Entry
Name
tRNA-5-taurinomethyluridine 2-sulfurtransferase;
MTU1 (gene name);
SLM3 (gene name);
MTO2 (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
[protein]-S-sulfanyl-L-cysteine:tRNA (5-taurinomethyluracil34 2-O)-sulfurtransferase
Reaction(IUBMB)
a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluracil34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouracil34 in tRNA + AMP + diphosphate + acceptor
Substrate
[protein]-S-sulfanyl-L-cysteine [CPD:
C21440 ];
5-taurinomethyluracil34 in tRNA;
ATP [CPD:
C00002 ];
reduced acceptor [CPD:
C00030 ]
Product
[protein]-L-cysteine [CPD:
C02743 ];
5-taurinomethyl-2-thiouracil34 in tRNA;
AMP [CPD:
C00020 ];
diphosphate [CPD:
C00013 ];
acceptor [CPD:
C00028 ]
Comment
The enzyme, found in mitochondria, catalyses formation of 5-taurinomethyl-2-thiouridine in the wobble position of mitochondrial tRNAGln, tRNALys and tRNAGlu.
History
EC 2.8.1.14 created 2015
Orthology
K21027 tRNA-5-taurinomethyluridine 2-sulfurtransferase
Genes
SRX : 107710739(trmu) 107721150
CCAR : 109069263 109070259(trmu)
CAUA : 113057888 113098989
ALIM : 106524851 106534360
OGO : 123994726(trmu) 124014620
CCLU : 121555009 121581259
CCOG : 133118869 133118870
AFIL : 140149255 140149261
DSI : Dsimw501_GD16539(Dsim_GD16539)
CQU : CpipJ_CPIJ004441 CpipJ_CPIJ009178
PBAR : 105422061 105422070
CFUM : 141429661 141429918
CFEL : 113386524 113386526 113386529
AFRA : 136031642 136031898
HAME : 121869997 121870401
CSCU : 111619872 111619873 111619874
CEL : CELE_B0035.16(mttu-1)
BMY : BM_BM1697(Bma-mttu-1)
MAEA : 128216646 128217664
LAK : 106152782 106171341 106180295
CSAT : 104742640 104758421 109124552
BNA : 106360502 106427425 125608896 125609524
AIP : 107610164 107624756 107639665
AHF : 112726661 112735078 112743734 112765885 112797103
MSYL : 126590856 126615351
PXB : 103938986 103938987 103963898 103965543
PCOX : 137715523 137742669
CSAV : 115695188 133034973
SSPL : 121773580 121776297 121789340
PSOM : 113310442 113320329
TDC : 119284577 119291593 119292700 119292844 119309628
TAES : 123084748 123090137 123093333 123098615 123112100
PVIR : 120647144 120690253
PAUA : 133910450 133916756
SMO : SELMODRAFT_44688 SELMODRAFT_44690
MNG : MNEG_0539 MNEG_12593
CSL : COCSUDRAFT_18285 COCSUDRAFT_35346
CVR : CHLNCDRAFT_139672 CHLNCDRAFT_35486
APRO : F751_0768 F751_2846
OLU : OSTLU_17350 OSTLU_43910
BPG : Bathy12g01880 Bathy13g01570
MIS : MICPUN_69547 MICPUN_87017
MPP : MICPUCDRAFT_4302 MICPUCDRAFT_44717
CME : CYME_CMT278C CYME_CMT380C
CCP : CHC_T00004341001 CHC_T00007882001
CGR : 2890017(GVI51_K01375)
NCS : NCAS_0I02100(NCAS0I02100)
NDI : NDAI_0A06680(NDAI0A06680)
TPF : TPHA_0A00900(TPHA0A00900)
TBL : TBLA_0F00880(TBLA0F00880)
TDL : TDEL_0D04640(TDEL0D04640)
KAF : KAFR_0F02180(KAFR0F02180)
KNG : KNAG_0K01750(KNAG0K01750)
LBG : 92206486(LODBEIA_P12900)
CAL : CAALFM_C114330WA(CaO19.7245)
CTEN : 18249039(PSN45_000334)
ASAU : 88171546(PUMCH_000477)
YLI : 2908454(YALI2_E01006g)
CDEC : 89993024(IAS62_006256)
CTEG : 91993106(I308_106251)
CBAS : 91986435(I312_106392)
CDEP : 91084236(L203_100020)
KMG : 30166843(I203_100457)
KNE : 92181932(IAR55_004674)
KDJ : 28971269(I303_107560)
KBI : 30205786(I302_102694)
KPIN : 30175695(I206_106787)
KSH : 87960074(IL334_007944)
KER : 91104101(V865_005300)
CCAC : CcaHIS019_0202340(CcaverHIS019_0202340)
ABP : AGABI1DRAFT67935(AGABI1DRAFT_67935)
ABV : AGABI2DRAFT215705(AGABI2DRAFT_215705)
SCM : SCHCO_02483564(SCHCODRAFT_02483564)
PSTR : Pst134EA_025977 Pst134EA_026002
PFH : PFHG_01493 PFHG_05474
PLAG : 39742061(PADL01_1018200)
PTI : PHATRDRAFT_15294 PHATRDRAFT_3425
FCY : FRACYDRAFT_182371 FRACYDRAFT_205230
TPS : THAPSDRAFT_269988 THAPSDRAFT_37327
LMAT : 92517161(LSCM1_07269)
LOI : 92362124(LSCM4_06266)
LEIS : 94181748(GH5_06443)
LENR : 94173718(CUR178_06543)
LEIN : 94190145(JIQ42_06538)
PHET : 94292402(JKF63_06375)
EHX : EMIHUDRAFT_437795 EMIHUDRAFT_70246
GTT : GUITHDRAFT_62025 GUITHDRAFT_76798
PCRE : NCTC12858_01528(mnmA)
COPR : Cop2CBH44_03300(mnmA1)
PMZ : HMPREF0659_A7159(trmU)
PDN : HMPREF9137_1005(trmU)
PHER : prwr041_04760(mnmA1)
POC : NCTC13071_00151(mnmA)
DPB : BABL1_gene_715(mnmA)
» show all
Taxonomy
Reference
Authors
Umeda N, Suzuki T, Yukawa M, Ohya Y, Shindo H, Watanabe K, Suzuki T
Title
Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.
Journal
Sequence
Reference
Authors
Wang X, Yan Q, Guan MX
Title
Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.14
ExPASy - ENZYME nomenclature database: 2.8.1.14