| Entry |
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| Name |
tRNA-5-taurinomethyluridine 2-sulfurtransferase;
MTU1 (gene name);
SLM3 (gene name);
MTO2 (gene name)
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| Class |
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
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| Sysname |
[protein]-S-sulfanyl-L-cysteine:tRNA (5-taurinomethyluracil34 2-O)-sulfurtransferase
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| Reaction(IUBMB) |
a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluracil34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouracil34 in tRNA + AMP + diphosphate + acceptor
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| Substrate |
[protein]-S-sulfanyl-L-cysteine [CPD: C21440];
5-taurinomethyluracil34 in tRNA;
ATP [CPD: C00002];
reduced acceptor [CPD: C00030]
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| Product |
[protein]-L-cysteine [CPD: C02743];
5-taurinomethyl-2-thiouracil34 in tRNA;
AMP [CPD: C00020];
diphosphate [CPD: C00013];
acceptor [CPD: C00028]
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| Comment |
The enzyme, found in mitochondria, catalyses formation of 5-taurinomethyl-2-thiouridine in the wobble position of mitochondrial tRNAGln, tRNALys and tRNAGlu.
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| History |
EC 2.8.1.14 created 2015
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| Orthology |
| K21027 | tRNA-5-taurinomethyluridine 2-sulfurtransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Umeda N, Suzuki T, Yukawa M, Ohya Y, Shindo H, Watanabe K, Suzuki T |
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| Title |
Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wang X, Yan Q, Guan MX |
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| Title |
Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.8.1.14 |
| ExPASy - ENZYME nomenclature database: | 2.8.1.14 |
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