KEGG ENZYME: 2.8.2.14

ENZYME: 2.8.2.14

Entry

EC 2.8.2.14                 Enzyme

Name

bile-salt sulfotransferase;
BAST I;
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase;
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase;
bile acid sulfotransferase I;
glycolithocholate sulfotransferase;
3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase

Class

Transferases;
Transferring sulfur-containing groups;
Sulfotransferases

Sysname

3'-phosphoadenylyl-sulfate:glycolithocholate sulfonotransferase

Reaction(IUBMB)

(1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate [RN:R07287];
(2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate [RN:R03987]

Reaction(KEGG)

R03987 R07287;
(other) R08977 R08978 R09444

Substrate

3'-phosphoadenylyl sulfate [CPD:C00053];
glycolithocholate [CPD:C15557];
taurolithocholate [CPD:C02592]

Product

adenosine 3',5'-bisphosphate [CPD:C00054];
glycolithocholate 3-sulfate [CPD:C11301];
taurolithocholate sulfate [CPD:C03642]

Comment

The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3].

History

EC 2.8.2.14 created 1978, modified 2005

Pathway

ec00980

Metabolism of xenobiotics by cytochrome P450

Orthology

K11822

bile-salt sulfotransferase

Genes

HSA:	6822(SULT2A1)

PTR:	456409(SULT2A1)

PPS:	100971784(SULT2A1)

GGO:	101137965(SULT2A1)

PON:	100431471(SULT2A1)

PPYG:

129020856(SULT2A1)

NLE:	100603984(SULT2A1)

HMH:	116479417(SULT2A1)

SSYN:

129460259(SULT2A1)

MCC:	717600(SULT2A1)

MCF:	102130325(SULT2A1)

MTHB:

126943497

MNI:	105478620(SULT2A1)

CSAB:

103234953(SULT2A1)

CATY:

105595217(SULT2A1)

PANU:

101000955(SULT2A1)

TGE:	112611897(SULT2A1)

MLEU:

105531904(SULT2A1)

RRO:	104673376(SULT2A1)

RBB:	108539899(SULT2A1)

TFN:	117091485(SULT2A1)

PTEH:

111520101(SULT2A1)

CANG:

105500701(SULT2A1)

CJC:	100413663(SULT2A1)

SBQ:	101034912 101040745

CIMI:

108283861(SULT2A1) 108316657

ANAN:

105713139 105713148(SULT2A1) 105726038

CSYR:

103256265(SULT2A1) 103268128 103272673

MMUR:

105868193 105868194 105869600(SULT2A1) 105873827

LCAT:

123623885(SULT2A1)

PCOQ:

105817707(SULT2A1)

OGA:	100942680 100949505 100954287 100954595 100954909 100956260 100956575 100956888 100957203 100957822 100958792

MMU:	20859(Sult2a1) 434121(Sult2a4) 434264(Sult2a5) 629203(Sult2a3) 629219(Sult2a6) 638251(Sult2a7) 76971(Sult2a8)

MCAL:

110287694 110297377 110298916 110299139(Sult2a1)

MPAH:

110315086(Sult2a1) 110315385

RNO:	120099768 134485278 24912(Sult2a1) 361510(Sult2a2)

MCOC:

116100275 116100375 116100378

ANU:	117698023 117700514 117700537 117700538 117700547

ASYL:

127674798 127674804 127674815 127683358 127683370 127683380 127683393

MUN:	110539543(Sult2a1)

CGE:	100751331 100751624 100751913 100752375 100752864 100753164 103160274 103160275 113837373

MAUA:

101826585 101831195 101841850 121132754

PROB:

127238495 127238564 127238873 127238874

PLEU:

114685237 114685239 114685241 114685242 114685243 114685244 114685245 114687068 114687069 114687072 114687323 114687325 114687331 114687332 114687333 114688384 114688385 114703904 114703946 114703954 114703956 114703959

MORG:

121449068 121449462 121449475 121449499 121449521 121449541

MFOT:

126494651 126494652 126494653 126494654 126494655 126496033

AAMP:

119820497 119820498 119820499 119820952

NGI:	103729182 103732419 103732424

HGL:	101704327(Sult2a1) 101704668 101705514

CPOC:

100379531(Std2) 100379581(Std1) 100721490 100729579 100730125 100731507

CCAN:

109675537

DORD:

106000940 106000941 106000942 106000944 106000945 106000946 106000948

DSP:	122125685 122125761 122125762 122125763 122125764 122125765 122125766 122125767 122125768 122125769 122125770 122125771 122125772 122125773 122125775 122125776 122125777 122125778 122125780 122125785 122125786 122125788

DMER:

138812014 138812034 138812573 138812849 138812852 138812853 138812854 138812855 138812856 138812857 138812858 138812859 138812862 138814539 138814555 138814556 138814563 138814567 138814576 138814583 138814589 138814594 138814619

PLOP:

125368085 125368428 125368429 125368431 125368432 125368433 125368434 125368435 125368436 125368437 125368442 125368443 125368444

NCAR:

124974873 124974875 124974876 124974882 124974883 124974884 124974887

MMMA:

107151302 107151305 107151307 107151308 107151585 107151666

ITI:	101961002 101961474 101962223 101962512 101962791 101963557 101964048 101964325 101964782 101965284 101965764 101966648 101967896 101968370 110599253 110599257 120888064

OCU:	100008598(SULT2A1)

OPI:	101532090(SULT2A1)

TUP:	102469211 102470067

GVR:	103607526(SULT2A1)

BTA:	514658 533560(SULT2A1)

BOM:	102268811 102269085 138991669

BIU:	109572833 109572834

BBUB:

102395145 102395467

BBIS:

104995597 104995599 104995707

CHX:	102181069 108633179

OAS:	101119842 101120103

BTAX:

128063820 128063825

CSUM:

138095841 138095942

ODA:	120872213 120872214

CCAD:

122420940 122421647 122421698

MREE:

136158849 136161501

OVR:	110125743(SULT2A1) 110150756

MBEZ:

129546189 129546190

SSC:	641359(SULT2A1)

CFR:	102518264(SULT2A1)

CBAI:

105062573(SULT2A1)

CDK:	105098927(SULT2A1)

VPC:	102528443(SULT2A1)

BACU:

103005028(SULT2A1)

BMUS:

118884579 118885428(SULT2A1)

OOR:

105747730

LALB:

132510191

GMF:

115849713

DDP:

132416947

DLE:

111180495

PSIU:

116743718

NASI:

112407796

ECB:	100050266 100050329 100050400 100050477(SULT2A1) 100050557 100052843 100052993

EPZ:	103555784 103567536

EAI:	106828268 106829389 106838230 106838231 106845150 123281273

MYB:	102240460 102254636(SULT2A1)

MYD:	102762349 102762941(SULT2A1)

MMYO:

118655128 118655129 118657508(SULT2A1)

MLF:	102421645 102431147 102437703

MDT:	132216046 132216047 132216656(SULT2A1)

MYUM:

138999569 138999570 138999756(SULT2A1)

PKL:	118715986(SULT2A1) 118716937

EFUS:

103297671(SULT2A1) 103303896 129147041

MNA:	107540047(SULT2A1)

DRO:	112312826(SULT2A1) 112313480

AJM:	119065861 128627865 128627903(SULT2A1)

PDIC:

114511474(SULT2A1)

PHAS:

123813613 123822928(SULT2A1)

PPAM:

129082573 129082891(SULT2A1)

HAI:	109390976(SULT2A1)

RFQ:	117034323(SULT2A1) 117034619

PALE:

102890032(SULT2A1)

PGIG:

120605973 120606999

PVP:	105304188(SULT2A1)

RAY:	107516041(SULT2A1)

SARA:

101551700 101551967 101552228 101552765 101553298 101553558 101553824 101554810 101555003 101555270 101555797

SFUM:

130043324 130044153 130044155 130044212 130044237 130044266 130044349

SETR:

126027521 126027526(SULT2A1) 126027529

LAV:	100654856 100655145 100655424 104845577

TMU:	101344801 101351802

ETF:	105979774 105979776

DNM:	101414352 101416234 101417110 101429367 101431737 101440175 101441775 101443992 101444147

MDO:	100018596 100018631

GAS:	123239008(SULT2A1)

SHR:	100920297 105750186

AFZ:	127556915 127557689 127557692

PCW:	110220147 110220161

TVP:	118835311 118835316 118838698(SULT2A1)

PBRV:

138173314(SULT2A1)

AJJ:	139972848 139972864 139979164

PFLL:

139145312 139145323 139145329

RSAN:

119373453

RMP:

119185533

VDE:

111242803

VJA:

111265783

CRG:	105318023 105340600 136269644 136269713 136270929 136270948 136270985 136271050

CANU:

128179979 128181726

OED:

125667857

PMAX:

117317893

WIJ:	BWZ20_04230

ALTI:

ALE3EI_0126

» show all

Reference

1 [PMID:831833]

Authors

Chen LJ, Bolt RJ, Admirand WH.

Title

Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts.

Journal

Biochim Biophys Acta 480:219-27 (1977)
DOI:10.1016/0005-2744(77)90335-7

Reference

2 [PMID:3470420]

Authors

Barnes S, Waldrop R, Crenshaw J, King RJ, Taylor KB.

Title

Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate.

Journal

J Lipid Res 27:1111-23 (1986)

Reference

3 [PMID:2754334]

Authors

Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB.

Title

Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties.

Journal

J Lipid Res 30:529-40 (1989)

Reference

4 [PMID:12543708]

Authors

Russell DW

Title

The enzymes, regulation, and genetics of bile acid synthesis.

Journal

Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712

Other DBs

ExplorEnz - The Enzyme Database:

2.8.2.14

IUBMB Enzyme Nomenclature:

2.8.2.14

ExPASy - ENZYME nomenclature database:

2.8.2.14

BRENDA, the Enzyme Database:

2.8.2.14

CAS:	65802-92-8

All links

Gene (20)   
   MGENES (9)   
   RefGene (11)   
Protein sequence (32)   
   UniProt (6)   
   SWISS-PROT (6)   
   RefSeq(pep) (12)   
   PDBSTR (8)   
DNA sequence (19)   
   RefSeq(nuc) (14)   
   GenBank (5)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   InterPro (2)   
All databases (77)   

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