KEGG ENZYME: 2.8.2.2

ENZYME: 2.8.2.2

Entry

EC 2.8.2.2                  Enzyme

Name

alcohol sulfotransferase;
hydroxysteroid sulfotransferase;
3beta-hydroxy steroid sulfotransferase;
Delta5-3beta-hydroxysteroid sulfokinase;
3-hydroxysteroid sulfotransferase;
HST;
5alpha-androstenol sulfotransferase;
cholesterol sulfotransferase;
dehydroepiandrosterone sulfotransferase;
estrogen sulfokinase;
estrogen sulfotransferase;
steroid alcohol sulfotransferase;
steroid sulfokinase;
steroid sulfotransferase;
sterol sulfokinase;
sterol sulfotransferase;
alcohol/hydroxysteroid sulfotransferase;
3beta-hydroxysteroid sulfotransferase;
3'-phosphoadenylyl-sulfate:alcohol sulfotransferase

Class

Transferases;
Transferring sulfur-containing groups;
Sulfotransferases

Sysname

3'-phosphoadenylyl-sulfate:alcohol sulfonotransferase

Reaction(IUBMB)

3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate [RN:R00629]

Reaction(KEGG)

R00629 > R03405 R08977 R08978

Substrate

3'-phosphoadenylyl sulfate [CPD:C00053];
alcohol [CPD:C00069]

Product

adenosine 3',5'-bisphosphate [CPD:C00054];
alkyl sulfate [CPD:C02000]

Comment

Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15 steroid sulfotransferase).

History

EC 2.8.2.2 created 1961, modified 1980

Pathway

ec00140

Steroid hormone biosynthesis

ec01100

Metabolic pathways

Orthology

K01015

alcohol sulfotransferase

Genes

HSA:	6820(SULT2B1)

PTR:	747360(SULT2B1)

PPS:	100993458(SULT2B1)

GGO:	101129679(SULT2B1)

PON:	100441770(SULT2B1)

PPYG:

129020267(SULT2B1)

NLE:	100587860(SULT2B1)

HMH:	116478250(SULT2B1)

SSYN:

129459292(SULT2B1)

MCC:	718739(SULT2B1)

MCF:	102147126(SULT2B1)

MTHB:

126943587

MNI:	105478644(SULT2B1)

CSAB:

103234980(SULT2B1)

CATY:

105595444(SULT2B1)

PANU:

101012116(SULT2B1)

TGE:	112612327(SULT2B1)

MLEU:

105539185(SULT2B1)

RRO:	104666566(SULT2B1)

RBB:	108523626(SULT2B1)

TFN:	117091512(SULT2B1)

PTEH:

111520064(SULT2B1)

CANG:

105514885(SULT2B1)

CJC:	100402576(SULT2B1)

SBQ:	101043923(SULT2B1)

CIMI:

108283964(SULT2B1)

ANAN:

135276693(SULT2B1)

CSYR:

103250053(SULT2B1)

MMUR:

105865660(SULT2B1)

LCAT:

123623869(SULT2B1)

PCOQ:

105809281(SULT2B1)

OGA:	100949637(SULT2B1)

MMU:	54200(Sult2b1)

MCAL:

110298618(Sult2b1)

MPAH:

110316585(Sult2b1)

RNO:	292915(Sult2b1)

MCOC:

116102233(Sult2b1)

ANU:	117712593(Sult2b1)

ASYL:

127668946(Sult2b1)

MUN:	110550470(Sult2b1)

CGE:	100774216(Sult2b1)

MAUA:

101822973(Sult2b1)

PROB:

127213938(Sult2b1)

PLEU:

114684722(Sult2b1)

MORG:

121446746(Sult2b1)

MFOT:

126488158

AAMP:

119802946(Sult2b1)

NGI:	103743615(Sult2b1)

HGL:	101723933(Sult2b1)

CPOC:

100730889(Sult2b1)

CCAN:

109682673(Sult2b1)

DORD:

105994134(Sult2b1)

DSP:	122125590(Sult2b1)

PLOP:

125338863(Sult2b1)

NCAR:

124967609

MMMA:

107151573(Sult2b1)

ITI:	101971938(Sult2b1)

OCU:	100008957(SULT2B1)

OPI:	101529733(SULT2B1)

TUP:	102477821(SULT2B1)

GVR:	103587737(SULT2B1)

CFA:	484403(SULT2B1)

CLUD:

112645203(SULT2B1)

VVP:	112931439(SULT2B1)

VLG:	121485128(SULT2B1)

NPO:	129500161(SULT2B1)

AML:	100480162(SULT2B1)

UMR:	103657236(SULT2B1)

UAH:	113243345(SULT2B1)

UAR:	123776363(SULT2B1)

ELK:

111160811

LLV:

125088649

MPUF:

101676565(SULT2B1)

MNP:	132005243(SULT2B1)

MLK:	131818248(SULT2B1)

NVS:	122911869(SULT2B1)

ORO:	101377746(SULT2B1)

EJU:	114199480(SULT2B1)

ZCA:	113936092(SULT2B1)

MLX:	117998223(SULT2B1)

NSU:	110572928(SULT2B1)

LWW:

102730298

FCA:	101086863(SULT2B1)

PYU:	121018885(SULT2B1)

PBG:	122494875(SULT2B1)

PVIV:

125153369(SULT2B1)

LRUF:

124510789

LGF:	123578101(SULT2B1)

AJU:

106988649

PTG:	107180097(SULT2B1)

PPAD:

109253129(SULT2B1)

PUC:

125916137

PLEZ:

122208433(SULT2B1)

HHV:	120240271(SULT2B1)

BTA:	531192(SULT2B1)

BOM:	102284976(SULT2B1)

BBUB:

102413917(SULT2B1)

BBIS:

104995719(SULT2B1)

CHX:	102183905(SULT2B1)

OAS:	101122543(SULT2B1)

BTAX:

128063680(SULT2B1)

CSUM:

138096651(SULT2B1)

ODA:	120872190(SULT2B1)

CCAD:

122421679(SULT2B1)

MREE:

136158862(SULT2B1)

OVR:	110133905(SULT2B1)

MBEZ:

129546590(SULT2B1)

SSC:	100626471(SULT2B1)

CFR:	102503575(SULT2B1)

CBAI:

105062751(SULT2B1)

CDK:	105102909(SULT2B1)

VPC:	102531952(SULT2B1)

BACU:

103009833(SULT2B1)

BMUS:

118884560(SULT2B1)

LVE:	103078205(SULT2B1)

OOR:	101269222(SULT2B1)

LALB:

132509969(SULT2B1)

DLE:	111180462(SULT2B1)

PCAD:

102993424(SULT2B1) 114484129

PSIU:

116744199(SULT2B1)

NASI:

112415554(SULT2B1)

ECB:	100147584(SULT2B1)

EPZ:	103540017(SULT2B1)

EAI:	106838308(SULT2B1)

MYB:	102258569(SULT2B1)

MYD:	102766101(SULT2B1)

MMYO:

118655351(SULT2B1)

MDT:	132216652(SULT2B1)

MYUM:

138999513(SULT2B1)

PKL:	118721088(SULT2B1)

EFUS:

103297662(SULT2B1)

MNA:	107531856(SULT2B1)

DRO:	112310043(SULT2B1)

AJM:	119061853(SULT2B1)

PDIC:

114511521(SULT2B1)

PHAS:

123830334(SULT2B1)

MMF:	118638877(SULT2B1)

PPAM:

129082902(SULT2B1)

HAI:	109391113(SULT2B1)

RFQ:	117034349(SULT2B1)

PALE:

102887796(SULT2B1)

PGIG:

120606972(SULT2B1)

PVP:	105301808(SULT2B1)

RAY:	107498807(SULT2B1)

MJV:	108393142(SULT2B1)

TOD:	119249517(SULT2B1)

SARA:

101557568(SULT2B1)

SFUM:

130043526(SULT2B1)

SETR:

126028606(SULT2B1)

LAV:	100677254(SULT2B1)

TMU:

101357729

ETF:	101646712(SULT2B1)

DNM:	101414748(SULT2B1)

MDO:	100015166 100032213(SULT2B1)

GAS:	123239818(SULT2B1) 123240896

SHR:	100933402(SULT2B1)

AFZ:

127556538

PCW:	110219960(SULT2B1)

TVP:	118836285(SULT2B1)

PBRV:

138173386(SULT2B1)

OAA:	100091264(SULT2B1)

TACU:

119933520(SULT2B1) 119942036

GGA:	426825(SULT2B1) 769841(SULT2B1L2)

MGP:	104915391 104916553

TPAI:

128091801

LMUT:

125685596

NMEL:

110390406

APLA:

101803633

ACYG:

106049358 136789329

CATA:

118259879

AFUL:

116500188

ATRC:

139587100

PHI:

102107518

CCAE:

111944211

ACOE:

138101531 138101568

ZLE:

135442044

SHAB:

115618821(SULT2B1)

ACHC:

115337793(SULT2B1)

HALD:

104319416(SULT2B1)

HLE:	104833448(SULT2B1)

AGEN:

126034857 126037443

HHAR:

128135787 128138207(SULT2B1)

GCL:

127028798

LDI:	104349876(SULT2B1)

AVIT:

104281055

EGZ:	104121797 104132607

NNI:

104022627

PCRI:

104034486

PCAO:

104044917

PADL:

103922156(SULT2B1)

AFOR:

103904101

FGA:	104079070(SULT2B1)

GSTE:

104261243(SULT2B1)

CBOY:

140644629 140644677(SULT2B1)

MUI:

104535911

CUCA:

128849790(SULT2B1)

BREG:

104634045(SULT2B1)

OHA:	104327266(SULT2B1)

ACAR:

104526599(SULT2B1)

CVF:	104291832(SULT2B1)

RTD:	128901519(SULT2B1)

CRID:

134507757(SULT2B1)

AAM:	106482022(SULT2B1)

AROW:

112967833 112977344(SULT2A1)

TGT:

104569199

DNE:

112993757

SCAM:

104144146(SULT2B1)

ASN:	102370043 102370269 102374158(SULT2B1) 112547856 112547865

AMJ:	102564321 102566944 102567072(SULT2B1) 102567166 102567399

PSS:	102444110 102445395 102445634 102451084 102455996 102459302 102460158 106731311

CMY:	102934596 102944260 102945897 102945923(SULT2A1) 102948381 119564114 119564115 119564130 119564220

CCAY:

125625885 125625886 125627963 125627973 125629393(SULT2A1)

DCC:	119846874(SULT2A1) 119846917 119846925 119847879 119847880

CPIC:

101931482 101934332 101940106 101940389 101941757 101949120 101951164

TST:	117869690 117870374 117887244

CABI:

116828383 116829841 116832324 116832364

MRV:	120388111(SULT2A1) 120388177 120388638 120390290 120390305 120390346 120390558 120394299 120394934

ACS:	100553860 100553861 100562572(sult2b1) 100563874(sult2a1) 100566507

ASAO:

132777853(SULT2B1) 132777856 132778016(SULT2A1) 132780226 132780260 132780261

PVT:	110070728 110070729 110071039 110071040 110071353 110081834(SULT2B1) 110086456(SULT2A1) 110090910

SUND:

121915722 121915723 121915850 121934429 121934544(SULT2A1) 121934833

PBI:	103055981 103057086(SULT2B1) 103065422(SULT2A1)

PMUR:

107283076 107283091(SULT2B1)

CTIG:

120304443(SULT2B1) 120304445

TSR:	106538457 106538474(SULT2B1)

PGUT:

117666712 117666715(SULT2B1)

APRI:

131198612(SULT2B1) 131198677

PTEX:

113443576(SULT2B1) 113443661

NSS:	113421782(SULT2B1) 113430279

VKO:	123025837 123026003 123026017 123026018 123032228(SULT2B1) 123033502(SULT2A1)

PMUA:

114581565 114581817(SULT2A1) 114582569 114602409 114603007 114603545 114603546 114603548 114603550

PRAF:

128399423 128400022 128400041(SULT2A1) 128418545 128418546 128418547 128418548 128418550 128418557 128419230

ZVI:	118082756 118086720 118086722 118086723 118086735 118086736 118087278 118087279 118094955(SULT2A1) 118095017 118095366

HCG:	128330521 128330523 128332473 128333006 128333007 128333009 128333029 128333039 128333108 128333416

GJA:	107109745(SULT2A1) 107111136(SULT2B1) 107111138 107116282 107119862 107119874 107119875

STOW:

125427909 125434879 125434880 125444931(SULT2A1) 125445171 125445173

EMC:	129329419 129338924(SULT2B1) 129339535 129340285(SULT2A1) 129342838 129343340 129343341 129343397

XLA:	100036899(sult2b1.L) 100037047(XB5850668.L) 108695914 108695915 108697829(sult2a1.S) 432283(sult2b1.S) 447414(XB986081.L) 496246(sult2a1.L)

XTR:	100144919 100144988(sult2a1) 100497264 100498051 493303(sult2b1)

NPR:	108785344 108804656 108804663 108804664 108804676

RTEM:

120915266 120915276 120915277 120915278 120915279

BBUF:

120986919 120986920 121002875 121002884 121002897 121002918 121002964

BGAR:

122926132 122926652 122926655 122926656 122926657 122926658 122928577

PWL:	138246167 138246230 138246238 138246239 138246240 138246241

MUO:	115466512 115466517 115466519 115466520 115466521 115466522

GSH:	117368057 117368187 117368437 117368666 117368669

DRE:	338214(sult2st1) 777792(sult2st3) 777793(sult2st2)

SRX:	107709748 107720447 107728452

SANH:

107653937 107666756 107686539

SGH:	107556976 107592535 107595631

CCAR:

109056133 109087782 109099995

CAUA:

113059248 113068185 113112028 113112029 113115751

CGIB:

127969043 127974651 128025731 128025744 128031017

PTET:

122332652 122332653 122332683 122359980(sult2st3)

LROH:

127174594(sult2st2) 127178349 127178350

OMC:	131521896(sult2st3) 131550769 131551154

PPRM:

120462270(sult2st3) 120464365 120464366

MAMB:

125243500(sult2st3) 125255744 125255745

CIDE:

127497016 127523858 127523859

CERY:

137007909 137008123 137028022(sult2st3)

MASI:

127423403 127427089 127453373 127454172

TROS:

130549351 130558498(sult2st3)

TDW:	130432904(sult2st3) 130439268(sult2st2)

MANU:

129420554 129420556 129420557 129448624(sult2st3)

PDAB:

135734654 135734655 135734656 135739218 135739405 135739406 135739407 135789124(sult2st3)

IPU:	108256624 108256625 108274314(sult2st2)

IFU:	128599756 128599757 128617287

PHYP:

113527546 113532983 113532984

SMEO:

124375572 124389035 124389131 124389449 124403721(sult2st3)

TFD:	113658242 113658494 113658501 113658511 113658516 113658531 113662517

TVC:	132839934 132840168 132840194(sult2st2) 132840244 132840312

CGAR:

128513931 128514208 128514303 128514315 128541520

NGRA:

132867973(sult2st3) 132897691 132898191

TRN:	134301169(sult2st3) 134322132 134322166(sult2st2)

AMEX:

103022604(sult2st2) 125783164 125801052(sult2st3)

CMAO:

118799114(sult2st3) 118809516 118809518

EEE:	113567889 113567890 113591225 113591233

CHAR:

105888823(sult2st2) 105891760 105891818 105891819

SPIL:

134069866 134069867 134069869 134070091 134082071(sult2st3) 134082741

TRU:	101063424 101073052

TFS:	130532860(sult2st3) 130539181

TNG:	GSTEN00010463G001 GSTEN00035347G001

LCO:	104928100 109139570 109141280

NCC:	104953899 104958048

TBEN:

117474514 117474599 117474600 117476984 117480712(sult2st3) 117482602 117482605

CGOB:

115021503 115024401

PGEO:

117443528 117443583 117461417(sult2st3) 117465036 117465154

GACU:

117540789(sult2st3) 117542154 117542155 117553498 117557329 117561472 117562402

EMAC:

134861420(sult2st3) 134870955 134871273

ELY:	117246828 117247673 117247675 117265516(sult2st3)

EFO:	125881225 125893068(sult2st3)

PLEP:

121945665 121946290(sult2st3) 121959155

SLUC:

116035284 116035286

ECRA:

117945698 117945699

ESP:	116690953 116690954

PFLV:

114557276 114557916

GAT:	120810920(sult2st3)

PPUG:

119198079(sult2st3)

AFB:	129091648(sult2st2) 129109117(sult2st3)

CLUM:

117745906(sult2st3) 117749070

PSWI:

130212769(sult2st3)

CANA:

137781310 137781387 137781388 137789918(sult2st2)

CVE:	137891545(sult2st3)

MSAM:

119896296 119897946(sult2st3) 119915713

SCHU:

122867796(sult2st2) 122881007(sult2st3)

CUD:	121513279 121513280 121528421(sult2st2)

SPUL:

138584389(sult2st3) 138593576(sult2st2)

LMIX:

132955041(sult2st2) 132984307

ALAT:

119006836(sult2st3) 119009692 119009730

ASTR:

137588409 137588448 137588528 137588765

MZE:	101464137 101464842 101465138

ONL:	100689712 100690729 100699736

OAU:	116314942 116314955 116330883

OLA:	101174401 105358383 110016637 111948904

OML:	112143258(sult2st3) 112154309

CSAI:

133419189 133440909(sult2st3)

XMA:	102227112 102233316

XCO:	114142100 114152265

XHE:	116717607 116727467

PRET:

103478312 103482099

PFOR:

103138712 103144293 103144306 103144321

PLAI:

106941170 106964850

PMEI:

106905856 106912445 106932097

GAF:	122822830(sult2st2) 122831532(sult2st3) 122831533

PPRL:

129367615(sult2st3) 129377536

CVG:	107100614 107102636

CTUL:

119786505(sult2st3) 119796021

GMU:	124865332(sult2st3) 124874895

NFU:	107378808 107378889 107378973 107388288

KMR:	108232169 108232170 108232171 108232222 108235891

ALIM:

106514200 106531616 106531619 106531627 106532538 106532779

NWH:	119409529 119410215 119423346

AOCE:

111570215 111570216 111586829(sult2st3) 111588291

EJA:	138194505(sult2st3) 138201862

BFRE:

138617810(sult2st3) 138626033(sult2st2)

MCEP:

125016691(sult2st3) 125022919 125022920

CSEM:

103382275 103388296(sult1a4)

POV:	109626928 109626929 109631988

SSEN:

122758785 122775271(sult2st3)

SSOE:

131448576 131448831 131470779(sult2st3)

HHIP:

117753415 117777521(sult2st3)

HSP:	118113851 118114381

PPLT:

128426341 128449963(sult2st3)

SMAU:

118288101 118307020(sult2st3) 124849426

LCF:	108884614 108888273(sult2st3)

SDU:	111219889 111220026 111227911

SLAL:

111651360 111652851 111658026

XGL:	120794342 120794475

HCQ:	109524798 109529640

SSCV:

125974682(sult2st3) 125991575

SBIA:

133495295 133500834(sult2st3)

PEE:	133401211(sult2st3) 133417730

PTAO:

133469384 133479447(sult2st3)

BPEC:

110153228 110153229 110165533 110171716

ENY:	140374349(sult2st3)

MALB:

109951549 109958493

BSPL:

114843459(sult2st3) 114846572 114850878

SJO:	128366309(sult2st3) 128381012 128381338

SSCO:

133983748(sult2st3) 134003232(sult2st2) 134003339

GMH:	115531230 115531231 115531232 115531233 115531239 115554407 115561388

SASA:

100196439(st2b1) 106577720

STRU:

115176607 115201290 115201291 115201292

OTW:	112224376(sult2st2) 112227238(sult2st3)

OMY:	110498876 110519921(sult2st3)

OGO:	124005617(sult2st3) 124040130(sult2st2)

ONE:	115102169 115144155

OKI:	109870546 109907335

OKE:	118357383 118367774(sult2st3)

OMM:	135520456(sult2st3) 135523735

OCLA:

139376673 139390596

SALP:

111959133 111964716

SNH:	120029754 120031105 120031110 120031207

CCLU:

121547439(sult2st2) 121556080(sult2st3)

ELS:	105019139 105025052

OEP:	134023422(sult2st3) 134031314 134031316 134031484 134031556 134031557

SFM:	108919138 108927345 108927354

PKI:	111842469 111848628 111848629

AANG:

118221788 118227988 118228002

AROT:

135237820(sult2st3) 135248310

CCOG:

133106962 133109648 133136255 133136276 133136431 133137641 133137655 133138497 133139475

LOC:	102686480 102687521

PSPA:

121296016 121296046 121299250

ARUT:

117424649 117424650 117434029 117964913

PSEX:

120517859

LCM:	102363673 102365349(SULT2B1)

CMK:	103182604 103185646

CPLA:

122562308

HOC:

132827901

LERI:

129693780 129708472

PMRN:

116940218

LRJ:	133350669 133350670 133363013

BFO:

118426989

BBEL:

109471310 109471690 109475895 109482973

AJJ:

139966823

ARUN:

117298341

AAMU:

139939759

AFIL:

140146354

SKO:	100366298 100370990 102801339 102804046

PFLL:

139114335 139115455 139118070 139119539 139120572 139121984 139124184 139124404 139124405 139124407 139124408 139128052 139129897 139132437 139132663 139135221 139150773 139150776 139152301

PPOI:

119104722

DSV:	119445450 119450457 119458867

RSAN:

119391075 119398872 119398873

RMP:	119169089 119179164

LSAX:

138977980

HRF:	124146885 124150766

HRJ:	124260243 124261640 124270675 124288627

HASI:

137282196

HCRA:

139462119

CRG:	105336931 117682159 136274631

CANU:

128160212 128162364 128164339

CVN:	111110170 111110187 111127935

OED:	125646093 125647087 125648255 125657065 125657067

PMAX:

117332293 117345165

MMER:

123533869 123535360 123545823

RPHI:

132712981 132726310 132727900 132728740 132741532 132741834 132757972 132757973

DPOL:

127836052 127840533 127842971 127864093

MAEA:

128207556

LAK:

106175170

LLON:

135485911

RBI:	RB2501_06690

MESQ:

C7H62_1064

» show all

Reference

1 [PMID:6935986]

Authors

Lyon ES, Jakoby WB.

Title

The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases.

Journal

Arch Biochem Biophys 202:474-81 (1980)
DOI:10.1016/0003-9861(80)90452-X

Reference

2 [PMID:6173569]

Authors

Lyon ES, Marcus CJ, Wang JL, Jakoby WB.

Title

Hydroxysteroid sulfotransferase.

Journal

Methods Enzymol 77:206-13 (1981)
DOI:10.1016/s0076-6879(81)77027-7

Other DBs

ExplorEnz - The Enzyme Database:

2.8.2.2

IUBMB Enzyme Nomenclature:

2.8.2.2

ExPASy - ENZYME nomenclature database:

2.8.2.2

BRENDA, the Enzyme Database:

2.8.2.2

CAS:

9032-76-2

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DNA sequence (123)   
   RefSeq(nuc) (27)   
   GenBank (76)   
   EMBL (20)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   InterPro (2)   
All databases (723)   

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