KEGG   ENZYME: 2.8.1.16
Entry
EC 2.8.1.16                 Enzyme                                 
Name
L-aspartate semialdehyde sulfurtransferase;
MA1821 (locus name);
MJ0100 (locus name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
Sysname
hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase
Reaction(IUBMB)
hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:R12505]
Reaction(KEGG)
R12505
Substrate
hydrogen sulfide [CPD:C00283];
L-aspartate 4-semialdehyde [CPD:C00441];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Product
L-homocysteine [CPD:C00155];
H2O [CPD:C00001];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Comment
The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.
History
EC 2.8.1.16 created 2019
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K23975  L-aspartate semialdehyde sulfurtransferase
Genes
HMRHipma_0164
DAVDESACE_02220
DFLDFE_2712
PSYFN1030_16530
DSBLN040_15305
DMADMR_46290
DCBC3Y92_19940
DGGDGI_1165
DDEDde_3007
DMSE8L03_15160
DSADesal_3782
DHYDESAM_20787
DAFDesaf_1190
DASDaes_3322
DPIBN4_12199
DEJAWY79_02770
PPRFDPRO_1935
PSELGM415_05005
DDNDND132_2281
PSEFPSDVSF_22760
PPORJCM14722_18180
PNWSYK_23440
PTHELF599_00085
DSXGD604_18225
DSDGD606_13500
PBIZLWC08_11720
DVUDVU_2938
DVLDvul_0430
DVMDvMF_1464
DVGDeval_2713
CLIHKPS_001748
TMURJBF11_09500
DBADbac_3098
DESUNLA06_15430
THEWTDMWS_05980
DRTDret_2469
DSFUWK_02633
DLMDPPLL_15440
DPRDespr_3243
DOGHP555_05040
DBKDGMP_14500
DDUGF1_17180
ECOMQTN59_05140
DALDalk_1368
DATHRM2_27800
DTOTOL2_C21940
DOVDSCO28_01030
DWDDSCW_12590
DALKDSCA_04730
DMLDmul_10250
DLIdnl_08380
DMMdnm_024620
DEKDSLASN_02770
SATSYN_01778
DAODesac_0386
DTIDesti_2525
SFUSfum_1059
DAXFDQ92_09500
DBRDeba_3156
DMPFAK_14090
TIDThein_1355
TOPTOPB45_0044
TCMHL41_05065
THETF1847_01765
CTHITHC_0177
TAVG4V39_02840
TMAIFVE67_05875
DHRLGS26_07215
CRSFQB35_11345
SWOSwol_1441
SLPSlip_0735
DORDesor_0315
DAIDesaci_0590
DMIDesmer_0317
DCADesca_0089
PTHPTH_1472
DRMDred_0101
DRUDesru_0171
DFGB0537_01265
DAEDtox_3584
DKUDesku_1645
DAUDaud_0911
TFRBR63_10460
FWADCMF_03305
TJRTherJR_1173
DGIDesgi_2433
ELMELI_3644
EMTCPZ25_018535
ELIMB2M23_08225
AWOAwo_c28040
AWICHL1_000701
ALKAJ0B03_00425
CSPOQNI18_01750
ADGAdeg_1432
TPZTph_c18160
TEPTepRe1_2592
TAETepiRe1_2794
HALSD7D81_00205
IFNGM661_16200
KMEH0A61_00691
CALKHUE98_00810
SYNslr0689
SYZMYO_14070
SYYSYNGTS_0403(slr0689)
SYTSYNGTI_0403(slr0689)
SYSSYNPCCN_0403(slr0689)
SYQSYNPCCP_0403(slr0689)
SYJD082_06630
SYOC7I86_02090
SYCsyc1103_c
SYUM744_00900
SYFSynpcc7942_0414
SYRSynRCC307_0741
CYACYA_1941
CYBCYB_0133
SYNESyn6312_3160
SYNPSyn7502_00796
SYNCCB0101_13020
DSLDacsa_1741
CGCCyagr_3295
CYICBM981_1238
WNAKA717_19995
CMPCha6605_4919
CYNCyan7425_0812
CEPCri9333_1242
TVNNIES2134_103410
SLWBRW62_11990
AMRAM1_4338
TELtll2362
THNNK55_08785
THECFFX45_06715
TSZOOK60_15975
LENLEP3755_12480
LETO77CONTIG1_03371
LBOLBWT_38250
KOVK9N68_18600
LSCKIK02_03005
LSKJ5X98_24355
HHGXM38_043210
PSEUPse7367_2607
PSERABRG53_1141
PGXOA858_05925
THEUHPC62_06500
TOGHNI00_10640
TSINOXH18_12005
GLPGlo7428_2384
CHONNIES4102_17580
GDUP0S91_03735
GENGM3709_1191
GEEGM3708_3030
CANCyan10605_3460
CSNCyast_0235
CYLAA637_05905
SYPSYNPCC7002_A0581
SYVAWQ23_03070
SYLAWQ21_03040
LEPLepto7376_4246
SYNNNIES970_03150
MARMAE_17670
MPKVL20_3116
MIQB5D77_16555
MVZmyaer102_50970
HAOPCC7418_0404
ENNFRE64_14180
CYTcce_2273
CWACwatDRAFT_3992
CYPPCC8801_2541
CYHCyan8802_3565
CYCPCC7424_5211
CYJCyan7822_1085
TERTery_2393
ARPNIES39_C02980
PAGHNIES204_23590
PPSUNO713_03154
PRUNPCC7821_02841
OXYHCG48_20610
MVAGD0A34_06710
LFSHFV01_11580
OACOscil6304_3994
ONIOsc7112_0745
MPROBJP34_25695
PHORJWS08_20780
PYHNEA10_12555
MICMic7113_6125
GEIGEI7407_3368
GVIglr3673
GLJGKIL_0338
GMLISF26_18310
ANAall1701
NPUNpun_F2759
NOSNos7107_1988
NOPNos7524_2333
NONNOS3756_00480
NFLCOO91_04664
NOECLI64_09945
NSHGXM_04842
NEDHUN01_20545
NPZACX27_23525
AVAAva_0664
NAZAazo_2809
ANBANA_C20754
ACYAnacy_2710
AWAAA650_18190
ANNEH233_29085
CSGCylst_3583
RSINB6N60_03724
HBQQI031_19890
CALOCal7507_3004
CALTCal6303_4507
CALHIJ00_20895
CALNNIES2098_63950
CALSNIES3974_18430
RIVRiv7116_1289
FISFIS3754_48300
NSPHBDGGKGIB_02331
DOUBMF77_03441
DFSHGD76_03375
DHTNG743_07150
CCURIAR63_07475
CRKL3I90_07915
AFLOHEQ12_02920
STOQK2F26_13650
AEEIM676_09535
RCSNIES932_05320
TOQHCG51_08075
ALAXNIES50_38630
NCNBZZ01_28855
CTHEChro_2043
PLPPle7327_0717
SCSSta7437_2930
STANSTA3757_20740
GLTGlitD10_2770
GCYLQF76_10780
CEOETSB_1648
CERRGRSB_1363
CEECP3F56_08435
DETDET0921
DEHcbdbA872
DEBDehaBAV1_0805
DEVDhcVS_792
DEGDehalGT_0766
DMCbtf_817
DMDdcmb_855
DMGGY50_0800
DMXX792_04160
DMYX793_04330
DMZX794_03960
DUCUCH007_07530
DEWDGWBC_0778
DFODform_00758
DETHHX448_05545
TNRThena_0230
TACITDSAC_0221
SSMSpirs_1309
OCKEXM22_00480
SBUSpiBuddy_0032
SGPSpiGrapes_1889
SASSMUG09_00165
SCDSpica_1547
BHCJFL75_11025
OSPOdosp_3419
BUYD8S85_03050
BVIRI6J59_10590
BFHF1611_05050
ACOUA5CBH24_17170
DORIFH5T_06660
DRCG0Q07_00095
MCOSGM418_14080
ANFAQPE_2027
TAMTheam_1635
DTEDester_1534
TTKTST_1097 TST_1600
TLETlet_1363
TTATheth_0529
PHYAJ81_01635
TMETmel_0733
TAFTHA_1098
TFEJYK00_07385
FNOFnod_1281
FPEFerpe_1660
FIANA23_08215
FRRIB67_03255
OCYOSSY52_04190
OCSOF820_01045
CPOCOPRO5265_0016
DTHDICTH_0569
DTUDtur_0732
ALAMRT761_01519
MJAMJ_0100
MFEMefer_0355
MVUMetvu_0926
MFSMFS40622_1018
MIFMetin_0262
MJHJH146_0779
MESGMLAUSG7_0883
MESAMLASG1_0976
MIGMetig_0741 Metig_1786
MMPMMP1359
MMQMmarC5_0219
MMXMmarC6_1314
MMZMmarC7_0604
MMDGYY_07625
MMAKMMKA1_15830
MMAOMMOS7_14640
MMADMMJJ_14800(guaB_5)
MAEMaeo_0793
MVNMevan_0669
MVOMvol_1031
MOKMetok_0495
METFCFE53_04920
MTHMTH_855
MMGMTBMA_c12520
MWOMWSIV6_1231
MTEEMTTB_05240
METCMTCT_0768
METEtca_00822
METZMETMT2_0925
METKFVF72_07270
MTHMFZP57_05850
METJFZP68_00355
MSIMsm_0085
MEBAbm4_0692
MMILsm9_0981
MEYETL18_05465
MOLYLM1_0877
MELMetbo_1965
MEWMSWAN_0653
METHMBMB1_0672
MFCBRM9_1523
MFIDSM1535_2225
MCUBMCBB_0683
MSUBBK009_01590
METNBK008_09335
METTCIT01_02115
METOCIT02_03405
MEMEHYG87_03580
MFEGGCM10025860_17380
MFVMfer_1260
MKAMK0907
AFUAF_1186
AFGAFULGI_00012860
APOArcpr_1399
AVEArcve_1085
ASTAsulf_01823
FPLFerp_1951
GACGACE_0621
GAHGAH_01959
MBAMbar_A2085
MBYMSBRM_2423
MBWMSBRW_2654
MBARMSBR2_2388
MBAKMSBR3_2445
MACMA_1821
MMAMM_0241
MMAZMmTuc01_0248
MMJMSMAS_1060
MMACMSMAC_2424
MVCMSVAZ_1104
MEKMSKOL_1059
MLSMSLAZ_2048
METMMSMTP_1092
MEFMSWH1_1180
MEQMSWHS_1256
MSJMSSAC_2171
MSZMSSIH_1745
MSWMSSIT_1805
MTHRMSTHT_0029
MTHEMSTHC_0699
MHORMSHOH_1266
MFZAOB57_002390
MBUMbur_0311
MMETMCMEM_0825
MELOJ7W08_02345
MMHMmah_1251
MHAZBHR79_07280
MPOTBKM01_03525
MEVMetev_1059
MZHMzhil_0894
MPYMpsy_0868
MZIHWN40_04325
MMAVRE476_05965
MSEBRE474_02390
MHZMetho_0925
MEHFMmiHf6_05210(impDH_1)
MEESMmiEs2_04710(impDH_2)
MTPMthe_0019
MCJMCON_1340
MHIMhar_2345
MHUMhun_0138
MRTJKHC33_13525
MLAMlab_0451
MEMMemar_1517
MBGBN140_1854
MEMAMMAB1_2385
MCHKMchiMG62_16830
MSUMOH143_01795
MRCR6Y96_08075
MPIMpet_1603
MENDL6E24_01840
MEFWF1737_03820
MAQERJ40_00260
MFKE2N92_02115
MOUOU421_01020
MESBL1S32_01980
MANQL1994_05340
MBNMboo_1272
MFOMetfor_2035
MPLMpal_1290
MPDMCP_0132
MEZMtc_0355
RCIRCIX1241
MELUMTLP_06200
MERMMINT_14480
MARCAR505_0724
BARBAOA66_0665(guaB_3)
FLTSv326_0760
LOKILokiarch_29370
 » show all
Reference
1  [PMID:25315403]
  Authors
Rauch BJ, Gustafson A, Perona JJ
  Title
Novel proteins for homocysteine biosynthesis in anaerobic microorganisms.
  Journal
Mol Microbiol 94:1330-42 (2014)
DOI:10.1111/mmi.12832
  Sequence
Reference
2  [PMID:25938369]
  Authors
Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH
  Title
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
  Journal
Biochemistry 54:3129-32 (2015)
DOI:10.1021/acs.biochem.5b00118
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.16
IUBMB Enzyme Nomenclature: 2.8.1.16
ExPASy - ENZYME nomenclature database: 2.8.1.16
BRENDA, the Enzyme Database: 2.8.1.16

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