KEGG   ENZYME: 2.8.1.16
Entry
EC 2.8.1.16                 Enzyme                                 

Name
L-aspartate semialdehyde sulfurtransferase;
MA1821 (locus name);
MJ0100 (locus name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
Sysname
hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase
Reaction(IUBMB)
hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:R12505]
Reaction(KEGG)
R12505
Substrate
hydrogen sulfide [CPD:C00283];
L-aspartate 4-semialdehyde [CPD:C00441];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Product
L-homocysteine [CPD:C00155];
H2O [CPD:C00001];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Comment
The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.
History
EC 2.8.1.16 created 2019
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K23975  L-aspartate semialdehyde sulfurtransferase
Genes
DVU: DVU_2938
DVL: Dvul_0430
DVM: DvMF_1464
DVG: Deval_2713
DDE: Dde_3007
DMA: DMR_46290
DGG: DGI_1165
DFL: DFE_2712
DCB: C3Y92_19940
DMS: E8L03_15160
DAS: Daes_3322
DPI: BN4_12199
PPRF: DPRO_1935
DBA: Dbac_3098
DRT: Dret_2469
DSF: UWK_02633
DAL: Dalk_1368
DALK: DSCA_04730
DLI: dnl_08380
SAT: SYN_01778
SFU: Sfum_1059
DBR: Deba_3156
SWO: Swol_1441
SLP: Slip_0735
DRM: Dred_0101
DAE: Dtox_3584
PTH: PTH_1472
DAU: Daud_0911
ELM: ELI_3644
ADG: Adeg_1432
TACI: TDSAC_0221
SYN: slr0689
SYZ: MYO_14070
SYY: SYNGTS_0403(slr0689)
SYT: SYNGTI_0403(slr0689)
SYS: SYNPCCN_0403(slr0689)
SYQ: SYNPCCP_0403(slr0689)
SYC: syc1103_c
CYA: CYA_1941
CYB: CYB_0133
AMR: AM1_4338
TEL: tll2362
MAR: MAE_17670
MPK: VL20_3116
CYT: cce_2273
TER: Tery_2393
GVI: glr3673
GLJ: GKIL_0338
ANA: all1701
NSH: GXM_04842
AVA: Ava_0664
NAZ: Aazo_2809
CALH: IJ00_20895
CTHE: Chro_2043
CEO: ETSB_1648
DET: DET0921
DEH: cbdbA872
DEV: DhcVS_792
DMC: btf_817
DMD: dcmb_855
DMG: GY50_0800
DORI: FH5T_06660
TLE: Tlet_1363
TME: Tmel_0733
TAF: THA_1098
FNO: Fnod_1281
DTU: Dtur_0732
CTHI: THC_0177
MJA: MJ_0100
MMP: MMP1359
MMD: GYY_07625
MMAD: MMJJ_14800(guaB_5)
MAE: Maeo_0793
MVO: Mvol_1031
MTH: MTH_855
METC: MTCT_0768
METE: tca_00822
MSI: Msm_0085
MEB: Abm4_0692
MMIL: sm9_0981
MEYE: TL18_05465
MOL: YLM1_0877
METH: MBMB1_0672
MFC: BRM9_1523
MCUB: MCBB_0683
MFV: Mfer_1260
MKA: MK0907
AFU: AF_1186
FPL: Ferp_1951
GAC: GACE_0621
GAH: GAH_01959
MBAR: MSBR2_2388
MBAK: MSBR3_2445
MAC: MA_1821
MMA: MM_0241
MMAC: MSMAC_2424
METM: MSMTP_1092
MTHR: MSTHT_0029
MTHE: MSTHC_0699
MHOR: MSHOH_1266
MBU: Mbur_0311
MMET: MCMEM_0825
MMH: Mmah_1251
MPY: Mpsy_0868
MTP: Mthe_0019
MCJ: MCON_1340
MHI: Mhar_2345
MHU: Mhun_0138
MLA: Mlab_0451
MEMA: MMAB1_2385
MPI: Mpet_1603
MBN: Mboo_1272
MPL: Mpal_1290
MPD: MCP_0132
MEZ: Mtc_0355
RCI: RCIX1241
MARC: AR505_0724
BARB: AOA66_0665(guaB_3)
 » show all
Reference
1  [PMID:25315403]
  Authors
Rauch BJ, Gustafson A, Perona JJ
  Title
Novel proteins for homocysteine biosynthesis in anaerobic microorganisms.
  Journal
Mol Microbiol 94:1330-42 (2014)
DOI:10.1111/mmi.12832
  Sequence
Reference
2  [PMID:25938369]
  Authors
Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH
  Title
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
  Journal
Biochemistry 54:3129-32 (2015)
DOI:10.1021/acs.biochem.5b00118
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.16
IUBMB Enzyme Nomenclature: 2.8.1.16
ExPASy - ENZYME nomenclature database: 2.8.1.16
BRENDA, the Enzyme Database: 2.8.1.16

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