Entry |
|
Name |
bile-salt sulfotransferase;
BAST I;
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase;
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase;
bile acid sulfotransferase I;
glycolithocholate sulfotransferase;
3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
|
Class |
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
|
Sysname |
3'-phosphoadenylyl-sulfate:glycolithocholate sulfonotransferase
|
Reaction(IUBMB) |
(1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate [RN: R07287];
(2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate [RN: R03987]
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Reaction(KEGG) |
|
Substrate |
3'-phosphoadenylyl sulfate [CPD: C00053];
glycolithocholate [CPD: C15557];
taurolithocholate [CPD: C02592]
|
Product |
adenosine 3',5'-bisphosphate [CPD: C00054];
glycolithocholate 3-sulfate [CPD: C11301];
taurolithocholate sulfate [CPD: C03642]
|
Comment |
The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3].
|
History |
EC 2.8.2.14 created 1978, modified 2005
|
Pathway |
ec00980 | Metabolism of xenobiotics by cytochrome P450 |
|
Orthology |
K11822 | bile-salt sulfotransferase |
|
Genes |
» show all
|
Reference |
|
Authors |
Chen LJ, Bolt RJ, Admirand WH. |
Title |
Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts. |
Journal |
|
Reference |
|
Authors |
Barnes S, Waldrop R, Crenshaw J, King RJ, Taylor KB. |
Title |
Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate. |
Journal |
J Lipid Res 27:1111-23 (1986) |
Reference |
|
Authors |
Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB. |
Title |
Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties. |
Journal |
J Lipid Res 30:529-40 (1989) |
Reference |
|
Authors |
Russell DW |
Title |
The enzymes, regulation, and genetics of bile acid synthesis. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.8.2.14 |
ExPASy - ENZYME nomenclature database: | 2.8.2.14 |
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