KEGG   ENZYME: 2.8.2.14
Entry
EC 2.8.2.14                 Enzyme                                 
Name
bile-salt sulfotransferase;
BAST I;
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase;
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase;
bile acid sulfotransferase I;
glycolithocholate sulfotransferase;
3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
Sysname
3'-phosphoadenylyl-sulfate:glycolithocholate sulfonotransferase
Reaction(IUBMB)
(1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate [RN:R07287];
(2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate [RN:R03987]
Reaction(KEGG)
R03987 R07287;
(other) R08977 R08978 R09444
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
glycolithocholate [CPD:C15557];
taurolithocholate [CPD:C02592]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
glycolithocholate 3-sulfate [CPD:C11301];
taurolithocholate sulfate [CPD:C03642]
Comment
The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3].
History
EC 2.8.2.14 created 1978, modified 2005
Pathway
ec00980  Metabolism of xenobiotics by cytochrome P450
Orthology
K11822  bile-salt sulfotransferase
Genes
HSA6822(SULT2A1)
PTR456409(SULT2A1)
PPS100971784(SULT2A1)
GGO101137965(SULT2A1)
PON100431471(SULT2A1)
NLE100603984(SULT2A1)
MCC717600(SULT2A1)
MCF102130325(SULT2A1)
MTHB126943497
CSAB103234953(SULT2A1)
CATY105595217(SULT2A1)
PANU101000955(SULT2A1)
TGE112611897(SULT2A1)
RRO104673376(SULT2A1)
RBB108539899(SULT2A1)
TFN117091485(SULT2A1)
PTEH111520101(SULT2A1)
CJC100413663(SULT2A1)
SBQ101034912 101040745
CSYR103256265(SULT2A1) 103268128 103272673
MMUR105868193 105868194 105869600(SULT2A1) 105873827
LCAT123623885(SULT2A1)
OGA100942680 100949505 100954287 100954595 100954909 100956260 100956575 100956888 100957203 100957822 100958792
MMU20859(Sult2a1) 434121(Sult2a4) 434264(Sult2a5) 629203(Sult2a3) 638251(Sult2a7) 76971(Sult2a8)
MCAL110287694 110297377 110298916 110299139(Sult2a1)
MPAH110315086(Sult2a1) 110315385
RNO24912(Sult2a1) 361510(Sult2a2)
MCOC116100275 116100375 116100378
CGE100751331 100751624 100751913 100752375 100752864 100753164 103160274 103160275 113837373
MAUA101826585 101831195 101841850 121132754
PLEU114685237 114685239 114685241 114685242 114685243 114685244 114685245 114687068 114687069 114687072 114687323 114687325 114687331 114687332 114687333 114688384 114688385 114703904 114703946 114703954 114703956 114703959
MORG121449068 121449462 121449475 121449499 121449521 121449541
MFOT126494651 126494652 126494653 126494654 126494655 126496033
AAMP119820497 119820498 119820499 119820952
NGI103729182 103732419 103732424
HGL101704327(Sult2a1) 101704668 101705514
CPOC100379531(Std2) 100379581(Std1) 100721490 100729579 100730125 100731507
CCAN109675537
DORD106000940 106000941 106000942 106000944 106000945 106000946 106000948
DSP122125685 122125761 122125762 122125763 122125764 122125765 122125766 122125767 122125768 122125769 122125770 122125771 122125772 122125773 122125775 122125776 122125777 122125778 122125780 122125785 122125786 122125788
NCAR124974873 124974875 124974876 124974882 124974883 124974884 124974887
OCU100008598(SULT2A1)
OPI101532090(SULT2A1)
TUP102469211 102470067
BTA514658 533560(SULT2A1)
BOM102268811 102269085
BIU109572833 109572834
BBUB102395145 102395467
CHX102181069 108633179
OAS101119842 101120103
ODA120872213 120872214
CCAD122420940 122421647 122421698
SSC641359(SULT2A1)
CFR102518264(SULT2A1)
CBAI105062573(SULT2A1)
CDK105098927(SULT2A1)
VPC102528443(SULT2A1)
BACU103005028(SULT2A1)
OOR105747730
DLE111180495
PSIU116743718
ECB100050266 100050329 100050400 100050477(SULT2A1) 100050557 100052843 100052993
EPZ103544219 103545059 103555781 103555782 103555784(SULT2A1) 103567536
EAI106828268 106829389 106838230 106838231 106845150 123281273
MYB102240460 102254636(SULT2A1)
MYD102762349 102762941(SULT2A1)
MMYO118655128 118655129 118657508(SULT2A1)
MLF102421645 102431147 102437703
MNA107540047(SULT2A1)
PKL118715986(SULT2A1) 118716937
HAI109390976(SULT2A1)
DRO112312826(SULT2A1) 112313480
AJM119061676 119065861(SULT2A1)
PDIC114511474(SULT2A1)
PHAS123813613 123822928(SULT2A1)
RFQ117034323(SULT2A1) 117034619
PALE102890032(SULT2A1)
PGIG120605973 120606999
PVP105304188(SULT2A1)
RAY107516041(SULT2A1)
SARA101551700 101551967 101552228 101552765 101553298 101553558 101553824 101554810 101555003 101555270 101555797
LAV100654856 100655145 100655424 104845577
TMU101344801 101351802
DNM101414352 101416234 101417110 101429367 101431737 101440175 101441775 101443992 101444147
MDO100018596 100018631
GAS123239008(SULT2A1)
SHR100920297 105750186
PCW110220147 110220161
DSV119444515 119459575
RSAN119373453
RMP119185533
VDE111242803
VJA111265783
CRG105318023 105340600
PMAX117317893
WIJBWZ20_04230
ALTIALE3EI_0126
 » show all
Reference
1  [PMID:831833]
  Authors
Chen LJ, Bolt RJ, Admirand WH.
  Title
Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts.
  Journal
Biochim Biophys Acta 480:219-27 (1977)
DOI:10.1016/0005-2744(77)90335-7
Reference
2  [PMID:3470420]
  Authors
Barnes S, Waldrop R, Crenshaw J, King RJ, Taylor KB.
  Title
Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate.
  Journal
J Lipid Res 27:1111-23 (1986)
Reference
3  [PMID:2754334]
  Authors
Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB.
  Title
Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties.
  Journal
J Lipid Res 30:529-40 (1989)
Reference
4  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.14
IUBMB Enzyme Nomenclature: 2.8.2.14
ExPASy - ENZYME nomenclature database: 2.8.2.14
BRENDA, the Enzyme Database: 2.8.2.14
CAS: 65802-92-8

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