985
PKB : B4V02_07485 B4V02_07965
PAIH : ASL14_20370 ASL14_20865
PLUT : EI981_02130 EI981_15530
PPOG : QPK24_06200 QPK24_07540(moaD)